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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities
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inferred← citeshttps://doi.org/10.2139/ssrn.4162524openalex-extracted
Identification and Analysis of Phenyl Methyl Carbamate Released from Adducted Hemoglobin for Methyl Isocyanate Exposure Verification
inferred← citeshttps://doi.org/10.1002/0471140856.tx1714s45openalex-snapshot
LC‐MS/MS Quantitation of Mercapturic Acid Conjugates of Lipid Peroxidation Products as Markers of Oxidative Stress
inferred← citeshttps://doi.org/10.1002/3527600418.bb10168stad0009openalex-snapshot
Diphenylmethan‐4,4′‐diisocyanat (einatembare Fraktion) [BAT Value Documentation in German language, 2000]
inferred← citeshttps://doi.org/10.1002/3527600418.bb10168stae0915openalex-snapshot
4,4′‐Methylene diphenyl diisocyanate (MDI) (inhalable fraction) [BAT Value Documentation, 2000]
inferred← citeshttps://doi.org/10.1002/9780470921920.edm074openalex-snapshot
Bioactivation by Phase‐ II ‐Enzyme‐Catalyzed Conjugation of Xenobiotics
inferred← citeshttps://doi.org/10.1002/cbdv.200890199openalex-snapshot
The Biochemistry of Drug Metabolism – An Introduction
inferred← citeshttps://doi.org/10.1002/em.20469openalex-snapshot
Analysis of cellular response to isocyanate using N‐succinimidyl N‐methylcarbamate exposure in cultured mammalian cells
inferred← citeshttps://doi.org/10.1002/hlca.19980810536openalex-snapshot
Synthesis and Spectroscopic Characterization of 4‐Chlorophenyl Isocyanate (= 1‐chloro‐4‐isocyanatobenzene) Adducts with Amino Acids as Potential Dosimeters for the Biomonitoring of Isocyanate Exposure
inferred← citeshttps://doi.org/10.1002/jat.2550130105openalex-snapshot
Influence of methylamine and N,N'‐dimethylurea, the hydrolysis products of methyl isocyanate, on its systemic toxicity
inferred← citeshttps://doi.org/10.1002/jbt.20260openalex-snapshot
Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes
inferred← citeshttps://doi.org/10.1002/jms.3306openalex-snapshot
Novel glutathione conjugates of phenyl isocyanate identified by ultra‐performance liquid chromatography/electrospray ionization mass spectrometry and nuclear magnetic resonance
inferred← citeshttps://doi.org/10.1002/ps.1135openalex-snapshot
Physical, chemical and environmental properties of selected chemical alternatives for the pre‐plant use of methyl bromide as soil fumigant
inferred← citeshttps://doi.org/10.1002/tera.1420460109openalex-snapshot
Toxicity of the methyl isocyanate metabolite S‐(N‐methylcarbamoyl)GSH on mouse embryos in culture
inferred← citeshttps://doi.org/10.1006/taap.1996.8083openalex-snapshot
Comparative Cytotoxicity of Monocrotaline and Its Metabolites in Cultured Pulmonary Artery Endothelial Cells
inferred← citeshttps://doi.org/10.1007/bf00198883openalex-snapshot
Bile duct hyperplasia and transient liver parenchymal cell alteration by methylisocyanate
inferred← citeshttps://doi.org/10.1007/bf02039657openalex-snapshot
Mechanistic studies on the conjugation of methyl isocyanate with N-acetyl-cysteine in rats
inferred← citeshttps://doi.org/10.1007/s00204-003-0462-yopenalex-snapshot
Changes in low molecular weight DNA fragmentation in white blood cells after diisocyanate exposure of workers
inferred← citeshttps://doi.org/10.1007/s00204-016-1846-0openalex-snapshot
Comparison of biological effects with albumin adducts of 4,4′-methylenediphenyl diisocyanate in workers
inferred← citeshttps://doi.org/10.1007/s002040050234openalex-snapshot
Effect of methyl isocyanate on rabbit cardiac Na+, K+-ATPase
inferred← citeshttps://doi.org/10.1007/s002040050507openalex-snapshot
N-methylcarbamoyl adducts at the N-terminal valine of globin in workers exposed to N,N-dimethylformamide
inferred← citeshttps://doi.org/10.1007/s00216-015-8719-xopenalex-snapshot
Analysis of 18 urinary mercapturic acids by two high-throughput multiplex-LC-MS/MS methods
inferred← citeshttps://doi.org/10.1007/s00280-003-0740-7openalex-snapshot
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O 6 -alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition
inferred← citeshttps://doi.org/10.1007/s00420-002-0371-zopenalex-snapshot
The effects of co-exposure to methyl ethyl ketone on the biological monitoring of occupational exposure to N,N-dimethylformamide
inferred← citeshttps://doi.org/10.1007/s10565-009-9127-9openalex-snapshot
