On the public citation graph

Characterization of single pacemaker channels in cardiac sino-atrial node cells

0 signed · 297 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00581064openalex-snapshot

Injection of catalytic subunit of cAMP-dependent protein kinase into isolated cardiac myocytes

inferredcites →https://doi.org/10.1007/bf00583909openalex-snapshot

Inward current activated during hyperpolarization in the rabbit sinoatrial node cell

inferredcites →https://doi.org/10.1007/bf00656997openalex-snapshot

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

inferredcites →https://doi.org/10.1016/0006-8993(82)90954-4openalex-snapshot

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

inferredcites →https://doi.org/10.1016/0079-6107(85)90008-2openalex-snapshot

The cardiac hyperpolarizing-activated current, if. origins and developments

inferredcites →https://doi.org/10.1016/0166-2236(85)90088-8openalex-snapshot

Ionic Channels of Excitable Membranes

inferredcites →https://doi.org/10.1016/0306-3623(85)90172-7openalex-snapshot

Ionic channels of excitable membranes

inferredcites →https://doi.org/10.1038/280235a0openalex-snapshot

How does adrenaline accelerate the heart?

inferredcites →https://doi.org/10.1038/294752a0openalex-snapshot

Inward current channels activated by intracellular Ca in cultured cardiac cells

inferredcites →https://doi.org/10.1038/298576a0openalex-snapshot

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

inferredcites →https://doi.org/10.1038/301569a0openalex-snapshot

Calcium channel modulation by neurotransmitters, enzymes and drugs

inferredcites →https://doi.org/10.1038/307371a0openalex-snapshot

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

inferredcites →https://doi.org/10.1038/newbio240181a0openalex-snapshot

Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres

inferredcites →https://doi.org/10.1073/pnas.80.8.2395openalex-snapshot

Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP.

inferredcites →https://doi.org/10.1085/jgp.64.3.293openalex-snapshot

Effects of Epinephrine on the Pacemaker Potassium Current of Cardiac Purkinje Fibers

inferredcites →https://doi.org/10.1085/jgp.64.3.320openalex-snapshot

Mode of Action of Chronotropic Agents in Cardiac Purkinje Fibers

inferredcites →https://doi.org/10.1113/jphysiol.1974.sp010716openalex-snapshot

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

inferredcites →https://doi.org/10.1113/jphysiol.1977.sp011657openalex-snapshot

The regulation of the calcium conductance of cardiac muscle by adrenaline.

inferredcites →https://doi.org/10.1113/jphysiol.1980.sp013474openalex-snapshot

Voltage‐clamp investigations of membrane currents underlying pace‐maker activity in rabbit sino‐atrial node.

inferredcites →https://doi.org/10.1113/jphysiol.1980.sp013475openalex-snapshot

Properties of the current if in the sino‐atrial node of the rabbit compared with those of the current iK, in Purkinje fibres.

inferredcites →https://doi.org/10.1113/jphysiol.1981.sp013713openalex-snapshot

A new interpretation of the pace‐maker current in calf Purkinje fibres.

inferredcites →https://doi.org/10.1113/jphysiol.1981.sp013714openalex-snapshot

A study of the ionic nature of the pace‐maker current in calf Purkinje fibres.

inferredcites →https://doi.org/10.1113/jphysiol.1982.sp014393openalex-snapshot

A patch‐clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.

inferredcites →https://doi.org/10.1113/jphysiol.1983.sp014747openalex-snapshot

A voltage‐clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.

inferredcites →https://doi.org/10.1113/jphysiol.1984.sp015086openalex-snapshot

Effect of changes in intra‐ and extracellular sodium on the inward (anomalous) rectification in salamander photoreceptors.

inferredcites →https://doi.org/10.1113/jphysiol.1986.sp016177openalex-snapshot

Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

inferredcites →https://doi.org/10.1126/science.162.3856.916openalex-snapshot

Adrenaline: Mechanism of Action on the Pacemaker Potential in Cardiac Purkinje Fibers

inferredcites →https://doi.org/10.1146/annurev.bb.06.060177.002021openalex-snapshot

CONDUCTANCE FLUCTUATIONS AND IONIC PORES IN MEMBRANES

inferredcites →https://doi.org/10.1146/annurev.ph.45.030183.002013openalex-snapshot

