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MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-4652(199712)173:3<310::aid-jcp2>3.0.co;2-qopenalex-snapshot
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype
inferredcites →https://doi.org/10.1002/eji.1830221136openalex-snapshot
Functional and molecular characterization of single, (4‐hydroxy‐3‐nitrophenyl)acetyl (NP)‐specific, IgG1+ B cells from antibody‐secreting and memory B cell pathways in the C57BL/6 immune response to NP
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05492.xopenalex-snapshot
MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
inferredcites →https://doi.org/10.1002/j.1460-2075.1995.tb07168.xopenalex-snapshot
ATF‐2 is preferentially activated by stress‐activated protein kinases to mediate c‐jun induction in response to genotoxic agents.
inferredcites →https://doi.org/10.1016/0014-5793(92)81216-9openalex-snapshot
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
inferredcites →https://doi.org/10.1016/0092-8674(94)90277-1openalex-snapshot
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
inferredcites →https://doi.org/10.1016/0092-8674(94)90278-xopenalex-snapshot
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
inferredcites →https://doi.org/10.1016/s0960-9822(98)70442-7openalex-snapshot
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
inferredcites →https://doi.org/10.1038/305315a0openalex-snapshot
Monensin inhibits initial spreading of cultured human fibroblasts
inferredcites →https://doi.org/10.1038/364798a0openalex-snapshot
Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
inferredcites →https://doi.org/10.1038/372739a0openalex-snapshot
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
inferredcites →https://doi.org/10.1038/386296a0openalex-snapshot
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
inferredcites →https://doi.org/10.1038/39622openalex-snapshot
Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection
inferredcites →https://doi.org/10.1073/pnas.76.11.5939openalex-snapshot
Galactosamine-induced sensitization to the lethal effects of endotoxin.
inferredcites →https://doi.org/10.1073/pnas.94.15.8093openalex-snapshot
Characterization of tumor necrosis factor-deficient mice
inferredcites →https://doi.org/10.1074/jbc.271.30.17920openalex-snapshot
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)
inferredcites →https://doi.org/10.1074/jbc.273.16.9373openalex-snapshot
The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways
inferredcites →https://doi.org/10.1084/jem.188.10.1817openalex-snapshot
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
inferredcites →https://doi.org/10.1093/emboj/16.8.1909openalex-snapshot
Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
inferredcites →https://doi.org/10.1093/emboj/16.8.1921openalex-snapshot
MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
inferredcites →https://doi.org/10.1093/emboj/17.12.3363openalex-snapshot
Leptomycin B‐sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
inferredcites →https://doi.org/10.1093/emboj/17.12.3372openalex-snapshot
PRAK, a novel protein kinase regulated by the p38 MAP kinase
inferredcites →https://doi.org/10.1093/emboj/17.15.4426openalex-snapshot
Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
inferredcites →https://doi.org/10.1111/j.1749-6632.1993.tb17149.xopenalex-snapshot
Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors
inferredcites →https://doi.org/10.1126/science.270.5240.1326openalex-snapshot
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
inferredcites →https://doi.org/10.1126/science.271.5253.1289openalex-snapshot
Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
inferredcites →https://doi.org/10.1126/science.272.5266.1347openalex-snapshot
Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase
inferredcites →https://doi.org/10.1126/science.280.5363.599openalex-snapshot
Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest
inferredcites →https://doi.org/10.1126/science.7914033openalex-snapshot
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
inferredcites →https://doi.org/10.1128/mcb.16.3.1247openalex-snapshot
MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway
inferredcites →https://doi.org/10.1128/mcb.16.3.868openalex-snapshot
3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4137330openalex-extracted
Cloning and Functional Analysis of Mapkapk2 in Hyriopsis Cumingii
inferred← citeshttps://doi.org/10.1002/1521-4141(200107)31:7<1962::aid-immu1962>3.0.co;2-vopenalex-snapshot
Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C / EBPβ and STAT1: role of CD14 and Toll-like receptors 2 and 4
inferred← citeshttps://doi.org/10.1002/9780470571224.pse446openalex-snapshot
Anti‐Inflammatory/Analgesics: An In‐Depth Look at p 38 MAP Kinases
inferred← citeshttps://doi.org/10.1002/9781119998624.ch8openalex-snapshot
Novel Anti‐Inflammatory Treatments for Asthma and COPD
inferred← citeshttps://doi.org/10.1002/acr2.11517openalex-snapshot
Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1002/adtp.202200083openalex-snapshot
Modulation of Neuroinflammation via Selective Nanoparticle‐Mediated Drug Delivery to Activated Microglia/Macrophages in Spinal Cord Injury
inferred← citeshttps://doi.org/10.1002/ar.21047openalex-snapshot
MAPK Signal Transduction Underlying Brain Inflammation and Gliosis as Therapeutic Target
inferred← citeshttps://doi.org/10.1002/ar.a.20191openalex-snapshot
Immunocytochemical localization of MAPKAPK‐2 and Hsp25 in the rat temporomandibular joint
inferred← citeshttps://doi.org/10.1002/art.11482openalex-snapshot
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin‐6, through a p38‐dependent pathway in rheumatoid arthritis synovial fibroblasts
inferred← citeshttps://doi.org/10.1002/art.21626openalex-snapshot
Activation of p38 MAPK is a key step in tumor necrosis factor–mediated inflammatory bone destruction
inferred← citeshttps://doi.org/10.1002/art.24485openalex-snapshot
Efficacy, pharmacodynamics, and safety of VX‐702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double‐blind, placebo‐controlled clinical studies
inferred← citeshttps://doi.org/10.1002/eji.200324660openalex-snapshot
AgC10, a mucin from Trypanosoma cruzi, destabilizes TNF and cyclooxygenase‐2 mRNA by inhibiting mitogen‐activated protein kinase p38
inferred← citeshttps://doi.org/10.1002/eji.200425897openalex-snapshot
Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice
inferred← citeshttps://doi.org/10.1002/eji.200737886openalex-snapshot
IRAK‐4 kinase activity‐dependent and ‐independent regulation of lipopolysaccharide‐inducible genes
inferred← citeshttps://doi.org/10.1002/eji.200838316openalex-snapshot
The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease
inferred← citeshttps://doi.org/10.1002/eji.201948154openalex-snapshot
IL‐33‐activated murine mast cells control the dichotomy between RORγt + and Helios + T regs via the MK2/3‐mediated IL‐6 production in vitro
inferred← citeshttps://doi.org/10.1002/jbmr.1816openalex-snapshot
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover
inferred← citeshttps://doi.org/10.1002/jcb.21154openalex-snapshot
Smooth muscle α‐actin expression and myofibroblast differentiation by TGFβ are dependent upon MK2
inferred← citeshttps://doi.org/10.1002/jcb.23294openalex-snapshot
Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages
inferred← citeshttps://doi.org/10.1002/jcp.1082openalex-snapshot
IL‐1‐ and TNF‐induced bone resorption is mediated by p38 mitogen activated protein kinase*
inferred← citeshttps://doi.org/10.1002/jcp.20169openalex-snapshot
Mitogen‐activated protein kinases and asthma
inferred← citeshttps://doi.org/10.1002/jcp.21539openalex-snapshot
Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr‐1 and NF‐κB pathways but is independent of p38 and JNK
inferred← citeshttps://doi.org/10.1002/jcp.22023openalex-snapshot
Mitogen‐activated protein kinase‐activated protein kinase 2 (MK2) in skeletal muscle atrophy and hypertrophy
inferred← citeshttps://doi.org/10.1002/jnr.20251openalex-snapshot
MAPKAP kinase‐2 is a primary response gene induced by depolarization in PC12 cells and in brain
inferred← citeshttps://doi.org/10.1002/jnr.24060openalex-snapshot
