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Hsp90 as a capacitor for morphological evolution

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00660.xopenalex-snapshot
The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj‐1 have distinct roles in recognition of a non‐native protein and protein refolding.
inferredcites →https://doi.org/10.1007/978-94-015-8054-0_8openalex-snapshot
Origins of Order in Evolution: Self-Organization and Selection
inferredcites →https://doi.org/10.1007/s004270050137openalex-snapshot
Naturally occurring genetic variation affects Drosophila photoreceptor determination
inferredcites →https://doi.org/10.1016/0020-711x(94)90119-8openalex-snapshot
The origins of order; self organization and selection in evolution
inferredcites →https://doi.org/10.1016/0092-8674(91)90065-7openalex-snapshot
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
inferredcites →https://doi.org/10.1016/0092-8674(94)90003-5openalex-snapshot
Protein folding and the regulation of signaling pathways
inferredcites →https://doi.org/10.1016/0092-8674(94)90442-1openalex-snapshot
Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila
inferredcites →https://doi.org/10.1016/0303-2647(84)90015-7openalex-snapshot
Coevolution of functionally constrained characters: Prerequisites for adaptive versatility
inferredcites →https://doi.org/10.1016/s0092-8674(00)81588-3openalex-snapshot
Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1
inferredcites →https://doi.org/10.1017/cbo9780511623486openalex-snapshot
The Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1038/150563a0openalex-snapshot
CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
inferredcites →https://doi.org/10.1038/348166a0openalex-snapshot
Reduced levels of hsp90 compromise steroid receptor action in vivo
inferredcites →https://doi.org/10.1038/scientificamerican1179-98openalex-snapshot
The Neutral Theory of Molecular Evolution
inferredcites →https://doi.org/10.1073/pnas.90.15.7074openalex-snapshot
Heat-shock protein hsp90 governs the activity of pp60v-src kinase.
inferredcites →https://doi.org/10.1073/pnas.91.18.8324openalex-snapshot
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
inferredcites →https://doi.org/10.1073/pnas.94.24.12949openalex-snapshot
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
inferredcites →https://doi.org/10.1074/jbc.270.13.7288openalex-snapshot
Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase
inferredcites →https://doi.org/10.1091/mbc.6.12.1833openalex-snapshot
A role for Hsp90 in retinoid receptor signal transduction.
inferredcites →https://doi.org/10.1093/emboj/16.8.1961openalex-snapshot
The heat shock protein 83 (Hsp83) is required for Raf‐mediated signalling in Drosophila
inferredcites →https://doi.org/10.1093/genetics/142.1.163openalex-snapshot
Mutations Modulating Raf Signaling in Drosophila Eye Development
inferredcites →https://doi.org/10.1093/genetics/147.3.1235openalex-snapshot
Genetic Variation Segregating in Natural Populations of Tribolium castaneum Affecting Traits Observed in Hybrids With T. freemani
inferredcites →https://doi.org/10.1093/genetics/52.6.1137openalex-snapshot
CANALISATION OF DEVELOPMENT OF SCUTELLAR BRISTLES IN DROSOPHILA BY CONTROL OF THE SCUTE LOCUS
inferredcites →https://doi.org/10.1093/genetics/84.1.77openalex-snapshot
ENVIRONMENTAL DETERMINATION OF SELECTIVE SIGNIFICANCE OR NEUTRALITY OF AMYLASE VARIANTS IN DROSOPHILA MELANOGASTER
inferredcites →https://doi.org/10.1093/genetics/96.4.801openalex-snapshot
SELECTIVE NEUTRALITY OF 6PGD ALLOZYMES IN E. COLI AND THE EFFECTS OF GENETIC BACKGROUND
inferredcites →https://doi.org/10.1101/gad.10.12.1491openalex-snapshot
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
inferredcites →https://doi.org/10.1111/j.1558-5646.1953.tb00070.xopenalex-snapshot
GENETIC ASSIMILATION OF AN ACQUIRED CHARACTER
inferredcites →https://doi.org/10.1111/j.1558-5646.1956.tb02824.xopenalex-snapshot
GENETIC ASSIMILATION OF THEBITHORAXPHENOTYPE
inferredcites →https://doi.org/10.1126/science.271.5246.200openalex-snapshot
Effect of Polymorphism in the Drosophila Regulatory Gene Ultrabithorax on Homeotic Stability
inferredcites →https://doi.org/10.1128/mcb.15.7.3917openalex-snapshot
Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase
inferredcites →https://doi.org/10.1128/mcb.18.9.4949openalex-snapshot
HSP90 Interacts with and Regulates the Activity of Heat Shock Factor 1 in Xenopus Oocytes
inferredcites →https://doi.org/10.1210/me.7.11.1418openalex-snapshot
Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes
inferredcites →https://doi.org/10.2307/2529912openalex-snapshot
Introduction to Quantitative Genetics.
