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Structure of tubulin at 6.5 Å and location of the taxol-binding site
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1985.tb03945.xopenalex-snapshot
Tubulin domains responsible for assembly of dimers and protofilaments.
inferredcites →https://doi.org/10.1006/jsbi.1993.1049openalex-snapshot
Tubulin Conformation in Zinc-Induced Sheets and Macrotubes
inferredcites →https://doi.org/10.1016/0003-9861(91)90595-aopenalex-snapshot
Studies of crystallization conditions for native and subtilisin-cleaved pig brain tubulin
inferredcites →https://doi.org/10.1016/0022-2836(79)90435-2openalex-snapshot
Three-dimensional reconstruction of tubulin in zinc-induced sheets
inferredcites →https://doi.org/10.1016/0022-2836(87)90184-7openalex-snapshot
Three-dimensional structure of the frozen-hydrated flagellar filament
inferredcites →https://doi.org/10.1016/0022-2836(87)90373-1openalex-snapshot
Microtubule structure at 18 Å resolution
inferredcites →https://doi.org/10.1016/0022-2836(91)90526-copenalex-snapshot
High-resolution electron crystallography of light-harvesting chlorophyll -protein complex in three different media
inferredcites →https://doi.org/10.1016/0022-2836(92)90132-4openalex-snapshot
Low resolution structure of microtubules in solution
inferredcites →https://doi.org/10.1016/0304-3991(86)90203-2openalex-snapshot
Structure of purple membrane from halobacterium halobium: recording, measurement and evaluation of electron micrographs at 3.5 Å resolution
inferredcites →https://doi.org/10.1016/0304-3991(92)90015-copenalex-snapshot
Automatic focus correction for spot-scan imaging of tilted specimens
inferredcites →https://doi.org/10.1016/1047-8477(92)90046-dopenalex-snapshot
Projection map of tubulin in zinc-induced sheets at 4 Å resolution
inferredcites →https://doi.org/10.1016/s0021-9258(17)41836-9openalex-snapshot
3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.
inferredcites →https://doi.org/10.1016/s0021-9258(18)42811-6openalex-snapshot
Preparation of a monoclonal antibody specific for the class IV isotype of beta-tubulin. Purification and assembly of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers from bovine brain.
inferredcites →https://doi.org/10.1016/s0021-9258(18)53113-6openalex-snapshot
Taxol-induced flexibility of microtubules and its reversal by MAP-2 and Tau.
inferredcites →https://doi.org/10.1016/s0021-9258(18)54123-5openalex-snapshot
Exchangeable GTP binding site of beta-tubulin. Identification of cysteine 12 as the major site of cross-linking by direct photoaffinity labeling.
inferredcites →https://doi.org/10.1016/s0021-9258(19)57307-0openalex-snapshot
Linkages between the effects of taxol, colchicine, and GTP on tubulin polymerization.
inferredcites →https://doi.org/10.1016/s0021-9258(19)66927-9openalex-snapshot
Structure of the tubulin dimer.
inferredcites →https://doi.org/10.1016/s0021-9258(19)68639-4openalex-snapshot
Taxol-induced polymerization of purified tubulin. Mechanism of action.
inferredcites →https://doi.org/10.1016/s0021-9258(20)65141-9openalex-snapshot
Interactions of the tau-tubulin-vinblastine complex with colchicine, podophyllotoxin, and N,N'-ethylenebis(iodoacetamide).
