On the public citation graph

Contributions of Human Enzymes in Carcinogen Metabolism

https://doi.org/10.1021/tx300132k
0 signed · 729 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1098-2744(199910)26:2<74::aid-mc2>3.0.co;2-9openalex-snapshot
A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes
inferredcites →https://doi.org/10.1002/1098-2280(2000)35:4<328::aid-em7>3.0.co;2-copenalex-snapshot
Activation of MeIQ (2-amino-3,4-dimethylimidazo- [4,5-f]quinoline) by sequence variants of recombinant human cytochrome P450 1A2
inferredcites →https://doi.org/10.1002/1098-2280(2000)36:2<121::aid-em6>3.0.co;2-popenalex-snapshot
Use of genetically engineeredSalmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterialO-acetyltransferase in SOS/umu assay
inferredcites →https://doi.org/10.1002/1098-2744(200011)29:3<170::aid-mc6>3.0.co;2-wopenalex-snapshot
Role of multidrug-resistance protein 2 in glutathioneS-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells
inferredcites →https://doi.org/10.1002/1099-0461(2000)14:6<303::aid-jbt2>3.0.co;2-8openalex-snapshot
Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes
inferredcites →https://doi.org/10.1002/cpt197925188openalex-snapshot
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism
inferredcites →https://doi.org/10.1002/em.10036openalex-snapshot
Predicting the mutagenicity of tobacco‐related N‐nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH–cytochrome P450 reductase
inferredcites →https://doi.org/10.1002/em.1045openalex-snapshot
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains
inferredcites →https://doi.org/10.1002/em.20073openalex-snapshot
DNA adduct formation by 7H‐dibenzo[c,g]carbazole and its tissue‐ and organ‐specific derivatives in Chinese hamster V79 cell lines stably expressing cytochrome P450 enzymes
inferredcites →https://doi.org/10.1002/em.20252openalex-snapshot
Screening and characterization of variant Theta‐class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen
inferredcites →https://doi.org/10.1002/em.20560openalex-snapshot
Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systems
inferredcites →https://doi.org/10.1002/em.20664openalex-snapshot
Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression
inferredcites →https://doi.org/10.1002/em.20665openalex-snapshot
Antigenotoxic activity of naturally occurring furanocoumarins
inferredcites →https://doi.org/10.1002/em.20696openalex-snapshot
Roles of human sulfotransferases in genotoxicity of carcinogens using genetically engineeredumutest strains
inferredcites →https://doi.org/10.1002/ijc.11143openalex-snapshot
Activation of 3‐nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells
inferredcites →https://doi.org/10.1002/ijc.20564openalex-snapshot
Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid‐DNA adducts found in patients with urothelial cancer
inferredcites →https://doi.org/10.1002/ijc.21122openalex-snapshot
Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogeno-anisidine
inferredcites →https://doi.org/10.1002/ijc.21480openalex-snapshot
Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
inferredcites →https://doi.org/10.1002/ijc.21665openalex-snapshot
Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract
inferredcites →https://doi.org/10.1002/ijc.22136openalex-snapshot
CYP2A13 expressed in human bladder metabolically activates 4‐aminobiphenyl
inferredcites →https://doi.org/10.1002/jbt.10055openalex-snapshot
A quantitative structure–activity relationship analysis on a series of alkyl benzenes metabolized by human cytochrome P450 2E1
inferredcites →https://doi.org/10.1002/jbt.20010openalex-snapshot
Benzene metabolism in human lung cell lines BEAS‐2B and A549 and cells overexpressing CYP2F1
inferredcites →https://doi.org/10.1002/jbt.20168openalex-snapshot
Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture
inferredcites →https://doi.org/10.1002/mc.20530openalex-snapshot
Potential role of cytochrome P450‐1B1 in the metabolic activation of 4‐aminobiphenyl in humans
inferredcites →https://doi.org/10.1002/mc.20869openalex-snapshot
Intestinal carcinogenesis of two food processing contaminants, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine and 5‐hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases
inferredcites →https://doi.org/10.1002/mc.2940020405openalex-snapshot
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity
inferredcites →https://doi.org/10.1002/mc.2940100307openalex-snapshot
The role of 12 cDNA‐expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans‐7, 8‐dihydrodiol
inferredcites →https://doi.org/10.1002/mnfr.200900447openalex-snapshot
Effect of sulforaphane on glutathione‐adduct formation and on glutathione_S_transferase‐dependent detoxification of acrylamide in Caco‐2 cells
inferredcites →https://doi.org/10.1006/abbi.1994.1330openalex-snapshot
Expression of Modified Human Cytochrome P450 1A1 in Escherichia coli: Effects of 5′ Substitution, Stabilization, Purification, Spectral Characterization, and Catalytic Properties
inferredcites →https://doi.org/10.1006/abbi.1995.1177openalex-snapshot
Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities
inferredcites →https://doi.org/10.1006/abbi.1996.0161openalex-snapshot
Metabolic Activation of the Potent Carcinogen Dibenzo[a,h]anthracene by cDNA-Expressed Human Cytochromes P450
inferredcites →https://doi.org/10.1006/abbi.1996.0373openalex-snapshot
Kinetic Analysis of the Activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Heterologously Expressed Human P450 Enzymes and the Effect of P450- Specific Chemical Inhibitors on This Activation in Human Liver Microsomes
inferredcites →https://doi.org/10.1006/abbi.1996.9781openalex-snapshot
Oxidation of Butadiene Monoxide tomeso-and (±)-Diepoxybutane by cDNA-Expressed Human Cytochrome P450s and by Mouse, Rat, and Human Liver Microsomes: Evidence for Preferential Hydration ofmeso-Diepoxybutane in Rat and Human Liver Microsomes
inferredcites →https://doi.org/10.1006/abbi.1997.0286openalex-snapshot
Expression of Cytochrome P450 3A7 inEscherichia coli:Effects of 5′ Modification and Catalytic Characterization of Recombinant Enzyme Expressed in Bicistronic Format with NADPH-Cytochrome P450 Reductase
inferredcites →https://doi.org/10.1006/abbi.1998.0808openalex-snapshot
Recombinant Human Cytochrome P450 1B1 Expression inEscherichia coli
inferredcites →https://doi.org/10.1006/bbrc.1997.7311openalex-snapshot
Activity of Four Allelic Forms of Glutathione S-Transferase hGSTP1-1 for Diol Epoxides of Polycyclic Aromatic Hydrocarbons
inferredcites →https://doi.org/10.1006/bbrc.1997.7775openalex-snapshot
Evidence for CYP2D6 Expression in Human Lung
inferredcites →https://doi.org/10.1006/bbrc.2000.3740openalex-snapshot
CYP4B1 Is a Possible Risk Factor for Bladder Cancer in Humans
inferredcites →https://doi.org/10.1006/bbrc.2001.4390openalex-snapshot
Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)
inferredcites →https://doi.org/10.1006/bbrc.2001.5055openalex-snapshot
A Transgenic Mouse Expressing Human CYP4B1 in the Liver
inferredcites →https://doi.org/10.1006/taap.1996.7975openalex-snapshot
Nasal Cytochrome P450 2A: Identification, Regional Localization, and Metabolic Activity toward Hexamethylphosphoramide, a Known Nasal Carcinogen
inferredcites →https://doi.org/10.1006/taap.1996.8040openalex-snapshot
Cytochrome P450-Dependent Metabolism of Trichloroethylene: Interindividual Differences in Humans
inferredcites →https://doi.org/10.1006/taap.1997.8233openalex-snapshot
Metabolism of Ethyl Carbamate by Pulmonary Cytochrome P450 and Carboxylesterase Isozymes: Involvement of CYP2E1 and Hydrolase A
inferredcites →https://doi.org/10.1006/taap.1999.8651openalex-snapshot
N-Nitrosodimethylamine-Mediated Cytotoxicity in a Cell Line Expressing P450 2E1: Evidence for Apoptotic Cell Death
inferredcites →https://doi.org/10.1007/0-387-27447-2_10openalex-snapshot
Human Cytochrome P450 Enzymes
inferredcites →https://doi.org/10.1007/978-0-387-77300-1_6openalex-snapshot
CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
inferredcites →https://doi.org/10.1007/978-1-4757-2391-5_14openalex-snapshot
Human Cytochrome P450 Enzymes
inferredcites →https://doi.org/10.1007/s002040050583openalex-snapshot
Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression
inferredcites →https://doi.org/10.1007/s002280050201openalex-snapshot
Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans
inferredcites →https://doi.org/10.1007/s002280050219openalex-snapshot
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: A meta- analysis
inferredcites →https://doi.org/10.1007/s00280-002-0453-3openalex-snapshot
Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA
inferredcites →https://doi.org/10.1007/s002800050863openalex-snapshot
Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs
inferredcites →https://doi.org/10.1016/0006-291x(78)90616-2openalex-snapshot
7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver
inferredcites →https://doi.org/10.1016/0006-2952(92)90068-topenalex-snapshot
Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes
inferredcites →https://doi.org/10.1016/0006-2952(94)90387-5openalex-snapshot
Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide
inferredcites →https://doi.org/10.1016/0006-2952(95)00168-yopenalex-snapshot
In vitro-in vivo correlations of human (s)-nicotine metabolism
inferredcites →https://doi.org/10.1016/0009-2797(96)03723-4openalex-snapshot
Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes
inferredcites →https://doi.org/10.1016/0041-008x(91)90090-2openalex-snapshot
Bioactivation of aflatoxin B1 by human liver microsomes: Role of cytochrome P450 IIIA enzymes
inferredcites →https://doi.org/10.1016/0300-483x(95)03216-3openalex-snapshot
Risk assessment: toxicity from chemical exposure resulting from enhanced expression of CYP2E1
inferredcites →https://doi.org/10.1016/0300-483x(96)03423-3openalex-snapshot
Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity
inferredcites →https://doi.org/10.1016/0926-6917(93)90052-ropenalex-snapshot
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene
inferredcites →https://doi.org/10.1016/0926-6917(95)90017-9openalex-snapshot
A NIH/3T3 cell line stably expressing human cytochrome P450-3A4 used in combination with a lacZ′ shuttle vector to study mutagenicity
inferredcites →https://doi.org/10.1016/0960-0760(93)90252-ropenalex-snapshot
Multiple functions of aromatase and the active site structure; aromatase is the placental estrogen 2-hydroxylase
inferredcites →https://doi.org/10.1016/0960-0760(94)90037-xopenalex-snapshot
The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase
inferredcites →https://doi.org/10.1016/j.abb.2003.11.019openalex-snapshot
Functional characterization of four allelic variants of human cytochrome P450 1A2
inferredcites →https://doi.org/10.1016/j.abb.2007.04.024openalex-snapshot
Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms
inferredcites →https://doi.org/10.1016/j.abb.2009.11.017openalex-snapshot
Human cytochrome P450 4F11: Heterologous expression in bacteria, purification, and characterization of catalytic function
inferredcites →https://doi.org/10.1016/j.bbapap.2010.05.016openalex-snapshot
Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency
inferredcites →https://doi.org/10.1016/j.bbrc.2005.12.200openalex-snapshot
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
inferredcites →https://doi.org/10.1016/j.bbrc.2009.06.123openalex-snapshot
Aldo–keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels
inferredcites →https://doi.org/10.1016/j.bcp.2004.02.014openalex-snapshot
Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4
inferredcites →https://doi.org/10.1016/j.bcp.2006.01.004openalex-snapshot
Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4
inferredcites →https://doi.org/10.1016/j.bcp.2011.06.003openalex-snapshot
Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
inferredcites →https://doi.org/10.1016/j.canlet.2004.10.007openalex-snapshot
Cytochrome P450-mediated metabolism of estrogens and its regulation in human
inferredcites →https://doi.org/10.1016/j.canlet.2005.03.035openalex-snapshot
Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases
inferredcites →https://doi.org/10.1016/j.canlet.2005.06.038openalex-snapshot
The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen
inferredcites →https://doi.org/10.1016/j.cbi.2006.02.007openalex-snapshot
On the species-specific biotransformation of dibenzo[a,l]pyrene
inferredcites →https://doi.org/10.1016/j.cbi.2006.03.012openalex-snapshot
Evaluation of nitroreductase and acetyltransferase participation in N-nitrosodiethylamine genotoxicity
inferredcites →https://doi.org/10.1016/j.cbi.2007.01.007openalex-snapshot
Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro
inferredcites →https://doi.org/10.1016/j.cbi.2008.10.021openalex-snapshot
Role of human aldo–keto-reductase AKR1B10 in the protection against toxic aldehydes
inferredcites →https://doi.org/10.1016/j.cbi.2009.09.008openalex-snapshot
Metabolic activation of phenanthrene by human and mouse cytochromes P450 and pharmacokinetics in CYP1A2 knockout mice
inferredcites →https://doi.org/10.1016/j.cbi.2010.09.009openalex-snapshot
1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation
inferredcites →https://doi.org/10.1016/j.cbi.2011.02.004openalex-snapshot
Human aldo–keto reductases 1B1 and 1B10: A comparative study on their enzyme activity toward electrophilic carbonyl compounds
inferredcites →https://doi.org/10.1016/j.cbi.2011.03.016openalex-snapshot
Herbal bioactivation, molecular targets and the toxicity relevance
inferredcites →https://doi.org/10.1016/j.fct.2007.08.040openalex-snapshot
SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.06.021openalex-snapshot
The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: Modulation by ERK, ROS, glutathione, and thioredoxin
inferredcites →https://doi.org/10.1016/j.jhep.2010.07.023openalex-snapshot
ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes
inferredcites →https://doi.org/10.1016/j.mce.2003.11.006openalex-snapshot
Structure–function of human 3α-hydroxysteroid dehydrogenases: genes and proteins
inferredcites →https://doi.org/10.1016/j.metabol.2007.03.001openalex-snapshot
Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA
inferredcites →https://doi.org/10.1016/j.mrfmmm.2004.06.033openalex-snapshot
Analysis of the involvement of human N-acetyltransferase 1 in the genotoxic activation of bladder carcinogenic arylamines using a SOS/umu assay system
inferredcites →https://doi.org/10.1016/j.mrfmmm.2004.11.007openalex-snapshot
The effect of UDP-glucuronosyltransferase 1A1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in CHO cells
inferredcites →https://doi.org/10.1016/j.mrfmmm.2005.01.028openalex-snapshot
Flavonoids and alkenylbenzenes: Mechanisms of mutagenic action and carcinogenic risk
inferredcites →https://doi.org/10.1016/j.mrfmmm.2007.04.004openalex-snapshot
Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (±)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1
inferredcites →https://doi.org/10.1016/j.mrfmmm.2008.06.003openalex-snapshot
Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes
inferredcites →https://doi.org/10.1016/j.mrgentox.2003.10.007openalex-snapshot
Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes
inferredcites →https://doi.org/10.1016/j.mrgentox.2004.06.003openalex-snapshot
Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens
inferredcites →https://doi.org/10.1016/j.mrgentox.2004.11.005openalex-snapshot
V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals
inferredcites →https://doi.org/10.1016/j.mrgentox.2004.12.002openalex-snapshot
Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
inferredcites →https://doi.org/10.1016/j.mrgentox.2008.04.013openalex-snapshot
Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains
inferredcites →https://doi.org/10.1016/j.mrgentox.2009.03.009openalex-snapshot
In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation
inferredcites →https://doi.org/10.1016/j.steroids.2005.01.002openalex-snapshot
NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms
inferredcites →https://doi.org/10.1016/j.taap.2004.12.022openalex-snapshot
Novel extrahepatic cytochrome P450s
inferredcites →https://doi.org/10.1016/j.taap.2011.03.022openalex-snapshot
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation—A mammalian cell-based mutagenesis approach
