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The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/bbrc.1998.8124openalex-snapshot

TGF-β-Activated Kinase 1 Stimulates NF-κB Activation by an NF-κB-Inducing Kinase-Independent Mechanism

inferredcites →https://doi.org/10.1016/0092-8674(95)90506-5openalex-snapshot

NF-κB: A lesson in family values

inferredcites →https://doi.org/10.1016/s0092-8674(00)80344-xopenalex-snapshot

Identification and Characterization of an IκB Kinase

inferredcites →https://doi.org/10.1016/s0092-8674(00)80406-7openalex-snapshot

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

inferredcites →https://doi.org/10.1016/s0092-8674(00)81092-2openalex-snapshot

Active and Inactive Protein Kinases: Structural Basis for Regulation

inferredcites →https://doi.org/10.1016/s0092-8674(00)81318-5openalex-snapshot

NF-κB: Ten Years After

inferredcites →https://doi.org/10.1016/s1074-7613(00)80402-1openalex-snapshot

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

inferredcites →https://doi.org/10.1038/26254openalex-snapshot

IKAP is a scaffold protein of the IκB kinase complex

inferredcites →https://doi.org/10.1038/383443a0openalex-snapshot

TRAF6 is a signal transducer for interleukin-1

inferredcites →https://doi.org/10.1038/385540a0openalex-snapshot

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

inferredcites →https://doi.org/10.1038/41493openalex-snapshot

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

inferredcites →https://doi.org/10.1073/pnas.94.18.9792openalex-snapshot

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

inferredcites →https://doi.org/10.1073/pnas.95.16.9067openalex-snapshot

JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

inferredcites →https://doi.org/10.1073/pnas.95.7.3792openalex-snapshot

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

inferredcites →https://doi.org/10.1074/jbc.271.23.13675openalex-snapshot

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

inferredcites →https://doi.org/10.1074/jbc.272.13.8141openalex-snapshot

TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

inferredcites →https://doi.org/10.1093/emboj/16.16.4973openalex-snapshot

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress‐induced activation of the p38 and JNK pathways

inferredcites →https://doi.org/10.1101/gad.9.22.2723openalex-snapshot

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

inferredcites →https://doi.org/10.1126/science.270.5244.2008openalex-snapshot

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

inferredcites →https://doi.org/10.1126/science.271.5252.1128openalex-snapshot

IRAK: A Kinase Associated with the Interleukin-1 Receptor

inferredcites →https://doi.org/10.1126/science.272.5265.1179openalex-snapshot

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

inferredcites →https://doi.org/10.1126/science.278.5339.860openalex-snapshot

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

inferredcites →https://doi.org/10.1126/science.278.5339.866openalex-snapshot

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

inferredcites →https://doi.org/10.1128/mcb.18.10.5899openalex-snapshot

Molecular Determinants of NF-κB-Inducing Kinase Action

inferredcites →https://doi.org/10.1182/blood.v87.6.2095.bloodjournal8762095openalex-snapshot

Biologic basis for interleukin-1 in disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1001/archderm.139.10.1347openalex-snapshot

Imiquimod

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TRAF ‐Mediated TNFR ‐Family Signaling

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TRAF‐Mediated TNFR‐Family Signaling

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Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-? production by the modulation of Jun-N-terminal kinase and the NF-?b signaling pathway in rat Kupffer cells

inferred← citeshttps://doi.org/10.1002/1521-4141(200112)31:12<3747::aid-immu3747>3.0.co;2-eopenalex-snapshot

IRAK and TAK1 are required for IL-18-mediated signaling

inferred← citeshttps://doi.org/10.1002/1521-4141(200206)32:6<1753::aid-immu1753>3.0.co;2-2openalex-snapshot

Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-κB activation and is a potent antiinflammatory compound in vivo

inferred← citeshttps://doi.org/10.1002/1521-4141(200212)32:12<3689::aid-immu3689>3.0.co;2-xopenalex-snapshot

