On the public citation graph
Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism
0 signed · 284 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cmdc.200600155openalex-snapshot
Prediction of ADMET Properties
inferredcites →https://doi.org/10.1002/mas.20059openalex-snapshot
Applications of accelerator mass spectrometry for pharmacological and toxicological research
inferredcites →https://doi.org/10.1002/rcm.1859openalex-snapshot
Increasing throughput and information content for in vitro drug metabolism experiments using ultra‐performance liquid chromatography coupled to a quadrupole time‐of‐flight mass spectrometer
inferredcites →https://doi.org/10.1002/rcm.2111openalex-snapshot
Accelerated throughput metabolic route screening in early drug discovery using high‐resolution liquid chromatography/quadrupole time‐of‐flight mass spectrometry and automated data analysis
inferredcites →https://doi.org/10.1002/rcm.2996openalex-snapshot
MS E with mass defect filtering for in vitro and in vivo metabolite identification
inferredcites →https://doi.org/10.1006/taap.2002.9440openalex-snapshot
Drug Metabolites in Safety Testing
inferredcites →https://doi.org/10.1007/s00210-006-0040-yopenalex-snapshot
Pharmacogenomics of human OATP transporters
inferredcites →https://doi.org/10.1007/s10928-005-0074-7openalex-snapshot
How Modeling and Simulation Have Enhanced Decision Making in New Drug Development
inferredcites →https://doi.org/10.1016/j.bbagen.2006.09.019openalex-snapshot
Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes
inferredcites →https://doi.org/10.1016/j.cbpa.2006.11.035openalex-snapshot
MALDI-MS-based imaging of small molecules and proteins in tissues
inferredcites →https://doi.org/10.1016/j.chroma.2004.08.119openalex-snapshot
High-field asymmetric waveform ion mobility spectrometry: A new tool for mass spectrometry
inferredcites →https://doi.org/10.1016/j.ejphar.2006.08.025openalex-snapshot
Selection of new chemical entities with decreased potential for adverse drug reactions
inferredcites →https://doi.org/10.1016/j.taap.2006.08.009openalex-snapshot
Complicating factors in safety testing of drug metabolites: Kinetic differences between generated and preformed metabolites
inferredcites →https://doi.org/10.1016/j.tox.2006.05.101openalex-snapshot
Toxicophores: Investigations in drug safety
inferredcites →https://doi.org/10.1016/j.vascn.2004.11.006openalex-snapshot
A semi-automated method for measuring the potential for protein covalent binding in drug discovery
inferredcites →https://doi.org/10.1016/s0009-2797(02)00051-0openalex-snapshot
A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity
inferredcites →https://doi.org/10.1016/s1359-6446(03)02888-5openalex-snapshot
Idiosyncratic toxicity: the role of toxicophores and bioactivation
inferredcites →https://doi.org/10.1021/ac034980sopenalex-snapshot
Integration of Knowledge-Based Metabolic Predictions with Liquid Chromatography Data-Dependent Tandem Mass Spectrometry for Drug Metabolism Studies: Application to Studies on the Biotransformation of Indinavir
inferredcites →https://doi.org/10.1021/ac0622781openalex-snapshot
Untargeted Analysis of Mass Spectrometry Data for Elucidation of Metabolites and Function of Enzymes
inferredcites →https://doi.org/10.1021/mp050095hopenalex-snapshot
Scientific Perspectives on Drug Transporters and Their Role in Drug Interactions
inferredcites →https://doi.org/10.1021/tx034170bopenalex-snapshot
Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development
inferredcites →https://doi.org/10.1021/tx0501738openalex-snapshot
Analysis of Protein Covalent Modification by Xenobiotics Using a Covert Oxidatively Activated Tag: Raloxifene Proof-of-Principle Study
inferredcites →https://doi.org/10.1021/tx050312lopenalex-snapshot
Cytosolic and Nuclear Protein Targets of Thiol-Reactive Electrophiles
inferredcites →https://doi.org/10.1021/tx060062oopenalex-snapshot
Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology
inferredcites →https://doi.org/10.1021/tx0602012openalex-snapshot
Metabolites and Safety: What Are the Concerns, and How Should We Address Them?
inferredcites →https://doi.org/10.1021/tx060203mopenalex-snapshot
A Regulatory Perspective on Issues and Approaches in Characterizing Human Metabolites
inferredcites →https://doi.org/10.1021/tx060213nopenalex-snapshot
Future of ToxicologyMechanisms of Toxicity and Drug Safety: Where Do We Go from Here?
inferredcites →https://doi.org/10.1021/tx6002547openalex-snapshot
Safety Assessment of Drug Metabolites: Characterization of Chemically Stable Metabolites
inferredcites →https://doi.org/10.1021/tx600260aopenalex-snapshot
Applying Mechanisms of Chemical Toxicity to Predict Drug Safety
inferredcites →https://doi.org/10.1021/tx6003166openalex-snapshot
A Proteomic Analysis of Bromobenzene Reactive Metabolite Targets in Rat Liver Cytosol in Vivo
inferredcites →https://doi.org/10.1021/tx600351gopenalex-snapshot
Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression
inferredcites →https://doi.org/10.1021/tx700031ropenalex-snapshot
Protein Targets of Reactive Electrophiles in Human Liver Microsomes
inferredcites →https://doi.org/10.1038/nature03193openalex-snapshot
Navigating chemical space for biology and medicine
inferredcites →https://doi.org/10.1038/nrd1032openalex-snapshot
ADMET in silico modelling: towards prediction paradise?
