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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.
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Characterization of the ligand‐dependent transactivation domain of thyroid hormone receptor.
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Activation function 2 (AF‐2) of retinoic acid receptor and 9‐cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF‐2 activity.
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TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.
inferredcites →https://doi.org/10.1016/0092-8674(94)90006-xopenalex-snapshot
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
inferredcites →https://doi.org/10.1016/0092-8674(95)90075-6openalex-snapshot
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
inferredcites →https://doi.org/10.1016/0092-8674(95)90199-xopenalex-snapshot
The nuclear receptor superfamily: The second decade
inferredcites →https://doi.org/10.1016/0960-894x(96)00382-4openalex-snapshot
Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1
inferredcites →https://doi.org/10.1016/s0021-9258(18)47403-0openalex-snapshot
Functional analysis of a transactivation domain in the thyroid hormone beta receptor.
inferredcites →https://doi.org/10.1016/s0076-6879(97)77033-2openalex-snapshot
[31] PHASES-95: A program package for processing and analyzing diffraction data from macromolecules
inferredcites →https://doi.org/10.1016/s0092-8674(00)80516-4openalex-snapshot
Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300
inferredcites →https://doi.org/10.1016/s0092-8674(00)81118-6openalex-snapshot
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
inferredcites →https://doi.org/10.1016/s0092-8674(00)81575-5openalex-snapshot
PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL
inferredcites →https://doi.org/10.1016/s0955-0674(97)80066-xopenalex-snapshot
Nuclear receptor coactivators
inferredcites →https://doi.org/10.1021/jm950395aopenalex-snapshot
The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones
inferredcites →https://doi.org/10.1038/26040openalex-snapshot
Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
inferredcites →https://doi.org/10.1038/34178openalex-snapshot
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
inferredcites →https://doi.org/10.1038/371528a0openalex-snapshot
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
inferredcites →https://doi.org/10.1038/375377a0openalex-snapshot
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
inferredcites →https://doi.org/10.1038/378681a0openalex-snapshot
Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
inferredcites →https://doi.org/10.1038/378690a0openalex-snapshot
A structural role for hormone in the thyroid hormone receptor
inferredcites →https://doi.org/10.1038/39645openalex-snapshot
Molecular basis of agonism and antagonism in the oestrogen receptor
inferredcites →https://doi.org/10.1038/42652openalex-snapshot
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
inferredcites →https://doi.org/10.1038/42750openalex-snapshot
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
inferredcites →https://doi.org/10.1056/nejm199411033311812openalex-snapshot
Insulin Resistance and the Prevention of Diabetes Mellitus
inferredcites →https://doi.org/10.1073/pnas.91.15.7355openalex-snapshot
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
inferredcites →https://doi.org/10.1073/pnas.94.9.4312openalex-snapshot
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
inferredcites →https://doi.org/10.1073/pnas.94.9.4318openalex-snapshot
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
inferredcites →https://doi.org/10.1074/jbc.270.22.12953openalex-snapshot
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
inferredcites →https://doi.org/10.1093/emboj/17.2.507openalex-snapshot
The coactivator TIF2 contains three nuclear receptor‐binding motifs and mediates transactivation through CBP binding‐dependent and ‐independent pathways
inferredcites →https://doi.org/10.1101/gad.10.8.974openalex-snapshot
Differential activation of adipogenesis by multiple PPAR isoforms.
inferredcites →https://doi.org/10.1101/gad.11.1.59openalex-snapshot
Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids.
