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Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.20634openalex-snapshot
Mechanisms of benzarone and benzbromarone‐induced hepatic toxicity†
inferredcites →https://doi.org/10.1002/hep.22439openalex-snapshot
Hepatocyte nuclear factor 4Α is implicated in endoplasmic reticulum stress–induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H Potential conflict of interest: Nothing to report.
inferredcites →https://doi.org/10.1002/minf.201000061openalex-snapshot
Best Practices for QSAR Model Development, Validation, and Exploitation
inferredcites →https://doi.org/10.1002/mnfr.200900169openalex-snapshot
The Japanese toxicogenomics project: Application of toxicogenomics
inferredcites →https://doi.org/10.1007/bf00566533openalex-snapshot
Disposition and oxidative metabolism of phenylbutazone in man
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Hierarchical QSAR technology based on the Simplex representation of molecular structure
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Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: Comparison with dihydrocoumarin and other coumarin metabolites
inferredcites →https://doi.org/10.1016/0378-4274(93)90045-yopenalex-snapshot
Genotoxicity studies of benzofuran dioxetanes and epoxides with isolated DNA, bacteria and mammalian cells
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A safety assessment of coumarin taking into account species-specificity of toxicokinetics
inferredcites →https://doi.org/10.1016/j.jhep.2006.06.004openalex-snapshot
ER stress: Can the liver cope?
inferredcites →https://doi.org/10.1016/j.taap.2008.01.036openalex-snapshot
Gene expression profiling in rat liver treated with compounds inducing phospholipidosis
inferredcites →https://doi.org/10.1016/j.tox.2008.05.013openalex-snapshot
A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats
inferredcites →https://doi.org/10.1016/j.toxlet.2008.09.017openalex-snapshot
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
inferredcites →https://doi.org/10.1016/s0006-2952(00)00586-4openalex-snapshot
Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase
inferredcites →https://doi.org/10.1016/s0026-895x(25)12345-6openalex-snapshot
Metabolic activation and toxicity of acetaminophen and related analogs. A theoretical study.
inferredcites →https://doi.org/10.1016/s0090-9556(25)06329-9openalex-snapshot
Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases.
inferredcites →https://doi.org/10.1016/s0090-9556(25)06364-0openalex-snapshot
Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.
inferredcites →https://doi.org/10.1021/ci034203topenalex-snapshot
Combinatorial QSAR of Ambergris Fragrance Compounds
inferredcites →https://doi.org/10.1021/ci0505269openalex-snapshot
A Structural Analogue Approach to the Prediction of the Octanol−Water Partition Coefficient
inferredcites →https://doi.org/10.1021/ci060117sopenalex-snapshot
On Outliers and Activity CliffsWhy QSAR Often Disappoints
inferredcites →https://doi.org/10.1021/ci100176xopenalex-snapshot
Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research
inferredcites →https://doi.org/10.1021/ci900203nopenalex-snapshot
Application of Random Forest Approach to QSAR Prediction of Aquatic Toxicity
inferredcites →https://doi.org/10.1021/ci980033mopenalex-snapshot
Novel Variable Selection Quantitative Structure−Property Relationship Approach Based on the k -Nearest-Neighbor Principle
inferredcites →https://doi.org/10.1021/tx900451ropenalex-snapshot
Modeling Liver-Related Adverse Effects of Drugs Using kNearest Neighbor Quantitative Structure−Activity Relationship Method
inferredcites →https://doi.org/10.1038/ng1175openalex-snapshot
Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis
inferredcites →https://doi.org/10.1073/pnas.091062498openalex-snapshot
Significance analysis of microarrays applied to the ionizing radiation response
inferredcites →https://doi.org/10.1093/toxsci/50.1.82openalex-snapshot
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice
inferredcites →https://doi.org/10.1093/toxsci/kfh162openalex-snapshot
Metabolic Detoxification Determines Species Differences in Coumarin-Induced Hepatotoxicity
inferredcites →https://doi.org/10.1093/toxsci/kfm131openalex-snapshot
Acute Hepatotoxicity: A Predictive Model Based on Focused Illumina Microarrays
inferredcites →https://doi.org/10.1093/toxsci/kfm150openalex-snapshot
Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses
inferredcites →https://doi.org/10.1093/toxsci/kfm156openalex-snapshot
A Gene Expression Biomarker Provides Early Prediction and Mechanistic Assessment of Hepatic Tumor Induction by Nongenotoxic Chemicals
inferredcites →https://doi.org/10.1158/0008-5472.can-09-0813openalex-snapshot
c-Myc and eIF4F Constitute a Feedforward Loop That Regulates Cell Growth: Implications for Anticancer Therapy
inferredcites →https://doi.org/10.1177/0960327109104528openalex-snapshot
Gene expression profiling in rat liver treated with compounds inducing elevation of bilirubin
inferredcites →https://doi.org/10.1186/1756-0500-7-157openalex-snapshot
In silico prediction of protein-protein interactions in human macrophages
inferredcites →https://doi.org/10.1198/016214507000001120openalex-snapshot
Distance-Weighted Discrimination
inferredcites →https://doi.org/10.1198/jasa.2010.tm08487openalex-snapshot
Weighted Distance Weighted Discrimination and Its Asymptotic Properties
inferredcites →https://doi.org/10.1289/ehp.1002476openalex-snapshot
Use of in Vitro HTS-Derived Concentration–Response Data as Biological Descriptors Improves the Accuracy of QSAR Models of in Vivo Toxicity
inferredcites →https://doi.org/10.1289/ehp.10573openalex-snapshot
Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure–Activity Relationship Models of Animal Carcinogenicity
inferredcites →https://doi.org/10.1517/17425255.4.6.759openalex-snapshot
Structure – ADME relationship: still a long way to go?