inferredcites →https://doi.org/10.1038/nrd1470openalex-snapshot
Can the pharmaceutical industry reduce attrition rates?
inferredcites →https://doi.org/10.1038/nrd2310openalex-snapshot
Interfering with disease: a progress report on siRNA-based therapeutics
inferredcites →https://doi.org/10.1038/sj.clpt.6100038openalex-snapshot
Effect of OATP1B Transporter Inhibition on the Pharmacokinetics of Atorvastatin in Healthy Volunteers
inferredcites →https://doi.org/10.1038/sj.clpt.6100051openalex-snapshot
Impact of Pharmacometric Reviews on New Drug Approval and Labeling Decisions—a Survey of 31 New Drug Applications Submitted Between 2005 and 2006
inferredcites →https://doi.org/10.1038/sj.clpt.6100052openalex-snapshot
ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise
inferredcites →https://doi.org/10.1038/sj.clpt.6100063openalex-snapshot
The Prospects for “Personalized Medicine” in Drug Development and Drug Therapy
inferredcites →https://doi.org/10.1038/sj.onc.1209372openalex-snapshot
Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions
inferredcites →https://doi.org/10.1080/03602530601021340openalex-snapshot
Application of Chimeric Mice with Humanized Liver for Predictive ADME
inferredcites →https://doi.org/10.1097/00007691-200404000-00018openalex-snapshot
Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy
inferredcites →https://doi.org/10.1101/gr.4356206openalex-snapshot
Functional genomics of membrane transporters in human populations
inferredcites →https://doi.org/10.1111/j.1365-2125.1988.tb03318.xopenalex-snapshot
Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985).
inferredcites →https://doi.org/10.1111/j.1742-7843.2006.pto_444.xopenalex-snapshot
Application of Genomics in Preclinical Drug Safety Evaluation
inferredcites →https://doi.org/10.1124/dmd.105.005041openalex-snapshot
SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING
inferredcites →https://doi.org/10.1124/dmd.106.009258openalex-snapshot
IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
inferredcites →https://doi.org/10.1124/jpet.105.093088openalex-snapshot
Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems
inferredcites →https://doi.org/10.1126/science.1096800openalex-snapshot
Organic Chemistry in Drug Discovery
inferredcites →https://doi.org/10.1126/science.1124619openalex-snapshot
Mass Spectrometry and Protein Analysis
inferredcites →https://doi.org/10.1126/science.1135308openalex-snapshot
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
inferredcites →https://doi.org/10.1146/annurev.pharmtox.47.120505.105150openalex-snapshot
Idiosyncratic Drug Reactions: Current Understanding
inferredcites →https://doi.org/10.1177/0091270006299092openalex-snapshot
American College of Clinical Pharmacology Position Statement on the Use of Microdosing in the Drug Development Process
inferredcites →https://doi.org/10.1177/0091270007299930openalex-snapshot
Nuclear Receptors and the Regulation of Drug‐Metabolizing Enzymes and Drug Transporters: Implications for Interindividual Variability in Response to Drugs
inferredcites →https://doi.org/10.1208/aapsj080112openalex-snapshot
Cytochrome P450s and other enzymes in drug metabolism and toxicity
inferredcites →https://doi.org/10.1517/17425255.1.1.23openalex-snapshot
The use of accelerator mass spectrometry to obtain early human ADME/PK data
inferredcites →https://doi.org/10.1517/17425255.1.1.91openalex-snapshot
Minimising the potential for metabolic activation in drug discovery
inferredcites →https://doi.org/10.1517/17425255.2.6.823openalex-snapshot
High-throughputinvitroprofiling assays: lessons learnt from experiences at Novartis
inferredcites →https://doi.org/10.1517/17425255.2.6.923openalex-snapshot
Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology
inferredcites →https://doi.org/10.1517/17425255.3.1.81openalex-snapshot
Transporter-mediated drug interactions: clinical implications andin vitroassessment
inferredcites →https://doi.org/10.2165/00003088-200544030-00005openalex-snapshot
Mechanism-Based Inhibition of Cytochrome P450 3A4 by Therapeutic Drugs
inferredcites →https://doi.org/10.2165/00003088-200544120-00002openalex-snapshot
Effect of Genetic Polymorphisms in Cytochrome P450 (CYP) 2C9 and CYP2C8 on the Pharmacokinetics of Oral Antidiabetic Drugs
inferredcites →https://doi.org/10.2165/00003088-200645030-00003openalex-snapshot
Genetic Polymorphisms of Drug-Metabolising Enzymes and Drug Transporters in the Chemotherapeutic Treatment of Cancer
inferredcites →https://doi.org/10.2174/1389200023337522openalex-snapshot
Cytochrome P450 Pharmacogenetics in Drug Development: In Vitro Studies and Clinical Consequences
inferredcites →https://doi.org/10.2174/1389200054021799openalex-snapshot
A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
inferredcites →https://doi.org/10.2174/138920005774330602openalex-snapshot
Utility of Recombinant Cytochrome P450 Enzymes: A Drug Metabolism Perspective
inferredcites →https://doi.org/10.2174/138920006777697945openalex-snapshot
Editorial [ Use of Mass Spectrometry for Drug Metabolism Studies (Guest Editor: Walter A. Korfmacher )]
inferredcites →https://doi.org/10.2174/138920006777697972openalex-snapshot
Utility of the Hybrid LTQ-FTMS for Drug Metabolism Applications
inferredcites →https://doi.org/10.2174/138920007779816002openalex-snapshot
Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy
inferredcites →https://doi.org/10.2174/1568026033452096openalex-snapshot
