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Genetic defect in secretion of complement C5 in mice

https://doi.org/10.1038/282207a0
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/s0021-9258(17)40279-1openalex-snapshot
Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells.
inferredcites →https://doi.org/10.1016/s0022-2836(76)80051-4openalex-snapshot
Mouse myeloma mutants blocked in the assembly, glycosylation and secretion of immunoglobulin
inferredcites →https://doi.org/10.1038/202102a0openalex-snapshot
Effect of Autologous Protein on the Specificity of the Antibody Response: Mouse and Rabbit Antibody to MuB1
inferredcites →https://doi.org/10.1073/pnas.70.11.3125openalex-snapshot
Cytogenetic Engineering In Vivo: Restoration of Biologic Complement Activity to C5-Deficient Mice by Intravenous Inoculation of Hybrid Cells
inferredcites →https://doi.org/10.1073/pnas.74.4.1707openalex-snapshot
Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).
inferredcites →https://doi.org/10.1084/jem.120.5.897openalex-snapshot
DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT
inferredcites →https://doi.org/10.1172/jci108407openalex-snapshot
Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.
inferredcites →https://doi.org/10.4049/jimmunol.114.2_part_2.815openalex-snapshot
Human C3 and C5: Subunit Structure and Modifications by Trypsin and C42-C423
inferredcites →https://doi.org/10.4049/jimmunol.89.6.861openalex-snapshot
Activity of Mouse Complement

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3927423openalex-extracted
Mouse Genomic Associations With ex vivo Sensitivity to Simulated Space Radiation
inferred← citeshttps://doi.org/10.1002/cpz1.313openalex-snapshot
Collagen‐Induced Arthritis Mouse Model
inferred← citeshttps://doi.org/10.1002/eji.1830190117openalex-snapshot
T cell immunity or tolerance as a consequence of self antigen presentation
inferred← citeshttps://doi.org/10.1002/ijc.20178openalex-snapshot
Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma
inferred← citeshttps://doi.org/10.1002/ijc.2910260215openalex-snapshot
Macrophage accumulation in primary and transplanted tumors growing in C5‐deficient B10.D2/oSn mice
inferred← citeshttps://doi.org/10.1007/978-1-4613-1603-9_18openalex-snapshot
The Molecular Biology of Complement Deficiency Syndromes
inferred← citeshttps://doi.org/10.1007/978-1-4684-8652-0_9openalex-snapshot
Complement Deficiencies of Laboratory Animals
inferred← citeshttps://doi.org/10.1007/978-1-4757-1445-6_10openalex-snapshot
Possible Autoregulatory Functions of the Secretory Products of Mononuclear Phagocytes
inferred← citeshttps://doi.org/10.1007/978-3-642-97038-2_2openalex-snapshot
Complement and Complement Reactions
inferred← citeshttps://doi.org/10.1016/0145-2126(82)90087-xopenalex-snapshot
Spontaneous regression of friend virus-induced erythroleukemia IX. Role of complement in leukemia regression
inferred← citeshttps://doi.org/10.1016/0167-5699(83)90070-1openalex-snapshot
The complement genes
inferred← citeshttps://doi.org/10.1016/0882-4010(88)90015-0openalex-snapshot
Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice
inferred← citeshttps://doi.org/10.1016/0890-8508(87)90022-3openalex-snapshot
Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-CS antibodies
inferred← citeshttps://doi.org/10.1016/b978-0-12-044220-1.50072-6openalex-snapshot
QUANTITATION OF SELECTED COMPLEMENT COMPONENTS
inferred← citeshttps://doi.org/10.1016/bs.ai.2021.09.003openalex-snapshot
Complement as a powerful “influencer” in the brain during development, adulthood and neurological disorders
inferred← citeshttps://doi.org/10.1016/j.bone.2025.117543openalex-snapshot
Investigating the role of complement 5a in systemic bone loss after myocardial infarction
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.11.034openalex-snapshot
Pulmonary platelet accumulation induced by catecholamines: Its involvement in lipopolysaccharide-induced anaphylaxis-like shock
inferred← citeshttps://doi.org/10.1016/s0002-9440(10)63466-9openalex-snapshot
Complement C5 in Experimental Autoimmune Encephalomyelitis (EAE) Facilitates Remyelination and Prevents Gliosis
inferred← citeshttps://doi.org/10.1016/s0021-9258(19)39817-5openalex-snapshot
Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon.
inferred← citeshttps://doi.org/10.1016/s0021-9258(19)69672-9openalex-snapshot
Characterization of human C4a anaphylatoxin.
