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γH2AX, pChk1, and Wip1 as Potential Markers of Persistent DNA Damage Derived from Dibenzo[a,l]pyrene and PAH-Containing Extracts from Contaminated Soils
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/em.20486openalex-snapshot
Exposure of HepG2 cells to low levels of PAH‐containing extracts from contaminated soils results in unpredictable genotoxic stress responses
inferredcites →https://doi.org/10.1002/etc.5620220701openalex-snapshot
DEGRADATION AND FORMATION OF POLYCYCLIC AROMATIC COMPOUNDS DURING BIOSLURRY TREATMENT OF AN AGED GASWORKS SOIL
inferredcites →https://doi.org/10.1002/mc.20385openalex-snapshot
Anti‐diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti‐diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation
inferredcites →https://doi.org/10.1007/978-3-7643-8336-7_6openalex-snapshot
On the impact of the molecule structure in chemical carcinogenesis
inferredcites →https://doi.org/10.1007/s00204-006-0140-yopenalex-snapshot
A comparison of the concentration–effect relationships of PAHs on CYP1A induction in HepG2 and Mcf7 cells
inferredcites →https://doi.org/10.1007/s10555-008-9127-xopenalex-snapshot
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
inferredcites →https://doi.org/10.1016/0092-8674(92)90416-aopenalex-snapshot
Proliferating cell nuclear antigen is required for DNA excision repair
inferredcites →https://doi.org/10.1016/j.bcp.2008.03.025openalex-snapshot
Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy
inferredcites →https://doi.org/10.1016/j.cbi.2008.09.015openalex-snapshot
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
inferredcites →https://doi.org/10.1016/j.dnarep.2004.03.024openalex-snapshot
H2AX: the histone guardian of the genome
inferredcites →https://doi.org/10.1016/j.dnarep.2011.06.002openalex-snapshot
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells
inferredcites →https://doi.org/10.1016/j.jhazmat.2009.07.023openalex-snapshot
Polycyclic aromatic hydrocarbons and their oxygenated derivatives in the urban atmosphere of Athens
inferredcites →https://doi.org/10.1016/j.molcel.2006.07.010openalex-snapshot
Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways
inferredcites →https://doi.org/10.1016/j.molcel.2008.03.016openalex-snapshot
Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
inferredcites →https://doi.org/10.1016/j.molcel.2010.09.019openalex-snapshot
The DNA Damage Response: Making It Safe to Play with Knives
inferredcites →https://doi.org/10.1016/j.mrfmmm.2009.08.014openalex-snapshot
Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures
inferredcites →https://doi.org/10.1016/j.scitotenv.2007.04.028openalex-snapshot
Polycyclic aromatic hydrocarbons (PAHs), nitrated PAHs and oxygenated PAHs in ambient air of the Marseilles area (South of France): Concentrations and sources
inferredcites →https://doi.org/10.1016/j.tiv.2007.08.014openalex-snapshot
Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size
inferredcites →https://doi.org/10.1016/j.tiv.2010.09.012openalex-snapshot
Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK
inferredcites →https://doi.org/10.1016/j.tox.2010.09.002openalex-snapshot
Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo[a]pyrene to form DNA adducts in human cells
inferredcites →https://doi.org/10.1016/s0006-2952(99)00310-xopenalex-snapshot
Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
inferredcites →https://doi.org/10.1016/s0027-5107(97)00297-2openalex-snapshot
Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens
inferredcites →https://doi.org/10.1021/ac052178fopenalex-snapshot
Simultaneous Extraction and Fractionation of Polycyclic Aromatic Hydrocarbons and Their Oxygenated Derivatives in Soil Using Selective Pressurized Liquid Extraction
inferredcites →https://doi.org/10.1021/bi101560yopenalex-snapshot
A Bulky DNA Lesion Derived from a Highly Potent Polycyclic Aromatic Tumorigen Stabilizes Nucleosome Core Particle Structure
inferredcites →https://doi.org/10.1021/tx0497090openalex-snapshot
Differential Removal of DNA Adducts Derived from anti-Diol Epoxides of Dibenzo[a,l]pyrene and Benzo[a]pyrene in Human Cells
inferredcites →https://doi.org/10.1021/tx049723copenalex-snapshot
Subway Particles Are More Genotoxic than Street Particles and Induce Oxidative Stress in Cultured Human Lung Cells
inferredcites →https://doi.org/10.1021/tx049828fopenalex-snapshot
Phenotypic Anchoring of Global Gene Expression Profiles Induced by N-Hydroxy-4-acetylaminobiphenyl and Benzo[a]pyrene Diol Epoxide Reveals Correlations between Expression Profiles and Mechanism of Toxicity
inferredcites →https://doi.org/10.1021/tx060197uopenalex-snapshot
Metabolic Enzyme Induction by HepG2 Cells Exposed to Oxygenated and Nonoxygenated Polycyclic Aromatic Hydrocarbons
inferredcites →https://doi.org/10.1038/leu.2010.6openalex-snapshot
γH2AX: a sensitive molecular marker of DNA damage and repair
inferredcites →https://doi.org/10.1038/modpathol.2010.121openalex-snapshot
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study
inferredcites →https://doi.org/10.1038/ncb1212openalex-snapshot
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
inferredcites →https://doi.org/10.1038/ncb1337openalex-snapshot
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
inferredcites →https://doi.org/10.1038/ng888openalex-snapshot
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
inferredcites →https://doi.org/10.1038/onc.2008.17openalex-snapshot
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage
inferredcites →https://doi.org/10.1038/onc.2009.501openalex-snapshot
Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition
