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Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
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Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology
inferredcites →https://doi.org/10.1002/hlca.200490087openalex-snapshot
Spectroscopic Properties of 4‐Pyridoxic Acid as a Function of pH and Solvent
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PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules
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Metabonomics of acute kidney injury in children after cardiac surgery
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The HF-SCF energy of HIV-1 MNgp120 V3 hairpin loop conformers
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Differential Contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in Vivo Renal Uptake of Uremic Toxins in Rats
inferredcites →https://doi.org/10.1016/j.autrev.2009.02.016openalex-snapshot
Autoimmune disease in the era of the metagenome
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inferredcites →https://doi.org/10.1016/j.jchromb.2009.11.040openalex-snapshot
Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry
inferredcites →https://doi.org/10.1016/j.tox.2004.08.023openalex-snapshot
d-Serine-induced nephrotoxicity: a HPLC–TOF/MS-based metabonomics approach
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XCMS2: Processing Tandem Mass Spectrometry Data for Metabolite Identification and Structural Characterization
inferredcites →https://doi.org/10.1021/ci000393lopenalex-snapshot
Internet Software for the Calculation of the Lipophilicity and Aqueous Solubility of Chemical Compounds
inferredcites →https://doi.org/10.1038/ncpneph0558openalex-snapshot
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
inferredcites →https://doi.org/10.1038/sj.bjp.0704482openalex-snapshot
Uraemic toxins induce proximal tubular injury via organic anion transporter 1‐mediated uptake
inferredcites →https://doi.org/10.1038/sj.ki.5000170openalex-snapshot
Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models
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Targeted Metabolomics Identifies Glucuronides of Dietary Phytoestrogens as a Major Class of MRP3 Substrates In Vivo
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Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney
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Interaction of Organic Cations with Organic Anion Transporters
inferredcites →https://doi.org/10.1074/jbc.m508050200openalex-snapshot
Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice
inferredcites →https://doi.org/10.1074/jbc.m703467200openalex-snapshot
Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs
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Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination
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KEGG: Kyoto Encyclopedia of Genes and Genomes
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The NIH Human Microbiome Project
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The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair
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The core gut microbiome, energy balance and obesity
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Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis
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Remote Communication through Solute Carriers and ATP Binding Cassette Drug Transporter Pathways: An Update on the Remote Sensing and Signaling Hypothesis
inferredcites →https://doi.org/10.1152/ajpcell.00619.2004openalex-snapshot
Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
inferredcites →https://doi.org/10.1152/ajprenal.00389.2009openalex-snapshot
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by1H-NMR-based metabonomics
inferredcites →https://doi.org/10.1152/ajprenal.00722.2009openalex-snapshot
A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease
inferredcites →https://doi.org/10.1152/physiolgenomics.00014.2004openalex-snapshot
Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
inferredcites →https://doi.org/10.1152/physiolgenomics.90309.2008openalex-snapshot
Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members
inferredcites →https://doi.org/10.1158/1055-9965.epi-08-0792openalex-snapshot
The Human Microbiome Project: Getting to the Guts of the Matter in Cancer Epidemiology
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Widespread ectopic expression of olfactory receptor genes