inferredcites →https://doi.org/10.1016/j.taap.2011.06.027openalex-snapshot
The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole
inferredcites →https://doi.org/10.1016/j.tox.2005.01.019openalex-snapshot
Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes
inferredcites →https://doi.org/10.1016/j.tox.2006.06.001openalex-snapshot
Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells
inferredcites →https://doi.org/10.1016/j.toxlet.2004.11.010openalex-snapshot
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid
inferredcites →https://doi.org/10.1016/j.toxlet.2005.06.011openalex-snapshot
Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene
inferredcites →https://doi.org/10.1016/j.toxlet.2005.11.003openalex-snapshot
Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition
inferredcites →https://doi.org/10.1016/j.toxlet.2008.10.008openalex-snapshot
Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression
inferredcites →https://doi.org/10.1016/j.toxlet.2009.04.010openalex-snapshot
Genotoxic activation of the environmental pollutant 3,6-dinitrobenzo[e]pyrene in Salmonella typhimurium umu strains expressing human cytochrome P450 and N-acetyltransferase
inferredcites →https://doi.org/10.1016/s0003-9861(02)00415-0openalex-snapshot
Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions
inferredcites →https://doi.org/10.1016/s0006-2952(01)00806-1openalex-snapshot
The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆
inferredcites →https://doi.org/10.1016/s0006-2952(02)00978-4openalex-snapshot
Thiourea toxicity in mouse C3H/10T12 cells expressing human flavin-dependent monooxygenase 3
inferredcites →https://doi.org/10.1016/s0006-2952(02)00994-2openalex-snapshot
Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases
inferredcites →https://doi.org/10.1016/s0006-2952(02)01072-9openalex-snapshot
Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes
inferredcites →https://doi.org/10.1016/s0006-2952(99)00410-4openalex-snapshot
Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide
inferredcites →https://doi.org/10.1016/s0009-2797(00)00149-6openalex-snapshot
Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
inferredcites →https://doi.org/10.1016/s0009-2797(00)00202-7openalex-snapshot
Sulfotransferases in the bioactivation of xenobiotics
inferredcites →https://doi.org/10.1016/s0009-2797(00)00237-4openalex-snapshot
Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)
inferredcites →https://doi.org/10.1016/s0009-2797(00)00304-5openalex-snapshot
Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta
inferredcites →https://doi.org/10.1016/s0009-2797(01)00214-9openalex-snapshot
The metabolism of β-chloroprene: preliminary in-vitro studies using liver microsomes
inferredcites →https://doi.org/10.1016/s0009-2797(97)00133-6openalex-snapshot
Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems
inferredcites →https://doi.org/10.1016/s0009-2797(98)00058-1openalex-snapshot
Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes
inferredcites →https://doi.org/10.1016/s0014-5793(98)01291-5openalex-snapshot
Detoxication of carcinogenic fjord‐region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1‐1 variants and glutathione
inferredcites →https://doi.org/10.1016/s0021-9258(17)39456-5openalex-snapshot
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.
inferredcites →https://doi.org/10.1016/s0021-9258(17)40345-0openalex-snapshot
Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.
inferredcites →https://doi.org/10.1016/s0021-9258(18)94484-4openalex-snapshot
Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture
inferredcites →https://doi.org/10.1016/s0022-3565(24)29399-xopenalex-snapshot
Characterization of the NADPH-Dependent Metabolism of 17β-Estradiol to Multiple Metabolites by Human Liver Microsomes and Selectively Expressed Human Cytochrome P450 3A4 and 3A5
inferredcites →https://doi.org/10.1016/s0022-3565(25)12251-9openalex-snapshot
Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.
inferredcites →https://doi.org/10.1016/s0022-3565(25)22379-5openalex-snapshot
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
inferredcites →https://doi.org/10.1016/s0026-895x(25)08872-8openalex-snapshot
Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.
inferredcites →https://doi.org/10.1016/s0026-895x(25)09010-8openalex-snapshot
Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450.
inferredcites →https://doi.org/10.1016/s0026-895x(25)09378-2openalex-snapshot
Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.
inferredcites →https://doi.org/10.1016/s0026-895x(25)09935-3openalex-snapshot
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.
inferredcites →https://doi.org/10.1016/s0026-895x(25)12526-1openalex-snapshot
The Effect of Epoxide Hydratase on Benzo[a]pyrene Diol Epoxide Hydrolysis and Binding to DNA and Mixed-Function Oxidase Proteins
inferredcites →https://doi.org/10.1016/s0026-895x(25)15384-4openalex-snapshot
Purification and Characterization of Human Liver Microsomal Cytochrome P-450 2A6
inferredcites →https://doi.org/10.1016/s0027-5107(01)00187-7openalex-snapshot
The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk
inferredcites →https://doi.org/10.1016/s0027-5107(01)00207-xopenalex-snapshot
Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects
inferredcites →https://doi.org/10.1016/s0027-5107(01)00223-8openalex-snapshot
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase
inferredcites →https://doi.org/10.1016/s0027-5107(01)00236-6openalex-snapshot
Cytochrome b5 coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium
inferredcites →https://doi.org/10.1016/s0027-5107(02)00165-3openalex-snapshot
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2
inferredcites →https://doi.org/10.1016/s0027-5107(02)00333-0openalex-snapshot
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies
inferredcites →https://doi.org/10.1016/s0027-5107(97)00073-0openalex-snapshot
Cytochrome P450 hydroxylation of carbon atoms of the alkyl chain of symmetrical N-nitrosodialkylamines by human liver microsomes
inferredcites →https://doi.org/10.1016/s0027-5107(97)00288-1openalex-snapshot
Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane
inferredcites →https://doi.org/10.1016/s0027-5107(97)00289-3openalex-snapshot
Activation and detoxication of aflatoxin B1
inferredcites →https://doi.org/10.1016/s0027-5107(98)00037-2openalex-snapshot
Activation of procarcinogens by human cytochrome P450 enzymes
inferredcites →https://doi.org/10.1016/s0076-6879(04)78003-9openalex-snapshot
Aldo-Keto Reductases and Formation of Polycyclic Aromatic Hydrocarbon o-Quinones
inferredcites →https://doi.org/10.1016/s0090-9556(24)02988-xopenalex-snapshot
BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES
inferredcites →https://doi.org/10.1016/s0090-9556(24)14934-3openalex-snapshot
Stereoselective Metabolism of Ifosfamide by Human P-450s 3A4 and 2B6. Favorable Metabolic Properties of R-Enantiomer
inferredcites →https://doi.org/10.1016/s0090-9556(24)15084-2openalex-snapshot
O-Glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1- (3-Pyridyl)-1-Butanol (nnal) by Human Udp-Glucuronosyltransferases 2b7 and 1a9
inferredcites →https://doi.org/10.1016/s0090-9556(24)15176-8openalex-snapshot
Size Limits of Thiocarbamides Accepted as Substrates by Human Flavin-Containing Monooxygenase 1
inferredcites →https://doi.org/10.1016/s0090-9556(24)15217-8openalex-snapshot
Role of CYP2B6 and CYP3A4 in the In Vitro N-Dechloroethylation of (R)- and (S)-Ifosfamide in Human Liver Microsomes
inferredcites →https://doi.org/10.1016/s0090-9556(24)15228-2openalex-snapshot
Specific Dehydrogenation of 3-Methylindole and Epoxidation of Naphthalene by Recombinant Human CYP2F1 Expressed in Lymphoblastoid Cells
inferredcites →https://doi.org/10.1016/s0090-9556(24)15302-0openalex-snapshot
Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles
inferredcites →https://doi.org/10.1016/s0090-9556(24)15305-6openalex-snapshot
Cytochrome P-450 3A and 2D6 Catalyze Ortho Hydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins
inferredcites →https://doi.org/10.1016/s0090-9556(25)07365-9openalex-snapshot
Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.