inferredcites →https://doi.org/10.2131/jts.31.471openalex-snapshot
PROFILING OF GENE EXPRESSION IN RAT LIVER AND RAT PRIMARY CULTURED HEPATOCYTES TREATED WITH PEROXISOME PROLIFERATORS
inferredcites →https://doi.org/10.2131/jts.32.469openalex-snapshot
IDENTIFICATION OF GLUTATHIONE DEPLETION-RESPONSIVE GENES USING PHORONE-TREATED RAT LIVER
inferredcites →https://doi.org/10.2131/jts.34.281openalex-snapshot
Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy
inferredcites →https://doi.org/10.2174/138161205774414510openalex-snapshot
Why Drugs Fail - A Study on Side Effects in New Chemical Entities
inferredcites →https://doi.org/10.2174/138161207782794257openalex-snapshot
Predictive QSAR Modeling Workflow, Model Applicability Domains, and Virtual Screening
inferredcites →https://doi.org/10.2174/157340908785747465openalex-snapshot
ISIDA - Platform for Virtual Screening Based on Fragment and Pharmacophoric Descriptors
inferredcites →https://doi.org/10.2217/pgs.10.37openalex-snapshot
Use of Transcriptomics in Understanding Mechanisms of Drug-Induced Toxicity
inferredcites →https://doi.org/10.3109/10408447309082019openalex-snapshot
Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage
inferredcites →https://doi.org/10.4155/fmc.10.194openalex-snapshot
Per Aspera Ad Astra : Application of Simplex Qsar Approach in Antiviral Research
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Drug‐Induced Hepatotoxicity: Advances in Preclinical Predictive Strategies and Tools
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Trust, but Verify II: A Practical Guide to Chemogenomics Data Curation
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Comparison of the Predictive Performance and Interpretability of Random Forest and Linear Models on Benchmark Data Sets
inferred← citeshttps://doi.org/10.1021/acs.jcim.6c00357openalex-snapshot
ToxCML: A Hybrid mfCoQ-RASAR-Based Platform Integrating Consensus QSAR and Read-Across for Comprehensive Multi-End Point Toxicity Assessment
inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00124openalex-snapshot
Multi-Descriptor Read Across (MuDRA): A Simple and Transparent Approach for Developing Accurate Quantitative Structure–Activity Relationship Models
inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00297openalex-snapshot
QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b01048openalex-snapshot
Three-Level Hepatotoxicity Prediction System Based on Adverse Hepatic Effects
inferred← citeshttps://doi.org/10.1021/acsestwater.3c00350openalex-snapshot
In Vitro Biodescriptors Derived from Time Series Toxicogenomics Data in In Silico QSAR Improve the Phenotypic Toxicity Prediction
inferred← citeshttps://doi.org/10.1021/acsomega.4c04474openalex-snapshot
Identification of Optimal Machine Learning Algorithms and Molecular Fingerprints for Explainable Toxicity Prediction Models Using ToxCast/Tox21 Bioassay Data
inferred← citeshttps://doi.org/10.1021/ci500342qopenalex-snapshot
Generalized Workflow for Generating Highly Predictive in Silico Off-Target Activity Models
inferred← citeshttps://doi.org/10.1021/tx400110fopenalex-snapshot
Integrative Chemical–Biological Read-Across Approach for Chemical Hazard Classification
inferred← citeshttps://doi.org/10.1021/tx500145hopenalex-snapshot
Big Data in Chemical Toxicity Research: The Use of High-Throughput Screening Assays To Identify Potential Toxicants
inferred← citeshttps://doi.org/10.1038/srep46277openalex-snapshot
Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
inferred← citeshttps://doi.org/10.1039/9781782624059-00001openalex-snapshot
Introduction to Predictive Toxicogenomics for Carcinogenicity
inferred← citeshttps://doi.org/10.1039/9781849737920-00163openalex-snapshot
Computers Instead of Cells: Computational Modeling of Chemical Toxicity
inferred← citeshttps://doi.org/10.1039/c6gc01147kopenalex-snapshot
A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives
inferred← citeshttps://doi.org/10.1039/d5sc04919aopenalex-snapshot
Structure–activity relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures
inferred← citeshttps://doi.org/10.1053/j.gastro.2013.12.032openalex-snapshot
Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives
inferred← citeshttps://doi.org/10.1063/1.4727854openalex-snapshot