The Role of Absorption, Distribution, Metabolism, Excretion and Toxicity in Drug Discovery
inferredcites →https://doi.org/10.2217/14622416.7.7.1025openalex-snapshot
Toxicogenomics in Drug Discovery and Development: Mechanistic Analysis of Compound/Class-Dependent Effects Using the Drugmatrix®Database
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4789126openalex-extracted
Multi Organ Model Assessment of Neurotoxicity Following Exposure of Liver Spheroids to Drugs
inferred← citeshttps://doi.org/10.1002/0471141755.ph0708s23openalex-snapshot
In Vitro Drug Metabolism Using Liver Microsomes
inferred← citeshttps://doi.org/10.1002/9780470439265.ch23openalex-snapshot
Chemical Mechanisms in Toxicology
inferred← citeshttps://doi.org/10.1002/9780470538951.ch5openalex-snapshot
The Role of Drug Metabolism in Drug Discovery
inferred← citeshttps://doi.org/10.1002/9780470571224.pse122openalex-snapshot
Chemical Mechanisms in Toxicology
inferred← citeshttps://doi.org/10.1002/9780470571224.pse536openalex-snapshot
ADME for Therapeutic Biologics: What Can We Leverage from Great Wealth of ADME Knowledge and Research for Small Molecules
inferred← citeshttps://doi.org/10.1002/9780470890387.ch7openalex-snapshot
Strategies for the Detection of Reactive Intermediates in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1002/9780470921920.edm029openalex-snapshot
Mass Balance Studies in Animals and Humans
inferred← citeshttps://doi.org/10.1002/9780470921920.edm053openalex-snapshot
Drug Bioactivation and Oxidative Stress
inferred← citeshttps://doi.org/10.1002/9780470921920.edm054openalex-snapshot
Drug Metabolism in Drug Safety Evaluation
inferred← citeshttps://doi.org/10.1002/9780470921920.edm127openalex-snapshot
Role of Metabolism in Toxicity of Drugs in Humans
inferred← citeshttps://doi.org/10.1002/9781118180730.ch6openalex-snapshot
LC‐MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective
inferred← citeshttps://doi.org/10.1002/9781118180778.ch20openalex-snapshot
Application of Accurate Mass Spectrometry for Metabolite Identification
inferred← citeshttps://doi.org/10.1002/9781118180778.ch4openalex-snapshot
Pharmacological and Toxicological Activity of Drug Metabolites
inferred← citeshttps://doi.org/10.1002/9781118180778.ch9openalex-snapshot
Technical Challenges and Recent Advances of Implementing Comprehensive ADMET Tools in Drug Discovery
inferred← citeshttps://doi.org/10.1002/9781118516157.ch12openalex-snapshot
Screening Reactive Metabolites: Role of Liquid Chromatography–High‐Resolution Mass Spectrometry in Combination with “Intelligent” Data Mining Tools
inferred← citeshttps://doi.org/10.1002/9781118541203.xen0002openalex-snapshot
Fundamentals of Organic Chemistry as Applicable to the Biotransformation of Foreign Compounds
inferred← citeshttps://doi.org/10.1002/9781118541203.xen0007openalex-snapshot
Role of Biotransformation in Drug Discovery
inferred← citeshttps://doi.org/10.1002/9781118541203.xen0015openalex-snapshot
In Vitro Experimental Models for Studying Drug Biotransformation
inferred← citeshttps://doi.org/10.1002/9781118541203.xen0017openalex-snapshot
Theory and Instrumentation of Mass Spectrometry and its Application to Drug Metabolism
inferred← citeshttps://doi.org/10.1002/9781118681121.ch24openalex-snapshot
Using Crystal Structures of Drug‐Metabolizing Enzymes in Mechanism‐Based Modeling for Drug Design
inferred← citeshttps://doi.org/10.1002/9781119851042.ch21openalex-snapshot
Chemical Mechanisms in Toxicology
inferred← citeshttps://doi.org/10.1002/9783527655748.ch13openalex-snapshot
Mitigating Toxicity Risks with Affinity Labeling Drug Candidates
inferred← citeshttps://doi.org/10.1002/9783527808694.ch6openalex-snapshot
Ceritinib: A Potent ALK Inhibitor for the Treatment of Crizotinib‐Resistant Non‐Small Cell Lung Cancer Tumors
inferred← citeshttps://doi.org/10.1002/ardp.202000231openalex-snapshot
Protective effect of corynoline in a murine allergic rhinitis model via inhibition of caspase‐1/NF‐κB
inferred← citeshttps://doi.org/10.1002/bdd.660openalex-snapshot
Metabolites in safety testing: metabolite identification strategies in discovery and development
inferred← citeshttps://doi.org/10.1002/bdd.720openalex-snapshot
Acyl glucuronides: the good, the bad and the ugly
inferred← citeshttps://doi.org/10.1002/bkcs.11287openalex-snapshot
Structure–Activity Relationship Study of 2,4‐Dianilinopyrimidine Containing Methanesulfonamide (TRE‐069) as Potent and Selective Epidermal Growth Factor Receptor T790M/C797S Mutant Inhibitor for Anticancer Treatment
inferred← citeshttps://doi.org/10.1002/bmc.4643openalex-snapshot
Characterization of ginsenoside compound K metabolites in rat urine and feces by ultra‐performance liquid chromatography with electrospray ionization quadrupole time‐of‐flight tandem mass spectrometry
inferred← citeshttps://doi.org/10.1002/cbdv.202400292openalex-snapshot
Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Ruellia tuberosa L.: A Review
inferred← citeshttps://doi.org/10.1002/chem.202501944openalex-snapshot
In Situ Electrochemical Synthesis of Redox‐Active o‐Hydroquinone Metabolite of Flufenamic Acid on MWCNT Surface: Lifespan Extension in C. elegans via SOD Pathway
inferred← citeshttps://doi.org/10.1002/cmdc.201900643openalex-snapshot
Amino Alcohol Acrylonitriles as Activators of the Aryl Hydrocarbon Receptor Pathway: An Unexpected MTT Phenotypic Screening Outcome
inferred← citeshttps://doi.org/10.1002/cpph.9openalex-snapshot