inferredcites →https://doi.org/10.1101/gad.8.10.1224openalex-snapshot
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
inferredcites →https://doi.org/10.1107/s0108767390010224openalex-snapshot
Improved methods for building protein models in electron density maps and the location of errors in these models
inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot
The CCP4 suite: programs for protein crystallography
inferredcites →https://doi.org/10.1126/science.277.5328.965openalex-snapshot
AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer
inferredcites →https://doi.org/10.1126/science.3283939openalex-snapshot
The Steroid and Thyroid Hormone Receptor Superfamily
inferredcites →https://doi.org/10.1128/mcb.16.8.4128openalex-snapshot
Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids
inferredcites →https://doi.org/10.1128/mcb.17.4.1832openalex-snapshot
AF-2 Activity and Recruitment of Steroid Receptor Coactivator 1 to the Estrogen Receptor Depend on a Lysine Residue Conserved in Nuclear Receptors
inferredcites →https://doi.org/10.1128/mcb.17.5.2735openalex-snapshot
GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors
inferredcites →https://doi.org/10.1210/en.135.2.798openalex-snapshot
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose- predominant expression and induction early in adipocyte differentiation
inferredcites →https://doi.org/10.1210/me.10.10.1167openalex-snapshot
Nuclear receptor coactivators and corepressors
inferredcites →https://doi.org/10.2174/1381612802666220920215821openalex-snapshot
The Glitazone Family of Antidiabetic Agents
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Insights into the PPARR Phosphorylation and Its Inhibition Through Direct and Allosteric Mechanisms
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Steroid hormone receptors: Evolution, ligands, and molecular basis of biologic function
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Regulated assembly of transcription factors and control of transcription initiation 1 1Edited by D. E. Draper
inferred← citeshttps://doi.org/10.1006/prep.1999.1053openalex-snapshot
Versatile Copurification Procedure for Rapid Isolation of Homogeneous RAR-RXR Heterodimers
inferred← citeshttps://doi.org/10.1007/1-4020-3579-9_20openalex-snapshot
Lipoxygenases, Apoptosis, and the Role of Antioxidants
inferred← citeshttps://doi.org/10.1007/1-4020-7960-5_17openalex-snapshot
Role of Nitric Oxide in Matrix Remodeling in Diabetes and Heart Failure
inferred← citeshttps://doi.org/10.1007/7081_021openalex-snapshot
QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold
inferred← citeshttps://doi.org/10.1007/7081_036openalex-snapshot
In silico Studies on PPARγ Agonistic Heterocyclic Systems
inferred← citeshttps://doi.org/10.1007/978-0-387-40049-5_16openalex-snapshot
Actions of Nuclear Receptors
inferred← citeshttps://doi.org/10.1007/978-1-0716-2728-0_39openalex-snapshot
Machine Learning and Computational Chemistry for the Endocannabinoid System
inferred← citeshttps://doi.org/10.1007/978-1-4419-7034-3_19openalex-snapshot
The Role of Environmental Obesogens in the Obesity Epidemic
inferred← citeshttps://doi.org/10.1007/978-1-4614-8915-3_17openalex-snapshot
The Role of PPARγ in Stroke
inferred← citeshttps://doi.org/10.1007/978-1-4615-0455-9_7openalex-snapshot
The Role of Nuclear Receptors in HDL Formation
inferred← citeshttps://doi.org/10.1007/978-1-4615-0515-0_6openalex-snapshot
The P160 Family of Steroid Hormone Receptor Coactivators
inferred← citeshttps://doi.org/10.1007/978-1-4615-1161-8_4openalex-snapshot
Androgen Receptor Interacting Proteins: Co-Activators And Co-Repressors
inferred← citeshttps://doi.org/10.1007/978-1-4615-1171-7_2openalex-snapshot
Design, Structure, and Function of Novel PPAR Ligands
inferred← citeshttps://doi.org/10.1007/978-1-4757-3600-7_12openalex-snapshot
Signal Transduction and Structure of Nuclear Receptors
inferred← citeshttps://doi.org/10.1007/978-1-4757-3600-7_14openalex-snapshot
Sensors for Metabolic Control