Electron attachment to antipyretics: Possible implications of their metabolic pathways
inferred← citeshttps://doi.org/10.1080/02772248.2014.961458openalex-snapshot
Rules relating hepatotoxicity with structural attributes of drugs
inferred← citeshttps://doi.org/10.1080/07391102.2023.2276889openalex-snapshot
Virtual screening, molecular docking, molecular dynamics, and MM-GBSA approaches identify prospective fructose-1,6-bisphosphatase inhibitors from pineapple for diabetes management
inferred← citeshttps://doi.org/10.1080/1062936x.2016.1197310openalex-snapshot
Investigation of the influence of protein corona composition on gold nanoparticle bioactivity using machine learning approaches
inferred← citeshttps://doi.org/10.1080/1062936x.2016.1201142openalex-snapshot
Chemical and in vitro biological information to predict mouse liver toxicity using recursive random forests
inferred← citeshttps://doi.org/10.1080/17425255.2018.1539076openalex-snapshot
A critical review of adverse effects to the kidney: mechanisms, data sources, and in silico tools to assist prediction
inferred← citeshttps://doi.org/10.1080/17425255.2020.1807936openalex-snapshot
Pharmacodynamic and safety considerations for influenza vaccine and adjuvant design
inferred← citeshttps://doi.org/10.1080/17425255.2022.2122810openalex-snapshot
Modeling drug-induced liver injury: current status and future prospects
inferred← citeshttps://doi.org/10.1080/17460441.2019.1664467openalex-snapshot
4D- quantitative structure–activity relationship modeling: making a comeback
inferred← citeshttps://doi.org/10.1080/17568919.2024.2379240openalex-snapshot
Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy
inferred← citeshttps://doi.org/10.1089/nat.2013.0436openalex-snapshot
Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern
inferred← citeshttps://doi.org/10.1093/bib/bbac196openalex-snapshot
The prediction approach of drug-induced liver injury: response to the issues of reproducible science of artificial intelligence in real-world applications
inferred← citeshttps://doi.org/10.1093/bib/bbz165openalex-snapshot
Predicting drug-induced hepatotoxicity based on biological feature maps and diverse classification strategies
inferred← citeshttps://doi.org/10.1093/bioinformatics/btu456openalex-snapshot
Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis
inferred← citeshttps://doi.org/10.1093/nar/gkw450openalex-snapshot
Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells
inferred← citeshttps://doi.org/10.1093/toxsci/kfaa005openalex-snapshot
Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data
inferred← citeshttps://doi.org/10.1093/toxsci/kfad041openalex-snapshot
A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo
inferred← citeshttps://doi.org/10.1093/toxsci/kfae078openalex-snapshot
A computational framework to in silico screen for drug-induced hepatocellular toxicity
inferred← citeshttps://doi.org/10.1093/toxsci/kfs095openalex-snapshot
Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data
inferred← citeshttps://doi.org/10.1093/toxsci/kfs159openalex-snapshot
A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening
inferred← citeshttps://doi.org/10.1093/toxsci/kfs223openalex-snapshot
A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science
inferred← citeshttps://doi.org/10.1093/toxsci/kfu234openalex-snapshot
FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology
inferred← citeshttps://doi.org/10.1093/toxsci/kfx287openalex-snapshot
In Silico Prediction of Chemical-Induced Hepatocellular Hypertrophy Using Molecular Descriptors
inferred← citeshttps://doi.org/10.1101/2022.01.25.477777openalex-snapshot
A high-throughput approach to identify reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1101/837773openalex-snapshot
PharmOmics: A Species- and Tissue-specific Drug Signature Database and Online Tool for Drug Repurposing
inferred← citeshttps://doi.org/10.1109/access.2018.2889151openalex-snapshot
A New Evolutionary Machine Learning Approach for Identifying Pyrene Induced Hepatotoxicity and Renal Dysfunction in Rats
inferred← citeshttps://doi.org/10.1109/icicip60808.2024.10477820openalex-snapshot
Drug Toxicity Classification Based on ReliefF and K-means Algorithm
inferred← citeshttps://doi.org/10.1109/jbhi.2025.3556766openalex-snapshot
