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Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mouse histocompatibility genes: structure and organisation of a Kd gene.
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The DNA sequence of the H‐2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.
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Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA‐CW3).
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Complete nucleotide sequence of a functional class I HLA gene, HLA‐A3: implications for the evolution of HLA genes.
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Exon shuffling in vivo can generate novel HLA class I molecules.
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Extent of Protein Polymorphism and the Neutral Mutation Theory
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Stochastic Theory of Population Genetics and Evolution
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DNA sequence of the coding region of the HLA-B44 gene
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Comparison of the structure of HLA-Bw47 to HLA-B13 and its relationship to 21-hydroxylase deficiency
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Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: Evolutionary aspects
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DNA sequence of HLA-A11: Remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells
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An H-2K gene of the t w32mutant at the T/t complex is a close parent of an H-2K qgene
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The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes
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The natural history of the major histocompatibility complex
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Human mumps virus-specific cytotoxic T lymphocytes: Quantitative analysis of HLA restriction
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Natural history of the major histo-compatibility complex
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H-2 Mutations: Their Genetics and Effect on Immune Functions
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Maintenance of Histocompatibility Polymorphisms
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Evolutionary Significance of the HL-A System
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Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex
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A potential donor gene for the bm1 gene conversion event in the C57BL mouse
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Accelerated evolution in the reactive centre regions of serine protease inhibitors
inferredcites →https://doi.org/10.1038/329506a0openalex-snapshot
Structure of the human class I histocompatibility antigen, HLA-A2
inferredcites →https://doi.org/10.1038/329512a0openalex-snapshot
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
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Allelic and nonallelic homology of a supergene family.
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Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.
inferredcites →https://doi.org/10.1073/pnas.80.9.2671openalex-snapshot
Unusual evolutionary conservation and frequent DNA segment exchange in class I genes of the major histocompatibility complex.
inferredcites →https://doi.org/10.1073/pnas.82.4.1175openalex-snapshot
DNA sequence of the mouse H-2Dd transplantation antigen gene.
inferredcites →https://doi.org/10.1073/pnas.83.5.1428openalex-snapshot
Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series.
inferredcites →https://doi.org/10.1093/genetics/104.3.449openalex-snapshot
EVIDENCE FOR BALANCING SELECTION AT HLA
inferredcites →https://doi.org/10.1093/genetics/98.2.441openalex-snapshot
GENETIC VARIABILITY MAINTAINED BY MUTATION AND OVERDOMINANT SELECTION IN FINITE POPULATIONS
inferredcites →https://doi.org/10.1093/nar/12.24.9473openalex-snapshot
Complete nucleotide sequence of the murine H-2kkgene. Comparison of three H-2K locus alleles
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a040333openalex-snapshot
Methods for computing the standard errors of branching points in an evolutionary tree and their application to molecular data from humans and apes.
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a040410openalex-snapshot
Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.
inferredcites →https://doi.org/10.1097/00007890-198301000-00001openalex-snapshot
IMMUNOGENETICS OF SPONTANEOUS ABORTIONS IN HUMANS
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Polymorphism of Qa and Tla loci of the mouse
inferredcites →https://doi.org/10.1126/science.2983425openalex-snapshot
Genetic Basis for Species Vulnerability in the Cheetah
inferredcites →https://doi.org/10.1126/science.7058332openalex-snapshot
DNA Sequence of a Gene Encoding a BALB/c Mouse L d Transplantation Antigen
inferredcites →https://doi.org/10.2307/3280070openalex-snapshot
Genetic Aspects of Host-Parasite Relationships
inferredcites →https://doi.org/10.4049/jimmunol.134.4.2727openalex-snapshot
Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.
inferredcites →https://doi.org/10.4049/jimmunol.136.9.3489openalex-snapshot
The nucleotide sequence and comparative analysis of the H-2Dp class I H-2 gene.
inferredcites →https://doi.org/10.4049/jimmunol.139.11.3878openalex-snapshot
DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary relationships to H-2 genes from four other mouse strains.
inferredcites →https://doi.org/10.4049/jimmunol.139.8.2818openalex-snapshot
Genetic analysis of the H-2D region using a new intra-D-region recombinant mouse strain.