inferredcites →https://doi.org/10.1016/s0090-9556(25)08198-xopenalex-snapshot
Characterization of cytochrome P-450 2B6 in human liver microsomes.
inferredcites →https://doi.org/10.1016/s0165-1161(96)90015-1openalex-snapshot
Stable expression of human CYP2E1 in chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing
inferredcites →https://doi.org/10.1016/s0165-1218(96)00160-7openalex-snapshot
Genotoxicity of ethyl carbamate (urethane) in Salmonella, yeast and human lymphoblastoid cells
inferredcites →https://doi.org/10.1016/s0278-6915(02)00032-7openalex-snapshot
Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines
inferredcites →https://doi.org/10.1016/s0301-4622(02)00383-6openalex-snapshot
Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions
inferredcites →https://doi.org/10.1016/s0304-3835(99)00137-8openalex-snapshot
Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2
inferredcites →https://doi.org/10.1016/s0378-4274(00)00281-2openalex-snapshot
Neoantigen formation and clastogenic action of hydrochlorofluorocarbons-123 and perchloroethylene in human MCL-5 cells
inferredcites →https://doi.org/10.1016/s0378-4274(00)00288-5openalex-snapshot
The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons
inferredcites →https://doi.org/10.1016/s0378-4274(01)00324-1openalex-snapshot
Oxidation of N,N-dimethylformamide and N,N-diethylformamide by human liver microsomes and human recombinant P450s
inferredcites →https://doi.org/10.1016/s0378-4274(03)00196-6openalex-snapshot
Inhibition of aflatoxin B1 mutagenicity by cyclopiazonic acid in the presence of human liver preparations
inferredcites →https://doi.org/10.1016/s0378-4274(98)00026-5openalex-snapshot
Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human
inferredcites →https://doi.org/10.1016/s0378-4274(99)00214-3openalex-snapshot
Sulfotransferases: genetics and role in toxicology
inferredcites →https://doi.org/10.1016/s0887-2333(01)00011-xopenalex-snapshot
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology
inferredcites →https://doi.org/10.1016/s1382-6689(97)10073-4openalex-snapshot
Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450
inferredcites →https://doi.org/10.1016/s1383-5718(00)00015-2openalex-snapshot
Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
inferredcites →https://doi.org/10.1016/s1383-5718(00)00087-5openalex-snapshot
Role of cytochrome P4501A1 in biotransformation of a tissue specific sarcomagen N-methyldibenzo[c,g]carbazole
inferredcites →https://doi.org/10.1016/s1383-5718(00)00117-0openalex-snapshot
Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108
inferredcites →https://doi.org/10.1016/s1383-5718(00)00138-8openalex-snapshot
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1
inferredcites →https://doi.org/10.1016/s1383-5718(01)00154-1openalex-snapshot
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase
inferredcites →https://doi.org/10.1016/s1383-5718(01)00254-6openalex-snapshot
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay
inferredcites →https://doi.org/10.1016/s1383-5718(02)00055-4openalex-snapshot
Mutagenicity of 7H-dibenzo[c,g]carbazole and its tissue specific derivatives in genetically engineered Chinese hamster V79 cell lines stably expressing cytochrome P450
inferredcites →https://doi.org/10.1016/s1383-5718(02)00141-9openalex-snapshot
Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay
inferredcites →https://doi.org/10.1016/s1383-5718(98)00193-4openalex-snapshot
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: Comparison of three types of expression systems
inferredcites →https://doi.org/10.1016/s1383-5718(99)00118-7openalex-snapshot
Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines
inferredcites →https://doi.org/10.1016/s1383-5718(99)00135-7openalex-snapshot
Mutagenicity of C24H14 PAH in human cells expressing CYP1A1
inferredcites →https://doi.org/10.1021/bi00021a007openalex-snapshot
Stereospecific Activation of the Procarcinogen Benzo[a]pyrene: A Probe for the Active Sites of the Cytochrome P450 Superfamily
inferredcites →https://doi.org/10.1021/bi00078a017openalex-snapshot
Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates
inferredcites →https://doi.org/10.1021/bi010872topenalex-snapshot
The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation
inferredcites →https://doi.org/10.1021/bi035593fopenalex-snapshot
Selection of Human Cytochrome P450 1A2 Mutants with Enhanced Catalytic Activity for Heterocyclic Amine N-Hydroxylation
inferredcites →https://doi.org/10.1021/bi047810yopenalex-snapshot
Dynamics of Glutathione Conjugation and Conjugate Efflux in Detoxification of the Carcinogen, 4-Nitroquinoline 1-Oxide: Contributions of Glutathione, GlutathioneS-Transferase, and MRP1
inferredcites →https://doi.org/10.1021/bi990142+openalex-snapshot
Selection and Characterization of Human Cytochrome P450 1A2 Mutants with Altered Catalytic Properties
inferredcites →https://doi.org/10.1021/bi992765topenalex-snapshot
Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4
inferredcites →https://doi.org/10.1021/ja00084a001openalex-snapshot
DNA Adduction by the Potent Carcinogen Aflatoxin B1: Mechanistic Studies
inferredcites →https://doi.org/10.1021/tx000176eopenalex-snapshot
Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]- quinoxaline in Human Hepatocytes: 2-Amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2
inferredcites →https://doi.org/10.1021/tx000181iopenalex-snapshot
Oxidation of 2,6-Dimethylaniline by Recombinant Human Cytochrome P450s and Human Liver Microsomes
inferredcites →https://doi.org/10.1021/tx00020a008openalex-snapshot
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
inferredcites →https://doi.org/10.1021/tx0002280openalex-snapshot
Reaction of Trichloroethylene and Trichloroethylene Oxide with Cytochrome P450 Enzymes: Inactivation and Sites of Modification
inferredcites →https://doi.org/10.1021/tx00022a001openalex-snapshot
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
inferredcites →https://doi.org/10.1021/tx000240sopenalex-snapshot
Metabolic Activation of Benzo[c]phenanthrene by Cytochrome P450 Enzymes in Human Liver and Lung
inferredcites →https://doi.org/10.1021/tx00026a009openalex-snapshot
Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1
inferredcites →https://doi.org/10.1021/tx00032a009openalex-snapshot
Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1