Calcium Channels in Excitable Cell Membranes

inferredcites →https://doi.org/10.1152/physrev.1982.62.2.505openalex-snapshot

Electrophysiology of the sinoatrial node.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4156324openalex-extracted

inferred← citeshttps://doi.org/10.1002/9783527696789.ch18openalex-snapshot

Chemistrode for High Temporal- and Spatial-Resolution Chemical Analysis

inferred← citeshttps://doi.org/10.1002/advs.202521090openalex-snapshot

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

inferred← citeshttps://doi.org/10.1002/cbic.202000116openalex-snapshot

Fluorophore‐Labeled Cyclic Nucleotides as Potent Agonists of Cyclic Nucleotide‐Regulated Ion Channels

inferred← citeshttps://doi.org/10.1002/clc.4960280603openalex-snapshot

Deciphering the sinus tachycardias

inferred← citeshttps://doi.org/10.1002/cphy.cp020118openalex-snapshot

Newly Cloned Threshold Channels

inferred← citeshttps://doi.org/10.1002/j.2040-4603.2002.tb00954.xopenalex-snapshot

Newly Cloned Threshold Channels

inferred← citeshttps://doi.org/10.1002/pds.3628openalex-snapshot

The efficacy and safety of ivabradine hydrochloride versus atenolol in Chinese patients with chronic stable angina pectoris

inferred← citeshttps://doi.org/10.1006/phrs.1999.0654openalex-snapshot

ISOLATED CARDIAC CELLS FOR ELECTROPHARMACOLOGICAL STUDIES

inferred← citeshttps://doi.org/10.1007/3-540-29715-4_2openalex-snapshot

Pacemaker Current and Automatic Rhythms: Toward a Molecular Understanding

inferred← citeshttps://doi.org/10.1007/978-1-0716-1006-0_231openalex-snapshot

Hyperpolarization-Activated Cyclic Nucleotide Gated Channels

inferred← citeshttps://doi.org/10.1007/978-1-4614-7320-6_231-2openalex-snapshot

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

inferred← citeshttps://doi.org/10.1007/978-1-4684-6015-5_10openalex-snapshot

Regulation of Ionic Channels by G Proteins

inferred← citeshttps://doi.org/10.1007/978-1-4757-9685-8_14openalex-snapshot

Hyperpolarization-Activated Chloride Channels in Aplysia Neurons

inferred← citeshttps://doi.org/10.1007/978-1-60327-237-7_9openalex-snapshot

Drugs in Cardiac CT

inferred← citeshttps://doi.org/10.1007/978-3-0348-7327-7_2openalex-snapshot

Nonselective Cation Channels: Physiological and Pharmacological Modulations of Channel Activity

inferred← citeshttps://doi.org/10.1007/978-3-319-01643-6_5openalex-snapshot

Autonomic Regulation and Pathophysiological Remodelling

inferred← citeshttps://doi.org/10.1007/978-3-319-01643-6_9openalex-snapshot

Discussion

inferred← citeshttps://doi.org/10.1007/978-3-319-31251-4_3openalex-snapshot

Excitation–Contraction Coupling of Cardiomyocytes

inferred← citeshttps://doi.org/10.1007/978-3-540-29678-2_2290openalex-snapshot

Hyperpolarization-activated Cyclic Nucleotide-gated Channels

inferred← citeshttps://doi.org/10.1007/978-3-642-19922-6openalex-snapshot

Ion Channels and Their Inhibitors

inferred← citeshttps://doi.org/10.1007/978-3-642-19922-6_2openalex-snapshot

Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels

inferred← citeshttps://doi.org/10.1007/978-3-642-74317-7_15openalex-snapshot

The Cardiac K Current System

inferred← citeshttps://doi.org/10.1007/978-3-642-84628-1_26openalex-snapshot

Cyclic AMP Regulation of the Pacemaker (If) Current in Heart

inferred← citeshttps://doi.org/10.1007/978-94-011-3990-8_2openalex-snapshot

The hyperpolarization-activated inward channel and cardiac pacemaker activity

inferred← citeshttps://doi.org/10.1007/978-94-011-3990-8_3openalex-snapshot

The hyperpolarization-activated (if) current: Autonomic regulation and the control of pacing

inferred← citeshttps://doi.org/10.1007/978-94-017-1512-6_9openalex-snapshot

Cardiac Inotropy and Ca Overload

inferred← citeshttps://doi.org/10.1007/bf00053024openalex-snapshot

Heart rate and heart rate variability, a pharmacological target

inferred← citeshttps://doi.org/10.1007/bf00168917openalex-snapshot

Inhibition of pacemaker current by the bradycardic agent ZD 7288 is lost use-dependently in sheep cardiac Purkinje fibres