inferredcites →https://doi.org/10.7312/nei-92038openalex-snapshot
Molecular Evolutionary Genetics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The complete mitochondrial genome of Thereuopoda clunifera (Chilopoda: Scutigeridae) and phylogenetic implications within Chilopoda
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Worldwide genetic diversity at the HLA-DQA1 locus
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Genetic signatures of natural selection
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Heterosis
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Positive Darwinian Selection (Positive Selection)
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The fate of duplicated major histocompatibility complex class Ia genes in a dodecaploid amphibian, Xenopus ruwenzoriensis
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Correction Vol. 32(6) 2002, pp 1593-1604 The fate of duplicated major histocompatibility complex class Ia genes in a dodecaploid amphibian, Xenopus ruwenzoriensis
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Protein Repertoire, Evolution of
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Gene Structure: Evolution
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Vertebrate Immune System: Evolution
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Major Histocompatibility Complex (MHC) Genes: Polymorphism
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Major Histocompatibility Complex ( MHC ) Genes: Polymorphism
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Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection
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Functional Evolution of the Major Histocompatibility Complex
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Positive Darwinian Selection (Positive Selection)
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HLA Polymorphism and Disease Susceptibility
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Runaway Sexual Selection Model
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A Preliminary Transcriptomic Study of Galaxiid Fishes Reveals a Larval Glycoprotein Gene Under Strong Positive Selection
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Evolution of Toxin
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Natural Selection
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Large-Scale Analyses of Positive Selection Using Codon Models
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Molecular Coevolution and the Three-Dimensionality of Natural Selection
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Trans-species Polymorphism of the Major Histocompatibility Complex (Mhc) Loci
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The DQ Loci
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MHC Genes, Immune Response, and Vaccines
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The Immune System of Cartilaginous Fish
inferred← citeshttps://doi.org/10.1007/978-3-642-71984-4_11openalex-snapshot
Plasticity Under Somatic Mutation in Antigen Receptors
inferred← citeshttps://doi.org/10.1007/978-3-642-77506-2_2openalex-snapshot
Origins of Mhc Diversity
inferred← citeshttps://doi.org/10.1007/978-3-642-77506-2_4openalex-snapshot
Class I and Class II HLA Proteins and Genes: An Overview of Structure, Polymorphism, and Expression
inferred← citeshttps://doi.org/10.1007/978-3-642-78536-8_8openalex-snapshot
MHC of Nonhuman Primates
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_10openalex-snapshot
Diversification of Class II Aα Within the Genus Mus
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_11openalex-snapshot
Molecular and Genetic Mechanisms Involved in the Generation of Mhc Diversity
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_13openalex-snapshot
Contributions of Interlocus Exchange to the Structural Diversity of the H-2K, D, and L Alleles
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_15openalex-snapshot
Evolution of New World Primate MHC Class I Genes
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_18openalex-snapshot
Selective Inactivation of the Primate Mhc-DQA2 Locus
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_27openalex-snapshot
Sequence and Evolution of Bovine MHC Class I Genes
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_3openalex-snapshot
Trans-Species Polymorphism of HLA Molecules, Founder Principle, and Human Evolution
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_33openalex-snapshot
HLA Associations with Malaria in Africa: Some Implications for MHC Evolution
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_34openalex-snapshot
The Evolution of MHC-Based Mating Preferences in Mus
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_35openalex-snapshot
Possible MHC Associated Heterozygous Advantage in Wild Mouse Populations
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_4openalex-snapshot
Calibrating Evolutionary Rates at Major Histocompatibility Complex Loci
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_5openalex-snapshot