IL-1?-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1

inferred← citeshttps://doi.org/10.1002/3527600906.mcb.200400142openalex-snapshot

Innate Immunity

inferred← citeshttps://doi.org/10.1002/adbi.202400384openalex-snapshot

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

inferred← citeshttps://doi.org/10.1002/advs.202001575openalex-snapshot

TAK1 Phosphorylates RASSF9 and Inhibits Esophageal Squamous Tumor Cell Proliferation by Targeting the RAS/MEK/ERK Axis

inferred← citeshttps://doi.org/10.1002/advs.202305653openalex-snapshot

Loss of ESRP2 Activates TAK1‐MAPK Signaling through the Fetal RNA‐Splicing Program to Promote Hepatocellular Carcinoma Progression

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Regulation of Transforming Growth Factor β–Activated Kinase Activation by Epigallocatechin‐3‐Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63‐Linked Autoubiquitination of Tumor Necrosis Factor Receptor–Associated Factor 6

inferred← citeshttps://doi.org/10.1002/bies.10352openalex-snapshot

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology

inferred← citeshttps://doi.org/10.1002/cbf.70202openalex-snapshot

Decoding P21 Activated Kinase‐1 (PAK1) and Drug‐Resistance Enigma

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Soluble Receptors for Advanced Glycation End Products (sRAGE) as a Predictor of Restenosis Following Percutaneous Coronary Intervention

inferred← citeshttps://doi.org/10.1002/cne.10262openalex-snapshot

Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin‐1

inferred← citeshttps://doi.org/10.1002/dvdy.22750openalex-snapshot

Hepatocyte growth factor–regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo

inferred← citeshttps://doi.org/10.1002/dvg.20418openalex-snapshot

Generation of a conditional mutant allele for Tab1 in mouse

inferred← citeshttps://doi.org/10.1002/eji.200838161openalex-snapshot

IRAK4 in TLR/IL‐1R signaling: Possible clinical applications

inferred← citeshttps://doi.org/10.1002/eji.201040718openalex-snapshot

Amplification of cytokine production through synergistic activation of NFAT and AP‐1 following stimulation of mast cells with antigen and IL‐33

inferred← citeshttps://doi.org/10.1002/glia.20648openalex-snapshot

Transforming growth factor‐activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury

inferred← citeshttps://doi.org/10.1002/hep.21777openalex-snapshot

Aging in rat causes hepatic hyperresposiveness to interleukin-1β which is mediated by neutral sphingomyelinase-2

inferred← citeshttps://doi.org/10.1002/ibd.20243openalex-snapshot

NF-κB and the intestine: Friend or foe?

inferred← citeshttps://doi.org/10.1002/ibd.3780060308openalex-snapshot

NF-κB signaling proteins as therapeutic targets for inflammatory bowel diseases

inferred← citeshttps://doi.org/10.1002/ijc.21734openalex-snapshot

TAK1‐mediated stress signaling pathways are essential for TNF‐α‐promoted pulmonary metastasis of murine colon cancer cells

inferred← citeshttps://doi.org/10.1002/j.1536-4801.2004.tb12128.xopenalex-snapshot

Interaction Between Resident Luminal Bacteria and the Host: Can a Healthy Relationship Turn Sour?

inferred← citeshttps://doi.org/10.1002/jbm.a.32618openalex-snapshot

Transforming growth factor‐β activated kinase 1 signaling pathways regulate TNF‐α production by titanium alloy particles in RAW 264.7 cells

inferred← citeshttps://doi.org/10.1002/jbmr.1857openalex-snapshot

Augmentation of smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice

inferred← citeshttps://doi.org/10.1002/jbmr.2183openalex-snapshot

Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation

inferred← citeshttps://doi.org/10.1002/jbmr.3334openalex-snapshot

A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IκBα-Mediated p65 Nuclear Translocation

inferred← citeshttps://doi.org/10.1002/jcb.24669openalex-snapshot

Disruption of Tumor Necrosis Factor Receptor Associated Factor 5 Exacerbates Pressure Overload Cardiac Hypertrophy and Fibrosis

inferred← citeshttps://doi.org/10.1002/jcb.30318openalex-snapshot

MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic Escherichia coli exposure

inferred← citeshttps://doi.org/10.1002/jcp.20860openalex-snapshot

The role of MAPK in Kupffer cell toll‐like receptor (TLR) 2‐, TLR4‐, and TLR9‐mediated signaling following trauma‐hemorrhage