inferred← citeshttps://doi.org/10.1007/bf00180659openalex-snapshot

On the mechanism of the ?specific bradycardic action? of the verapamil derivative UL-FS 49

inferred← citeshttps://doi.org/10.1007/bf00370945openalex-snapshot

Hyperpolarization-activated cationic channels in smooth muscle cells are stretch sensitive

inferred← citeshttps://doi.org/10.1007/bf00372956openalex-snapshot

Evidence for two types of calcium currents in frog cardiac sinus venosus cells

inferred← citeshttps://doi.org/10.1007/bf00374258openalex-snapshot

Voltage- and time-dependent block of If by Sr2+ in rabbit sino-atrial node cells

inferred← citeshttps://doi.org/10.1007/bf00374672openalex-snapshot

High selectivity of the i f channel to Na+ and K+ in rabbit isolated sinoatrial node cells

inferred← citeshttps://doi.org/10.1007/bf00374739openalex-snapshot

External K+ increases Na+ conductance of the hyperpolarization-activated current in rabbit cardiac pacemaker cells

inferred← citeshttps://doi.org/10.1007/bf00374740openalex-snapshot

Ca2+ and Mg-ATP activated potassium channels from rat pulmonary artery

inferred← citeshttps://doi.org/10.1007/bf00374956openalex-snapshot

Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes

inferred← citeshttps://doi.org/10.1007/bf00581808openalex-snapshot

Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp

inferred← citeshttps://doi.org/10.1007/bf00581906openalex-snapshot

Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current,i f

inferred← citeshttps://doi.org/10.1007/bf00581909openalex-snapshot

Characterization of the ionic mechanism responsible for the hyperpolarization-activated current in frog sinus venosus

inferred← citeshttps://doi.org/10.1007/s00018-008-8525-0openalex-snapshot

HCN channels: Structure, cellular regulation and physiological function

inferred← citeshttps://doi.org/10.1007/s00210-011-0599-9openalex-snapshot

Effect of dronedarone on Na+, Ca2+ and HCN channels

inferred← citeshttps://doi.org/10.1007/s00232-014-9742-0openalex-snapshot

HCN2 Channels: A Permanent Open State and Conductance Changes

inferred← citeshttps://doi.org/10.1007/s00232-020-00111-8openalex-snapshot

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region

inferred← citeshttps://doi.org/10.1007/s00392-008-0690-5openalex-snapshot

Effects of ivabradine on allograft function and exercise performance in heart transplant recipients with permanent sinus tachycardia

inferred← citeshttps://doi.org/10.1007/s00392-011-0402-4openalex-snapshot

Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study

inferred← citeshttps://doi.org/10.1007/s00392-017-1165-3openalex-snapshot

Control of cardiac chronotropic function in patients after heart transplantation: effects of ivabradine and metoprolol succinate on resting heart rate in the denervated heart

inferred← citeshttps://doi.org/10.1007/s00392-020-01692-zopenalex-snapshot

Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation

inferred← citeshttps://doi.org/10.1007/s00424-009-0687-6openalex-snapshot

Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift

inferred← citeshttps://doi.org/10.1007/s004240050430openalex-snapshot

Tyrosine kinase inhibition reduces i f in rabbit sinoatrial node myocytes

inferred← citeshttps://doi.org/10.1007/s11357-021-00420-3openalex-snapshot

Slowing down as we age: aging of the cardiac pacemaker’s neural control

inferred← citeshttps://doi.org/10.1007/s12325-008-0130-yopenalex-snapshot

Ivabradine: Beyond heart rate control

inferred← citeshttps://doi.org/10.1007/s12325-010-0014-9openalex-snapshot

Ivabradine: from molecular basis to clinical effectiveness

inferred← citeshttps://doi.org/10.1007/s12325-010-0030-9openalex-snapshot

Heart rate in ischemic heart disease. The innovation of ivabradine: More than pure heart rate reduction

inferred← citeshttps://doi.org/10.1016/0079-6107(88)90014-4openalex-snapshot

Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems

inferred← citeshttps://doi.org/10.1016/1050-1738(91)90030-iopenalex-snapshot

Generation and control of cardiac pacing the pacemaker current

inferred← citeshttps://doi.org/10.1016/b0-7216-0323-8/50015-4openalex-snapshot

Pacemaker Channels and Normal Automaticity

inferred← citeshttps://doi.org/10.1016/b978-0-12-550640-3.50027-7openalex-snapshot