In Vitro Drug Metabolism Using Liver Microsomes
inferred← citeshttps://doi.org/10.1002/ejoc.201300419openalex-snapshot
A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine
inferred← citeshttps://doi.org/10.1002/jat.4384openalex-snapshot
Cytogenotoxicity assessment of 3‐(3,4‐dihydroxyphenyl)‐7,8‐dihydroxycoumarin on HepG2/C3A cells and leukocytes
inferred← citeshttps://doi.org/10.1002/jlcr.4133openalex-snapshot
Synthesis of Carbon 14 and Deuterium‐Labelled Nerandomilast (BI 1015550)
inferred← citeshttps://doi.org/10.1002/jms.1610openalex-snapshot
Mass defect filter technique and its applications to drug metabolite identification by high‐resolution mass spectrometry
inferred← citeshttps://doi.org/10.1002/med.21273openalex-snapshot
The Generation, Detection, and Effects of Reactive Drug Metabolites
inferred← citeshttps://doi.org/10.1002/rcm.10164openalex-snapshot
In Vitro Metabolite Profiling of 4,4‐Diaminodiphenylmethane Using Human Liver S9 Fractions and LC‐Orbitrap HRMS: In Silico Toxicity Studies of Its Metabolites
inferred← citeshttps://doi.org/10.1002/rcm.3472openalex-snapshot
High‐throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time‐of‐flight system as a ‘first‐line’ approach for metabolite identification studies
inferred← citeshttps://doi.org/10.1002/rcm.3854openalex-snapshot
IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers
inferred← citeshttps://doi.org/10.1002/rcm.4753openalex-snapshot
Enhanced metabolite identification with MS E and a semi‐automated software for structural elucidation
inferred← citeshttps://doi.org/10.1002/rcm.8823openalex-snapshot
An integrated strategy for profiling the chemical components of Scutellariae Radix and their exogenous substances in rats by ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry
inferred← citeshttps://doi.org/10.1007/7355_2016_19openalex-snapshot
γ-Secretase Modulators as Aβ42-Lowering Pharmacological Agents to Treat Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/978-1-0716-1554-6_4openalex-snapshot
Multienzyme Kinetics and Sequential Metabolism
inferred← citeshttps://doi.org/10.1007/978-1-4471-5553-9_4openalex-snapshot
Toxicodynamics: How Chemicals Harm Cells
inferred← citeshttps://doi.org/10.1007/978-1-60761-849-2_17openalex-snapshot
Protocols of In Vitro Protein Covalent Binding Studies in Liver
inferred← citeshttps://doi.org/10.1007/978-1-61779-222-9_13openalex-snapshot
Pharmacokinetic and Pharmacodynamic Interactions Between Alcohol and Other Drugs
inferred← citeshttps://doi.org/10.1007/978-1-62703-122-6_17openalex-snapshot
Targeted Proteomics for Metabolic Pathway Optimization
inferred← citeshttps://doi.org/10.1007/978-1-62703-758-7_6openalex-snapshot
Multienzyme Kinetics and Sequential Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-030-54490-4_19openalex-snapshot
Parameters and Strategies to Overcome Barriers to Systemic Delivery
inferred← citeshttps://doi.org/10.1007/978-3-031-20806-5_2openalex-snapshot
Techniques for the Detection, Quantifications, and Identification of Pharmaceutically Active Compounds and Their Removal Mechanisms
inferred← citeshttps://doi.org/10.1007/978-3-642-00663-0_19openalex-snapshot
Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery
inferred← citeshttps://doi.org/10.1007/s00044-023-03144-5openalex-snapshot
Acyl-CoA thioesters as chemically-reactive intermediates of carboxylic acid-containing drugs
inferred← citeshttps://doi.org/10.1007/s00204-011-0693-2openalex-snapshot
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
inferred← citeshttps://doi.org/10.1007/s10646-020-02239-8openalex-snapshot
Diazepam, metformin, omeprazole and simvastatin: a full discussion of individual and mixture acute toxicity
inferred← citeshttps://doi.org/10.1007/s10822-011-9479-0openalex-snapshot
In silico prediction of acyl glucuronide reactivity
inferred← citeshttps://doi.org/10.1007/s11030-012-9364-3openalex-snapshot
QSAR classification of metabolic activation of chemicals into covalently reactive species
inferred← citeshttps://doi.org/10.1007/s12678-024-00907-5openalex-snapshot
Electrochemical Oxidative Degradation and Trapping of the Mefenamic Acid Drug as a Redox-Active Hydroxy Metabolite on a Carbon Black Surface: Mediated Oxidation and Sensing of Thiol Biomarker
inferred← citeshttps://doi.org/10.1007/s40495-018-0144-3openalex-snapshot
LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury
inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.01127-1openalex-snapshot
Ovarian Metabolism of Xenobiotics
inferred← citeshttps://doi.org/10.1016/b978-0-12-387815-1.00002-2openalex-snapshot
ADME in Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.02155-3openalex-snapshot
Ovarian Metabolism of Xenobiotics
inferred← citeshttps://doi.org/10.1016/b978-0-12-803620-4.00003-7openalex-snapshot
ADME in Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-823944-5.00014-4openalex-snapshot
Hepatoprotective potential of bioflavonoids
inferred← citeshttps://doi.org/10.1016/b978-0-323-85704-8.00010-4openalex-snapshot
Overview of ADME Science
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.11008-3openalex-snapshot
Ovarian Metabolism of Xenobiotics
inferred← citeshttps://doi.org/10.1016/b978-0-443-06959-8.00024-8openalex-snapshot
Inhaled Anesthetics: Metabolism and Toxicity
inferred← citeshttps://doi.org/10.1016/b978-0-443-13474-6.00025-1openalex-snapshot
Treatment of heavy metal induced neurotoxicity via advanced drug delivery systems