inferred← citeshttps://doi.org/10.1002/jcp.21886openalex-snapshot

Oxidized low density lipoprotein decreases Rankl‐induced differentiation of osteoclasts by inhibition of Rankl signaling

inferred← citeshttps://doi.org/10.1002/jcp.24646openalex-snapshot

Beclin‐1 Is Required for RANKL‐Induced Osteoclast Differentiation

inferred← citeshttps://doi.org/10.1002/jcp.30529openalex-snapshot

TGF‐β signaling: A recap of SMAD‐independent and SMAD‐dependent pathways

inferred← citeshttps://doi.org/10.1002/jcp.70108openalex-snapshot

The Effect and Mechanism of DNAJA1‐Mediated Met/Leu Promoting the Proliferation of Bovine Mammary Epithelial Cells

inferred← citeshttps://doi.org/10.1002/jlb.3mir0817-346rrropenalex-snapshot

Modulating inflammation through the negative regulation of NF-κB signaling

inferred← citeshttps://doi.org/10.1002/jlb.3mir1218-483rropenalex-snapshot

Below the surface: The inner lives of TLR4 and TLR9

inferred← citeshttps://doi.org/10.1002/jlb.67.4.508openalex-snapshot

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

inferred← citeshttps://doi.org/10.1002/jlb.67.6.885openalex-snapshot

Activation of TNF-α transcription utilizes distinct MAP kinase pathways in different macrophage populations

inferred← citeshttps://doi.org/10.1002/jmv.29104openalex-snapshot

SADS‐CoV nsp1 inhibits the IFN‐β production by preventing TBK1 phosphorylation and inducing CBP degradation

inferred← citeshttps://doi.org/10.1002/stem.3083openalex-snapshot

Transforming Growth Factor β-Activated Kinase 1 Regulates Mesenchymal Stem Cell Proliferation Through Stabilization of Yap1/Taz Proteins

inferred← citeshttps://doi.org/10.1002/term.3113openalex-snapshot

Promotion of the immunomodulatory properties and osteogenic differentiation of adipose‐derived mesenchymal stem cells in vitro by lentivirus‐mediated mir‐146a sponge expression

inferred← citeshttps://doi.org/10.1006/bbrc.2000.2860openalex-snapshot

Both Amino- and Carboxyl-Terminal Domains of TRAF3 Negatively Regulate NF-κB Activation Induced by OX40 Signaling

inferred← citeshttps://doi.org/10.1006/bbrc.2000.3680openalex-snapshot

E-73, an Acetoxyl Analogue of Cycloheximide, Blocks the Tumor Necrosis Factor-Induced NF-κB Signaling Pathway

inferred← citeshttps://doi.org/10.1006/cyto.2001.0921openalex-snapshot

A20 INHIBITS NF-κB ACTIVATION DOWNSTREAM OF MULTIPLE MAP3 KINASES AND INTERACTS WITH THE IκB SIGNALOSOME

inferred← citeshttps://doi.org/10.1006/dbio.2001.0388openalex-snapshot

Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network?

inferred← citeshttps://doi.org/10.1006/excr.1999.4733openalex-snapshot

Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling

inferred← citeshttps://doi.org/10.1006/excr.2002.5573openalex-snapshot

Lymphotoxin β Receptor Induces Interleukin 8 Gene Expression via NF-κB and AP-1 Activation

inferred← citeshttps://doi.org/10.1006/geno.2001.6640openalex-snapshot

From PREDs and Open Reading Frames to cDNA Isolation: Revisiting the Human Chromosome 21 Transcription Map