inferred← citeshttps://doi.org/10.1007/978-1-4939-6798-8_6openalex-snapshot
Highly Flexible Protein-Peptide Docking Using CABS-Dock
inferred← citeshttps://doi.org/10.1007/978-1-4939-9195-2_22openalex-snapshot
Molecular Modeling Approach to Study the PPARγ–Ligand Interactions
inferred← citeshttps://doi.org/10.1007/978-1-59259-032-2_23openalex-snapshot
CREB Binding Protein—Coactivator Complexes
inferred← citeshttps://doi.org/10.1007/978-1-59259-157-2_4openalex-snapshot
SERM Modulation of Gene Expression
inferred← citeshttps://doi.org/10.1007/978-1-59259-221-0_16openalex-snapshot
The Androgen Receptor, Androgen Insensitivity, and Prostate Cancer
inferred← citeshttps://doi.org/10.1007/978-1-59259-297-5_7openalex-snapshot
Peroxisome Proliferator-Activated Receptor Gamma Agonists
inferred← citeshttps://doi.org/10.1007/978-1-59259-302-6_14openalex-snapshot
Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention
inferred← citeshttps://doi.org/10.1007/978-1-60327-575-0_1openalex-snapshot
Nuclear Receptors: One Big Family
inferred← citeshttps://doi.org/10.1007/978-1-60327-829-4_5openalex-snapshot
Androgen Receptor Biology in Prostate Cancer
inferred← citeshttps://doi.org/10.1007/978-1-62703-155-4_10openalex-snapshot
PPAR SUMOylation: Some Useful Experimental Tips
inferred← citeshttps://doi.org/10.1007/978-1-62703-420-3_3openalex-snapshot
Peroxisome Proliferator-Activated Receptors
inferred← citeshttps://doi.org/10.1007/978-1-62703-420-3_5openalex-snapshot
Tissue Distribution and Versatile Functions of PPARs
inferred← citeshttps://doi.org/10.1007/978-2-287-33475-7_20openalex-snapshot
Régulation de ľexpression génique par les macronutriments
inferred← citeshttps://doi.org/10.1007/978-3-030-11488-6_3openalex-snapshot
Understanding Peroxisome Proliferator-Activated Receptors: From the Structure to the Regulatory Actions on Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-030-21737-2_3openalex-snapshot
Cannabinoid Interactions with Proteins: Insights from Structural Studies
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_10openalex-snapshot
Design of Novel PPAR Agonist for Neurodegenerative Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_20openalex-snapshot
Ligand-Independent Coactivation of Peroxisome Proliferator-Activated Receptor Gamma
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_6openalex-snapshot
PPARα and δ Ligand Design: Honing the Traditional Empirical Method with a More Holistic Overview
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_7openalex-snapshot
Pregnane X Receptor: Understanding Its Function and Activity at the Molecular Level
inferred← citeshttps://doi.org/10.1007/978-3-031-11836-4_11openalex-snapshot
AR Structural Variants and Prostate Cancer
inferred← citeshttps://doi.org/10.1007/978-3-0348-8012-1_3openalex-snapshot
Therapeutic role of peroxisome proliferator-activated receptors in obesity, diabetes and inflammation
inferred← citeshttps://doi.org/10.1007/978-3-0348-8393-1_9openalex-snapshot
Peroxisome proliferator activated receptor agonists
inferred← citeshttps://doi.org/10.1007/978-3-0348-8454-9_22openalex-snapshot
Therapeutic uses of retinoic acid receptor antagonists and inverse agonists
inferred← citeshttps://doi.org/10.1007/978-3-319-01008-3_3openalex-snapshot
The Liver in Metabolic Syndrome
inferred← citeshttps://doi.org/10.1007/978-3-319-18729-7_9openalex-snapshot
Assembly and Regulation of Nuclear Receptor Corepressor Complexes
inferred← citeshttps://doi.org/10.1007/978-3-319-43365-3_6openalex-snapshot
Immunosenescence and the Ageing Lung
inferred← citeshttps://doi.org/10.1007/978-3-319-99350-8_4openalex-snapshot
Structural Studies with Coactivators for the Estrogen Receptor
inferred← citeshttps://doi.org/10.1007/978-3-642-55742-2_2openalex-snapshot
Transcription Factors That Regulate Macrophage Development and Function
inferred← citeshttps://doi.org/10.1007/978-3-662-04050-8_11openalex-snapshot
Recruitment of p160 Coactivators to Androgen Receptors