Exogenous progesterone is neuroprotective following injury to the male zebra finch brain
inferred← citeshttps://doi.org/10.1002/mc.20660openalex-snapshot
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment
inferred← citeshttps://doi.org/10.1002/mc.23348openalex-snapshot
Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer
inferred← citeshttps://doi.org/10.1002/mco2.154openalex-snapshot
Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions
inferred← citeshttps://doi.org/10.1002/pro.294openalex-snapshot
High‐resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand
inferred← citeshttps://doi.org/10.1002/psc.1168openalex-snapshot
Design of a bioactive cell‐penetrating peptide: when a transduction domain does more than transduce
inferred← citeshttps://doi.org/10.1002/wrna.13openalex-snapshot
Networks controlling mRNA decay in the immune system
inferred← citeshttps://doi.org/10.1006/abbi.2001.2625openalex-snapshot
Identification of a Phosphorylation Site on Skeletal Muscle Myosin Light Chain Kinase That Becomes Phosphorylated during Muscle Contraction
inferred← citeshttps://doi.org/10.1006/cyto.2002.0895openalex-snapshot
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN INFLAMMATION
inferred← citeshttps://doi.org/10.1007/2789_2007_038openalex-snapshot
Post-transcriptional Regulators in Inflammation: Exploring New Avenues in Biological Therapeutics
inferred← citeshttps://doi.org/10.1007/3-540-26670-4_4openalex-snapshot
Pharmacological Potential of p38 MAPK Inhibitors
inferred← citeshttps://doi.org/10.1007/4735_2007_0248openalex-snapshot
Control of mRNA Stability by SAPKs
inferred← citeshttps://doi.org/10.1007/4735_2007_0252openalex-snapshot
Protein Kinases as Substrates for SAPKs
inferred← citeshttps://doi.org/10.1007/978-0-387-85816-6_11openalex-snapshot
Targeting Signal Transduction Pathways in Hematopoietic Disorders
inferred← citeshttps://doi.org/10.1007/978-1-4419-0461-4_531openalex-snapshot
Mapkap Kinase 2/3 (MK2/3)
inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_531-1openalex-snapshot
Mapkap Kinase 2/3 (MK2/3)
inferred← citeshttps://doi.org/10.1007/978-1-4614-6828-8_8openalex-snapshot
The p38 MAPK Pathway in Prostate Cancer
inferred← citeshttps://doi.org/10.1007/978-1-61779-337-0_2openalex-snapshot
Small-Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for Their Evaluation
inferred← citeshttps://doi.org/10.1007/978-2-8178-0466-8_17openalex-snapshot
Posttranscriptional Regulation of Angiogenesis Through AU-Rich mRNA Degradation: Potential Application in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-3-030-42990-4_5openalex-snapshot
Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-68748-9_17openalex-snapshot
Redox and Inflammatory Signaling, the Unfolded Protein Response, and the Pathogenesis of Pulmonary Hypertension
inferred← citeshttps://doi.org/10.1007/978-3-0348-8012-1_2openalex-snapshot
Potential of p38 MAP kinase inhibitors in the treatment of cancer
inferred← citeshttps://doi.org/10.1007/978-3-0348-8450-1_10openalex-snapshot
Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase
inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_531openalex-snapshot
Mapkap Kinase 2/3 (MK2/3)
inferred← citeshttps://doi.org/10.1007/978-3-642-31659-3_7openalex-snapshot
Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer
inferred← citeshttps://doi.org/10.1007/978-3-642-56107-8_9openalex-snapshot
The Intracellular Signaling Pathways of Inflammatory Stress
inferred← citeshttps://doi.org/10.1007/978-3-642-56348-5_8openalex-snapshot
sHsp-Phosphorylation: Enzymes, Signaling Pathways and Functional Implications
inferred← citeshttps://doi.org/10.1007/978-3-642-59467-0_9openalex-snapshot
Inhibition of p38 Mitogen Activated Protein Kinase: A Novel Strategy in Sepsis?
inferred← citeshttps://doi.org/10.1007/978-90-481-9522-0_4openalex-snapshot
Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis
inferred← citeshttps://doi.org/10.1007/s00018-005-5039-xopenalex-snapshot
Intestinal epithelial barrier and mucosal immunity
inferred← citeshttps://doi.org/10.1007/s00018-021-04004-4openalex-snapshot
Autophagy and apoptosis cascade: which is more prominent in neuronal death?