inferredcites →https://doi.org/10.1021/tx00036a017openalex-snapshot
Epoxidation of acrylonitrile by rat and human cytochromes P450
inferredcites →https://doi.org/10.1021/tx00038a009openalex-snapshot
Metabolism of the Chlorofluorocarbon Substitute 1,1-Dichloro-2,2,2-trifluoroethane by Rat and Human Liver Microsomes: The Role of Cytochrome P450 2E1
showing the first 200 of 458 · page through all 458

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4758162openalex-extracted
Computational Exploration of Small Molecules as Inhibitor Targeting Cytochrome P4502d6
inferred← citeshttps://doi.org/10.1002/9781119000822.hfcm023openalex-snapshot
Chemical Carcinogenesis
inferred← citeshttps://doi.org/10.1002/9781119000822.hfcm023.pub2openalex-snapshot
Chemical Carcinogenesis
inferred← citeshttps://doi.org/10.1002/9783527673261.ch01openalex-snapshot
Metabolism in Drug Development
inferred← citeshttps://doi.org/10.1002/9783527673261.ch08openalex-snapshot
Experimental Approaches to Analysis of Reactions of Cytochrome P450 Enzymes
inferred← citeshttps://doi.org/10.1002/ange.202003687openalex-snapshot
Fortschritte bei aktivitätsbasierten Sonden für die isoformselektive Bildgebung enzymatischer Aktivität
inferred← citeshttps://doi.org/10.1002/anie.202003687openalex-snapshot
Advances in Activity‐Based Sensing Probes for Isoform‐Selective Imaging of Enzymatic Activity
inferred← citeshttps://doi.org/10.1002/app.48707openalex-snapshot
Alternative monomers for 4,4′‐methylenedianiline in thermosetting epoxy resins
inferred← citeshttps://doi.org/10.1002/cam4.2367openalex-snapshot
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
inferred← citeshttps://doi.org/10.1002/cbin.10108openalex-snapshot
Effect of bixin and norbixin on the expression of cytochrome P450 in Hep G 2 cell line
inferred← citeshttps://doi.org/10.1002/cctc.202101564openalex-snapshot
Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4
inferred← citeshttps://doi.org/10.1002/chem.201802413openalex-snapshot
Ruthenium‐Catalyzed Cycloisomerization of 2‐Alkynylstyrenes via 1,2‐Carbon Migration That Leads to Substituted Naphthalenes
inferred← citeshttps://doi.org/10.1002/cptc.70260openalex-snapshot
Photocatalytic Enantioselective Oxidation by Artificial Monooxygenases Using Molecular Oxygen as a Green Oxidant
inferred← citeshttps://doi.org/10.1002/em.22059openalex-snapshot
Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts
inferred← citeshttps://doi.org/10.1002/em.22309openalex-snapshot
Micronuclei Formation by Promutagens in Metabolism‐Incompetent V79 Cells Interacting With Activation‐Proficient Cells in Various Experimental Settings
inferred← citeshttps://doi.org/10.1002/hlca.202100056openalex-snapshot
Fe‐Catalyzed Intramolecular Cross‐Dehydrogenative Arylation (CDA), Efficient Synthesis of 1‐Arylnaphthalenes and 4‐Arylcoumarins
inferred← citeshttps://doi.org/10.1002/jat.4574openalex-snapshot
A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions
inferred← citeshttps://doi.org/10.1002/mas.21570openalex-snapshot
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
inferred← citeshttps://doi.org/10.1002/mc.22784openalex-snapshot
Differentiation‐associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic‐metabolizing activity of “luminal” muscle‐invasive bladder cancers
inferred← citeshttps://doi.org/10.1002/mc.23232openalex-snapshot
SlowN‐acetylation as a possible contributor to bladder carcinogenesis
inferred← citeshttps://doi.org/10.1002/minf.201400168openalex-snapshot
Novel Uses of In Vitro Data to Develop Quantitative Biological Activity Relationship Models for in Vivo Carcinogenicity Prediction
inferred← citeshttps://doi.org/10.1002/pro.2583openalex-snapshot
Molecular dynamics of the P 450cam– P dx complex reveals complex stability and novel interface contacts
inferred← citeshttps://doi.org/10.1002/qua.27121openalex-snapshot
Exploration of the binding of antifungal drugs to human P450 2C9 based on docking and molecular dynamics simulation
inferred← citeshttps://doi.org/10.1007/978-1-4614-1531-2_354openalex-snapshot
Bioactivation of Carcinogens
inferred← citeshttps://doi.org/10.1007/978-1-4614-6436-5_354-1openalex-snapshot
Bioactivation of Carcinogens
inferred← citeshttps://doi.org/10.1007/978-3-030-15950-4_44openalex-snapshot
Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and Its Future Use for the Molecular Epidemiology of Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-16443-0_17openalex-snapshot
Xenobiotic Metabolism by Cytochrome P450 Enzymes: Insights Gained from Molecular Simulations
inferred← citeshttps://doi.org/10.1007/978-3-031-51552-1_1openalex-snapshot
Enzymatic Processes as a Basis for the Creation of Advanced Chemical Catalysts
inferred← citeshttps://doi.org/10.1007/978-3-032-28619-2_5openalex-snapshot
DNA Adduct Mediated Carcinogenesis: The Consequences of Xenobiotic Bioactivation
inferred← citeshttps://doi.org/10.1007/978-3-319-06068-2_18openalex-snapshot
Mass Spectrometric DNA Adduct Quantification by Multiple Reaction Monitoring and Its Future Use for the Molecular Epidemiology of Cancer
inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_10openalex-snapshot
Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes
inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_3openalex-snapshot
Activation of Molecular Oxygen in Cytochromes P450
inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_9openalex-snapshot
Human Cytochrome P450 Enzymes
inferred← citeshttps://doi.org/10.1007/978-3-319-98788-0_2openalex-snapshot
Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens
inferred← citeshttps://doi.org/10.1007/978-4-431-54992-5_17openalex-snapshot
Species, Ethnic, and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes
inferred← citeshttps://doi.org/10.1007/978-4-431-54992-5_2openalex-snapshot
Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes?
inferred← citeshttps://doi.org/10.1007/978-981-15-8807-5_6openalex-snapshot
Circadian Clock and Phase II Metabolism
inferred← citeshttps://doi.org/10.1007/s00204-013-1016-6openalex-snapshot
Excretion of mercapturic acids in human urine after occupational exposure to 2-chloroprene
inferred← citeshttps://doi.org/10.1007/s00204-014-1443-zopenalex-snapshot
The mycotoxin patulin reacts with DNA bases with and without previous conjugation to GSH: implication for related α,β-unsaturated carbonyl compounds?