BFGTP: A BERT-Guided Two-Stage Molecular Representation Learning Framework for Toxicity Prediction
inferred← citeshttps://doi.org/10.1109/tcbb.2018.2858756openalex-snapshot
Developing a Multi-Dose Computational Model for Drug-Induced Hepatotoxicity Prediction Based on Toxicogenomics Data
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2012.01411.xopenalex-snapshot
Prediction of Organ Toxicity Endpoints by QSAR Modeling Based on Precise Chemical‐Histopathology Annotations
inferred← citeshttps://doi.org/10.1124/jpet.117.242354openalex-snapshot
Synergistic Cytotoxicity from Drugs and Cytokines In Vitro as an Approach to Classify Drugs According to Their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof-of-Concept Study
inferred← citeshttps://doi.org/10.1145/3428757.3429147openalex-snapshot
Chemoinformatics for Data Scientists
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-011112-140248openalex-snapshot
Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization
inferred← citeshttps://doi.org/10.1155/2020/4795140openalex-snapshot
Machine‐Learning Prediction of Oral Drug‐Induced Liver Injury (DILI) via Multiple Features and Endpoints
inferred← citeshttps://doi.org/10.1155/2021/2293871openalex-snapshot
Joint Decision-Making Model Based on Consensus Modeling Technology for the Prediction of Drug-Induced Liver Injury
inferred← citeshttps://doi.org/10.1177/026119291304100307openalex-snapshot
Is Phenylbutazone a Genotoxic Carcinogen? A Weight-of-Evidence Assessment
inferred← citeshttps://doi.org/10.1177/026119291604400603openalex-snapshot
Comparing the CORAL and Random Forest Approaches for Modelling the In Vitro Cytotoxicity of Silica Nanomaterials
inferred← citeshttps://doi.org/10.1186/1471-2105-15-s16-s2openalex-snapshot
An integrative model of multi-organ drug-induced toxicity prediction using gene-expression data
inferred← citeshttps://doi.org/10.1186/s13020-022-00617-4openalex-snapshot
Developing an artificial intelligence method for screening hepatotoxic compounds in traditional Chinese medicine and Western medicine combination
inferred← citeshttps://doi.org/10.1186/s13321-018-0304-9openalex-snapshot
Evaluating parameters for ligand-based modeling with random forest on sparse data sets
inferred← citeshttps://doi.org/10.1186/s13321-018-0325-4openalex-snapshot
Large scale comparison of QSAR and conformal prediction methods and their applications in drug discovery
inferred← citeshttps://doi.org/10.1186/s13321-019-0359-2openalex-snapshot
An integrated quantitative structure and mechanism of action-activity relationship model of human serum albumin binding
inferred← citeshttps://doi.org/10.1186/s13321-019-0383-2openalex-snapshot
SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data
inferred← citeshttps://doi.org/10.1186/s13321-023-00758-0openalex-snapshot
School of cheminformatics in Latin America
inferred← citeshttps://doi.org/10.1248/cpb.c12-00475openalex-snapshot
Poly(DL-lactide-co-glycolic acid) Nanoparticle Design and Payload Prediction: A Molecular Descriptor Based Study
inferred← citeshttps://doi.org/10.1289/ehp.1104782openalex-snapshot
Wind of Change Challenges Toxicological Regulators
inferred← citeshttps://doi.org/10.1289/ehp.1509763openalex-snapshot
Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data
inferred← citeshttps://doi.org/10.1371/journal.pone.0097640openalex-snapshot
Cross-Platform Toxicogenomics for the Prediction of Non-Genotoxic Hepatocarcinogenesis in Rat
inferred← citeshttps://doi.org/10.1371/journal.pone.0155419openalex-snapshot
Integrated Computational Solution for Predicting Skin Sensitization Potential of Molecules
inferred← citeshttps://doi.org/10.1371/journal.pone.0253855openalex-snapshot
Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs
inferred← citeshttps://doi.org/10.14309/crj.0000000000000480openalex-snapshot
Drug-Induced Liver Injury Caused by “Khat,” an Herbal Stimulant
inferred← citeshttps://doi.org/10.14573/altex.1602071openalex-snapshot
Hepatotoxicity prediction by systems biology modeling of disturbed metabolic pathways using gene expression data
inferred← citeshttps://doi.org/10.14573/altex.1610201openalex-snapshot
In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method