inferred← citeshttps://doi.org/10.1016/s0039-6060(99)70175-3openalex-snapshot
Intestinal ischemia-reperfusion injury is mediated by the membrane attack complex
inferred← citeshttps://doi.org/10.1016/s0580-9517(02)32094-4openalex-snapshot
Isolation and preparation of lymphocytes from infected animals for in vitro analysis
inferred← citeshttps://doi.org/10.1016/s0580-9517(08)70680-9openalex-snapshot
2 In Vitro Analysis
inferred← citeshttps://doi.org/10.1021/bi00405a012openalex-snapshot
Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9
inferred← citeshttps://doi.org/10.1038/nm.2543openalex-snapshot
Identification of a central role for complement in osteoarthritis
inferred← citeshttps://doi.org/10.1038/sj.gene.6364345openalex-snapshot
Gene expression profiling in a mouse model for African trypanosomiasis
inferred← citeshttps://doi.org/10.1046/j.1440-1711.2001.01006.xopenalex-snapshot
Complement and myoblast transfer therapy: Donor myoblast survival is enhanced following depletion of host complement C3 using cobra venom factor, but not in the absence of C5
inferred← citeshttps://doi.org/10.1056/nejm198103123041107openalex-snapshot
Genetics and Biosynthesis of Complement Proteins
inferred← citeshttps://doi.org/10.1084/jem.154.3.763openalex-snapshot
Human monocyte spreading induced by factor Bb of the alternative pathway of complement activation. A possible role for C5 in monocyte spreading.
inferred← citeshttps://doi.org/10.1084/jem.165.5.1442openalex-snapshot
The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency.
inferred← citeshttps://doi.org/10.1084/jem.168.6.2007openalex-snapshot
Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5).
inferred← citeshttps://doi.org/10.1084/jem.169.1.285openalex-snapshot
Role of the thymus in natural tolerance to an autologous protein antigen.
inferred← citeshttps://doi.org/10.1089/neur.2023.0024openalex-snapshot
Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model
inferred← citeshttps://doi.org/10.1093/infdis/157.1.85openalex-snapshot
Complement-Mediated Early Clearance of Haemophilus influenzae Type b from Blood is Independent of Serum Lytic Activity
inferred← citeshttps://doi.org/10.1111/j.1365-2567.2006.02424.xopenalex-snapshot
Essential role of neutrophils in anti‐type II collagen antibody and lipopolysaccharide‐induced arthritis
inferred← citeshttps://doi.org/10.1111/j.1365-3083.1991.tb02534.xopenalex-snapshot
C5 Does Not Play a Major Role in the Immune Response of Mice to SRBC In Vivo
inferred← citeshttps://doi.org/10.1111/j.1439-0450.1983.tb01883.xopenalex-snapshot
Comparative Chemiluminescence Studies with elicited Peritoneal and Spleen Cells of different Strains of Mice and Rats and the Guinea pig
inferred← citeshttps://doi.org/10.1128/9781555816513.ch54openalex-snapshot
Bacillus anthracis
inferred← citeshttps://doi.org/10.1128/iai.00350-08openalex-snapshot
Comparison of the Susceptibilities of C57BL/6 and A/J Mouse Strains toStreptococcus suisSerotype 2 Infection
inferred← citeshttps://doi.org/10.1128/iai.29.2.494-499.1980openalex-snapshot
Genetic Control of Susceptibility to Cryptococcus neoformans in Mice
inferred← citeshttps://doi.org/10.1128/iai.30.1.58-61.1980openalex-snapshot
Activation of the alternative complement pathway by Naegleria fowleri
inferred← citeshttps://doi.org/10.1128/iai.41.3.1071-1076.1983openalex-snapshot
Impaired lung defenses against Staphylococcus aureus in mice with hereditary deficiency of the fifth component of complement
inferred← citeshttps://doi.org/10.1128/iai.49.2.265-269.1985openalex-snapshot
Effect of chemotactins released by Staphylococcus aureus and Pseudomonas aeruginosa on the murine respiratory tract
inferred← citeshttps://doi.org/10.1128/iai.51.3.795-800.1986openalex-snapshot
Differences in susceptibility of inbred mice to Bacillus anthracis
inferred← citeshttps://doi.org/10.1128/iai.52.3.853-857.1986openalex-snapshot
Lung defenses against Pseudomonas aeruginosa in C5-deficient mice with different genetic backgrounds
inferred← citeshttps://doi.org/10.1128/iai.67.10.5186-5191.1999openalex-snapshot
Complement-Dependent Accumulation and Degradation of Platelets in the Lung and Liver Induced by Injection of Lipopolysaccharides
inferred← citeshttps://doi.org/10.1128/iai.68.12.6720-6728.2000openalex-snapshot
Multiple Roles forBordetellaLipopolysaccharide Molecules during Respiratory Tract Infection
inferred← citeshttps://doi.org/10.1128/iai.72.10.5868-5876.2004openalex-snapshot
Dysregulated Inflammatory Response toCandida albicansin a C5-Deficient Mouse Strain
inferred← citeshttps://doi.org/10.1128/jvi.00514-09openalex-snapshot
Host Genetic Variation Affects Resistance to Infection with a Highly Pathogenic H5N1 Influenza A Virus in Mice
inferred← citeshttps://doi.org/10.1152/ajpendo.00042.2019openalex-snapshot
Impaired insulin signaling in the B10.D2-Hc0H2dH2-T18c/oSnJ mouse model of complement factor 5 deficiency
inferred← citeshttps://doi.org/10.1172/jci.insight.136533openalex-snapshot
Humoral immune responses mediate the development of a restrictive phenotype of chronic lung allograft dysfunction
inferred← citeshttps://doi.org/10.1172/jci113472openalex-snapshot
Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways.