inferred← citeshttps://doi.org/10.1007/0-306-47572-3_3openalex-snapshot

Cytokine Activation of Transcription

inferred← citeshttps://doi.org/10.1007/0-387-24534-0_2openalex-snapshot

Toll-like Receptor 9 and Autoimmunity

inferred← citeshttps://doi.org/10.1007/0-387-33573-0_3openalex-snapshot

Receptors and Adaptors for NF-κB Signaling

inferred← citeshttps://doi.org/10.1007/0-387-34573-6_6openalex-snapshot

Fas—More Than an Apoptosis Inducer

inferred← citeshttps://doi.org/10.1007/82_2010_98openalex-snapshot

IKK Regulation and Human Genetics

inferred← citeshttps://doi.org/10.1007/978-0-387-70630-6_7openalex-snapshot

Ubiquitination and TRAF signaling

inferred← citeshttps://doi.org/10.1007/978-1-4020-5476-1_13openalex-snapshot

Molecular Mechanism of TAK1-Induced Repression of hTERT Transcription

inferred← citeshttps://doi.org/10.1007/978-1-4020-8831-5_18openalex-snapshot

Role of Neutral Sphingomyelinases in Aging and Inflammation

inferred← citeshttps://doi.org/10.1007/978-1-4419-8999-4_25openalex-snapshot

Interaction of Innate and Acquired Immune Response: Toll Receptors— Potential Link of Infection to Rejection

inferred← citeshttps://doi.org/10.1007/978-1-4615-0793-2_19openalex-snapshot

Carcinogenic metals and NF-κB activation

inferred← citeshttps://doi.org/10.1007/978-1-4615-1565-4_4openalex-snapshot

Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression

inferred← citeshttps://doi.org/10.1007/978-1-4615-1565-4_6openalex-snapshot

Activation of Nuclear Factor-κB

inferred← citeshttps://doi.org/10.1007/978-1-59259-278-4_28openalex-snapshot

The Molecular Pharmacology of Osteoporosis

inferred← citeshttps://doi.org/10.1007/978-3-030-49844-3_7openalex-snapshot

Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect

inferred← citeshttps://doi.org/10.1007/978-3-030-56319-6_2openalex-snapshot

Intracellular TLR4 Signaling

inferred← citeshttps://doi.org/10.1007/978-3-0348-0620-6_37-1openalex-snapshot

MAP Kinase Pathways

inferred← citeshttps://doi.org/10.1007/978-3-0348-8450-1_10openalex-snapshot

Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase

inferred← citeshttps://doi.org/10.1007/978-3-319-04111-7_4openalex-snapshot

Contribution of Receptors, Transcription Factors, and Genes in the Induction of Neuroinflammation

inferred← citeshttps://doi.org/10.1007/978-3-319-08046-8_6openalex-snapshot

Proinflammatory Chemical Signaling: Cytokines

inferred← citeshttps://doi.org/10.1007/978-3-642-18670-7_3openalex-snapshot

Analogies Between Drosophila and Mammalian TRAF Pathways

inferred← citeshttps://doi.org/10.1007/978-3-642-18932-6_11openalex-snapshot

NF-κB: Critical Regulator of Inflammation and the Immune Response

inferred← citeshttps://doi.org/10.1007/978-3-642-41199-1_16openalex-snapshot

Arrestins in Apoptosis

inferred← citeshttps://doi.org/10.1007/978-3-642-55661-6_7openalex-snapshot

Infektion und Entzündung

inferred← citeshttps://doi.org/10.1007/978-3-7643-8550-7_37openalex-snapshot

MAP Kinase Pathways

inferred← citeshttps://doi.org/10.1007/978-4-431-54421-0_7openalex-snapshot

Inflammation and Cytokines in Endometriosis

inferred← citeshttps://doi.org/10.1007/978-4-431-55561-2_10openalex-snapshot

Regulation of NF-κB Pathway by Linkage-Specific Ubiquitin-Binding Domains

inferred← citeshttps://doi.org/10.1007/978-94-010-0163-2_11openalex-snapshot

Genetic Analysis of NF-κB-Dependent Signaling Pathways in Mammalian Cells

inferred← citeshttps://doi.org/10.1007/978-94-010-0163-2_2openalex-snapshot

NF-κB Activation by Tumor Necrosis Factor and Interleukin-1

inferred← citeshttps://doi.org/10.1007/978-94-010-0163-2_6openalex-snapshot

The Role of Ubiquitin In NF-кB Signaling

inferred← citeshttps://doi.org/10.1007/978-981-13-9367-9_10openalex-snapshot

NF-κB, IκB, and IKK: Integral Components of Immune System Signaling

inferred← citeshttps://doi.org/10.1007/bf02967472openalex-snapshot

Estrogen receptor-mediated cross-talk with growth factor signaling pathways

inferred← citeshttps://doi.org/10.1007/bf02982639openalex-snapshot

The Molecular Basis for the Generation of Hodgkin and Reed-Sternberg Cells in Hodgkin’s Lymphoma