Hyperpolarization-Activated (if) Current in Heart

inferred← citeshttps://doi.org/10.1016/b978-012065310-2/50027-8openalex-snapshot

Bibliography

inferred← citeshttps://doi.org/10.1016/b978-012656975-9/50020-1openalex-snapshot

Cardiac Pacemaker Currents

inferred← citeshttps://doi.org/10.1016/j.amjcard.2011.08.025openalex-snapshot

Ivabradine Versus Metoprolol for Heart Rate Reduction Before Coronary Computed Tomography Angiography

inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.12.127openalex-snapshot

Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation

inferred← citeshttps://doi.org/10.1016/j.bmc.2019.03.024openalex-snapshot

Chemical synthesis and biological activity of novel brominated 7-deazaadenosine-3′,5′-cyclic monophosphate derivatives

inferred← citeshttps://doi.org/10.1016/j.bpj.2013.08.027openalex-snapshot

Elementary Functional Properties of Single HCN2 Channels

inferred← citeshttps://doi.org/10.1016/j.bpj.2015.08.054openalex-snapshot

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides

inferred← citeshttps://doi.org/10.1016/j.bpj.2019.05.006openalex-snapshot

Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function

inferred← citeshttps://doi.org/10.1016/j.bpj.2022.04.024openalex-snapshot

Ion behavior in the selectivity filter of HCN1 channels

inferred← citeshttps://doi.org/10.1016/j.brainres.2004.01.062openalex-snapshot

Characterisation of hyperpolarization-activated currents (Ih) in the medial septum/diagonal band complex in the mouse

inferred← citeshttps://doi.org/10.1016/j.cardiores.2005.02.011openalex-snapshot

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model

inferred← citeshttps://doi.org/10.1016/j.ejphar.2003.10.042openalex-snapshot

Effect of ethanol on the electrophysiological characteristics of pulmonary vein cardiomyocytes

inferred← citeshttps://doi.org/10.1016/j.etap.2025.104659openalex-snapshot

Chlordecone reduces hyperpolarization-activated-current (Ih) conductance in honeybee

inferred← citeshttps://doi.org/10.1016/j.hrthm.2011.10.008openalex-snapshot

The case for the funny current and the calcium clock

inferred← citeshttps://doi.org/10.1016/j.hrthm.2014.03.049openalex-snapshot

Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals

inferred← citeshttps://doi.org/10.1016/j.jacep.2025.06.007openalex-snapshot

Microvascular Rarefaction in the Sinoatrial Node

inferred← citeshttps://doi.org/10.1016/j.jsb.2007.01.014openalex-snapshot

Functional expression of mammalian receptors and membrane channels in different cells

inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120919openalex-snapshot

Ivabradine Treatment Lowers Blood Pressure and Promotes Cardiac and Renal Protection in Spontaneously Hypertensive Rats

inferred← citeshttps://doi.org/10.1016/j.mehy.2006.07.048openalex-snapshot

Atrial fibrillation may be a vascular disease: The role of the pulmonary vein

inferred← citeshttps://doi.org/10.1016/j.molcel.2021.05.033openalex-snapshot

Gating movements and ion permeation in HCN4 pacemaker channels

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2005.05.003openalex-snapshot

Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2020.08.004openalex-snapshot

Autonomic modulation of sinoatrial node: Role of pacemaker current and calcium sensitive adenylyl cyclase isoforms

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2021.06.003openalex-snapshot

The funny current in genetically modified mice

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2021.06.009openalex-snapshot

HCN1 channels: A versatile tool for signal processing by primary sensory neurons

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2021.06.010openalex-snapshot

Regulation of sinoatrial funny channels by cyclic nucleotides: From adrenaline and IK2 to direct binding of ligands to protein subunits

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2005.01.005openalex-snapshot

Physiology and pharmacology of the cardiac pacemaker (“funny”) current

inferred← citeshttps://doi.org/10.1016/j.xcrm.2022.100871openalex-snapshot

MicroRNA-dependent suppression of biological pacemaker activity induced by TBX18

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2006.09.018openalex-snapshot

Localization of f-channels to caveolae mediates specific β2-adrenergic receptor modulation of rate in sinoatrial myocytes

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2009.01.010openalex-snapshot

In situ co-distribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2009.11.022openalex-snapshot

Considerations on the size of currents required for pacemaking

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2014.09.008openalex-snapshot