inferred← citeshttps://doi.org/10.1007/s00204-016-1808-6openalex-snapshot
Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone
inferred← citeshttps://doi.org/10.1007/s00204-018-2162-7openalex-snapshot
Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice
inferred← citeshttps://doi.org/10.1007/s00204-018-2249-1openalex-snapshot
High-throughput metabolism-induced toxicity assays demonstrated on a 384-pillar plate
inferred← citeshttps://doi.org/10.1007/s00204-020-02971-4openalex-snapshot
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update
inferred← citeshttps://doi.org/10.1007/s00204-022-03292-4openalex-snapshot
Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells
inferred← citeshttps://doi.org/10.1007/s00204-022-03304-3openalex-snapshot
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
inferred← citeshttps://doi.org/10.1007/s00204-026-04565-yopenalex-snapshot
2-Amino-3-methylimadazo[4,5-f]quinoline (IQ) induces cytochrome P450 1A through the canonical AhR-XRE pathway in human hepatocytes
inferred← citeshttps://doi.org/10.1007/s00210-019-01724-0openalex-snapshot
Metabolism of carcinogenic alpha-asarone by human cytochrome P450 enzymes
inferred← citeshttps://doi.org/10.1007/s00210-024-03326-xopenalex-snapshot
Effects of Berberis vulgaris, and its active constituent berberine on cytochrome P450: a review
inferred← citeshttps://doi.org/10.1007/s00210-024-03525-6openalex-snapshot
Effects of Crocus sativus and its active constituents on cytochrome P450: a review
inferred← citeshttps://doi.org/10.1007/s00280-019-03905-3openalex-snapshot
Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes
inferred← citeshttps://doi.org/10.1007/s10238-020-00611-wopenalex-snapshot
Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention
inferred← citeshttps://doi.org/10.1007/s11033-014-3359-3openalex-snapshot
RETRACTED ARTICLE: Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis
inferred← citeshttps://doi.org/10.1007/s11033-015-3896-4openalex-snapshot
Retraction Note to: Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis
inferred← citeshttps://doi.org/10.1007/s11596-021-2341-2openalex-snapshot
Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment
inferred← citeshttps://doi.org/10.1007/s12032-026-03297-4openalex-snapshot
ExposoGraph: An Interactive Platform for Carcinogen Bioactivation and Detoxification Pathway Visualization
inferred← citeshttps://doi.org/10.1007/s12094-025-03920-2openalex-snapshot
Interplay between the gut microbiota, its metabolites and carcinogens
inferred← citeshttps://doi.org/10.1007/s12161-013-9601-0openalex-snapshot
Optimization and Application of a HS-SPME-GC-MS Methodology for Quantification of Furanic Compounds in Espresso Coffee
inferred← citeshttps://doi.org/10.1007/s13277-013-0783-2openalex-snapshot
CYP3A5*3 polymorphism and cancer risk: a meta-analysis and meta-regression
inferred← citeshttps://doi.org/10.1007/s43188-024-00275-8openalex-snapshot
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism
inferred← citeshttps://doi.org/10.1007/s43188-026-00356-wopenalex-snapshot
In vitro study of inhibitory effects on cytochrome P450 by thirty-nine natural products with pharmacological activities
inferred← citeshttps://doi.org/10.1007/s44169-025-00088-2openalex-snapshot
Biomonitoring Xenobiotics in Human Biospecimens: Challenges, Advances, and the Future of Exposome Characterization
inferred← citeshttps://doi.org/10.1007/s44313-024-00007-9openalex-snapshot
Impact of CYP1A1 variants on the risk of acute lymphoblastic leukemia: evidence from an updated meta-analysis
inferred← citeshttps://doi.org/10.1016/b978-0-12-417205-0.00024-9openalex-snapshot
Biotransformation Reactions and their Enzymes
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.01960-7openalex-snapshot
Cytochrome P450 Enzymes
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.02080-8openalex-snapshot
Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.65030-4openalex-snapshot
Aflatoxins
inferred← citeshttps://doi.org/10.1016/b978-0-12-804274-8.00031-xopenalex-snapshot
Cytochrome P450 and Oxidative Stress in the Liver
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00001-3openalex-snapshot
Drug Metabolism: Cytochrome P450
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.99996-1openalex-snapshot
Drug Metabolism: Cytochrome P450
inferred← citeshttps://doi.org/10.1016/b978-0-12-820490-0.00018-3openalex-snapshot
Toxicological Assessment In Vitro
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00006-1openalex-snapshot
The Importance of Biotransformation
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00058-9openalex-snapshot
Mechanistic and Clinical Chemoprevention
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00103-0openalex-snapshot
Chronic Effects of Cigarette Smoke on the Respiratory Tract
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00163-7openalex-snapshot
Cytochrome P450 Enzymes
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00193-5openalex-snapshot
Aromatic Amines, Aromatic Amides, and Heterocyclic Aromatic Amines
inferred← citeshttps://doi.org/10.1016/bs.mie.2017.06.036openalex-snapshot
Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions
inferred← citeshttps://doi.org/10.1016/bs.mie.2023.09.011openalex-snapshot
Bacterial cytochrome P450 enzymes: Semi-rational design and screening of mutant libraries in recombinant Escherichia coli cells
inferred← citeshttps://doi.org/10.1016/j.apcatb.2014.05.003openalex-snapshot
Oxidation of organosulfur compounds using an iron(III) porphyrin complex: An environmentally safe and efficient approach
inferred← citeshttps://doi.org/10.1016/j.apsb.2019.11.016openalex-snapshot
New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
inferred← citeshttps://doi.org/10.1016/j.bbagen.2014.12.015openalex-snapshot
Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.09.026openalex-snapshot
Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation
inferred← citeshttps://doi.org/10.1016/j.bcp.2015.03.008openalex-snapshot
Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo
inferred← citeshttps://doi.org/10.1016/j.bcp.2016.09.010openalex-snapshot
Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.11.013openalex-snapshot
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116241openalex-snapshot
Recombinant expression and characterization of novel P450s from Actinosynnema mirum
inferred← citeshttps://doi.org/10.1016/j.cbi.2018.01.006openalex-snapshot
Bioactivation of 1-chloro-2-hydroxy-3-butene, an in vitro metabolite of 1,3-butadiene, by rat liver microsomes
inferred← citeshttps://doi.org/10.1016/j.cbi.2020.109077openalex-snapshot
7H-Dibenzo[c,g]carbazole: Metabolic pathways and toxicity
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111088openalex-snapshot
Specific human CYP enzymes-dependent mutagenicity of tris(2-butoxyethyl) phosphate (an organophosphorus flame retardant) in human and hamster cell lines
inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213740openalex-snapshot
Fluorescent probes for the detection and imaging of Cytochrome P450
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2015.03.074openalex-snapshot
Stage-dependent ethoxyresorufin-O-deethylase (EROD) in vivo activity in medaka (Oryzias latipes) embryos
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.114158openalex-snapshot
Effects of multi-walled carbon nanotubes in soil on earthworm growth and reproduction, enzymatic activities, and metabolomics
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.119838openalex-snapshot
Host-gut microbial metabolic profiles and enzymatic targets of common organic compounds
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.114003openalex-snapshot
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.08.035openalex-snapshot
The prenylated phenolic natural product isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107458openalex-snapshot
Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU)
inferred← citeshttps://doi.org/10.1016/j.envint.2024.109187openalex-snapshot
Genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway: An experimental model for environmental carcinogenesis and pharmacological research
inferred← citeshttps://doi.org/10.1016/j.envpol.2014.10.003openalex-snapshot
Metabolic transformation as a diagnostic tool for the selection of candidate promutagens in effect-directed analysis
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.123514openalex-snapshot
In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism
inferred← citeshttps://doi.org/10.1016/j.eujim.2026.102707openalex-snapshot
Advancing planetary health through integrative evaluation of Mentha pulegium L.: Phytochemical characterization and biological activity assessment
inferred← citeshttps://doi.org/10.1016/j.fct.2016.08.010openalex-snapshot
Hepatic expression of cytochrome P450 in Zucker diabetic fatty rats
inferred← citeshttps://doi.org/10.1016/j.genrep.2020.100768openalex-snapshot
CYP2D6 gene polymorphisms and breast cancer risk in Moroccan population: A case-control study
inferred← citeshttps://doi.org/10.1016/j.hazl.2025.100155openalex-snapshot
Sulfotransferases in mediating the chlorophenol metabolism: Metabolites identification and metabolic characterization
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.138611openalex-snapshot
Efficient ribavirin removal from medical wastewater by microalgae-centric: Microbial biological action and application of double-layer network hydrogel
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2020.111095openalex-snapshot
Redox reactions of heme proteins with flavonoids
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2020.111120openalex-snapshot
Conformational selection is present in ligand binding to cytochrome P450 19A1 lipoprotein nanodiscs
inferred← citeshttps://doi.org/10.1016/j.jmgm.2022.108151openalex-snapshot
Structural dynamics of the cooperative binding of small inhibitors in human cytochrome P450 2C9
inferred← citeshttps://doi.org/10.1016/j.jpba.2014.03.018openalex-snapshot
A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologies
inferred← citeshttps://doi.org/10.1016/j.jsps.2021.05.006openalex-snapshot
Anticancer, antiplatelet, gastroprotective and hepatoprotective effects of camel urine: A scoping review
inferred← citeshttps://doi.org/10.1016/j.molcata.2015.04.021openalex-snapshot
An immobilized imidazolyl manganese porphyrin for the oxidation of olefins
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.138895openalex-snapshot
Synthesis, single crystal investigations, and quantum computational investigation of a new 1,1′-(3,5-dhydroxy-3-methyl-2′-nitro-1,2,3,4-tetrahydro-[1,1′-biphenyl]-2,6-diyl)bis(ethan-1-one) as a potent inhibitor for Cytochrome P450 3A4
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2016.08.004openalex-snapshot
Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2018.09.001openalex-snapshot
Bacterial mutagenicity of selected procarcinogens in the presence of recombinant human or rat cytochrome P4501A1
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2020.503162openalex-snapshot
Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2016.07.014openalex-snapshot
Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.redox.2014.09.007openalex-snapshot
Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction
inferred← citeshttps://doi.org/10.1016/j.redox.2014.11.008openalex-snapshot
Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications
inferred← citeshttps://doi.org/10.1016/j.reprotox.2017.07.019openalex-snapshot
Prenatal exposure to drinking-water chlorination by-products, cytochrome P450 gene polymorphisms and small-for-gestational-age neonates
inferred← citeshttps://doi.org/10.1016/j.rvsc.2016.12.003openalex-snapshot
Constitutive expression and activity of cytochrome P450 in conventional pigs
inferred← citeshttps://doi.org/10.1016/j.tet.2024.134285openalex-snapshot
An acid-mediated synthesis of substituted naphthalenes from ortho-alkynyl tertiary benzylic alcohols
inferred← citeshttps://doi.org/10.1016/j.tiv.2019.04.004openalex-snapshot
Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport
inferred← citeshttps://doi.org/10.1016/j.tjnut.2026.101600openalex-snapshot
Meat Intake, Genetic Predispositions, and the Risk of Steatotic Liver Disease in a Cohort Study
inferred← citeshttps://doi.org/10.1016/j.tox.2022.153175openalex-snapshot
Influence of aryl hydrocarbon receptor and sulfotransferase 1A1 on bisphenol AF-induced clastogenesis in human hepatoma cells
inferred← citeshttps://doi.org/10.1016/j.toxlet.2014.05.018openalex-snapshot
Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals
inferred← citeshttps://doi.org/10.1016/j.toxlet.2016.07.023openalex-snapshot
Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds
inferred← citeshttps://doi.org/10.1016/j.toxlet.2021.04.004openalex-snapshot
Application of HepG2/C3A liver spheroids as a model system for genotoxicity studies
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.04.010openalex-snapshot
Cytochrome P450 Activity in Ex Vivo Cornea Models and a Human Cornea Construct
inferred← citeshttps://doi.org/10.1016/j.ygeno.2020.05.023openalex-snapshot
CYP3A4 genetic variants are associated with susceptibility of non-small cell lung cancer in a Shaanxi Han population
inferred← citeshttps://doi.org/10.1016/s1155-1976(23)43858-2openalex-snapshot
10.1016/s1155-1976(23)43858-2
inferred← citeshttps://doi.org/10.1016/s1875-5364(22)60163-8openalex-snapshot
Inhibition of Escherichia coli nitroreductase by the constituents in Syzygium aromaticum
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b01638openalex-snapshot
TiO2 Photocatalysis–DESI-MS Rotating Array Platform for High-Throughput Investigation of Oxidation Reactions
inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00027openalex-snapshot
Biophysical Techniques for Distinguishing Ligand Binding Modes in Cytochrome P450 Monooxygenases
inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00728openalex-snapshot
Solution Architecture of Ancestral Cytochrome P450 Reductase Lipoprotein Nanodiscs
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.0c00170openalex-snapshot
LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00372openalex-snapshot
Multiple Instance Learning Improves Ames Mutagenicity Prediction for Problematic Molecular Species
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00083openalex-snapshot
Structure–Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00226openalex-snapshot
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00256openalex-snapshot
Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00286openalex-snapshot
Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.7b00111openalex-snapshot
Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes
inferred← citeshttps://doi.org/10.1021/acs.est.1c02189openalex-snapshot
Influence of Bisphenol Compounds at Nanomolar Concentrations on Chromosome Damage Induced by Metabolically Activated Carcinogens in HepG2 Cells
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.1c02786openalex-snapshot
To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme
inferred← citeshttps://doi.org/10.1021/acs.jcim.0c00360openalex-snapshot
Metabolic Forest: Predicting the Diverse Structures of Drug Metabolites
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c00503openalex-snapshot
The COMPAS Project: A Computational Database of Polycyclic Aromatic Systems. Phase 1: cata -Condensed Polybenzenoid Hydrocarbons
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00494openalex-snapshot
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2
inferred← citeshttps://doi.org/10.1021/acs.joc.9b01240openalex-snapshot
Palladium-Catalyzed Aerobic Oxidative Coupling of ortho-(Alkynyl)styrenes with Allylic Alcohols via 6-endo-dig Cyclization: Regioselective Construction of Polysubstituted Naphthalenes
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6c00048openalex-snapshot
Heteroatom-Induced Metabolic Differences: Computational Study on the Mechanism of CYP1A1-Mediated Metabolic Activation of Dibenz[ a , j ]acridine