inferred← citeshttps://doi.org/10.1007/s00011-024-01924-2openalex-snapshot

The role of Pim-1 kinases in inflammatory signaling pathways

inferred← citeshttps://doi.org/10.1007/s00018-007-7012-3openalex-snapshot

Regulatory mechanisms of mitogen-activated kinase signaling

inferred← citeshttps://doi.org/10.1007/s00018-009-0059-6openalex-snapshot

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

inferred← citeshttps://doi.org/10.1007/s00018-010-0410-yopenalex-snapshot

Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

inferred← citeshttps://doi.org/10.1007/s00018-016-2130-4openalex-snapshot

The DNA damage-induced cell death response: a roadmap to kill cancer cells

inferred← citeshttps://doi.org/10.1007/s00044-014-1221-8openalex-snapshot

3D QSAR modeling study on 7-aminofuro [2,3-c] pyridine derivatives as TAK1 inhibitors using CoMFA and COMSIA

inferred← citeshttps://doi.org/10.1007/s00109-003-0450-yopenalex-snapshot

Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes

inferred← citeshttps://doi.org/10.1007/s00109-004-0612-6openalex-snapshot

Mechanistic insight into osteoclast differentiation in osteoimmunology

inferred← citeshttps://doi.org/10.1007/s00109-004-0622-4openalex-snapshot

Modulation of Toll?interleukin 1 receptor mediated signaling

inferred← citeshttps://doi.org/10.1007/s00125-017-4401-5openalex-snapshot

VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells

inferred← citeshttps://doi.org/10.1007/s00296-008-0561-4openalex-snapshot

Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways

inferred← citeshttps://doi.org/10.1007/s00424-024-02905-4openalex-snapshot

Intercalated cell function, kidney innate immunity, and urinary tract infections

inferred← citeshttps://doi.org/10.1007/s00535-013-0931-xopenalex-snapshot

TAK1 regulates hepatic cell survival and carcinogenesis

inferred← citeshttps://doi.org/10.1007/s00705-011-1097-6openalex-snapshot

Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation

inferred← citeshttps://doi.org/10.1007/s00726-013-1644-4openalex-snapshot

Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1007/s00726-014-1886-9openalex-snapshot

Bioactive dietary peptides and amino acids in inflammatory bowel disease

inferred← citeshttps://doi.org/10.1007/s00774-003-0453-3openalex-snapshot

The function of nuclear receptors in bone tissues

inferred← citeshttps://doi.org/10.1007/s10456-021-09787-5openalex-snapshot

TAK1 signaling is a potential therapeutic target for pathological angiogenesis

inferred← citeshttps://doi.org/10.1007/s10495-018-1490-7openalex-snapshot

TAK1 mediates convergence of cellular signals for death and survival

inferred← citeshttps://doi.org/10.1007/s10495-018-1498-zopenalex-snapshot

NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo

inferred← citeshttps://doi.org/10.1007/s10557-020-06996-wopenalex-snapshot

TAK1-AMPK Pathway in Macrophages Regulates Hypothyroid Atherosclerosis

inferred← citeshttps://doi.org/10.1007/s10571-023-01389-7openalex-snapshot

Progress in Pathological and Therapeutic Research of HIV-Related Neuropathic Pain

inferred← citeshttps://doi.org/10.1007/s10620-017-4472-7openalex-snapshot

MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-κB Pathway In Vitro

inferred← citeshttps://doi.org/10.1007/s10753-009-9155-xopenalex-snapshot

Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-κB Signaling Pathway

inferred← citeshttps://doi.org/10.1007/s10753-018-0731-9openalex-snapshot

Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets

inferred← citeshttps://doi.org/10.1007/s10753-022-01776-0openalex-snapshot

Fibrosis in Liver and Pancreas: a Review on Pathogenic Significance, Diagnostic Options, and Current Management Strategies

inferred← citeshttps://doi.org/10.1007/s11064-022-03671-4openalex-snapshot

Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and Neuropathic Pain Induced by Sciatic Nerve Injury Through Inactivating NF-κB and JNK

inferred← citeshttps://doi.org/10.1007/s11302-012-9292-9openalex-snapshot

Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling

inferred← citeshttps://doi.org/10.1007/s11357-012-9416-8openalex-snapshot

MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case–control study using a multilocus genotyping