inferredcites →https://doi.org/10.1016/s0022-2836(05)80271-2openalex-snapshot
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
inferredcites →https://doi.org/10.1021/bi00062a003openalex-snapshot
Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry, and competition
inferredcites →https://doi.org/10.1021/bi00089a023openalex-snapshot
Thermodynamics of ligand-induced assembly of tubulin
inferredcites →https://doi.org/10.1021/bi00187a038openalex-snapshot
Predominant Labeling of .beta.- over .alpha.-Tubulin from Porcine Brain by a Photoactivatable Taxoid Derivative
inferredcites →https://doi.org/10.1021/bi00212a023openalex-snapshot
Molecular mechanism of colchicine action: Induced local unfolding of .beta.-tubulin
inferredcites →https://doi.org/10.1021/bi00289a031openalex-snapshot
Taxol effect on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis
inferredcites →https://doi.org/10.1021/bi00514a041openalex-snapshot
Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins
inferredcites →https://doi.org/10.1021/bi00565a014openalex-snapshot
Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism
inferredcites →https://doi.org/10.1038/257028a0openalex-snapshot
Three-dimensional model of purple membrane obtained by electron microscopy
inferredcites →https://doi.org/10.1038/277665a0openalex-snapshot
Promotion of microtubule assembly in vitro by taxol
inferredcites →https://doi.org/10.1038/279607a0openalex-snapshot
The three-dimensional structure of tubulin protofilaments
inferredcites →https://doi.org/10.1038/350130a0openalex-snapshot
Three-dimensional structure of plant light-harvesting complex determined by electron crystallography
inferredcites →https://doi.org/10.1038/367614a0openalex-snapshot
Atomic model of plant light-harvesting complex by electron crystallography
inferredcites →https://doi.org/10.1073/pnas.74.8.3370openalex-snapshot
Microtubule structure at low resolution by x-ray diffraction.
inferredcites →https://doi.org/10.1073/pnas.77.3.1561openalex-snapshot
Taxol stabilizes microtubules in mouse fibroblast cells.
inferredcites →https://doi.org/10.1083/jcb.103.6.2209openalex-snapshot
Different structural states of a microtubule cross-linking molecule, captured by quick-freezing motile axostyles in protozoa.
inferredcites →https://doi.org/10.1083/jcb.91.2.479openalex-snapshot
Taxol binds to polymerized tubulin in vitro
inferredcites →https://doi.org/10.1083/jcb.94.3.688openalex-snapshot
Taxol binds to cellular microtubules.
inferredcites →https://doi.org/10.1091/mbc.4.5.445openalex-snapshot
Are tubulin isotypes functionally significant.
inferredcites →https://doi.org/10.1093/jnci/84.10.785openalex-snapshot
Direct Photoaffinity Labeling of Tubulin With Taxol
inferredcites →https://doi.org/10.1111/j.1432-1033.1977.tb11726.xopenalex-snapshot
Microtubule Assembly in vitro. Purification of Assembly-Promoting Factors
inferredcites →https://doi.org/10.1126/science.1846047openalex-snapshot
Spot-Scan Imaging in Transmission Electron Microscopy
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Discovery and Mechanistic Insights into Thieno[3,2-D]Pyrimidine and Heterocyclic Fused Pyrimidines Inhibitors Targeting Tubulin for Cancer Therapy
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Inhibition of flagellar beat frequency by a new anti-β-tubulin antibody
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Fluorescent taxoids as probes of the microtubule cytoskeleton
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Molecular effects of paclitaxel: Myths and reality (a critical review)
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Taxol induces concomitant hyperphosphorylation and reorganization of vimentin intermediate filaments in 9l rat brain tumor cells
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Opioid agonists modify breast cancer cell proliferation by blocking cells to the G2/M phase of the cycle: Involvement of cytoskeletal elements
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Overview of Macromolecular Electron Microscopy: An Essential Tool in Protein Structural Analysis
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Drug Discovery and Development for Kinetoplastid Diseases
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Inhibition of activator protein 1 activity by paclitaxel suppresses interleukin-1-induced collagenase and stromelysin expression by bovine chondrocytes
inferred← citeshttps://doi.org/10.1002/9781119000822.hfcm061openalex-snapshot
Agents Targeting Microtubules and Mitotic Processes
inferred← citeshttps://doi.org/10.1002/9781119000822.hfcm061.pub2openalex-snapshot
Microtubule Inhibitors
inferred← citeshttps://doi.org/10.1002/9783527619764.ch13openalex-snapshot
Tamm‐Horsfall Protein to Tyrosin Hydroxylase
inferred← citeshttps://doi.org/10.1002/9783527676545.ch04openalex-snapshot
Taxol, Taxoids, and Related Taxanes
inferred← citeshttps://doi.org/10.1002/adfm.202105786openalex-snapshot
Cascade‐Amplifying Synergistic Therapy for Intracranial Glioma via Endogenous Reactive Oxygen Species‐Triggered “All‐in‐One” Nanoplatform
inferred← citeshttps://doi.org/10.1002/ana.24930openalex-snapshot
A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination
inferred← citeshttps://doi.org/10.1002/ange.19951072328openalex-snapshot
Fluoreszierende, wasserlösliche Taxolderivate
inferred← citeshttps://doi.org/10.1002/ange.19971091917openalex-snapshot
Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin‐Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen
inferred← citeshttps://doi.org/10.1002/ange.201107616openalex-snapshot
Niedermolekulare Stabilisatoren von Protein‐Protein‐Wechselwirkungen: ein unterschätztes Konzept in der Wirkstoffentwicklung?