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

inferred← citeshttps://doi.org/10.1016/s0006-3495(87)83192-2openalex-snapshot

Na channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells

inferred← citeshttps://doi.org/10.1016/s0006-3495(90)82422-xopenalex-snapshot

A novel action of isoproterenol to inactivate a cardiac K+ current is not blocked by beta and alpha adrenergic blockers

inferred← citeshttps://doi.org/10.1016/s0006-3495(93)81289-xopenalex-snapshot

Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node

inferred← citeshttps://doi.org/10.1016/s0008-6363(95)00228-6openalex-snapshot

A list of vertebrate cardiac ionic currents Nomenclature, properties, function and cloned equivalents

inferred← citeshttps://doi.org/10.1016/s0014-5793(00)01979-7openalex-snapshot

Expression of T‐ and L‐type calcium channel mRNA in murine sinoatrial node

inferred← citeshttps://doi.org/10.1016/s0092-8674(00)81434-8openalex-snapshot

Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain

inferred← citeshttps://doi.org/10.1016/s0167-4781(99)00092-5openalex-snapshot

The human gene coding for HCN2, a pacemaker channel of the heart

inferred← citeshttps://doi.org/10.1016/s0896-6273(00)80508-5openalex-snapshot

Not So Funny Anymore

inferred← citeshttps://doi.org/10.1016/s1520-765x(03)90006-xopenalex-snapshot

Ivabradine ? a selective and specific If inhibitor: efficacy and safety in stable angina

inferred← citeshttps://doi.org/10.1016/s1574-3349(07)18009-1openalex-snapshot

Development of the Conduction System: Picking up the Pace

inferred← citeshttps://doi.org/10.1038/351145a0openalex-snapshot

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

inferred← citeshttps://doi.org/10.1038/nchembio.747openalex-snapshot

How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels

inferred← citeshttps://doi.org/10.1038/ncpcardio0052openalex-snapshot

Drug Insight: If inhibitors as specific heart-rate-reducing agents

inferred← citeshttps://doi.org/10.1038/ncpcardio0068openalex-snapshot

The sinus tachycardias

inferred← citeshttps://doi.org/10.1038/nn1028openalex-snapshot

Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel

inferred← citeshttps://doi.org/10.1038/nrcardio.2017.165openalex-snapshot

Next-generation pacemakers: from small devices to biological pacemakers

inferred← citeshttps://doi.org/10.1038/nrneph.2009.170openalex-snapshot

Early intervention in acute kidney injury

inferred← citeshttps://doi.org/10.1038/s41401-018-0162-zopenalex-snapshot

Identification and characterization of a series of novel HCN channel inhibitors

inferred← citeshttps://doi.org/10.1038/s41467-021-23062-7openalex-snapshot

Electromechanical coupling mechanism for activation and inactivation of an HCN channel

inferred← citeshttps://doi.org/10.1038/s41467-023-42363-7openalex-snapshot

Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization

inferred← citeshttps://doi.org/10.1038/s41467-024-49599-xopenalex-snapshot

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

inferred← citeshttps://doi.org/10.1038/s41467-025-57358-9openalex-snapshot

HCN4 channels sense temperature and determine heart rate responses to heat

inferred← citeshttps://doi.org/10.1038/s41467-026-72257-3openalex-snapshot

HCN1 is a primary HCN Pacemaker Channel in Neurons

inferred← citeshttps://doi.org/10.1038/s41594-019-0259-1openalex-snapshot

The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization

inferred← citeshttps://doi.org/10.1038/s41598-018-33050-5openalex-snapshot

Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation

inferred← citeshttps://doi.org/10.1038/s41598-020-76049-7openalex-snapshot

Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity

inferred← citeshttps://doi.org/10.1038/sj.cr.7290140openalex-snapshot

Developmental changes in functional expression and β-adrenergic regulation of If in the heart of mouse embryo

inferred← citeshttps://doi.org/10.1038/srep00894openalex-snapshot

Architecture of the HCN selectivity filter and control of cation permeation

inferred← citeshttps://doi.org/10.1046/j.1460-9592.2003.t01-1-00235.xopenalex-snapshot