Regulation of isocyanate-induced apoptosis, oxidative stress, and inflammation in cultured human neutrophils
inferred← citeshttps://doi.org/10.1007/s11095-011-0500-zopenalex-snapshot
Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice
inferred← citeshttps://doi.org/10.1007/s11356-020-12135-7openalex-snapshot
Characterization of US population levels of urinary methylcarbamoyl mercapturic acid, a metabolite of N,N-dimethylformamide and methyl isocyanate, in the National Health and Nutrition Examination Survey (NHANES) 2005–2006 and 2011–2016
inferred← citeshttps://doi.org/10.1016/0006-2952(94)90290-9openalex-snapshot
Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes
inferred← citeshttps://doi.org/10.1016/0006-2952(94)90392-1openalex-snapshot
Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate
inferred← citeshttps://doi.org/10.1016/0041-008x(90)90100-9openalex-snapshot
Glutathione conjugate mediated toxicities*1
inferred← citeshttps://doi.org/10.1016/0168-1176(92)85066-9openalex-snapshot
Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology
inferred← citeshttps://doi.org/10.1016/b978-0-12-374484-5.00021-3openalex-snapshot
Methyl Isocyanate: The Bhopal Gas
inferred← citeshttps://doi.org/10.1016/b978-0-12-819090-6.00026-xopenalex-snapshot
Methyl isocyanate: the Bhopal gas
inferred← citeshttps://doi.org/10.1016/b978-0-444-88871-6.50020-9openalex-snapshot
Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology
inferred← citeshttps://doi.org/10.1016/b978-012088523-7/50008-9openalex-snapshot
The Bhopal Accident and Methyl Isocyanate Toxicity
inferred← citeshttps://doi.org/10.1016/j.bcp.2005.02.016openalex-snapshot
Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine™ and BCNU
inferred← citeshttps://doi.org/10.1016/j.cbi.2003.06.003openalex-snapshot
Studies on the methyl isocyanate adducts with globin
inferred← citeshttps://doi.org/10.1016/j.cbi.2006.12.008openalex-snapshot
Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide
inferred← citeshttps://doi.org/10.1016/j.cbi.2013.06.005openalex-snapshot
Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
inferred← citeshttps://doi.org/10.1016/j.cellbi.2009.03.008openalex-snapshot
Induction of genomic instability in cultured human colon epithelial cells following exposure to isocyanates
inferred← citeshttps://doi.org/10.1016/j.chroma.2022.463454openalex-snapshot
Identification and determination of phenyl methyl carbamate released from adducted hemoglobin for methyl isocyanate exposure verification
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2009.10.025openalex-snapshot
Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study
inferred← citeshttps://doi.org/10.1016/j.ijheh.2025.114730openalex-snapshot
Deconjugation enzymes - pitfalls, contamination risks, and practical insights from human biomonitoring of bisphenols, phthalates, and oxidative stress markers
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2011.03.009openalex-snapshot
Micronuclei, hemoglobin adducts and respiratory tract irritation in mice after inhalation of toluene diisocyanate (TDI) and 4,4′-methylenediphenyl diisocyanate (MDI)
inferred← citeshttps://doi.org/10.1016/j.msec.2017.05.084openalex-snapshot
Hemostatic kaolin-polyurethane foam composites for multifunctional wound dressing applications
inferred← citeshttps://doi.org/10.1016/j.tiv.2016.07.011openalex-snapshot
Identification of novel reaction products of methylene-bis - phenylisocyanate (“MDI”) with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction
inferred← citeshttps://doi.org/10.1016/j.tox.2006.02.014openalex-snapshot
Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct
inferred← citeshttps://doi.org/10.1016/j.toxlet.2016.08.008openalex-snapshot
Determination of albumin adducts of 4,4′-methylenediphenyl diisocyanate after specific inhalative challenge tests in workers
inferred← citeshttps://doi.org/10.1016/j.yrtph.2011.09.007openalex-snapshot
Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology
inferred← citeshttps://doi.org/10.1016/s0045-6535(97)00081-7openalex-snapshot
The lessons of bhopal [toxic] MIC gas disaster scope for expanding global biomonitoring and environmental specimen banking
inferred← citeshttps://doi.org/10.1016/s0378-4347(01)00242-0openalex-snapshot
Analysis of urinary N-acetyl-S-(N-methylcarbamoyl)cysteine, the mercapturic acid derived from N,N-dimethylformamide