inferred← citeshttps://doi.org/10.1172/jci46387openalex-snapshot
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
inferred← citeshttps://doi.org/10.1177/09680519010070061001openalex-snapshot
Complement-dependent platelet degradation and anaphylactoid shock in mice induced by lipopolysaccharide carrying the mannose homopolymer
inferred← citeshttps://doi.org/10.1179/030801884791925771openalex-snapshot
Interdisciplinary Palaeontology
inferred← citeshttps://doi.org/10.1182/blood-2002-01-0252openalex-snapshot
LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system
inferred← citeshttps://doi.org/10.1186/ar2613openalex-snapshot
BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance
inferred← citeshttps://doi.org/10.1186/s12864-018-5339-9openalex-snapshot
Screening of Streptococcus Suis serotype 2 resistance genes with GWAS and transcriptomic microarray analysis
inferred← citeshttps://doi.org/10.1203/01.pdr.0000228332.38159.4fopenalex-snapshot
Plasma Proteins in Health and Disease: A Scientific Symposium to Celebrate the Career and Accomplishments of Harvey R. Colten, M.D.
inferred← citeshttps://doi.org/10.1248/bpb.29.240openalex-snapshot
Candida albicans Derived Fungal PAMPS, CAWS, Water Soluble Mannoprotein-.BETA.-Glucan Complex Shows Similar Immunotoxicological Activity with Bacterial Endotoxin from Escherichia coli O9
inferred← citeshttps://doi.org/10.1371/journal.pntd.0001435openalex-snapshot
Identification of Loci Controlling Restriction of Parasite Growth in Experimental Taenia crassiceps Cysticercosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0125897openalex-snapshot
DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1371/journal.ppat.1006023openalex-snapshot
Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies
inferred← citeshttps://doi.org/10.1385/1-59259-805-6:295openalex-snapshot
The Mouse Model of Collagen-Induced Arthritis
inferred← citeshttps://doi.org/10.1538/expanim.14-0085openalex-snapshot
A simple PCR-based method for the rapid genotyping of inherited fifth complement component (C5)-deficient mice
inferred← citeshttps://doi.org/10.1538/expanim.18-0185openalex-snapshot
Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research
inferred← citeshttps://doi.org/10.1538/expanim.24-0023openalex-snapshot
Mouse NOD/Shi and NSY/Hos strains infected with Plasmodium berghei ANKA are models for experimental cerebral malaria
inferred← citeshttps://doi.org/10.2307/3282750openalex-snapshot
Plasma Levels of Proteins of the Alternative Complement Pathway in Inbred Mice That Differ in Resistance to Trypanosoma congolense Infections
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00582openalex-snapshot
African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?
inferred← citeshttps://doi.org/10.3389/ftubr.2024.1417939openalex-snapshot
Mucosal BCG delivery provides a spectrum of protection from different Mycobacterium tuberculosis strains across susceptible and resistant mouse backgrounds
inferred← citeshttps://doi.org/10.3390/vaccines6020030openalex-snapshot
Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment
inferred← citeshttps://doi.org/10.4049/jimmunol.167.6.3029openalex-snapshot
Cutting Edge: The Spirochetemia of Murine Relapsing Fever Is Cleared by Complement-Independent Bactericidal Antibodies
inferred← citeshttps://doi.org/10.4049/jimmunol.174.1.485openalex-snapshot
TNF-α Is a Critical Effector and a Target for Therapy in Antiphospholipid Antibody-Induced Pregnancy Loss
inferred← citeshttps://doi.org/10.4161/viru.20142openalex-snapshot
Mouse models for the study of fungal pneumonia
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