Concerted Mutagenesis: Its Potential Impact on Interpretation of Evolutionary Relationships
inferred← citeshttps://doi.org/10.1007/978-3-642-84622-9_6openalex-snapshot
Two Models of Evolution of the Class I MHC
inferred← citeshttps://doi.org/10.1007/978-3-662-22162-4_2openalex-snapshot
The MHC Genes
inferred← citeshttps://doi.org/10.1007/978-3-662-40279-5_2openalex-snapshot
Evolution of the AChR and Other Ligand-Gated Ion Channels
inferred← citeshttps://doi.org/10.1007/978-4-431-56603-8_11openalex-snapshot
Global Landscapes of Human Phenotypic Variation in Inherited Traits
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_13openalex-snapshot
Nucleotide diversity within the human major histocompatibility complex: function of hitchhiking effect, duplications, indels and recombination
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_15openalex-snapshot
Comparative aspects of the MHC class I-related MR1, CD1D, and MIC genes in primates
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_25openalex-snapshot
Evolution of HLA-DRB loci, DRB1 lineages, and alleles: analyses of intron-1 and -2 sequences
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_29openalex-snapshot
Evolution of Catarrhini DPB1 exon 2 under intragenic recombination
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_30openalex-snapshot
The effect of mutation, recombination and selection on HLA non-coding sequences
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_33openalex-snapshot
HLA class I alleles in Australian aborigines and their peptide binding profiles
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_35openalex-snapshot
MIC-A polymorphism and a MIC-A-MIC-B null haplotype with ~ 100-kb deletion
inferred← citeshttps://doi.org/10.1007/978-4-431-65868-9_36openalex-snapshot
Repertoire forecast of MHC class I binding peptides with peptide libraries
inferred← citeshttps://doi.org/10.1007/978-4-431-68302-5_10openalex-snapshot
Evolution of the Multigene Family
inferred← citeshttps://doi.org/10.1007/978-81-8489-992-4_16openalex-snapshot
Pathogen pressure and molecular evolutionary genetics of innate immunity genes in humans
inferred← citeshttps://doi.org/10.1007/978-90-481-2770-2_7openalex-snapshot
Sex and the Red Queen
inferred← citeshttps://doi.org/10.1007/978-90-481-9023-2_23openalex-snapshot
Devil Facial Tumour Disease (DFTD): Using Genetics and Genomics to Investigate Infectious Disease in an Endangered Marsupial
inferred← citeshttps://doi.org/10.1007/978-94-009-0077-6_10openalex-snapshot
Natural selection at the class II major histocompatibility complex loci of mammals
inferred← citeshttps://doi.org/10.1007/978-94-009-0077-6_11openalex-snapshot
The role of infectious disease, inbreeding and mating preferences in maintaining MHC genetic diversity: an experimental test
inferred← citeshttps://doi.org/10.1007/978-94-009-1057-7_2openalex-snapshot
Biological Significance of the MHC
inferred← citeshttps://doi.org/10.1007/978-94-010-0263-9_20openalex-snapshot
Maximum likelihood methods for detecting adaptive evolution after gene duplication
inferred← citeshttps://doi.org/10.1007/978-94-011-4221-2_1openalex-snapshot
Evolution of genes and taxa: a primer
inferred← citeshttps://doi.org/10.1007/978-94-011-4221-2_10openalex-snapshot
The evolution of disease resistance genes
inferred← citeshttps://doi.org/10.1007/978-94-011-4830-6_19openalex-snapshot
Allelic Variation at the MN Locus Varies with Climatic Variation in Africans and Native Americans
inferred← citeshttps://doi.org/10.1007/978-94-011-5210-5_14openalex-snapshot
Selection, convergence, and intragenic recombination in HLA diversity
inferred← citeshttps://doi.org/10.1007/978-94-017-1669-7_11openalex-snapshot
Self-incompatibility: theoretical concepts and evolution
inferred← citeshttps://doi.org/10.1007/978-94-017-1671-0_22openalex-snapshot
Genes of the major histocompatibility complex and the evolutionary genetics of lifespan
inferred← citeshttps://doi.org/10.1007/978-981-13-9632-8_4openalex-snapshot
Plant-Insect Host Switching Mechanism
inferred← citeshttps://doi.org/10.1007/bf00160480openalex-snapshot
Adaptive evolution in the rat olfactory receptor gene family
inferred← citeshttps://doi.org/10.1007/bf00162975openalex-snapshot
Revisiting junk DNA
inferred← citeshttps://doi.org/10.1007/bf00163806openalex-snapshot
Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat
inferred← citeshttps://doi.org/10.1007/bf00164983openalex-snapshot
HLA-B alleles of the Cayapa of Ecuador: new B39 and B15 alleles
inferred← citeshttps://doi.org/10.1007/bf00166832openalex-snapshot
The evolutionary origin of the HLA-DR3 haplotype
inferred← citeshttps://doi.org/10.1007/bf00167076openalex-snapshot
The cotton-top tamarin revisited: Mhc class I polymorphism of wild tamarins, and polymorphism and allelic diversity of the class II DQA1, DQB1, and DRB loci
inferred← citeshttps://doi.org/10.1007/bf00167078openalex-snapshot
Structure, diversity, and evolution of the T-cell receptor VB gene repertoire in primates
inferred← citeshttps://doi.org/10.1007/bf00167113openalex-snapshot
New methods for estimating the numbers of synonymous and nonsynonymous substitutions