inferred← citeshttps://doi.org/10.1016/b978-0-443-23740-9.00003-xopenalex-snapshot
Chemical interactive behaviors of drugs
inferred← citeshttps://doi.org/10.1016/b978-0-443-33524-2.00005-3openalex-snapshot
Research needs: Setting priorities for future directions
inferred← citeshttps://doi.org/10.1016/bs.apha.2022.06.001openalex-snapshot
Use of engineered cytochromes P450 for accelerating drug discovery and development
inferred← citeshttps://doi.org/10.1016/bs.apha.2025.02.003openalex-snapshot
Pharmacological potential of calorie restriction mimetics in mitigating brain aging
inferred← citeshttps://doi.org/10.1016/j.ab.2014.03.022openalex-snapshot
Evaluation of coumarin-based fluorogenic P450 BM3 substrates and prospects for competitive inhibition screenings
inferred← citeshttps://doi.org/10.1016/j.aca.2010.11.014openalex-snapshot
Strategy of using microsome-based metabolite production to facilitate the identification of endogenous metabolites by liquid chromatography mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.aca.2022.339814openalex-snapshot
Mass defect filter technique combined with stable isotope tracing for drug metabolite identification using high-resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.addr.2020.06.018openalex-snapshot
Advanced drug delivery 2020 and beyond: Perspectives on the future
inferred← citeshttps://doi.org/10.1016/j.bbagen.2012.05.011openalex-snapshot
Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.113796openalex-snapshot
Is there enough evidence to classify cycloalkyl amine substituents as structural alerts?
inferred← citeshttps://doi.org/10.1016/j.cbi.2008.09.014openalex-snapshot
Recent advances in applications of liquid chromatography–tandem mass spectrometry to the analysis of reactive drug metabolites
inferred← citeshttps://doi.org/10.1016/j.cbi.2008.10.010openalex-snapshot
Tissue slices for the evaluation of metabolism-based toxicity with the example of diclofenac
inferred← citeshttps://doi.org/10.1016/j.cbi.2010.09.003openalex-snapshot
Handling reactive metabolite positives in drug discovery: What has retrospective structure–toxicity analyses taught us?
inferred← citeshttps://doi.org/10.1016/j.cbi.2011.01.005openalex-snapshot
Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design
inferred← citeshttps://doi.org/10.1016/j.cbi.2014.10.014openalex-snapshot
Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111620openalex-snapshot
Thiazole-fused thiazoliniums with ketone warheads as covalent inhibitors targeting Cys44 of SARS-CoV-2 3CLpro
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.01.028openalex-snapshot
Engineering and application of P450 monooxygenases in pharmaceutical and metabolite synthesis
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2025.144149openalex-snapshot
Allium cepa exposed to Nativo® fungicide with and without swine liver enzyme biotransformation: A comparative genotoxicity study
inferred← citeshttps://doi.org/10.1016/j.chroma.2020.461501openalex-snapshot
Understanding performance of 3D-printed sorbent in study of metabolic stability
inferred← citeshttps://doi.org/10.1016/j.comtox.2025.100344openalex-snapshot
Drugs inhibition prediction in P-gp enzyme: a comparative study of machine learning and graph neural network
inferred← citeshttps://doi.org/10.1016/j.coph.2026.102609openalex-snapshot
Pharmacological silence: Revisiting the clinical and molecular impact of inactive metabolites
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.119634openalex-snapshot
Developmental neurotoxic effects of dibutyl phthalate and its metabolite mono-n-butyl phthalate on Danio rerio
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120018openalex-snapshot
Metabolism matters: Interspecies variability and ecological traits of biotransformation kinetics
inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.10.026openalex-snapshot
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. part 3
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.10.069openalex-snapshot
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112551openalex-snapshot
Development of a metabolically stable topoisomerase I poison as anticancer agent
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115989openalex-snapshot
The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.11.008openalex-snapshot
The biological significance of methionine sulfoxide stereochemistry
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.03.046openalex-snapshot
A target-group-change strategy based on the UPLC-Q-TOF-MS E method for the metabolites identification of Fufang-Xialian-Capsule in rat's plasma
inferred← citeshttps://doi.org/10.1016/j.jep.2015.04.039openalex-snapshot
UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.134056openalex-snapshot
Vital role of CYP450 in the biodegradation of antidiabetic drugs in the aerobic activated sludge system and the mechanisms
inferred← citeshttps://doi.org/10.1016/j.jics.2024.101274openalex-snapshot
Identification of new inhibitors for the avian H1N1 virus through molecular docking and dynamic simulation approaches
inferred← citeshttps://doi.org/10.1016/j.jpba.2023.115607openalex-snapshot
Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.117034openalex-snapshot
Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver
inferred← citeshttps://doi.org/10.1016/j.matpr.2019.06.464openalex-snapshot
Voltammetric detection and determination of mefenamic acid at silver-doped TiO2 nanoparticles modified electrode