inferred← citeshttps://doi.org/10.1016/s0378-4347(99)00372-2openalex-snapshot
Simultaneous determination of two human urinary metabolites of N,N-dimethylformamide using gas chromatography–thermionic sensitive detection with mass spectrometric confirmation
inferred← citeshttps://doi.org/10.1016/s0887-2333(97)00094-5openalex-snapshot
Potency of monomethyl-, dimethylformamide and some of their metabolites to induce abnormal development in a limb Bud organ culture
inferred← citeshttps://doi.org/10.1016/s1054-3589(08)61032-7openalex-snapshot
Reversibility in Glutathione-Conjugate Formation
inferred← citeshttps://doi.org/10.1016/s1570-0232(02)00501-9openalex-snapshot
Mercapturic acids in the biological monitoring of occupational exposure to chemicals
inferred← citeshttps://doi.org/10.1021/ac9506544openalex-snapshot
Design and Evaluation of a New Thermospray Liquid/Liquid Extractor for the Extraction of Semivolatile and Nonvolatile Organic Compounds from Water
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00266openalex-snapshot
New Method to Biomonitor Workers Exposed to 1,6-Hexamethylene Diisocyanate
inferred← citeshttps://doi.org/10.1021/acsami.3c06873openalex-snapshot
Controlled Degradation of Polycaprolactone Polymers through Ultrasound Stimulation
inferred← citeshttps://doi.org/10.1021/ar00009a003openalex-snapshot
Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo
inferred← citeshttps://doi.org/10.1021/tx000029gopenalex-snapshot
Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne
inferred← citeshttps://doi.org/10.1021/tx020063qopenalex-snapshot
Bioactivation of Benzylamine to Reactive Intermediates in Rodents: Formation of Glutathione, Glutamate, and Peptide Conjugates
inferred← citeshttps://doi.org/10.1021/tx034238nopenalex-snapshot
Characterization of Glutathione Conjugates of the Remoxipride Hydroquinone Metabolite NCQ-344 Formed in Vitro and Detection following Oxidation by Human Neutrophils
inferred← citeshttps://doi.org/10.1021/tx0600853openalex-snapshot
Biomarkers for Isocyanate Exposure: Synthesis of Isocyanate DNA Adducts
inferred← citeshttps://doi.org/10.1021/tx060093jopenalex-snapshot
Identification of Potential Genomic Biomarkers of Hepatotoxicity Caused by Reactive Metabolites of N -Methylformamide: Application of Stable Isotope Labeled Compounds in Toxicogenomic Studies
inferred← citeshttps://doi.org/10.1021/tx2002433openalex-snapshot
Toluene Diisocyanate Reactivity with Glutathione Across a Vapor/Liquid Interface and Subsequent Transcarbamoylation of Human Albumin
inferred← citeshttps://doi.org/10.1021/tx300347eopenalex-snapshot
Synthetic Approaches To Obtain Amino Acid Adducts of 4,4′-Methylenediphenyl Diisocyanate
inferred← citeshttps://doi.org/10.1021/tx5005002openalex-snapshot
Glutathione Reaction Products with a Chemical Allergen, Methylene-diphenyl Diisocyanate, Stimulate Alternative Macrophage Activation and Eosinophilic Airway Inflammation
inferred← citeshttps://doi.org/10.1021/tx900270zopenalex-snapshot
New Isocyanate-Specific Albumin Adducts of 4,4′-Methylenediphenyl Diisocyanate (MDI) in Rats
inferred← citeshttps://doi.org/10.1021/tx950201uopenalex-snapshot
Microsomal Oxidation of N,N-Diethylformamide and Its Effect on P450-Dependent Monooxygenases in Rat Liver
inferred← citeshttps://doi.org/10.1021/tx960201+openalex-snapshot
Formation, Solvolysis, and Transcarbamoylation Reactions of Bis(S-glutathionyl) Adducts of 2,4- and 2,6-Diisocyanatotoluene
inferred← citeshttps://doi.org/10.1021/tx990096eopenalex-snapshot
Isocyanate-Specific Hemoglobin Adduct in Rats Exposed to 4,4‘-Methylenediphenyl Diisocyanate
inferred← citeshttps://doi.org/10.1039/c0em00595aopenalex-snapshot
Protein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam
inferred← citeshttps://doi.org/10.1074/jbc.273.39.25079openalex-snapshot
Free Radical Intermediates of Phenytoin and Related Teratogens
inferred← citeshttps://doi.org/10.1080/00039896.1992.9938379openalex-snapshot
On the Bioavailability of Methyl Isocyanate in the Bhopal Gas Leak
inferred← citeshttps://doi.org/10.1080/00498254.2017.1329569openalex-snapshot
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
inferred← citeshttps://doi.org/10.1080/01480545.2018.1517773openalex-snapshot
Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats
inferred← citeshttps://doi.org/10.1080/03602532.2016.1225756openalex-snapshot