inferredcites →https://doi.org/10.1073/pnas.0706013104openalex-snapshot
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
inferredcites →https://doi.org/10.1073/pnas.0802776105openalex-snapshot
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans -dihydrodiol activation in human lung A549 cells
inferredcites →https://doi.org/10.1073/pnas.1100600108openalex-snapshot
Two-phase dynamics of p53 in the DNA damage response
inferredcites →https://doi.org/10.1073/pnas.190030497openalex-snapshot
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
inferredcites →https://doi.org/10.1074/jbc.c100466200openalex-snapshot
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
inferredcites →https://doi.org/10.1074/jbc.m109.042143openalex-snapshot
Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione
inferredcites →https://doi.org/10.1074/jbc.m109.071696openalex-snapshot
Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair
inferredcites →https://doi.org/10.1074/jbc.m307254200openalex-snapshot
In Vivo Recruitment of XPC to UV-induced Cyclobutane Pyrimidine Dimers by the DDB2 Gene Product
inferredcites →https://doi.org/10.1093/carcin/19.4.591openalex-snapshot
Involvement of the proliferating cell nuclear antigen (PCNA) in DNA repair induced by alkylating agents and oxidative damage in human fibroblasts
inferredcites →https://doi.org/10.1093/nar/gkn1075openalex-snapshot
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
inferredcites →https://doi.org/10.1093/toxsci/kfm305openalex-snapshot
Mdm2 as a Sensitive and Mechanistically Informative Marker for Genotoxicity Induced by Benzo[a]pyrene and Dibenzo[a,l]pyrene
inferredcites →https://doi.org/10.1093/toxsci/kfq214openalex-snapshot
Time Series Analysis of Benzo[A]Pyrene-Induced Transcriptome Changes Suggests That a Network of Transcription Factors Regulates the Effects on Functional Gene Sets
inferredcites →https://doi.org/10.1101/gad.1291305openalex-snapshot
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
inferredcites →https://doi.org/10.1101/gad.14.12.1448openalex-snapshot
Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint
inferredcites →https://doi.org/10.1111/0272-4332.00008openalex-snapshot
Cancer Risk Estimation for Mixtures of Coal Tars and Benzo(a)pyrene
inferredcites →https://doi.org/10.1111/j.1751-1097.2011.00995.xopenalex-snapshot
γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”
inferredcites →https://doi.org/10.1158/0008-5472.can-09-4244openalex-snapshot
Wip1 Directly Dephosphorylates γ-H2AX and Attenuates the DNA Damage Response
inferredcites →https://doi.org/10.1158/0008-5472.can-10-0697openalex-snapshot
Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway
inferredcites →https://doi.org/10.1186/1471-2164-7-260openalex-snapshot
Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2
inferredcites →https://doi.org/10.1289/ehp.110-1241197openalex-snapshot
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.
inferredcites →https://doi.org/10.1579/0044-7447(2007)36[475:sfatho]2.0.co;2openalex-snapshot
Sources, Fate, and Toxic Hazards of Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs) at PAH- contaminated Sites
inferredcites →https://doi.org/10.4161/cc.4.8.1876openalex-snapshot
Reversal of the ATM/ATR-Mediated DNA Damage Response by the Oncogenic Phosphatase PPM1D
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/em.22377openalex-snapshot
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Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene
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Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers
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inferred← citeshttps://doi.org/10.1016/j.envint.2024.108942openalex-snapshot
Application of an in vitro new approach methodology to determine relative cancer potency factors of air pollutants based on whole mixtures
inferred← citeshttps://doi.org/10.1016/j.envpol.2018.12.092openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envpol.2019.113381openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envpol.2021.116838openalex-snapshot
A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs
inferred← citeshttps://doi.org/10.1016/j.envres.2019.108989openalex-snapshot
Polycyclic aromatic compounds in urban soils of Stockholm City: Occurrence, sources and human health risk assessment
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2014.03.006openalex-snapshot
Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2014.07.004openalex-snapshot
Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2015.07.008openalex-snapshot
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2013.06.088openalex-snapshot
Chemical-based risk assessment and in vitro models of human health effects induced by organic pollutants in soils from the Olona valley
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Amino and hydroxy substitution influences pyrene–DNA binding
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Interaction between polycyclic aromatic hydrocarbons and thymine (T)-base induces double-strand DNA distortion in different species
inferred← citeshttps://doi.org/10.1016/j.taap.2012.11.026openalex-snapshot
Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter
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Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment
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4-Aminobiphenyl suppresses homologous recombination repair by a reactive oxygen species-dependent p53/miR-513a-5p/p53 loop
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Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells
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