inferred← citeshttps://doi.org/10.1007/s00044-011-9910-zopenalex-snapshot
Computation of pharmacophore models for the prediction of mitogen-activated protein kinase activated protein kinase-2 inhibitory activity of pyrrolopyridines
inferred← citeshttps://doi.org/10.1007/s00044-013-0820-0openalex-snapshot
Molecular docking and 3D-QSAR studies on the MAPKAP-K2 inhibitors
inferred← citeshttps://doi.org/10.1007/s00109-010-0688-0openalex-snapshot
Anti-inflammatory effect of methyl dehydrojasmonate (J2) is mediated by the NF-κB pathway
inferred← citeshttps://doi.org/10.1007/s00134-002-1330-6openalex-snapshot
Clinical implications of antibiotic-induced endotoxin release in septic shock
inferred← citeshttps://doi.org/10.1007/s00438-002-0786-yopenalex-snapshot
Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1
inferred← citeshttps://doi.org/10.1007/s00438-007-0221-5openalex-snapshot
Cytoplasmatic post-transcriptional regulation and intracellular signalling
inferred← citeshttps://doi.org/10.1007/s00726-010-0669-1openalex-snapshot
Functional analysis of proteins and protein species using shotgun proteomics and linear mathematics
inferred← citeshttps://doi.org/10.1007/s10295-008-0367-0openalex-snapshot
Molecular and phenotypic comparison of phaeochromycin-producing strains of Streptomyces phaeochromogenes and Streptomyces ederensis
inferred← citeshttps://doi.org/10.1007/s10571-019-00755-8openalex-snapshot
Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain
inferred← citeshttps://doi.org/10.1007/s10571-021-01127-xopenalex-snapshot
Differential Effects of Toll-Like Receptor Activation and Differential Mediation by MAP Kinases of Immune Responses in Microglial Cells
inferred← citeshttps://doi.org/10.1007/s10637-017-0532-2openalex-snapshot
Phase 1 and pharmacokinetic study of LY3007113, a p38 MAPK inhibitor, in patients with advanced cancer
inferred← citeshttps://doi.org/10.1007/s10753-011-9350-4openalex-snapshot
A Novel Synthetic Mono-Carbonyl Analogue of Curcumin, A13, Exhibits Anti-Inflammatory Effects In vivo by Inhibition of Inflammatory Mediators
inferred← citeshttps://doi.org/10.1007/s10753-018-0752-4openalex-snapshot
Anti-Inflammatory Effects of Hypophyllanthin and Niranthin Through Downregulation of NF-κB/MAPKs/PI3K-Akt Signaling Pathways
inferred← citeshttps://doi.org/10.1007/s10787-017-0349-9openalex-snapshot
Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice
inferred← citeshttps://doi.org/10.1007/s10822-018-0173-3openalex-snapshot
Mycobacterium tuberculosis serine/threonine protein kinases: structural information for the design of their specific ATP-competitive inhibitors
inferred← citeshttps://doi.org/10.1007/s11033-024-09305-yopenalex-snapshot
Crosstalk between vault RNAs and innate immunity
inferred← citeshttps://doi.org/10.1007/s11033-024-09722-zopenalex-snapshot
Syringin from Tinospora crispa downregulates pro-inflammatory mediator production through MyD88-dependent pathways in lipopolysaccharide (LPS)-induced U937 macrophages
inferred← citeshttps://doi.org/10.1007/s11248-006-9052-0openalex-snapshot
In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice
inferred← citeshttps://doi.org/10.1007/s11274-009-0120-5openalex-snapshot
Mitogen-activated protein kinases and tumor necrosis factor alpha responses of macrophages infected with Orientia tsutsugamushi
inferred← citeshttps://doi.org/10.1007/s11605-016-3303-zopenalex-snapshot
Regulation of Postoperative Ileus by Lentivirus-Mediated HuR RNA Interference via the p38/MK2 Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s11626-008-9088-yopenalex-snapshot
Rapid and quantitative detection of p38 kinase pathway in mouse blood monocyte
inferred← citeshttps://doi.org/10.1007/s12026-025-09650-5openalex-snapshot
The mechanism of p38 MAPK, NF-κB, and IL-6 in T-2 toxin and/or selenium deficiency induced spleen injury
inferred← citeshttps://doi.org/10.1007/s12031-016-0717-8openalex-snapshot
The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke
inferred← citeshttps://doi.org/10.1007/s12033-010-9360-8openalex-snapshot
A Flexible Approach to Studying Post-Transcriptional Gene Regulation in Stably Transfected Mammalian Cells
inferred← citeshttps://doi.org/10.1007/s12192-009-0101-5openalex-snapshot
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia
inferred← citeshttps://doi.org/10.1007/s13238-010-0019-9openalex-snapshot
MAPK signaling in inflammation-associated cancer development
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00164-9openalex-snapshot
Mammalian MAP Kinases
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00270-9openalex-snapshot
Regulation of mRNA Turnover by Cellular Stress
inferred← citeshttps://doi.org/10.1016/b978-0-12-407178-0.00006-5openalex-snapshot
Inflammatory Pathways in Spinal Cord Injury
inferred← citeshttps://doi.org/10.1016/b978-0-12-801732-6.00016-1openalex-snapshot
Inflammation and Secondary Damage after Spinal Cord Injury
inferred← citeshttps://doi.org/10.1016/b978-012124546-7/50545-3openalex-snapshot
Xc,v Mammalian MAP Kinases
inferred← citeshttps://doi.org/10.1016/b978-012124546-7/50674-4openalex-snapshot