inferred← citeshttps://doi.org/10.1007/s11373-005-9003-4openalex-snapshot

Acetaldehyde-induced interleukin-1β and tumor necrosis factor-α production is inhibited by berberine through nuclear factor-κB signaling pathway in HepG2 cells

inferred← citeshttps://doi.org/10.1007/s11802-019-3683-2openalex-snapshot

Molecular Characterization, Expression Profiles, and Immunostimulation Responses of TRAF6 and TAK1 in Japanese Flounder (Paralichthys olivaceus)

inferred← citeshttps://doi.org/10.1007/s11882-012-0278-zopenalex-snapshot

Mechanisms of Respiratory Syncytial Virus Modulation of Airway Immune Responses

inferred← citeshttps://doi.org/10.1007/s12033-018-0064-9openalex-snapshot

Identification of a Constitutively Active Mutant Mouse IRAK2 by Retroviral Expression Screening

inferred← citeshttps://doi.org/10.1007/s12185-017-2345-7openalex-snapshot

TAK1 inhibition ameliorates survival from graft-versus-host disease in an allogeneic murine marrow transplantation model

inferred← citeshttps://doi.org/10.1007/s12250-008-2999-7openalex-snapshot

Herpes simplex viruses and induction of interferon responses

inferred← citeshttps://doi.org/10.1007/s12250-015-3709-xopenalex-snapshot

Differential gene expression in porcine SK6 cells infected with wild-type and SAP domain-mutant foot-and-mouth disease virus

inferred← citeshttps://doi.org/10.1007/s12291-026-01396-7openalex-snapshot

Modulatory Effects of Interleukin 1-alpha (IL-1α) in Lung Cancer Cell Line A549

inferred← citeshttps://doi.org/10.1007/s13238-012-2080-zopenalex-snapshot

Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection

inferred← citeshttps://doi.org/10.1007/s13238-012-2104-8openalex-snapshot

Regulation of TLR7/9 signaling in plasmacytoid dendritic cells

inferred← citeshttps://doi.org/10.1007/s43440-021-00255-xopenalex-snapshot

Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective

inferred← citeshttps://doi.org/10.1016/b978-0-12-369441-6.00015-5openalex-snapshot

Activation of the Innate immune System: The Toll-like Receptor 4 and Signalling through Ubiquitylation

inferred← citeshttps://doi.org/10.1016/b978-0-12-373884-4.00069-0openalex-snapshot

Bone Morphogenetic Protein Receptors and Actions

inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00083-8openalex-snapshot

Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling

inferred← citeshttps://doi.org/10.1016/b978-0-12-394803-8.00013-9openalex-snapshot

Activation of the Innate Immune System

inferred← citeshttps://doi.org/10.1016/b978-0-12-819612-0.00016-xopenalex-snapshot

The role of Raf kinase inhibitory protein in inflammation

inferred← citeshttps://doi.org/10.1016/b978-0-12-820661-4.00016-9openalex-snapshot

Novel therapeutic strategy: antiinflammatory reagents

inferred← citeshttps://doi.org/10.1016/b978-0-323-35214-7.00128-1openalex-snapshot

Cytokines and Inflammatory Response in the Fetus and Neonate

inferred← citeshttps://doi.org/10.1016/b978-012098652-1.50153-0openalex-snapshot

Bone Morphogenetic Protein Receptors and Actions

inferred← citeshttps://doi.org/10.1016/b978-1-4160-3479-7.10156-9openalex-snapshot

Cytokines and Inflammatory Response in the Fetus and Neonate

inferred← citeshttps://doi.org/10.1016/bs.acr.2016.05.005openalex-snapshot

Cytokine Regulation of Metastasis and Tumorigenicity

inferred← citeshttps://doi.org/10.1016/j.ab.2005.11.010openalex-snapshot

Comparative analysis of various in vitro COT kinase assay formats and their applications in inhibitor identification and characterization

inferred← citeshttps://doi.org/10.1016/j.abb.2005.06.020openalex-snapshot

Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-κB1 p105

inferred← citeshttps://doi.org/10.1016/j.abb.2014.03.011openalex-snapshot

Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

inferred← citeshttps://doi.org/10.1016/j.abb.2019.04.006openalex-snapshot

Role of Sirt1 in innate immune mechanisms against Mycobacterium tuberculosis via the inhibition of TAK1 activation

inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.02.016openalex-snapshot

De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation

inferred← citeshttps://doi.org/10.1016/j.aqrep.2024.102043openalex-snapshot

Evaluation of spray-dried blood meal for application in commercial-like feed for juvenile swimming crab (Portunus trituberculatus)

inferred← citeshttps://doi.org/10.1016/j.aqrep.2026.103613openalex-snapshot

Towards sustainable mud crab (Scylla paramamosain) aquaculture: Pacific krill (Euphausia pacifica) meal as a partial replacement for fish meal

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2021.737820openalex-snapshot

Effect of dietary replacement of fish meal with low-gossypol cottonseed protein concentrate on growth performance and expressions of genes related to protein metabolism for swimming crab (Portunus trituberculatus)

inferred← citeshttps://doi.org/10.1016/j.arabjc.2020.102934openalex-snapshot

Anti-atherosclerotic activity of Betulinic acid loaded polyvinyl alcohol/methylacrylate grafted Lignin polymer in high fat diet induced atherosclerosis model rats

inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2012.05.004openalex-snapshot

META060 attenuates TNF-α-activated inflammation, endothelial–monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes

inferred← citeshttps://doi.org/10.1016/j.bbadis.2014.12.023openalex-snapshot

γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor

inferred← citeshttps://doi.org/10.1016/j.bbagen.2009.08.005openalex-snapshot

Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2007.03.010openalex-snapshot

p38 MAP-Kinases pathway regulation, function and role in human diseases

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2009.04.005openalex-snapshot

Cross interference with TNF-α-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding protein 1

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.06.019openalex-snapshot

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.10.003openalex-snapshot

IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2014.11.011openalex-snapshot

Downregulation of diacylglycerol kinase ζ enhances activation of cytokine-induced NF-κB signaling pathway

inferred← citeshttps://doi.org/10.1016/j.bbii.2026.100163openalex-snapshot

Orchestrating neuroinflammation: A symphony of Interleukin-1 and cell type-specific Interleukin-1 receptor type 1 signaling in the brain

inferred← citeshttps://doi.org/10.1016/j.bbrc.2003.09.100openalex-snapshot

Amyloid β peptide (Aβ42) activates PLC-δ1 promoter through the NF-κB binding site

inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.09.070openalex-snapshot

The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination

inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.11.144openalex-snapshot

Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-γ

inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.12.002openalex-snapshot

CaMKII activates ASK1 and NF-κB to induce cardiomyocyte hypertrophy

inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.12.155openalex-snapshot

TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40

inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.04.006openalex-snapshot

A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling

inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.06.121openalex-snapshot

Small interfering RNAs generated by recombinant dicer induce inflammatory gene expression independent from the TAK1-NFκB-MAPK signaling pathways

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.03.125openalex-snapshot

HTLV-1 Tax-induced NFκB activation is independent of Lys-63-linked-type polyubiquitination

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.10.172openalex-snapshot

HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein

inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.02.052openalex-snapshot

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1β signaling pathway

inferred← citeshttps://doi.org/10.1016/j.bbrc.2009.08.062openalex-snapshot

Toll-like receptors and innate immunity

inferred← citeshttps://doi.org/10.1016/j.bbrc.2010.02.094openalex-snapshot

Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-β1-induced negative regulation of IL-1R/TLR signaling

inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.02.127openalex-snapshot

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts

inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.09.032openalex-snapshot

PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte

inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.12.138openalex-snapshot

Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer

inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.10.007openalex-snapshot

WNK1–TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages

inferred← citeshttps://doi.org/10.1016/j.bcp.2007.02.012openalex-snapshot

Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T cells toward a Th1 polarizing phenotype through the activation of dendritic cells

inferred← citeshttps://doi.org/10.1016/j.bcp.2007.08.033openalex-snapshot

Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization

inferred← citeshttps://doi.org/10.1016/j.bcp.2009.01.004openalex-snapshot

Denbinobin inhibits nuclear factor-κB and induces apoptosis via reactive oxygen species generation in human leukemic cells