inferred← citeshttps://doi.org/10.1016/j.nexres.2026.102150openalex-snapshot
Enzymes define pathways and metabolic relationships
inferred← citeshttps://doi.org/10.1016/j.pharma.2010.11.001openalex-snapshot
Brief historical overview and recent progress on cytochromes P450: Adaptation of aerobic organisms to their chemical environment and new mechanisms of prodrug bioactivation
inferred← citeshttps://doi.org/10.1016/j.pharma.2010.12.001openalex-snapshot
Importance de l’oxydation métabolique des médicaments et autres xénobiotiques : développements récents
inferred← citeshttps://doi.org/10.1016/j.rechem.2023.101282openalex-snapshot
A facile synthesis of 2-(4-((4-chlorophenyl)(hydroxy)methyl) phenoxy)-2-methylpropanoic acid: Metabolite of anti-hyperlipidemic drug Fenofibrate
inferred← citeshttps://doi.org/10.1016/j.tiv.2019.06.015openalex-snapshot
A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform
inferred← citeshttps://doi.org/10.1016/j.tiv.2022.105392openalex-snapshot
Pracaxi oil affects xenobiotic metabolisms, cellular proliferation, and oxidative stress without cytotogenotoxic effects in HepG2/C3A cells
inferred← citeshttps://doi.org/10.1016/j.tiv.2022.105474openalex-snapshot
Differential mRNA expression in the induction of DNA damage, G2/M arrest, and cell death by zerumbone in HepG2/C3A cells
inferred← citeshttps://doi.org/10.1016/j.tox.2014.10.006openalex-snapshot
Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data
inferred← citeshttps://doi.org/10.1016/j.xpro.2023.102086openalex-snapshot
Protocol to study in vitro drug metabolism and identify montelukast metabolites from purified enzymes and primary cell cultures by mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ymben.2010.12.005openalex-snapshot
Targeted proteomics for metabolic pathway optimization: Application to terpene production
inferred← citeshttps://doi.org/10.1016/s0065-7743(09)04422-4openalex-snapshot
Chapter 22 Safety Testing of Drug Metabolites
inferred← citeshttps://doi.org/10.1016/s1872-0854(09)00003-4openalex-snapshot
Chapter 3 Applications of Quadrupole-Linear Ion Trap Mass Spectrometry to the Analysis of Reactive Metabolites in Drug Discovery and Development
inferred← citeshttps://doi.org/10.1017/cbo9780511779053.014openalex-snapshot
Mechanism-based toxicity studies for drug development
inferred← citeshttps://doi.org/10.1021/ac802096popenalex-snapshot
Screening for DNA Adducts by Data-Dependent Constant Neutral Loss-Triple Stage Mass Spectrometry with a Linear Quadrupole Ion Trap Mass Spectrometer
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c04712openalex-snapshot
An Electrochemical Pipette for the Study of Drug Metabolite
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00046openalex-snapshot
Filtration Suppresses Laser-Induced Nucleation of Glycine in Aqueous Solutions
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.3c00164openalex-snapshot
Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.3c00402openalex-snapshot
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00147openalex-snapshot
Mass Spectrometric and Functional Aspects of Drug–Protein Conjugation
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00332openalex-snapshot
Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens
inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00404openalex-snapshot
Limitations of Ligand-Only Approaches for Predicting the Reactivity of Covalent Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00796openalex-snapshot
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01293openalex-snapshot
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01305openalex-snapshot
Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib
inferred← citeshttps://doi.org/10.1021/acs.joc.2c01311openalex-snapshot
One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites
inferred← citeshttps://doi.org/10.1021/bc900289mopenalex-snapshot
Fluorescence-Based Liver Microsomal Assay for Screening of Pharmaceutical Reactive Metabolites Using a Glutathione Conjugated 96-Well Plate
inferred← citeshttps://doi.org/10.1021/cs300001xopenalex-snapshot
Tuning P450 Enzymes as Oxidation Catalysts
inferred← citeshttps://doi.org/10.1021/jm200153popenalex-snapshot
Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
inferred← citeshttps://doi.org/10.1021/jm400402qopenalex-snapshot
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase…
inferred← citeshttps://doi.org/10.1021/jm501531vopenalex-snapshot
Discovery of AZD6642, an Inhibitor of 5-Lipoxygenase Activating Protein (FLAP) for the Treatment of Inflammatory Diseases
inferred← citeshttps://doi.org/10.1021/ml400316popenalex-snapshot
Preparative Microfluidic Electrosynthesis of Drug Metabolites
inferred← citeshttps://doi.org/10.1021/tx200290sopenalex-snapshot
Pulmonary Toxicity and Metabolic Activation of Tetrandrine in CD-1 Mice
inferred← citeshttps://doi.org/10.1021/tx3002466openalex-snapshot
In Vitro Bioactivation of a Selective Estrogen Receptor Modulator (2S,3R)-(+)-3-(3-Hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in Liver Microsomes: Formation of Adenine Adducts
inferred← citeshttps://doi.org/10.1021/tx3003998openalex-snapshot
Bioactivation of 2-(Alkylthio)-1,3,4-Thiadiazoles and 2-(Alkylthio)-1,3-Benzothiazoles
inferred← citeshttps://doi.org/10.1021/tx500181popenalex-snapshot
Identification of Human Liver Microsomal Proteins Adducted by a Reactive Metabolite Using Shotgun Proteomics