inferred← citeshttps://doi.org/10.1007/978-3-662-05314-0_4openalex-snapshot
Chemical Genomics of Orphan Nuclear Receptors
inferred← citeshttps://doi.org/10.1007/978-3-662-10595-5_5openalex-snapshot
Corepressors and Nuclear Hormone Receptor Function
inferred← citeshttps://doi.org/10.1007/978-3-662-10595-5_6openalex-snapshot
Regulation of SMRT and N-CoR Corepressor Function
inferred← citeshttps://doi.org/10.1007/978-90-481-3303-1_10openalex-snapshot
PPARs: Important Regulators in Metabolism and Inflammation
inferred← citeshttps://doi.org/10.1007/978-94-017-9050-5_2openalex-snapshot
Architecture of DNA Bound RAR Heterodimers
inferred← citeshttps://doi.org/10.1007/978-94-024-0945-1_7openalex-snapshot
Non-classical Transcriptional Activity of Retinoic Acid
inferred← citeshttps://doi.org/10.1007/978-981-99-2196-6_46-1openalex-snapshot
Advances in Cancer Therapeutics: Potential Probiotics on Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-981-99-6263-1_46openalex-snapshot
Advances in Cancer Therapeutics: Potential Probiotics on Cancer Therapy
inferred← citeshttps://doi.org/10.1007/pl00000656openalex-snapshot
Structural studies on nuclear receptors
inferred← citeshttps://doi.org/10.1007/pl00000856openalex-snapshot
Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors
inferred← citeshttps://doi.org/10.1007/s00005-008-0037-yopenalex-snapshot
Structure and physiological functions of the human peroxisome proliferator-activated receptor γ
inferred← citeshttps://doi.org/10.1007/s00018-007-7278-5openalex-snapshot
Lipid sensing and lipid sensors
inferred← citeshttps://doi.org/10.1007/s00044-008-9102-7openalex-snapshot
Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor α
inferred← citeshttps://doi.org/10.1007/s00044-010-9428-9openalex-snapshot
Ligand-based in silico 3D-QSAR study of PPAR-γ agonists
inferred← citeshttps://doi.org/10.1007/s00044-011-9548-xopenalex-snapshot
Rigid and flexible docking studies on PPAR-γ agonists: key interactions for a better antihyperglycemic activity and in silico pharmacodynamic activity versus experimental in vivo activity
inferred← citeshttps://doi.org/10.1007/s00044-011-9818-7openalex-snapshot
The application of comparative molecular field analysis for the design of α-anilino substituted-3-phenyl propanoic acids as novel PPARα/γ dual ligands
inferred← citeshttps://doi.org/10.1007/s00044-012-0003-4openalex-snapshot
3D-QSAR study of tyrosine and propanoic acid derivatives as PPARα/γ dual agonists using CoMSIA
inferred← citeshttps://doi.org/10.1007/s00044-013-0814-yopenalex-snapshot
Design and synthesis of non-TZD peroxisome proliferator-activated receptor γ (PPARγ) modulator
inferred← citeshttps://doi.org/10.1007/s00044-014-1278-4openalex-snapshot
Molecular modeling design, synthesis, and anti-hyprglycemic evaluation of certain 5-(aryl-alkoxy-benzylidine)-imidazolidine-2,4-dione derivatives as potential PPARγ agonists
inferred← citeshttps://doi.org/10.1007/s00044-015-1343-7openalex-snapshot
Two homoisoflavonoids act as peroxisome proliferator-activated receptor agonists
inferred← citeshttps://doi.org/10.1007/s00044-016-1621-zopenalex-snapshot
Identifying potential PPARγ agonist/partial agonist from plant molecules to control type 2 diabetes using in silico and in vivo models
inferred← citeshttps://doi.org/10.1007/s00044-017-1867-0openalex-snapshot
Structure-based design, synthesis, PPAR-γ activation, and molecular docking of N-substituted phthalimides
inferred← citeshttps://doi.org/10.1007/s00044-020-02628-yopenalex-snapshot
In vitro dual-target activities and in vivo antidiabetic effect of 3-hydroxy-N-(p-hydroxy-phenethyl) phthalimide in high-fat diet and streptozotocin-induced diabetic golden hamsters
inferred← citeshttps://doi.org/10.1007/s001090000145openalex-snapshot
The pleiotropic functions of peroxisome proliferator-activated receptor γ
inferred← citeshttps://doi.org/10.1007/s00125-002-0899-1openalex-snapshot
Thiazolidinediones: metabolic actions in vitro
inferred← citeshttps://doi.org/10.1007/s00125-003-1037-4openalex-snapshot