Pathophysiology of the Pulmonary Vein as an Atrial Fibrillation Initiator:

inferred← citeshttps://doi.org/10.1053/j.jvca.2025.03.029openalex-snapshot

Advances in Cardiovascular Pharmacotherapy. II. Ivabradine, an Inhibitor of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel

inferred← citeshttps://doi.org/10.1063/1.166065openalex-snapshot

A minimal single-channel model for the regularity of beating in the sinoatrial node

inferred← citeshttps://doi.org/10.1073/pnas.1401917111openalex-snapshot

Family of prokaryote cyclic nucleotide-modulated ion channels

inferred← citeshttps://doi.org/10.1073/pnas.1405371111openalex-snapshot

Double electron–electron resonance reveals cAMP-induced conformational change in HCN channels

inferred← citeshttps://doi.org/10.1073/pnas.2104668118openalex-snapshot

Bidirectional flow of the funny current (I f ) during the pacemaking cycle in murine sinoatrial node myocytes

inferred← citeshttps://doi.org/10.1073/pnas.2400523121openalex-snapshot

Missing validation of key features in HCN single-channel recordings

inferred← citeshttps://doi.org/10.1073/pnas.2402259121openalex-snapshot

Structural determinants of ivabradine block of the open pore of HCN4

inferred← citeshttps://doi.org/10.1073/pnas.2402992121openalex-snapshot

Reply to Benndorff and DiFrancesco: Reliable human HCN4 single-channel recordings using the cell-attached configuration in expression systems

inferred← citeshttps://doi.org/10.1073/pnas.2422533122openalex-snapshot

Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution

inferred← citeshttps://doi.org/10.1073/pnas.2502136122openalex-snapshot

Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease

inferred← citeshttps://doi.org/10.1074/jbc.m100830200openalex-snapshot

Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1 Is a Molecular Determinant of the Cardiac Pacemaker Current I f

inferred← citeshttps://doi.org/10.1074/jbc.m203485200openalex-snapshot

Separable Gating Mechanisms in a Mammalian Pacemaker Channel

inferred← citeshttps://doi.org/10.1074/jbc.m400518200openalex-snapshot

Structural Elements of Instantaneous and Slow Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

inferred← citeshttps://doi.org/10.1074/jbc.m610978200openalex-snapshot

HCN2 and HCN4 Isoforms Self-assemble and Co-assemble with Equal Preference to Form Functional Pacemaker Channels

inferred← citeshttps://doi.org/10.1074/jbc.r800075200openalex-snapshot

Cyclic Nucleotide-regulated Cation Channels

inferred← citeshttps://doi.org/10.1074/jbc.ra119.010246openalex-snapshot

N6-modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels

inferred← citeshttps://doi.org/10.1081/cbi-100101057openalex-snapshot

PACEMAKER OSCILLATIONS IN HEART AND BRAIN: A KEY ROLE FOR HYPERPOLARIZATION-ACTIVATED CATION CHANNELS

inferred← citeshttps://doi.org/10.1085/jgp.117.2.91openalex-snapshot

Blocker State Dependence and Trapping in Hyperpolarization-Activated Cation Channels

inferred← citeshttps://doi.org/10.1085/jgp.200609599openalex-snapshot

Cooperative Gating between Single HCN Pacemaker Channels

inferred← citeshttps://doi.org/10.1085/jgp.200709868openalex-snapshot

Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape “Slow” Channels

inferred← citeshttps://doi.org/10.1085/jgp.201311019openalex-snapshot

Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear

inferred← citeshttps://doi.org/10.1085/jgp.201511559openalex-snapshot

Patch-clamp fluorometry–based channel counting to determine HCN channel conductance

inferred← citeshttps://doi.org/10.1085/jgp.201711935openalex-snapshot

All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner

inferred← citeshttps://doi.org/10.1085/jgp.201812023openalex-snapshot

Ligand binding and activation properties of the purified bacterial cyclic nucleotide–gated channel SthK

inferred← citeshttps://doi.org/10.1085/jgp.202513874openalex-snapshot

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

inferred← citeshttps://doi.org/10.1085/jgp.202513899openalex-snapshot

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

inferred← citeshttps://doi.org/10.1085/jgp.202513925openalex-snapshot

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

inferred← citeshttps://doi.org/10.1085/jgp.94.4.719openalex-snapshot

Ionic channels of the inner segment of tiger salamander cone photoreceptors.

inferred← citeshttps://doi.org/10.1093/cvr/cvn032openalex-snapshot

Direct evidence for calcium conductance of hyperpolarization-activated cyclic nucleotide-gated channels and human native If at physiological calcium concentrations

inferred← citeshttps://doi.org/10.1093/eurheartj/ehi586openalex-snapshot

Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina

inferred← citeshttps://doi.org/10.1093/eurheartj/sui047openalex-snapshot

Ivabradine in clinical practice: benefits of If inhibition

inferred← citeshttps://doi.org/10.1093/eurheartj/sup018openalex-snapshot

Heart rate and atherosclerosis

inferred← citeshttps://doi.org/10.1093/eurheartj/sur017openalex-snapshot

Coronary artery disease management with ivabradine in clinical practice

inferred← citeshttps://doi.org/10.1093/function/zqac019openalex-snapshot

Weak Cation Selectivity in HCN Channels Results From K+-Mediated Release of Na+ From Selectivity Filter Binding Sites

inferred← citeshttps://doi.org/10.1093/function/zqac052openalex-snapshot

When Is a Potassium Channel Not a Potassium Channel?