Non-cytochrome P450-mediated bioactivation and its toxicological relevance
inferred← citeshttps://doi.org/10.1080/10715760903037699openalex-snapshot
Mitochondrial oxidative stress elicits chromosomal instability after exposure to isocyanates in human kidney epithelial cells
inferred← citeshttps://doi.org/10.1080/13547500701395636openalex-snapshot
Determination of isocyanate biomarkers in construction site workers
inferred← citeshttps://doi.org/10.1080/135475097231599openalex-snapshot
Reactions of 4 methylphenyl isocyanate with amino acids
inferred← citeshttps://doi.org/10.1080/135475098231101openalex-snapshot
Mercapturic acids as biomarkers of exposure to electrophilic chemicals:applications to environmental and industrial chemicals
inferred← citeshttps://doi.org/10.1080/15287399309531816openalex-snapshot
The Bhopal accident and methyl isocyanate toxicity
inferred← citeshttps://doi.org/10.1080/200140911116861openalex-snapshot
Biological Effects of Acetamide, Formamide, and Their Mono and Dimethyl Derivatives: An Update
inferred← citeshttps://doi.org/10.1080/20014091111974openalex-snapshot
Carcinogenic Risk of Toluene Diisocyanate and 4,4′-Methylenediphenyl Diisocyanate: Epidemiological and Experimental Evidence
inferred← citeshttps://doi.org/10.1093/carcin/17.4.715openalex-snapshot
Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions
inferred← citeshttps://doi.org/10.1093/mutage/13.4.345openalex-snapshot
Mitotic disturbance by carbaryl and the metabolite 1-naphthol may involve kinase-mediatedphosphorylation of 1-naphthol to the protein phosphatase inhibitor 1-naphthylphosphate
inferred← citeshttps://doi.org/10.1093/toxsci/kfh202openalex-snapshot
Developmental Toxicity of the Dithiocarbamate Pesticide Sodium Metam in Zebrafish
inferred← citeshttps://doi.org/10.1097/00008571-200107000-00007openalex-snapshot
Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure.
inferred← citeshttps://doi.org/10.1097/00008571-200204000-00007openalex-snapshot
N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk
inferred← citeshttps://doi.org/10.1111/nyas.14344openalex-snapshot
Alleviation of methyl isocyanate−induced airway obstruction and mortality by tissue plasminogen activator
inferred← citeshttps://doi.org/10.1136/oem.2004.017129openalex-snapshot
The use of biomarkers of exposure ofN,N-dimethylformamide in health risk assessment and occupational hygiene in the polyacrylic fibre industry
inferred← citeshttps://doi.org/10.1165/ajrcmb.20.1.3320openalex-snapshot
Expression and Inducibility of Alpha, Pi, and Mu Glutathione S- Transferase Protein and mRNA in Murine Lung
inferred← citeshttps://doi.org/10.1177/096032719301200207openalex-snapshot
Do the Hydrolysis Products, Methylamine and N,N'-Dimethylurea, Play any Role in the Methyl Isocyanate-Induced Haematological and Biochemical Changes in Rabbits?
inferred← citeshttps://doi.org/10.1186/1745-6673-6-9openalex-snapshot
Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies
inferred← citeshttps://doi.org/10.3109/00498254.2015.1118576openalex-snapshot
In vitrocleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1
inferred← citeshttps://doi.org/10.3109/00498259309059420openalex-snapshot
Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent
inferred← citeshttps://doi.org/10.3109/10409239509083491openalex-snapshot
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I
inferred← citeshttps://doi.org/10.3109/10409239509083492openalex-snapshot
The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part II
inferred← citeshttps://doi.org/10.3109/1354750x.2010.490880openalex-snapshot
Determination of a new biomarker in subjects exposed to 4,4′-methylenediphenyl diisocyanate
inferred← citeshttps://doi.org/10.3109/1354750x.2016.1172117openalex-snapshot
Determination of albumin adducts of 4,4′-methylenediphenyl diisocyanate in workers of a 4,4′-methylenedianiline factory
inferred← citeshttps://doi.org/10.3390/biom13020329openalex-snapshot
Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4
inferred← citeshttps://doi.org/10.4172/2157-2518.1000171openalex-snapshot
Evaluation of Microsatellite Instability and Apoptosis in Gall Bladder Malignancy from Patients of a Cohort Exposed to Methylisocyanate
inferred← citeshttps://doi.org/10.4238/vol8-1gmr544openalex-snapshot
Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
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