inferred← citeshttps://doi.org/10.1021/tx500255ropenalex-snapshot
Use of Electrochemical Oxidation and Model Peptides To Study Nucleophilic Biological Targets of Reactive Metabolites: The Case of Rimonabant
inferred← citeshttps://doi.org/10.1021/tx800292mopenalex-snapshot
Structure−Activity Relationships for Degradation Reaction of 1-β- O -Acyl Glucuronides: Kinetic Description and Prediction of Intrinsic Electrophilic Reactivity under Physiological Conditions
inferred← citeshttps://doi.org/10.1021/tx800323wopenalex-snapshot
Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats
inferred← citeshttps://doi.org/10.1021/tx800397eopenalex-snapshot
Identification of Quinone Methide Metabolites of Dauricine in Human Liver Microsomes and in Rat Bile
inferred← citeshttps://doi.org/10.1021/tx800432copenalex-snapshot
Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development
inferred← citeshttps://doi.org/10.1021/tx8004357openalex-snapshot
Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
inferred← citeshttps://doi.org/10.1021/tx9002963openalex-snapshot
Structure−Activity Relationships for the Degradation Reaction of 1-β- O -Acyl Glucuronides. Part 3: Electronic and Steric Descriptors Predicting the Reactivity of Aralkyl Carboxylic Acid 1-β- O -Acyl Glucuronides
inferred← citeshttps://doi.org/10.1038/aps.2011.174openalex-snapshot
Covalent protein binding and tissue distribution of houttuynin in rats after intravenous administration of sodium houttuyfonate
inferred← citeshttps://doi.org/10.1038/nrd3408openalex-snapshot
Managing the challenge of chemically reactive metabolites in drug development
inferred← citeshttps://doi.org/10.1038/s44386-025-00020-7openalex-snapshot
Cystobactamid off-target profiling reveals favorable safety, superoxide reduction, and SCARB1 inhibition in eukaryotes
inferred← citeshttps://doi.org/10.1039/c0cc03165hopenalex-snapshot
Cytochromes P450 as useful biocatalysts: addressing the limitations
inferred← citeshttps://doi.org/10.1039/c5ra22581gopenalex-snapshot
Electro-sensing base for mefenamic acid on a 5% barium-doped zinc oxide nanoparticle modified electrode and its analytical application
inferred← citeshttps://doi.org/10.1039/c8ra01934gopenalex-snapshot
Latest perspectives of orally bioavailable 2,4-diarylaminopyrimidine analogues (DAAPalogues) as anaplastic lymphoma kinase inhibitors: discovery and clinical developments
inferred← citeshttps://doi.org/10.1039/d0lc00263aopenalex-snapshot
A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes
inferred← citeshttps://doi.org/10.1039/d0sc06270gopenalex-snapshot
Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy
inferred← citeshttps://doi.org/10.1074/jbc.r110.200055openalex-snapshot
Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry
inferred← citeshttps://doi.org/10.1080/00498254.2021.1875515openalex-snapshot
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes
inferred← citeshttps://doi.org/10.1080/03602532.2016.1225756openalex-snapshot
Non-cytochrome P450-mediated bioactivation and its toxicological relevance
inferred← citeshttps://doi.org/10.1080/03602532.2019.1655570openalex-snapshot
Bioactivation of herbal constituents: mechanisms and toxicological relevance
inferred← citeshttps://doi.org/10.1080/03602532.2025.2582864openalex-snapshot
Phase II metabolism in xenobiotic biotransformation: general mechanisms and the underestimated role of microbial systems
inferred← citeshttps://doi.org/10.1080/10286020.2014.960856openalex-snapshot
Hepatic metabolism: a key component of herbal drugs research
inferred← citeshttps://doi.org/10.1080/15287394.2023.2274331openalex-snapshot
Study of the DNA damage and cell death in human peripheral blood mononuclear and HepG2/C3A cells exposed to the synthetic 3-(3-hydroxyphenyl)-7-hydroxycoumarin
inferred← citeshttps://doi.org/10.1080/19420862.2016.1186322openalex-snapshot
Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2009.00899.xopenalex-snapshot
Structure‐based Drug Metabolism Predictions for Drug Design
inferred← citeshttps://doi.org/10.1124/dmd.111.039412openalex-snapshot
Bioactivation Pathways of the Cannabinoid Receptor 1 Antagonist Rimonabant
inferred← citeshttps://doi.org/10.1124/dmd.112.046102openalex-snapshot
Metabolic Activation of Mefenamic Acid Leading to Mefenamyl-S-Acyl-Glutathione Adduct Formation In Vitro and In Vivo in Rat
inferred← citeshttps://doi.org/10.1124/dmd.114.057026openalex-snapshot
Generation of Major Human Excretory and Circulating Drug Metabolites Using a Hepatocyte Relay Method
inferred← citeshttps://doi.org/10.1124/dmd.114.058347openalex-snapshot
Biotransformation and In Vivo Stability of Protein Biotherapeutics: Impact on Candidate Selection and Pharmacokinetic Profiling
inferred← citeshttps://doi.org/10.1124/dmd.115.069112openalex-snapshot
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans
inferred← citeshttps://doi.org/10.1124/dmd.117.079012openalex-snapshot
New Pioglitazone Metabolites and Absence of Opened-Ring Metabolites in New N-Substituted Thiazolidinedione
inferred← citeshttps://doi.org/10.1124/dmd.121.000633openalex-snapshot
Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
inferred← citeshttps://doi.org/10.1201/9781420092219-c6openalex-snapshot
Reactive Metabolite Screening and Covalent-Binding Assays
inferred← citeshttps://doi.org/10.1208/s12248-012-9353-6openalex-snapshot
ADME of Biologics—What Have We Learned from Small Molecules?