inferred← citeshttps://doi.org/10.1097/crd.0b013e31822f0b3eopenalex-snapshot

Inappropriate Sinus Tachycardia

inferred← citeshttps://doi.org/10.1101/2021.01.06.425635openalex-snapshot

Noncanonical Electromechanical Coupling Mechanism of an HCN Channel

inferred← citeshttps://doi.org/10.1101/2022.06.22.497267openalex-snapshot

Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells

inferred← citeshttps://doi.org/10.1101/2024.09.02.610748openalex-snapshot

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

inferred← citeshttps://doi.org/10.1101/2025.07.28.666606openalex-snapshot

An Allosteric Model for Electromechanical Coupling in Cardiac CNBD Channels

inferred← citeshttps://doi.org/10.1111/j.1365-2125.2005.02544.xopenalex-snapshot

Comparative effects of ivabradine, a selective heart rate‐lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise

inferred← citeshttps://doi.org/10.1111/j.1365-2826.2006.01438.xopenalex-snapshot

Dependence of Hyperpolarisation‐Activated Cyclic Nucleotide‐Gated Channel Activity on Basal Cyclic Adenosine Monophosphate Production in Spontaneously Firing GH3 Cells

inferred← citeshttps://doi.org/10.1111/j.1469-7793.1997.591bd.xopenalex-snapshot

A novel slow hyperpolarization‐activated potassium current (IK(SHA)) from a mouse hippocampal cell line

inferred← citeshttps://doi.org/10.1111/j.1469-7793.1999.367ac.xopenalex-snapshot

Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node

inferred← citeshttps://doi.org/10.1111/j.1469-7793.2000.t01-2-00377.xopenalex-snapshot

Functional expression and regulation of the hyperpolarization activated non‐selective cation current in embryonic stem cell‐derived cardiomyocytes

inferred← citeshttps://doi.org/10.1111/j.1469-7793.2001.00467.xopenalex-snapshot

Electrophysiological analysis of the negative chronotropic effect of endothelin‐1 in rabbit sinoatrial node cells

inferred← citeshttps://doi.org/10.1111/j.1476-5381.2010.00901.xopenalex-snapshot

Induction of a novel cation current in cardiac ventricular myocytes by flufenamic acid and related drugs

inferred← citeshttps://doi.org/10.1111/j.1530-0277.2012.01826.xopenalex-snapshot

Ethanol Enhances Human Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Currents

inferred← citeshttps://doi.org/10.1111/j.1540-8167.1992.tb00978.xopenalex-snapshot

The Cardiac Pacemaker Current if

inferred← citeshttps://doi.org/10.1111/j.1540-8167.1994.tb01176.xopenalex-snapshot

Is the “Funny” Current Funnier Than We Thought?

inferred← citeshttps://doi.org/10.1111/j.1540-8167.2006.00736.xopenalex-snapshot

The Pacemaker Current: From Basics to the Clinics

inferred← citeshttps://doi.org/10.1111/jcmm.12365openalex-snapshot

Anchored protein kinase A signalling in cardiac cellular electrophysiology

inferred← citeshttps://doi.org/10.1113/jp287209openalex-snapshot

Structure mirroring function: What's the ‘matter’ with the funny current?

inferred← citeshttps://doi.org/10.1113/jphysiol.1988.sp017343openalex-snapshot

Inhibition of the hyperpolarization‐activated current (if) induced by acetylcholine in rabbit sino‐atrial node myocytes.

inferred← citeshttps://doi.org/10.1113/jphysiol.1988.sp017344openalex-snapshot

Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes.

inferred← citeshttps://doi.org/10.1113/jphysiol.1989.sp017766openalex-snapshot

Role of the sodium pump in pacemaker generation in dog colonic smooth muscle.

inferred← citeshttps://doi.org/10.1113/jphysiol.1990.sp018332openalex-snapshot

Noradrenergic and serotonergic modulation of a hyperpolarization‐activated cation current in thalamic relay neurones.

inferred← citeshttps://doi.org/10.1113/jphysiol.1991.sp018384openalex-snapshot

Suppression of steady membrane currents by acetylcholine in single smooth muscle cells of the guinea‐pig gastric fundus.