inferred← citeshttps://doi.org/10.1021/acscentsci.5b00131openalex-snapshot
Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network
inferred← citeshttps://doi.org/10.1021/acsomega.1c00123openalex-snapshot
Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
inferred← citeshttps://doi.org/10.1021/acsomega.8b01088openalex-snapshot
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[ a ]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1
inferred← citeshttps://doi.org/10.1021/bi301092copenalex-snapshot
Oxidation of Methyl and Ethyl Nitrosamines by Cytochrome P450 2E1 and 2B1
inferred← citeshttps://doi.org/10.1021/jm4003654openalex-snapshot
Pyranoflavones: A Group of Small-Molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1
inferred← citeshttps://doi.org/10.1021/tx300492jopenalex-snapshot
Binding of Diverse Environmental Chemicals with Human Cytochromes P450 2A13, 2A6, and 1B1 and Enzyme Inhibition
inferred← citeshttps://doi.org/10.1021/tx400139popenalex-snapshot
Reduction of Aromatic and Heterocyclic AromaticN-Hydroxylamines by Human Cytochrome P450 2S1
inferred← citeshttps://doi.org/10.1021/tx500072mopenalex-snapshot
Biochemical Characterization of Eight Genetic Variants of Human DNA Polymerase κ Involved in Error-Free Bypass across Bulky N2-Guanyl DNA Adducts
inferred← citeshttps://doi.org/10.1021/tx500444eopenalex-snapshot
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals
inferred← citeshttps://doi.org/10.1038/s41389-023-00489-9openalex-snapshot
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
inferred← citeshttps://doi.org/10.1038/s41467-025-58749-8openalex-snapshot
Decoding the selective chemical modulation of CYP3A4
inferred← citeshttps://doi.org/10.1038/s41586-024-07754-wopenalex-snapshot
Gut microbiota carcinogen metabolism causes distal tissue tumours
inferred← citeshttps://doi.org/10.1038/s41598-019-43736-zopenalex-snapshot
Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population
inferred← citeshttps://doi.org/10.1038/s41598-025-12781-2openalex-snapshot
Proanthocyanidins inhibit CYP1B1 through mixed-type kinetics and stable binding in molecular dynamics simulations
inferred← citeshttps://doi.org/10.1039/c2dt31833dopenalex-snapshot
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
inferred← citeshttps://doi.org/10.1039/c4tx00116hopenalex-snapshot
The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
inferred← citeshttps://doi.org/10.1039/c6cp03692aopenalex-snapshot
Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2
inferred← citeshttps://doi.org/10.1039/c6em00071aopenalex-snapshot
Biotransformation of 8:2 fluorotelomer alcohol by recombinant human cytochrome P450s, human liver microsomes and human liver cytosol
inferred← citeshttps://doi.org/10.1039/c6mb00210bopenalex-snapshot
Network analysis and cross species comparison of protein–protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics
inferred← citeshttps://doi.org/10.1039/d1em00307kopenalex-snapshot
Emerging investigator series: human CYP2A6 catalyzes the oxidation of 6:2 fluorotelomer alcohol
inferred← citeshttps://doi.org/10.1039/d6np00008hopenalex-snapshot
Challenges and opportunities in the synthesis of biologically relevant flavonoids and their glycosides
inferred← citeshttps://doi.org/10.1074/jbc.m113.452953openalex-snapshot
Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism
inferred← citeshttps://doi.org/10.1074/jbc.m116.773937openalex-snapshot
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol
inferred← citeshttps://doi.org/10.1074/jbc.r113.452805openalex-snapshot
Structural Diversity of Eukaryotic Membrane Cytochrome P450s
inferred← citeshttps://doi.org/10.1074/jbc.r113.462275openalex-snapshot
Unusual Cytochrome P450 Enzymes and Reactions
inferred← citeshttps://doi.org/10.1074/jbc.ra117.000961openalex-snapshot
Membrane-embedded substrate recognition by cytochrome P450 3A4
inferred← citeshttps://doi.org/10.1074/jbc.ra118.005033openalex-snapshot
The aryl hydrocarbon receptor–cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly
inferred← citeshttps://doi.org/10.1074/jbc.ra118.005588openalex-snapshot
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands
inferred← citeshttps://doi.org/10.1080/00498254.2017.1288945openalex-snapshot
R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys
inferred← citeshttps://doi.org/10.1080/00498254.2017.1321811openalex-snapshot
Terfenadinet-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines
inferred← citeshttps://doi.org/10.1080/03602532.2023.2177671openalex-snapshot
Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol
inferred← citeshttps://doi.org/10.1080/15287394.2014.951757openalex-snapshot
Directed-Evolution Analysis of Human Cytochrome P450 2A6 for Enhanced Enzymatic Catalysis
inferred← citeshttps://doi.org/10.1080/26896583.2021.1880242openalex-snapshot
Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
inferred← citeshttps://doi.org/10.1088/1757-899x/546/6/062005openalex-snapshot
Synthesis of 2-methyl-5-methoxy-1,4-benzoquinone and In-silico Activity Profiling Toward Cytochrome P450-3A4
inferred← citeshttps://doi.org/10.1089/ars.2022.0116openalex-snapshot
Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy
inferred← citeshttps://doi.org/10.1093/carcin/bgy058openalex-snapshot
The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
inferred← citeshttps://doi.org/10.1093/molbev/msac116openalex-snapshot
Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates
inferred← citeshttps://doi.org/10.1093/mutage/geae011openalex-snapshot
Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition
inferred← citeshttps://doi.org/10.1093/mutage/get039openalex-snapshot
Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium
inferred← citeshttps://doi.org/10.1093/mutage/gey025openalex-snapshot
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells
inferred← citeshttps://doi.org/10.1093/mutage/gez044openalex-snapshot
Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models
inferred← citeshttps://doi.org/10.1093/toxsci/kfad012openalex-snapshot
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment
inferred← citeshttps://doi.org/10.1093/toxsci/kfae132openalex-snapshot
Multi-defense pathways against electrophiles through adduct formation by low molecular weight substances with sulfur atoms
inferred← citeshttps://doi.org/10.1093/toxsci/kfy184openalex-snapshot
The Evolution of Carcinogenesis
inferred← citeshttps://doi.org/10.1097/fpc.0b013e32835c2ddfopenalex-snapshot
Functional characterization of eight human CYP1A2 variants
inferred← citeshttps://doi.org/10.1101/2023.03.03.530858openalex-snapshot
Early life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life
inferred← citeshttps://doi.org/10.1101/2024.05.20.595058openalex-snapshot
Systematic analysis of gut bacterial carcinogen metabolism and its functional consequences
inferred← citeshttps://doi.org/10.1101/2025.09.15.676391openalex-snapshot
Systematic identification and characterization of regulators of aryl hydrocarbon receptor signaling
inferred← citeshttps://doi.org/10.1111/cbdd.13669openalex-snapshot
Inhibition of human CYP1 enzymes by a classical inhibitor α‐naphthoflavone and a novel inhibitor N‐(3, 5‐dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study
inferred← citeshttps://doi.org/10.1111/jfbc.12783openalex-snapshot
Cooking has the potential to decrease the antitumor effect of fresh Betong watercress
inferred← citeshttps://doi.org/10.1111/jfs.12532openalex-snapshot
Aflatoxins in cereals: State of the art
inferred← citeshttps://doi.org/10.1124/dmd.119.089607openalex-snapshot
Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate
inferred← citeshttps://doi.org/10.1124/dmd.121.000403openalex-snapshot
Characterization of a Novel CYP1A2 Knockout Rat Model Constructed by CRISPR/Cas9
inferred← citeshttps://doi.org/10.1124/dmd.123.001500openalex-snapshot
Construction of Humanized CYP1A2 Rats Using CRISPR/CRISPR-Associated Protein 9 to Promote Drug Metabolism and Pharmacokinetic Research
showing the first 200 of 271 · page through all 271
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.