inferred← citeshttps://doi.org/10.13045/jar.25.0037openalex-snapshot
Clinical Applicability of Pharmacopuncture Therapy for Osteoarthritis: A Narrative Review Focused on Drug Delivery Systems and Herbal Component Mechanisms
inferred← citeshttps://doi.org/10.1371/journal.pone.0315997openalex-snapshot
Examination of common culture medium for human hepatocytes and engineered heart tissue: Towards an evaluation of cardiotoxicity associated with hepatic drug metabolism in vitro
inferred← citeshttps://doi.org/10.1515/jvetres-2017-0042openalex-snapshot
Comparison of albendazole cytotoxicity in terms of metabolite formation in four model systems
inferred← citeshttps://doi.org/10.1517/17425250802665706openalex-snapshot
Analytical strategies for the screening and evaluation of chemically reactive drug metabolites
inferred← citeshttps://doi.org/10.1517/17425250903431040openalex-snapshot
Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation
inferred← citeshttps://doi.org/10.1517/17425255.2011.629186openalex-snapshot
A review of the use ofin silicomethods to predict the chemistry of molecular initiating events related to drug toxicity
inferred← citeshttps://doi.org/10.1517/17425255.2012.652084openalex-snapshot
Preclinicalin vivoADME studies in drug development: a critical review
inferred← citeshttps://doi.org/10.1517/17425255.2015.1048222openalex-snapshot
Detecting reactive drug metabolites for reducing the potential for drug toxicity
inferred← citeshttps://doi.org/10.1517/17425255.2015.980814openalex-snapshot
Applying machine learning techniques for ADME-Tox prediction: a review
inferred← citeshttps://doi.org/10.1517/17460441.2014.877881openalex-snapshot
Selecting oral bioavailability enhancing formulations during drug discovery and development
inferred← citeshttps://doi.org/10.17863/cam.16274openalex-snapshot
Molecular Similarity and Xenobiotic Metabolism
inferred← citeshttps://doi.org/10.18632/oncotarget.9731openalex-snapshot
A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway
inferred← citeshttps://doi.org/10.2133/dmpk.dmpk-10-rv-089openalex-snapshot
Role of Biotransformation in Drug-Induced Toxicity: Influence of Intra- and Inter-Species Differences in Drug Metabolism
inferred← citeshttps://doi.org/10.2139/ssrn.5413337openalex-snapshot
Metabolism Matters: Interspecies Variability and Ecological Traits of Biotransformation Kinetics using Pyrene as an Example
inferred← citeshttps://doi.org/10.2174/0929867323666160425113058openalex-snapshot
Drug-like Properties and ADME of Xanthone Derivatives: The Antechamber of Clinical Trials
inferred← citeshttps://doi.org/10.2174/9798898814328126010006openalex-snapshot
Pharmacodynamic Interactions
inferred← citeshttps://doi.org/10.25439/rmt.27332868openalex-snapshot
Bioinformatic studies of the disposition pathways and targets of synthetic drugs and herbal medicines
inferred← citeshttps://doi.org/10.31024/ajpp.2019.5.1.24openalex-snapshot
In vitro metabolite identification of Tamsulosin using LC-Q-TOF mass spectrometry
inferred← citeshttps://doi.org/10.3109/01480541003782302openalex-snapshot
In vivocytogenetic studies on rat’s bone-marrow cells of structurally related Schiff base complexes
inferred← citeshttps://doi.org/10.3109/03602530903401658openalex-snapshot
Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective
inferred← citeshttps://doi.org/10.3390/antiox13020180openalex-snapshot
Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways
inferred← citeshttps://doi.org/10.3390/catal10010026openalex-snapshot
Photocatalysis as a Tool for in Vitro Drug Metabolism Simulation: Multivariate Comparison of Twelve Metal Oxides on a Set of Twenty Model Drugs
inferred← citeshttps://doi.org/10.3390/molecules24224082openalex-snapshot
Synthesis, Characterization, Antimicrobial Activity, and Genotoxicity Assessment of Two Heterocyclic Compounds Containing 1,2,3-Selena- or 1,2,3-Thiadiazole Rings
inferred← citeshttps://doi.org/10.3390/molecules26071951openalex-snapshot
Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice
inferred← citeshttps://doi.org/10.3390/molecules27072050openalex-snapshot
Amino Alcohols as Potential Antibiotic and Antifungal Leads
inferred← citeshttps://doi.org/10.3892/ol.2018.8713openalex-snapshot
Pro‑apoptotic effects of Kangfuxin on human stomach cancer cells and its underlying mechanism
showing the first 200 of 210 · page through all 210
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.