Regulation of mRNA Turnover by Cellular Stress
inferred← citeshttps://doi.org/10.1016/b978-012369393-8/50011-0openalex-snapshot
PROGRESS IN ACHIEVING PROOF OF CONCEPT FOR p38 KINASE INHIBITORS
inferred← citeshttps://doi.org/10.1016/b978-012473335-0/50012-xopenalex-snapshot
FcɛRI-mediated Induction of TNF-a Gene Expression in Mast Cell Lines
inferred← citeshttps://doi.org/10.1016/j.ab.2005.05.011openalex-snapshot
Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38α protein kinase
inferred← citeshttps://doi.org/10.1016/j.ab.2007.11.004openalex-snapshot
Staurosporine-based binding assay for testing the affinity of compounds to protein kinases
inferred← citeshttps://doi.org/10.1016/j.abb.2006.03.018openalex-snapshot
Effect of construct design on MAPKAP kinase-2 activity, thermodynamic stability and ligand-binding affinity
inferred← citeshttps://doi.org/10.1016/j.autrev.2012.10.019openalex-snapshot
p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris
inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.10.026openalex-snapshot
Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.bbadis.2016.05.022openalex-snapshot
Mixed – Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.07.015openalex-snapshot
Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167203openalex-snapshot
Tumor microenvironment and immune response: A gateway to novel therapies in gastrointestinal cancers
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2007.03.010openalex-snapshot
p38 MAP-Kinases pathway regulation, function and role in human diseases
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2008.04.009openalex-snapshot
Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: An obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27
inferred← citeshttps://doi.org/10.1016/j.bbapap.2005.08.017openalex-snapshot
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.02.107openalex-snapshot
A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.09.001openalex-snapshot
Stress-induced nuclear export of 5-lipoxygenase
inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.04.104openalex-snapshot
MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization
inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.09.091openalex-snapshot
Regulation of p21Waf1 expression and TNFα biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.03.056openalex-snapshot
Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor
inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.08.062openalex-snapshot
Toll-like receptors and innate immunity
inferred← citeshttps://doi.org/10.1016/j.bbrc.2012.03.088openalex-snapshot
Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages
inferred← citeshttps://doi.org/10.1016/j.bbrep.2021.101065openalex-snapshot
A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.10.032openalex-snapshot
Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling
inferred← citeshttps://doi.org/10.1016/j.bcp.2010.06.021openalex-snapshot
MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
inferred← citeshttps://doi.org/10.1016/j.bcp.2017.08.002openalex-snapshot
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
inferred← citeshttps://doi.org/10.1016/j.biocel.2010.08.002openalex-snapshot
Inactivation of p38 MAPK during liver regeneration
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.03.041openalex-snapshot
Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2005.01.067openalex-snapshot
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.05.056openalex-snapshot
Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.05.070openalex-snapshot
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.12.037openalex-snapshot
Pyrazinoindolone inhibitors of MAPKAP-K2
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.01.119openalex-snapshot
Synthesis and SAR studies of indole-based MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.10.039openalex-snapshot
Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.02.015openalex-snapshot
Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.088openalex-snapshot
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.10.102openalex-snapshot
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.10.138openalex-snapshot
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.06.107openalex-snapshot
4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.04.016openalex-snapshot
Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.04.018openalex-snapshot
Structure-based lead identification of ATP-competitive MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.11.074openalex-snapshot
A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.09.016openalex-snapshot
Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.canlet.2008.09.003openalex-snapshot
A food-born heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), suppresses tumor necrosis factor-α expression in lipoteichoic acid-stimulated RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.cca.2017.08.021openalex-snapshot
MicroRNAs and bioactive compounds on TLR/MAPK signaling in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.ccell.2016.01.006openalex-snapshot