inferred← citeshttps://doi.org/10.1007/bf00170662openalex-snapshot
Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci
inferred← citeshttps://doi.org/10.1007/bf00172064openalex-snapshot
Major histocompatibility complex class II A gene polymorphism in the striped bass
inferred← citeshttps://doi.org/10.1007/bf00173153openalex-snapshot
Constraints on mutability in a multiallelic gene family
inferred← citeshttps://doi.org/10.1007/bf00175811openalex-snapshot
The evolution of the type I interferon gene family in mammals
inferred← citeshttps://doi.org/10.1007/bf00176440openalex-snapshot
Natural selection on the peptide-binding regions of major histocompatibility complex molecules
inferred← citeshttps://doi.org/10.1007/bf00176673openalex-snapshot
Characterization of Mhc genes in a multigenerational family of ring-necked pheasants
inferred← citeshttps://doi.org/10.1007/bf00178246openalex-snapshot
Exchanges of short polymorphic DNA segments predating speciation in feline major histocompatibility complex class I genes
inferred← citeshttps://doi.org/10.1007/bf00178595openalex-snapshot
Patterns of nucleotide substitutions inferred from the phylogenies of the class I major histocompatibility complex genes
inferred← citeshttps://doi.org/10.1007/bf00178874openalex-snapshot
Mammalian gene evolution: Nucleotide sequence divergence between mouse and rat
inferred← citeshttps://doi.org/10.1007/bf00179403openalex-snapshot
Extensive MHC class II DRB3 diversity in African and European cattle
inferred← citeshttps://doi.org/10.1007/bf00182314openalex-snapshot
The MHC E locus in macaques is polymorphic and is conserved between macaques and humans
inferred← citeshttps://doi.org/10.1007/bf00184521openalex-snapshot
Zebrafish Mhc class II ? chain-encoding genes: polymorphism, expression, and function
inferred← citeshttps://doi.org/10.1007/bf00187453openalex-snapshot
Primate ABO glycosyltransferases: Evidence for trans-species evolution
inferred← citeshttps://doi.org/10.1007/bf00189892openalex-snapshot
The multi-locus H-2D w16 region has an organization distinct from the D d region
inferred← citeshttps://doi.org/10.1007/bf00189896openalex-snapshot
Exonic polymorphism vs intronic simple repeat hypervariability in MHC-DRB genes
inferred← citeshttps://doi.org/10.1007/bf00190901openalex-snapshot
Characterization of the rhesus macaque (Macaca mulatta) equivalent of HLA-F
inferred← citeshttps://doi.org/10.1007/bf00191221openalex-snapshot
Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes
inferred← citeshttps://doi.org/10.1007/bf00205819openalex-snapshot
Origins of H-2 polymorphism in the house mouse. II. characterization of a model population and evidence for heterozygous advantage
inferred← citeshttps://doi.org/10.1007/bf00205822openalex-snapshot
Segmental exchange between MHC class I genes in a higher primate: recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene
inferred← citeshttps://doi.org/10.1007/bf00210819openalex-snapshot
Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus)
inferred← citeshttps://doi.org/10.1007/bf00211522openalex-snapshot
Exon-intron organization of fish major histocompatibility complex class II B genes
inferred← citeshttps://doi.org/10.1007/bf00215282openalex-snapshot
Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles
inferred← citeshttps://doi.org/10.1007/bf00215290openalex-snapshot
Some comments on calibration of molecular evolutionary rates
inferred← citeshttps://doi.org/10.1007/bf00216385openalex-snapshot
Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle
inferred← citeshttps://doi.org/10.1007/bf00216391openalex-snapshot
Evidence of positive selection at the Lyb-2 locus of the mouse
inferred← citeshttps://doi.org/10.1007/bf00216696openalex-snapshot
Independent gene duplications, not concerted evolution, explain relationships among class I MHC genes of murine rodents
inferred← citeshttps://doi.org/10.1007/bf00218041openalex-snapshot
Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM
inferred← citeshttps://doi.org/10.1007/bf00223540openalex-snapshot
Trans-species origin of Mhc-DRB polymorphism in the chimpanzee
inferred← citeshttps://doi.org/10.1007/bf00230501openalex-snapshot
Testing for interlocus genetic exchange in the MHC: a reply to Andersson and co-workers
inferred← citeshttps://doi.org/10.1007/bf00241630openalex-snapshot
Major histocompatibility complex class I genes of Peromyscus leucopus
inferred← citeshttps://doi.org/10.1007/bf00292335openalex-snapshot
Structure and evolution of a member of a new subfamily of GTP-binding proteins mapping to the human MHC class I region
inferred← citeshttps://doi.org/10.1007/bf00352360openalex-snapshot
A family of rapidly evolving genes from the sex reversal critical region in Xp21
inferred← citeshttps://doi.org/10.1007/bf00352847openalex-snapshot
Sequence analysis of the C3H H-2K1 k gene: relationship to the H-2 loci
inferred← citeshttps://doi.org/10.1007/bf00587298openalex-snapshot
Stem-loop potential in MHC genes: a new way of evaluating positive Darwinian selection?
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