inferredcites →https://doi.org/10.5860/choice.34-1536openalex-snapshot
The shape of life: genes, development, and the evolution of animal form
inferredcites →https://doi.org/10.7208/chicago/9780226256573.001.0001openalex-snapshot
The Shape of Life

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Stress Response that Allows Highly Mutated Eukaryotic Cells to Survive and Proliferate
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Epigenetics at the Epicenter of Modern Medicine
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Is Hsp90 a regulator of evolvability?
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The evolutionary challenges of extreme environments (Part 1)
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Homeobox genes, fossils, and the origin of species
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Protein misfolding and degradation in genetic diseases
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Hormesis: an adaptive expectation with emphasis on ionizing radiation
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Canalization in evolutionary genetics: a stabilizing theory?
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Heat‐Shock Proteins
inferred← citeshttps://doi.org/10.1002/0471203076.emm0758openalex-snapshot
HSP 90
inferred← citeshttps://doi.org/10.1002/0471203076.emm2003openalex-snapshot
Molecular Chaperone
inferred← citeshttps://doi.org/10.1002/1097-010x(20001215)288:4<304::aid-jez3>3.0.co;2-gopenalex-snapshot
Epigenetic mechanisms of character origination
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From genotype to phenotype: buffering mechanisms and the storage of genetic information
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Molekulare Chaperone: zelluläre Maschinen für die Proteinfaltung
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Molecular Chaperones—Cellular Machines for Protein Folding
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Identification of novel in vivo obligate GroEL/ES substrates based on data from a cell‐free proteomics approach
inferred← citeshttps://doi.org/10.1002/1873-3468.13499openalex-snapshot
HSP 90 and co‐chaperones: a multitaskers’ view on plant hormone biology
inferred← citeshttps://doi.org/10.1002/3527600906.mcb.200500068openalex-snapshot
Stress-Induced Expression of Heat Shock Proteins and Action of the Heat Shock Protein Effectors
inferred← citeshttps://doi.org/10.1002/9780470015902.a0001801.pub3openalex-snapshot
Molecular Evolution: Nearly Neutral Theory
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Molecular Evolution: Nearly Neutral Theory
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Gene Structure: Evolution
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Gene Structure: Evolution
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Protein Misfolding and Degradation in Genetic Disease
inferred← citeshttps://doi.org/10.1002/9780470015902.a0006116openalex-snapshot
Genetic Redundancy
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Genetic Redundancy
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The Complexity of Genetic Redundancy
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Mutation Rates: Evolution
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Mutation Rates: Evolution
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Ecological Development Biology
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Higher Order Genetic Interactions and Complex Trait Variation
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Molecular Evolution: Nearly Neutral Theory
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The Theory of Biological Robustness and its Implication to Cancer
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Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development
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Mccrearamycins A–D, Geldanamycin‐Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe
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Mccrearamycins A–D, Geldanamycin‐Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe
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Gene duplications, robustness and evolutionary innovations
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Importance of Considering the Plastic Expression of Phenotypes When Determining Evolutionary Relationships
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Molecular chaperones, stress proteins and redox homeostasis
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Hsp90 and co‐chaperones twist the functions of diverse client proteins
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Identifying protein stabilizing ligands using GroEL
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Hsp90 as a Target for Drug Development
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Odorants as cell‐type specific activators of a heat shock response in the rat olfactory mucosa
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Heat‐Shock Proteins
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A novel mode of action for COX‐2 inhibition: Targeting ATPase domain of HSP90 induces ubiquitin degradation of new client protein COX‐2
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Genetically determined phenotype covariation networks control bone strength
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Treatment of human neuroblastoma cell line SH‐SY5Y with HSP27 siRNA tagged‐exosomes decreased differentiation rate into mature neurons
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Regulation of metamorphosis in ascidians involves NO/cGMP signaling and HSP90
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Evolutionary challenges of extreme environments (part 2)
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DnaJ chaperones contribute to canalization
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Fifty years later: I. Michael Lerner'sGenetic Homeostasis (1954)—a valiant attempt to integrate genes, organisms and environment
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Evolutionary innovations in the fossil record: the intersection of ecology, development, and macroevolution
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EvoDevo and niche construction: building bridges
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Snail phenotypic variation and stress proteins: do different heat response strategies contribute to Waddington's widget in field populations?