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
inferred← citeshttps://doi.org/10.1016/j.ccr.2006.11.024openalex-snapshot
p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage
inferred← citeshttps://doi.org/10.1016/j.ceca.2026.103193openalex-snapshot
Intracellular Ca2+ balances the anti-inflammatory potential of IL-33-activated mast cells (MCs)
inferred← citeshttps://doi.org/10.1016/j.cell.2008.08.034openalex-snapshot
Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength
inferred← citeshttps://doi.org/10.1016/j.cellimm.2011.04.001openalex-snapshot
A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: Modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium
inferred← citeshttps://doi.org/10.1016/j.cellsig.2004.04.006openalex-snapshot
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
inferred← citeshttps://doi.org/10.1016/j.cellsig.2006.07.010openalex-snapshot
Feedback control of MKP-1 expression by p38
inferred← citeshttps://doi.org/10.1016/j.cellsig.2008.05.007openalex-snapshot
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
inferred← citeshttps://doi.org/10.1016/j.cellsig.2010.02.009openalex-snapshot
Characterization of the expression and regulation of MK5 in the murine ventricular myocardium
inferred← citeshttps://doi.org/10.1016/j.cellsig.2010.05.019openalex-snapshot
Characterization of a novel MK3 splice variant from murine ventricular myocardium
inferred← citeshttps://doi.org/10.1016/j.cellsig.2012.01.018openalex-snapshot
The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.12.016openalex-snapshot
Oncostatin M regulates SOCS3 mRNA stability via the MEK–ERK1/2-pathway independent of p38MAPK/MK2
inferred← citeshttps://doi.org/10.1016/j.cellsig.2015.03.009openalex-snapshot
PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling
inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.02.007openalex-snapshot
Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture
inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.09.002openalex-snapshot
Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP)
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.05.024openalex-snapshot
Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2
inferred← citeshttps://doi.org/10.1016/j.clim.2024.110301openalex-snapshot
Integrated multi-omics analysis and machine learning developed diagnostic markers and prognostic model based on Efferocytosis-associated signatures for septic cardiomyopathy
inferred← citeshttps://doi.org/10.1016/j.coph.2004.03.009openalex-snapshot
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease
inferred← citeshttps://doi.org/10.1016/j.cyto.2005.11.017openalex-snapshot
Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages
inferred← citeshttps://doi.org/10.1016/j.cyto.2011.11.024openalex-snapshot
Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA
inferred← citeshttps://doi.org/10.1016/j.ejphar.2005.12.054openalex-snapshot
RETRACTED: Kinase inhibitors and airway inflammation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2011.08.035openalex-snapshot
Structure–function relationships of citrus limonoids on p38 MAP kinase activity in human aortic smooth muscle cells
inferred← citeshttps://doi.org/10.1016/j.expneurol.2021.113892openalex-snapshot
Nonsteroidal anti-inflammatory drug (ketoprofen) delivery differentially impacts phrenic long-term facilitation in rats with motor neuron death induced by intrapleural CTB-SAP injections
inferred← citeshttps://doi.org/10.1016/j.fct.2017.07.007openalex-snapshot
Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111521openalex-snapshot
Crocin: A fighter against inflammation and pain
inferred← citeshttps://doi.org/10.1016/j.febslet.2006.01.027openalex-snapshot
Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase‐1 and p38 MAP kinase
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.07.011openalex-snapshot
Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells
inferred← citeshttps://doi.org/10.1016/j.fsi.2010.07.014openalex-snapshot
Extracellular products from virulent strain of Edwardsiella tarda stimulate mouse macrophages (RAW264.7) to produce nitric oxide (NO) and tumor necrosis factor (TNF)-α
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2013.03.056openalex-snapshot
Comparative anti-inflammatory activity of poly(amidoamine) (PAMAM) dendrimer–dexamethasone conjugates with dexamethasone-liposomes
inferred← citeshttps://doi.org/10.1016/j.immuni.2005.06.009openalex-snapshot
The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1
inferred← citeshttps://doi.org/10.1016/j.immuni.2013.05.013openalex-snapshot
RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44
inferred← citeshttps://doi.org/10.1016/j.immuni.2018.12.010openalex-snapshot
Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life
inferred← citeshttps://doi.org/10.1016/j.intimp.2007.12.014openalex-snapshot
Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways
inferred← citeshttps://doi.org/10.1016/j.intimp.2018.01.001openalex-snapshot
Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways
inferred← citeshttps://doi.org/10.1016/j.isci.2021.103406openalex-snapshot
Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation
inferred← citeshttps://doi.org/10.1016/j.jacc.2006.02.072openalex-snapshot
Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor
inferred← citeshttps://doi.org/10.1016/j.jaci.2015.08.056openalex-snapshot
Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.103043openalex-snapshot
p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111338openalex-snapshot
Chronic activation of p38α in skeletal muscle causes necrotic changes, but also abolishes expression of MK2, MK3, and MKK6 and the muscle recovers
inferred← citeshttps://doi.org/10.1016/j.jconrel.2011.05.007openalex-snapshot
Cell-penetrating peptides can confer biological function: Regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides
inferred← citeshttps://doi.org/10.1016/j.jep.2022.116003openalex-snapshot
Clinacanthus nutans aqueous leaves extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway
inferred← citeshttps://doi.org/10.1016/j.jhep.2015.08.012openalex-snapshot
MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections
inferred← citeshttps://doi.org/10.1016/j.jid.2019.08.451openalex-snapshot
Inhibition of p38/MK2 Signaling Prevents Vascular Invasion of Melanoma
inferred← citeshttps://doi.org/10.1016/j.jmb.2007.03.004openalex-snapshot
Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2
inferred← citeshttps://doi.org/10.1016/j.joca.2008.05.001openalex-snapshot
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology
inferred← citeshttps://doi.org/10.1016/j.jpeds.2003.10.034openalex-snapshot
Primary Immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling
inferred← citeshttps://doi.org/10.1016/j.jss.2011.01.043openalex-snapshot
Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions
inferred← citeshttps://doi.org/10.1016/j.jss.2013.05.028openalex-snapshot
Inhibition of MK2 shows promise for preventing postoperative ileus in mice
inferred← citeshttps://doi.org/10.1016/j.molimm.2007.02.006openalex-snapshot
Cloning and characterisation of p38 MAP kinase from Atlantic salmon
inferred← citeshttps://doi.org/10.1016/j.molimm.2007.03.019openalex-snapshot
Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands
inferred← citeshttps://doi.org/10.1016/j.molimm.2007.05.017openalex-snapshot
Tristetraprolin regulates TNF TNF-α mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
inferred← citeshttps://doi.org/10.1016/j.molimm.2008.09.022openalex-snapshot
LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-κB-dependent pathway
inferred← citeshttps://doi.org/10.1016/j.molimm.2010.04.016openalex-snapshot
Central role of extracellular signal-regulated kinase and Toll-like receptor 4 in IL-10 production in regulatory dendritic cells induced by Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.molimm.2011.06.439openalex-snapshot
Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase
inferred← citeshttps://doi.org/10.1016/j.molimm.2012.03.019openalex-snapshot
The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1
inferred← citeshttps://doi.org/10.1016/j.molimm.2017.11.026openalex-snapshot
Molecular mechanism of LPS-induced TNF-α biosynthesis in polarized human macrophages
inferred← citeshttps://doi.org/10.1016/j.molmed.2005.06.002openalex-snapshot
Linking Kaposi virus to cancer-associated cytokines
inferred← citeshttps://doi.org/10.1016/j.molmed.2017.11.002openalex-snapshot
Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer
inferred← citeshttps://doi.org/10.1016/j.msec.2019.110501openalex-snapshot
Electrochemical endotoxin aptasensor based on a metal-organic framework labeled analytical platform
inferred← citeshttps://doi.org/10.1016/j.mvr.2010.11.010openalex-snapshot
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
inferred← citeshttps://doi.org/10.1016/j.mvr.2022.104311openalex-snapshot
Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model
inferred← citeshttps://doi.org/10.1016/j.neuron.2024.10.029openalex-snapshot
Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2007.02.011openalex-snapshot
Mechanisms of regulation for interleukin-1β in neurodegenerative disease
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2019.05.024openalex-snapshot
The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning
inferred← citeshttps://doi.org/10.1016/j.pep.2005.09.011openalex-snapshot
Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells
inferred← citeshttps://doi.org/10.1016/j.peptides.2017.02.004openalex-snapshot
Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2006.08.003openalex-snapshot
Shaping of monocyte and macrophage function by adenosine receptors
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2007.01.002openalex-snapshot
Modulation of mRNA stability as a novel therapeutic approach
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2007.06.013openalex-snapshot
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2022.108153openalex-snapshot
Targeting the p38α pathway in chronic inflammatory diseases: Could activation, not inhibition, be the appropriate therapeutic strategy?
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