A dominant negative PPARγ mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells
inferred← citeshttps://doi.org/10.1007/s00125-012-2777-9openalex-snapshot
Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes
inferred← citeshttps://doi.org/10.1007/s001250051268openalex-snapshot
PPARγ, the ultimate thrifty gene
inferred← citeshttps://doi.org/10.1007/s00204-014-1410-8openalex-snapshot
SEURAT-1 liver gold reference compounds: a mechanism-based review
inferred← citeshttps://doi.org/10.1007/s00204-018-2268-yopenalex-snapshot
Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models
inferred← citeshttps://doi.org/10.1007/s00210-007-0251-xopenalex-snapshot
Peroxisome proliferator activated receptor γ and oxidized docosahexaenoic acids as new class of ligand
inferred← citeshttps://doi.org/10.1007/s00214-018-2277-1openalex-snapshot
Molecular dynamics simulation of human estrogen receptor free and bound to morpholine ether benzophenone inhibitor
inferred← citeshttps://doi.org/10.1007/s00216-008-2004-1openalex-snapshot
Detecting mitochondrial RNA and other cellular events in living cells
inferred← citeshttps://doi.org/10.1007/s00227-005-0210-3openalex-snapshot
Imposex in marine gastropods may be caused by binding of organotins to retinoid X receptor
inferred← citeshttps://doi.org/10.1007/s00249-007-0220-9openalex-snapshot
Ligand-escape pathways from the ligand-binding domain of PPARγ receptor as probed by molecular dynamics simulations
inferred← citeshttps://doi.org/10.1007/s00249-008-0369-xopenalex-snapshot
Ligand unbinding pathways from the vitamin D receptor studied by molecular dynamics simulations
inferred← citeshttps://doi.org/10.1007/s00249-010-0608-9openalex-snapshot
Dynamic correlation networks in human peroxisome proliferator-activated receptor-γ nuclear receptor protein
inferred← citeshttps://doi.org/10.1007/s00432-007-0277-yopenalex-snapshot
Peroxisome proliferator-activated receptor γ (PPARγ) and colorectal carcinogenesis
inferred← citeshttps://doi.org/10.1007/s00894-003-0175-4openalex-snapshot
3D QSAR studies on peroxisome proliferator-activated receptor ? agonists using CoMFA and CoMSIA
inferred← citeshttps://doi.org/10.1007/s00894-004-0227-4openalex-snapshot
Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity
inferred← citeshttps://doi.org/10.1007/s10254-005-0002-0openalex-snapshot
Role of the Mediator complex in nuclear hormone receptor signaling
inferred← citeshttps://doi.org/10.1007/s10549-008-0103-5openalex-snapshot
Role of melatonin in the epigenetic regulation of breast cancer
inferred← citeshttps://doi.org/10.1007/s10557-006-0643-zopenalex-snapshot
Molecular Mechanisms of Cross-talk between Thyroid Hormone and Peroxisome Proliferator Activated Receptors: Focus on the Heart
inferred← citeshttps://doi.org/10.1007/s10620-007-9794-4openalex-snapshot
Expression of Peroxisome Proliferator-Activated Receptor-γ in Colon Cancer: Correlation with Histopathological Parameters, Cell Cycle-Related Molecules, and Patients’ Survival
inferred← citeshttps://doi.org/10.1007/s10695-022-01152-7openalex-snapshot
Genome-wide identification and expression of the peroxisome proliferator-activated receptor gene family in the Tibetan highland fish Gymnocypris przewalskii
inferred← citeshttps://doi.org/10.1007/s10741-008-9114-xopenalex-snapshot
PPAR transcriptional activator complex polymorphisms and the promise of individualized therapy for heart failure
inferred← citeshttps://doi.org/10.1007/s10787-026-02253-yopenalex-snapshot
The anti‑inflammatory activity of 2‑iminothiazolidines: the role of PPARγ and M2 macrophage subpopulations
inferred← citeshttps://doi.org/10.1007/s10822-014-9791-6openalex-snapshot
Identification of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists using molecular modeling method
inferred← citeshttps://doi.org/10.1007/s10822-015-9831-xopenalex-snapshot
Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands
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