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Developmental Plasticity and the Origin of Novel Forms: Unveiling Cryptic Genetic Variation Via“Use and Disuse”
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Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function
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Molecular mechanisms of paralogous compensation and the robustness of cellular networks
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Computing the Extended Synthesis: Mapping the Dynamics and Conceptual Structure of the Evolvability Research Front
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Embryonic canalization and its limits—A view from temperature
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Inhibition of HSP90 causes morphological variation in the invasive ant Cardiocondyla obscurior
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Transcriptomic bases of a polyphenism
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Hsp90 inhibitors: Small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation
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Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer
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Globacrochordiceras gen. nov. (Acrochordiceratidae, late Early Triassic) and its significance for stress-induced evolutionary jumps in ammonoid lineages (cephalopods)
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E. E. Just's broad, yet hidden, influence on modern cell and developmental biology
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Molecular characterization of heat shock proteins 90 (HSP83?) and 70 in tropical strains of Bombyx mori
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Group II archaeal chaperonin recognition of partially folded human γD‐crystallin mutants
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Reframing prosegment‐dependent folding and limits on natural protein folding landscapes from an evolutionary perspective
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Stress‐induced evolution of herbicide resistance and related pleiotropic effects
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Research on plant‐parasitic nematode biology conducted by the United States Department of Agriculture–Agricultural Research Service
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Goldfish morphology as a model for evolutionary developmental biology
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The La and related RNA ‐binding proteins (LARPs): structures, functions, and evolving perspectives
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The complex role of genetic background in shaping the effects of spontaneous and induced mutations
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The HTL1 gene (YCR020W‐b) of Saccharomyces cerevisiae is necessary for growth at 37°C, and for the conservation of chromosome stability and fertility
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Sequence Features and Phylogenetic Analysis of the Stress Protein Hsp90α in Chinook Salmon (Oncorhynchus tshawytscha), a Poikilothermic Vertebrate
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Magnetic Field Exposure Stimulates Transposition through the Induction of DnaK/J Synthesis
inferred← citeshttps://doi.org/10.1006/cbir.2001.0789openalex-snapshot
HEAT SHOCK RESPONSE AND AGEING: MECHANISMS AND APPLICATIONS
inferred← citeshttps://doi.org/10.1006/dbio.1999.9262openalex-snapshot
Disruption of Zebrafish Somite Development by Pharmacologic Inhibition of Hsp90
inferred← citeshttps://doi.org/10.1006/dbio.2001.0210openalex-snapshot
Ecological Developmental Biology: Developmental Biology Meets the Real World
inferred← citeshttps://doi.org/10.1006/excr.2002.5501openalex-snapshot
Exogenous Expression of Heat Shock Protein 90kDa Retards the Cell Cycle and Impairs the Heat Shock Response
inferred← citeshttps://doi.org/10.1006/excr.2002.5620openalex-snapshot
Unique Behavior of a Dictyostelium Homologue of TRAP-1, Coupling with Differentiation of D. discoideum Cells
inferred← citeshttps://doi.org/10.1006/jtbi.1999.1015openalex-snapshot
Maintaining Life and Health by Natural Selection of Protein Molecules
inferred← citeshttps://doi.org/10.1006/jtbi.2000.2189openalex-snapshot
Gene Conversion may aid Adaptive Peak Shifts