inferred← citeshttps://doi.org/10.1016/j.bcp.2015.03.014openalex-snapshot

Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent

inferred← citeshttps://doi.org/10.1016/j.bcp.2025.116764openalex-snapshot

Downregulation of RSAD2 ameliorates keratinocyte hyperproliferation and skin inflammation in psoriasis via the TAK1/NF-κB axis

inferred← citeshttps://doi.org/10.1016/j.biocel.2009.12.023openalex-snapshot

The TAK1–TRAF6 signalling pathway

inferred← citeshttps://doi.org/10.1016/j.biochi.2003.09.009openalex-snapshot

Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb

inferred← citeshttps://doi.org/10.1016/j.biopha.2005.08.007openalex-snapshot

TAK1 downregulation reduces IL-1β induced expression of MMP13, MMP1 and TNF-alpha

inferred← citeshttps://doi.org/10.1016/j.biopha.2008.06.028openalex-snapshot

TLR4-mediated MyD88-dependent signaling pathway is activated by cerebral ischemia–reperfusion in cortex in mice

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.09.037openalex-snapshot

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

inferred← citeshttps://doi.org/10.1016/j.bmc.2016.07.006openalex-snapshot

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

inferred← citeshttps://doi.org/10.1016/j.bmc.2016.11.035openalex-snapshot

Structure-guided development of covalent TAK1 inhibitors

inferred← citeshttps://doi.org/10.1016/j.bone.2018.08.014openalex-snapshot

MicroRNA-155 induces autophagy in osteoclasts by targeting transforming growth factor β-activated kinase 1-binding protein 2 upon lipopolysaccharide stimulation

inferred← citeshttps://doi.org/10.1016/j.ccr.2010.08.006openalex-snapshot

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

inferred← citeshttps://doi.org/10.1016/j.cdev.2026.204099openalex-snapshot

Crosstalk between the Wnt pathway and other signaling pathways

inferred← citeshttps://doi.org/10.1016/j.cellbi.2009.01.003openalex-snapshot

JNK‐binding protein 1 regulates NF‐κB activation through TRAF2 and TAK1

inferred← citeshttps://doi.org/10.1016/j.cellimm.2010.05.011openalex-snapshot

Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells

inferred← citeshttps://doi.org/10.1016/j.cellsig.2005.08.020openalex-snapshot

Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB

inferred← citeshttps://doi.org/10.1016/j.cellsig.2005.10.016openalex-snapshot

TRAF6 and Src kinase activity regulates Cot activation by IL-1

inferred← citeshttps://doi.org/10.1016/j.cellsig.2006.08.003openalex-snapshot

Zn2+-induced NF-κB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation

inferred← citeshttps://doi.org/10.1016/j.cellsig.2008.12.001openalex-snapshot

Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells

inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.03.015openalex-snapshot

Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling

inferred← citeshttps://doi.org/10.1016/j.cellsig.2020.109773openalex-snapshot

IL-36 family cytokines in protective versus destructive inflammation

inferred← citeshttps://doi.org/10.1016/j.cellsig.2023.110684openalex-snapshot

IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling

inferred← citeshttps://doi.org/10.1016/j.celrep.2015.01.001openalex-snapshot

The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65

inferred← citeshttps://doi.org/10.1016/j.celrep.2018.08.020openalex-snapshot

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116404openalex-snapshot

Limited activation interdependence and differing patterns of the in vivo effects of IKK1 and IKK2 downstream of NIK

inferred← citeshttps://doi.org/10.1016/j.chembiol.2013.12.009openalex-snapshot

TAB1: A Target of Triptolide in Macrophages

inferred← citeshttps://doi.org/10.1016/j.chom.2010.11.008openalex-snapshot

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

inferred← citeshttps://doi.org/10.1016/j.clim.2006.10.004openalex-snapshot

IL-1β stimulates divergent upper and lower airway epithelial cell CCL5 secretion

inferred← citeshttps://doi.org/10.1016/j.critrevonc.2023.104200openalex-snapshot

Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies

inferred← citeshttps://doi.org/10.1016/j.cyto.2006.03.009openalex-snapshot

Evolution of cytokine responses: IL-1β directly affects intracellular Ca2+ concentration of teleost fish leukocytes through a receptor-mediated mechanism

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