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Molecular structure input on the web
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A Branch-and-Bound approach for tautomer enumeration
inferredcites →https://doi.org/10.1373/clinchem.2008.107565openalex-snapshot
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Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human health
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Meta-analysis of untargeted metabolomic data from multiple profiling experiments
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Deletion of Multispecific Organic Anion Transporter Oat1/Slc22a6 Protects against Mercury-induced Kidney Injury
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Human Urinary Composition Controls Antibacterial Activity of Siderocalin*
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Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
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Beyond drug-drug interactions: effects of transporter inhibition on endobiotics, nutrients and toxins
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Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease
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From old uraemic toxins to new uraemic toxins: place of ‘omics’
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Differences in proximal tubular solute clearance across common etiologies of chronic kidney disease
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000427openalex-snapshot
The systems biology of uric acid transporters
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New insights into uremia-induced alterations in metabolic pathways
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The Impact of Uremia and Intestinal Dysbiosis on Hepatic Drug Metabolism in a Rat Model of Progressive Chronic Kidney Disease
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Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate
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The spectrum of kidney dysfunction requiring chronic dialysis therapy: Implications for clinical practice and future clinical trials
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Organic Anion Transporter 3 Interacts Selectively with Lipophilic β-Lactam Antibiotics
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6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects
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“Target-Site” Drug Metabolism and Transport
inferred← citeshttps://doi.org/10.1124/dmd.115.065250openalex-snapshot
Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
inferred← citeshttps://doi.org/10.1124/dmd.115.068254openalex-snapshot
Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers
inferred← citeshttps://doi.org/10.1124/dmd.116.074492openalex-snapshot
Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins
inferred← citeshttps://doi.org/10.1124/dmd.117.077586openalex-snapshot
Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys
inferred← citeshttps://doi.org/10.1124/dmd.121.000486openalex-snapshot
Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition
inferred← citeshttps://doi.org/10.1124/dmd.121.000702openalex-snapshot
Emerging Roles of the Human Solute Carrier 22 Family
inferred← citeshttps://doi.org/10.1124/jpet.116.232660openalex-snapshot
Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach
inferred← citeshttps://doi.org/10.1126/sciadv.ads5405openalex-snapshot
Structures and membrane interactions of human OAT1 in complex with clinical used drugs
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010611-134748openalex-snapshot
Xenobiotic Metabolomics: Major Impact on the Metabolome
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010617-052713openalex-snapshot
The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-030322-084058openalex-snapshot
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory
inferred← citeshttps://doi.org/10.1152/ajprenal.00252.2022openalex-snapshot
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease
inferred← citeshttps://doi.org/10.1152/ajprenal.00262.2021openalex-snapshot
Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease
inferred← citeshttps://doi.org/10.1152/physrev.00009.2021openalex-snapshot
Regulation of solute carriers oct2 and OAT1/3 in the kidney: a phylogenetic, ontogenetic, and cell dynamic perspective
inferred← citeshttps://doi.org/10.1152/physrev.00025.2013openalex-snapshot
The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
inferred← citeshttps://doi.org/10.1152/physrev.00027.2022openalex-snapshot
Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
inferred← citeshttps://doi.org/10.1152/physrev.00035.2018openalex-snapshot
Metabolomics for Investigating Physiological and Pathophysiological Processes
inferred← citeshttps://doi.org/10.1159/000346223openalex-snapshot
Review of Protein-Bound Toxins, Possibility for Blood Purification Therapy
inferred← citeshttps://doi.org/10.1159/000441578openalex-snapshot
Uremic Solutes Produced by Colon Microbes
inferred← citeshttps://doi.org/10.1161/circulationaha.123.065517openalex-snapshot
Metabolic Communication by SGLT2 Inhibition
inferred← citeshttps://doi.org/10.1172/jci.insight.133817openalex-snapshot
Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease
inferred← citeshttps://doi.org/10.1172/jci.insight.160437openalex-snapshot
The kidney drug transporter OAT1 regulates gut microbiome–dependent host metabolism
inferred← citeshttps://doi.org/10.1172/jci.insight.172341openalex-snapshot
Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis
inferred← citeshttps://doi.org/10.1177/20543581211057708openalex-snapshot
A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol
inferred← citeshttps://doi.org/10.1186/s11658-024-00550-4openalex-snapshot
Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
inferred← citeshttps://doi.org/10.1186/s12882-019-1249-6openalex-snapshot
Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course
inferred← citeshttps://doi.org/10.1194/jlr.m027433openalex-snapshot
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis
inferred← citeshttps://doi.org/10.1208/s12248-012-9413-yopenalex-snapshot
Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease
inferred← citeshttps://doi.org/10.1271/bbb.130178openalex-snapshot
Transport of Xanthurenic Acid by Rat/Human Organic Anion Transporters OAT1 and OAT3
inferred← citeshttps://doi.org/10.1371/journal.pone.0040796openalex-snapshot
Organic Anion and Cation SLC22 “Drug” Transporter (Oat1, Oat3, and Oct1) Regulation during Development and Maturation of the Kidney Proximal Tubule
inferred← citeshttps://doi.org/10.1371/journal.pone.0086223openalex-snapshot
Mealtime, Temporal, and Daily Variability of the Human Urinary and Plasma Metabolomes in a Tightly Controlled Environment
inferred← citeshttps://doi.org/10.1371/journal.pone.0152969openalex-snapshot
Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2
inferred← citeshttps://doi.org/10.1371/journal.pone.0168117openalex-snapshot
Uremic Solutes in Chronic Kidney Disease and Their Role in Progression
inferred← citeshttps://doi.org/10.1371/journal.pone.0260449openalex-snapshot
High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein
inferred← citeshttps://doi.org/10.1515/hsz-2018-0446openalex-snapshot
Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells
inferred← citeshttps://doi.org/10.1667/rr2950.1openalex-snapshot
Radiation Metabolomics. 5. Identification of Urinary Biomarkers of Ionizing Radiation Exposure in Nonhuman Primates by Mass Spectrometry-Based Metabolomics
inferred← citeshttps://doi.org/10.1681/asn.0000000943openalex-snapshot
Sodium-Glucose Cotransporter 2 Inhibitors in Autosomal Dominant Polycystic Kidney Disease
inferred← citeshttps://doi.org/10.1681/asn.2013020126openalex-snapshot
Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
inferred← citeshttps://doi.org/10.1681/asn.2013060597openalex-snapshot
Prominent Accumulation in Hemodialysis Patients of Solutes Normally Cleared by Tubular Secretion
inferred← citeshttps://doi.org/10.17076/eb622openalex-snapshot
ORGANIC ANION TRANSPORTERS. MOLECULAR DIVERSITY, STRUCTURE, CONTRIBUTION TO THE FUNCTIONING OF THE XENOBIOTIC BIOTRANSFORMATION SYSTEM IN ANIMALS (A REWIEW)
inferred← citeshttps://doi.org/10.18632/oncotarget.5633openalex-snapshot
Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma
inferred← citeshttps://doi.org/10.21007/etd.cghs.2018.0457openalex-snapshot
Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
inferred← citeshttps://doi.org/10.21007/etd.cghs.2018.0461openalex-snapshot
Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
inferred← citeshttps://doi.org/10.2147/ijnrd.s216673openalex-snapshot
The Importance of Tubular Function in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.2215/cjn.02440314openalex-snapshot
Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters
inferred← citeshttps://doi.org/10.2215/cjn.05610519openalex-snapshot
Alterations of Proximal Tubular Secretion in Autosomal Dominant Polycystic Kidney Disease
inferred← citeshttps://doi.org/10.2215/cjn.10350818openalex-snapshot
Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation
inferred← citeshttps://doi.org/10.2215/cjn.11120919openalex-snapshot
Association of Tubular Solute Clearance with Symptom Burden in Incident Peritoneal Dialysis
inferred← citeshttps://doi.org/10.2215/cjn.12001017openalex-snapshot
Proximal Tubular Secretory Clearance
inferred← citeshttps://doi.org/10.2220/biomedres.35.223openalex-snapshot
Diuresis by intravenous administration of xanthurenic acid in rats, and inhibition by probenecid
inferred← citeshttps://doi.org/10.25772/nk8t-g774openalex-snapshot
ASSESSMENT OF THE DRUG-DRUG INTERACTION POTENTIAL OF ANIONIC COMPONENTS IN THE DIET AND HERBAL MEDICINES ON ORGANIC ANION TRANSPORTERS (SLC22 FAMILY)
inferred← citeshttps://doi.org/10.3164/jcbn.14-61openalex-snapshot
Therapeutic effect of Xue Niao An on glyoxylate-induced calcium oxalate crystal deposition based on urinary metabonomics approach
inferred← citeshttps://doi.org/10.33448/rsd-v11i4.27237openalex-snapshot
Online hemodiafiltration (HDF) versus high-flux hemodialysis (hf-HD): A review
inferred← citeshttps://doi.org/10.3389/fmed.2021.592602openalex-snapshot
Uremic Toxins in Organ Crosstalk
inferred← citeshttps://doi.org/10.3389/fmed.2021.790783openalex-snapshot
The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword
inferred← citeshttps://doi.org/10.3389/fphar.2021.802539openalex-snapshot
The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates
inferred← citeshttps://doi.org/10.3390/cancers14194772openalex-snapshot
Organic Anion Transporters (OAT) and Other SLC22 Transporters in Progression of Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/fishes9020051openalex-snapshot
A Review of P-Glycoprotein Function and Regulation in Fish
inferred← citeshttps://doi.org/10.3390/ijms21051791openalex-snapshot
Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs
inferred← citeshttps://doi.org/10.3390/ijms26136328openalex-snapshot
Transporter-Mediated Interactions Between Uremic Toxins and Drugs: A Hidden Driver of Toxicity in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3390/jpm8020014openalex-snapshot
Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition
inferred← citeshttps://doi.org/10.3390/molecules18054844openalex-snapshot
Metabolomics in Adult and Pediatric Nephrology
inferred← citeshttps://doi.org/10.3390/nu16142242openalex-snapshot
In Vivo Regulation of Small Molecule Natural Products, Antioxidants, and Nutrients by OAT1 and OAT3
inferred← citeshttps://doi.org/10.3390/pharmaceutics13101720openalex-snapshot
Molecular Properties of Drugs Handled by Kidney OATs and Liver OATPs Revealed by Chemoinformatics and Machine Learning: Implications for Kidney and Liver Disease
inferred← citeshttps://doi.org/10.3390/pharmaceutics16111355openalex-snapshot
Recent Advances on the Regulations of Organic Anion Transporters
inferred← citeshttps://doi.org/10.3390/pharmaceutics17060685openalex-snapshot
Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease
inferred← citeshttps://doi.org/10.3390/pharmaceutics18080975openalex-snapshot
Slc22a23 Proficiency Influences Rat Behavioral Responses After Lysophosphatidylcholine C20:4n6 Administration
inferred← citeshttps://doi.org/10.3390/toxins10010033openalex-snapshot
Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update
inferred← citeshttps://doi.org/10.3390/toxins10060226openalex-snapshot
Uremic Toxin Clearance and Cardiovascular Toxicities
inferred← citeshttps://doi.org/10.3390/toxins14030177openalex-snapshot
The Interplay between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction
inferred← citeshttps://doi.org/10.3390/toxins8120358openalex-snapshot
Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies
inferred← citeshttps://doi.org/10.3892/mmr.2024.13256openalex-snapshot
Mechanism of flavonoids in the treatment of gouty arthritis (Review)
inferred← citeshttps://doi.org/10.4155/bio-2017-0265openalex-snapshot
A Pharmaceutical Industry Perspective on Transporter and CYP-Mediated Drug–Drug Interactions: Kidney Transporter Biomarkers
inferred← citeshttps://doi.org/10.5281/zenodo.38156openalex-snapshot
Synthesis Of Bireciprocal Wave Digital Filters With Equiripple Amplitude And Phase
inferred← citeshttps://doi.org/10.5772/intechopen.80335openalex-snapshot
Towards Metabolic Biomarkers for the Diagnosis and Prognosis of CKD
inferred← citeshttps://doi.org/10.70675/560e6547z0ad3z4f54zaebfz75c173de646dopenalex-snapshot
Influence des toxines urémiques sur la morbi-mortalité cardiovasculaire des patients en Maladie Rénale Chronique dans la cohorte CKD-REIN
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