inferred← citeshttps://doi.org/10.1006/tpbi.2000.1508openalex-snapshot
Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction
inferred← citeshttps://doi.org/10.1007/0-306-46817-4_31openalex-snapshot
Heat Shock Proteins in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/0-387-25856-6_11openalex-snapshot
Molecular Roles of Chaperones in Assisted Folding and Assembly of Proteins
inferred← citeshttps://doi.org/10.1007/0-387-26015-3_5openalex-snapshot
Protein Folding and Binding
inferred← citeshttps://doi.org/10.1007/0-387-27445-6_1openalex-snapshot
Introduction
inferred← citeshttps://doi.org/10.1007/0-387-30395-2_13openalex-snapshot
Heat Shock Proteins in Brain Function
inferred← citeshttps://doi.org/10.1007/0-387-30741-9_16openalex-snapshot
Bacteriocyte-Associated Endosymbionts of Insects
inferred← citeshttps://doi.org/10.1007/10_2013_208openalex-snapshot
Tribolium castaneum as a Model for High-Throughput RNAi Screening
inferred← citeshttps://doi.org/10.1007/128_2012_356openalex-snapshot
Hsp90: Structure and Function
inferred← citeshttps://doi.org/10.1007/3-540-27998-9_14openalex-snapshot
Molecular chaperones—holding and folding
inferred← citeshttps://doi.org/10.1007/3-540-29717-0_11openalex-snapshot
Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin
inferred← citeshttps://doi.org/10.1007/3-540-29717-0_13openalex-snapshot
Molecular Chaperones and Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/3-540-29717-0_14openalex-snapshot
Hsp90 Inhibitors in the Clinic
inferred← citeshttps://doi.org/10.1007/3-540-29717-0_7openalex-snapshot
HSFs in Development
inferred← citeshttps://doi.org/10.1007/7515_2020_7openalex-snapshot
Threading Microarrays into Novel Applications
inferred← citeshttps://doi.org/10.1007/978-0-387-30440-3_35openalex-snapshot
Biological Development and Evolution, Complexity and Self-organization in
inferred← citeshttps://doi.org/10.1007/978-0-387-33532-2_33openalex-snapshot
Imaging the Neural Systems for Motivated Behavior and Their Dysfunction in Neuropsychiatric Illness
inferred← citeshttps://doi.org/10.1007/978-0-387-34817-9openalex-snapshot
Hypoxia and Exercise
inferred← citeshttps://doi.org/10.1007/978-0-387-39717-7_15openalex-snapshot
Targeting Hsp90 in Cancer and Neurodegenerative Disease
inferred← citeshttps://doi.org/10.1007/978-0-387-39717-7_18openalex-snapshot
Heat Shock Proteins and Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1007/978-0-387-39717-7_19openalex-snapshot
Heat Shock Proteins in the Progression of Cancer
inferred← citeshttps://doi.org/10.1007/978-0-387-39954-6_1openalex-snapshot
Heat Shock Proteins
inferred← citeshttps://doi.org/10.1007/978-0-387-39975-1openalex-snapshot
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
inferred← citeshttps://doi.org/10.1007/978-0-387-39975-1_15openalex-snapshot
The Stress of Misfolded Proteins
inferred← citeshttps://doi.org/10.1007/978-0-387-39975-1_16openalex-snapshot
Hsp90 and Developmental Networks
inferred← citeshttps://doi.org/10.1007/978-0-387-39975-1_6openalex-snapshot
Chaperones as Parts of Cellular Networks
inferred← citeshttps://doi.org/10.1007/978-1-4020-5963-6_6openalex-snapshot
HSP90 Co-Chaperones in Saccharomyces Cerevisiae
inferred← citeshttps://doi.org/10.1007/978-1-4020-6335-0_13openalex-snapshot
Multidisciplinary Aspects of Regulatory Systems Relevant to Multiple Stressors: Aging, Xenobiotics and Radiation
inferred← citeshttps://doi.org/10.1007/978-1-4020-6401-2_12openalex-snapshot
Heat Shock Protein 90: The Cancer Chaperone
inferred← citeshttps://doi.org/10.1007/978-1-4020-6401-2_13openalex-snapshot
Targeting Hsp90 Function to Treat Cancer: Much More to Be Learned
inferred← citeshttps://doi.org/10.1007/978-1-4020-6401-2_15openalex-snapshot
Drugging the Hsp90 molecular chaperone machine for cancer treatment
inferred← citeshttps://doi.org/10.1007/978-1-4020-6869-0_6openalex-snapshot
Hormetic Modulation of Aging in Human Cells
inferred← citeshttps://doi.org/10.1007/978-1-4419-7002-2_11openalex-snapshot
Protein Homeostasis in Models of Aging and Age-Related Conformational Disease
inferred← citeshttps://doi.org/10.1007/978-1-4471-5125-8_5openalex-snapshot
Living as Languaging: Distributed Knowledge in Living Beings
inferred← citeshttps://doi.org/10.1007/978-1-4614-5305-5_16openalex-snapshot
Yeast Prions Are Pathogenic, In-Register Parallel Amyloids