inferred← citeshttps://doi.org/10.1113/jphysiol.1991.sp018457openalex-snapshot

The contribution of the ‘pacemaker’ current (if) to generation of spontaneous activity in rabbit sino‐atrial node myocytes.

inferred← citeshttps://doi.org/10.1113/jphysiol.1991.sp018459openalex-snapshot

Voltage clamp measurements of the hyperpolarization‐activated inward current I(f) in single cells from rabbit sino‐atrial node.

inferred← citeshttps://doi.org/10.1113/jphysiol.1992.sp019109openalex-snapshot

Isoprenaline, Ca2+ and the Na(+)‐K+ pump in guinea‐pig ventricular myocytes.

inferred← citeshttps://doi.org/10.1113/jphysiol.1992.sp019230openalex-snapshot

Control of the hyperpolarization‐activated cation current by external anions in rabbit sino‐atrial node cells.

inferred← citeshttps://doi.org/10.1113/jphysiol.1994.sp020038openalex-snapshot

Modulation of single hyperpolarization‐activated channels (i(f)) by cAMP in the rabbit sino‐atrial node.

inferred← citeshttps://doi.org/10.1113/jphysiol.1994.sp020204openalex-snapshot

Cation‐dependent gating of the hyperpolarization‐activated cation current in the rabbit sino‐atrial node cells.

inferred← citeshttps://doi.org/10.1113/jphysiol.1997.sp022049openalex-snapshot

Differential control of the hyperpolarization‐activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino‐atrial node myocytes.

inferred← citeshttps://doi.org/10.1113/jphysiol.2002.017640openalex-snapshot

Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors

inferred← citeshttps://doi.org/10.1113/jphysiol.2002.027698openalex-snapshot

Heteromeric HCN1–HCN4 Channels: A Comparison with Native Pacemaker Channels from the Rabbit Sinoatrial Node

inferred← citeshttps://doi.org/10.1113/jphysiol.2005.086835openalex-snapshot

Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after‐hyperpolarization and excitability control in CA1 hippocampal pyramidal cells

inferred← citeshttps://doi.org/10.1113/jphysiol.2005.093161openalex-snapshot

Single channel properties of hyperpolarization‐activated cation currents in acutely dissociated rat hippocampal neurones

inferred← citeshttps://doi.org/10.1113/jphysiol.2007.136465openalex-snapshot

Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core

inferred← citeshttps://doi.org/10.1113/jphysiol.2013.268540openalex-snapshot

Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel‐containing membrane microdomains

inferred← citeshttps://doi.org/10.1124/pr.117.014035openalex-snapshot

The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

inferred← citeshttps://doi.org/10.1126/science.1697697openalex-snapshot

Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel

inferred← citeshttps://doi.org/10.1142/s0218127403008843openalex-snapshot

DYNAMICS OF CARDIAC INTRACELLULAR Ca 2+HANDLING — FROM EXPERIMENTS TO VIRTUAL CELLS

inferred← citeshttps://doi.org/10.1146/annurev.ph.54.030192.001431openalex-snapshot

Ionic Current Mechanisms Generating Vertebrate Primary Cardiac Pacemaker Activity At The Single Cell Level: An Integrative View

inferred← citeshttps://doi.org/10.1146/annurev.ph.55.030193.002323openalex-snapshot

Pacemaker Mechanisms in Cardiac Tissue

inferred← citeshttps://doi.org/10.1146/annurev.ph.58.030196.001503openalex-snapshot

Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons

inferred← citeshttps://doi.org/10.1146/annurev.physiol.63.1.235openalex-snapshot

Molecular Diversity of Pacemaker Ion Channels

inferred← citeshttps://doi.org/10.1146/annurev.physiol.65.092101.142734openalex-snapshot

Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function

inferred← citeshttps://doi.org/10.1146/annurev.physiol.68.040104.134728openalex-snapshot

CNG AND HCN CHANNELS: Two Peas, One Pod

inferred← citeshttps://doi.org/10.1152/ajpheart.1999.276.1.h205openalex-snapshot

Effect of isoprenaline, carbachol, and Cs+on Na+activity and pacemaker potential in rabbit SA node cells

inferred← citeshttps://doi.org/10.1152/jn.00818.2011openalex-snapshot

Cocaine sensitization inhibits the hyperpolarization-activated cation current Ih and reduces cell size in dopamine neurons of the ventral tegmental area

showing the first 200 of 267 · page through all 267

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.