inferred← citeshttps://doi.org/10.14573/altex.1610201sopenalex-snapshot
In vitro to in vivo extrapolation for drug-induced liver injury using a pair ranking method_suppl
inferred← citeshttps://doi.org/10.14573/altex.1710141openalex-snapshot
Computational approaches to chemical hazard assessment
inferred← citeshttps://doi.org/10.14573/altex.2002291openalex-snapshot
Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs
inferred← citeshttps://doi.org/10.14573/altex.2002291sopenalex-snapshot
Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs_suppl
inferred← citeshttps://doi.org/10.14573/altex.2006262openalex-snapshot
Grouping of UVCB substances with new approach methodologies (NAMs) data
inferred← citeshttps://doi.org/10.14573/altex.2006262sopenalex-snapshot
Grouping of UVCB substances with new approach methodologies (NAMs) data_suppl
inferred← citeshttps://doi.org/10.14573/altex.2107051openalex-snapshot
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays
inferred← citeshttps://doi.org/10.1504/ijbnn.2013.054508openalex-snapshot
Protein expression profiles of intestinal epithelial co-cultures: effect of functionalised carbon nanotube exposure
inferred← citeshttps://doi.org/10.1517/17425255.2012.648613openalex-snapshot
In silicomodels for drug-induced liver injury – current status
inferred← citeshttps://doi.org/10.1517/17460441.2012.651122openalex-snapshot
The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery
inferred← citeshttps://doi.org/10.1787/9789264274792-enopenalex-snapshot
Fundamental And Guiding Principles For (Q)SAR Analysis Of Chemical Carcinogens with Mechanistic Considerations
inferred← citeshttps://doi.org/10.18063/jmds.2016.01.001openalex-snapshot
Investigative safety strategies to improve success in drug development
inferred← citeshttps://doi.org/10.2131/jts.37.723openalex-snapshot
Predictive genomic biomarkers for drug-induced nephrotoxicity in mice
inferred← citeshttps://doi.org/10.2131/jts.47.337openalex-snapshot
CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis
inferred← citeshttps://doi.org/10.2174/1381612822666160420141435openalex-snapshot
Modelling DNA Repair Pathways: Recent Advances and Future Directions
inferred← citeshttps://doi.org/10.2174/1381612826666201019104712openalex-snapshot
Stem Cell Based Preclinical Drug Development and Toxicity Prediction
inferred← citeshttps://doi.org/10.2174/1568026614666140506121116openalex-snapshot
Integrative Approaches for Predicting In Vivo Effects of Chemicals from their Structural Descriptors and the Results of Short-Term Biological Assays
inferred← citeshttps://doi.org/10.2174/1568026614666140929120749openalex-snapshot
Virtual Screening Strategies in Medicinal Chemistry: The State of the Art and Current Challenges
inferred← citeshttps://doi.org/10.2217/bmm.13.146openalex-snapshot
Toward Predictive Models for Drug-Induced Liver Injury in Humans: Are we There Yet?
inferred← citeshttps://doi.org/10.24729/00000582openalex-snapshot
Studies on Toxicity Biomarker Research and Usability Validation Based on Toxicogenomic Technologies : Particular Reference to Drug-induced Nephrotoxicity and Myelosuppressive Anemia
inferred← citeshttps://doi.org/10.3109/10408444.2013.811215openalex-snapshot
Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action
inferred← citeshttps://doi.org/10.3389/fchem.2025.1527008openalex-snapshot
Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis
inferred← citeshttps://doi.org/10.3389/fgene.2017.00168openalex-snapshot
A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics
inferred← citeshttps://doi.org/10.3389/fphar.2019.00042openalex-snapshot
Deep Neural Network Models for Predicting Chemically Induced Liver Toxicity Endpoints From Transcriptomic Responses
inferred← citeshttps://doi.org/10.3389/fphar.2022.879907openalex-snapshot
RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across
inferred← citeshttps://doi.org/10.3389/fphar.2022.910205openalex-snapshot
Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms
inferred← citeshttps://doi.org/10.3390/app10217727openalex-snapshot
Synthesis, Molecular Docking, Druglikeness Analysis, and ADMET Prediction of the Chlorinated Ethanoanthracene Derivatives as Possible Antidepressant Agents
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