inferred← citeshttps://doi.org/10.1007/978-1-4614-6280-4_5openalex-snapshot
Hsp90 as a Capacitor of Both Genetic and Epigenetic Changes in the Genome During Cancer Progression and Evolution
inferred← citeshttps://doi.org/10.1007/978-1-4614-6280-4_7openalex-snapshot
Microsatellite Repeats: Canaries in the Coalmine
inferred← citeshttps://doi.org/10.1007/978-1-4615-1209-7_12openalex-snapshot
Selective Breeding for an Infantile Phenotype (Isolation Calling)
inferred← citeshttps://doi.org/10.1007/978-1-4757-4947-2_27openalex-snapshot
Cell System Complexity and Biological Evolution
inferred← citeshttps://doi.org/10.1007/978-1-4939-1130-1_15openalex-snapshot
The Interaction Networks of E. coli Chaperones
inferred← citeshttps://doi.org/10.1007/978-1-4939-1130-1_8openalex-snapshot
The Candida albicans Hsp90 Chaperone Network Is Environmentally Flexible and Evolutionarily Divergent
inferred← citeshttps://doi.org/10.1007/978-1-4939-1136-3_13openalex-snapshot
Molecular Chaperone Functions in Plastids
inferred← citeshttps://doi.org/10.1007/978-1-4939-2155-3_10openalex-snapshot
Capacitating Epistasis—Detection and Role in the Genetic Architecture of Complex Traits
inferred← citeshttps://doi.org/10.1007/978-1-4939-2155-3_4openalex-snapshot
Epistasis for Quantitative Traits in Drosophila
inferred← citeshttps://doi.org/10.1007/978-1-4939-2404-2_8openalex-snapshot
Systems Biology of Aging
inferred← citeshttps://doi.org/10.1007/978-1-4939-3070-8_1openalex-snapshot
MiRNAs’ Function and Role in Evolution: Under the View of Genomic Enhancement Phenomena
inferred← citeshttps://doi.org/10.1007/978-1-4939-6460-4_5openalex-snapshot
How Do Mutant Clones Expand in Normal Tissue
inferred← citeshttps://doi.org/10.1007/978-1-4939-7477-1_20openalex-snapshot
Computational Analysis of the Chaperone Interaction Networks
inferred← citeshttps://doi.org/10.1007/978-1-59259-767-3_22openalex-snapshot
Pharmacological Intervention With Multistep Oncogenesis
inferred← citeshttps://doi.org/10.1007/978-1-59745-337-0_4openalex-snapshot
17-AAG
inferred← citeshttps://doi.org/10.1007/978-1-59745-356-1_5openalex-snapshot
Differential dependence of EGFR and ErbB2 on the molecular chaperone Hsp90
inferred← citeshttps://doi.org/10.1007/978-1-59745-531-2_1openalex-snapshot
Scientific Challenges in Systems Biology
inferred← citeshttps://doi.org/10.1007/978-3-030-03952-3_2openalex-snapshot
Heat Shock Proteins (HSP) in Stress-Related Inflammatory Diseases
inferred← citeshttps://doi.org/10.1007/978-3-030-06128-9_10openalex-snapshot
Emergent Properties and Stability in Hierarchical Biosystems: There Is no Privileged Level of Causation
inferred← citeshttps://doi.org/10.1007/978-3-030-18667-8_1openalex-snapshot
What Makes Evolution Tick?
inferred← citeshttps://doi.org/10.1007/978-3-030-23158-3_2openalex-snapshot
HSP90-Based Heterocomplex as Essential Regulator for Cancer Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-23158-3_21openalex-snapshot
Hsp90 Chaperone in Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-23158-3_27openalex-snapshot
HSP90 et al.: Chaperome and Proteostasis Deregulation in Human Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-23158-3_4openalex-snapshot
Hsp90 in the Migration of Primordial Germ Cells: A Model to Study Long-Distance Cell Migration and Perhaps Cancer?
inferred← citeshttps://doi.org/10.1007/978-3-030-23158-3_9openalex-snapshot
Hsp90 Is a Pivotal Player in Retinal Disease and Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-40204-4_5openalex-snapshot
The Multifaceted Role of HSF1 in Tumorigenesis
inferred← citeshttps://doi.org/10.1007/978-3-030-78397-6_5openalex-snapshot
Role of Hsp90 in Plasmodium falciparum Malaria
inferred← citeshttps://doi.org/10.1007/978-3-031-22028-9_5openalex-snapshot
The Creativity of Natural Selection and the Creativity of Organisms: Their Roles in Traditional Evolutionary Theory and Some Proposed Extensions
inferred← citeshttps://doi.org/10.1007/978-3-031-53626-7_9openalex-snapshot
Plastic Ontogenesis: Memory, Closure, and Habitual Teleology in Development
inferred← citeshttps://doi.org/10.1007/978-3-031-54982-3_12openalex-snapshot
Some Remarks on Catastrophe Theory and Biology
inferred← citeshttps://doi.org/10.1007/978-3-031-65183-0_4openalex-snapshot
Diversity in Oxidative Status: Roles of Stress Response, Metabolism, Rhythmicity, and (Epi)Genetics
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