inferred← citeshttps://doi.org/10.1002/ange.202412649openalex-snapshot
Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol
inferred← citeshttps://doi.org/10.1002/anie.199527101openalex-snapshot
New Fluorescent Water‐Soluble Taxol Derivatives
inferred← citeshttps://doi.org/10.1002/anie.199720971openalex-snapshot
Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol‐Resistant Tumor Cells
inferred← citeshttps://doi.org/10.1002/anie.201107616openalex-snapshot
Small‐Molecule Stabilization of Protein–Protein Interactions: An Underestimated Concept in Drug Discovery?
inferred← citeshttps://doi.org/10.1002/anie.202412649openalex-snapshot
Highly Potent and Intestine Specific P‐Glycoprotein Inhibitor to Enable Oral Delivery of Taxol
inferred← citeshttps://doi.org/10.1002/app.11957openalex-snapshot
Organic–inorganic polymer hybrids and porous materials obtained on their basis
inferred← citeshttps://doi.org/10.1002/art.1780400612openalex-snapshot
Paclitaxel selectively induces mitotic arrest and apoptosis in proliferating bovine synoviocytes
inferred← citeshttps://doi.org/10.1002/chem.201904523openalex-snapshot
Designing Molecular Spanners to Throw in the Protein Networks
inferred← citeshttps://doi.org/10.1002/cm.20494openalex-snapshot
Tau isoform‐specific modulation of kinesin‐driven microtubule gliding rates and trajectories as determined with tau‐stabilized microtubules
inferred← citeshttps://doi.org/10.1002/cm.21369openalex-snapshot
High‐throughput cell mechanical phenotyping for label‐free titration assays of cytoskeletal modifications
inferred← citeshttps://doi.org/10.1002/cm.21813openalex-snapshot
Cevipabulin induced abnormal tubulin protofilaments polymerization by binding to Vinblastine site and The Seventh site
inferred← citeshttps://doi.org/10.1002/cmdc.201700530openalex-snapshot
Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β‐Tubulin
inferred← citeshttps://doi.org/10.1002/cmdc.70426openalex-snapshot
Twenty Years of Benzimidazole Scaffold Optimization in Antiparasitic Drug Discovery
inferred← citeshttps://doi.org/10.1002/dneu.22745openalex-snapshot
Alpha‐ and beta‐tubulin isotypes are differentially expressed during brain development
inferred← citeshttps://doi.org/10.1002/hlca.19960790821openalex-snapshot
Synthesis of Lipid Derivatives of Colchicine
inferred← citeshttps://doi.org/10.1002/iub.42openalex-snapshot
Microtubule assembly dynamics: An attractive target for anticancer drugs
inferred← citeshttps://doi.org/10.1002/jlac.199619961224openalex-snapshot
Ethynylation of Aryl Halides by a Modified Suzuki Reaction: Application to the Syntheses of Combretastatin A‐4, A‐5 and Lunularic Acid
inferred← citeshttps://doi.org/10.1002/med.20097openalex-snapshot
Anti‐mitotic activity of colchicine and the structural basis for its interaction with tubulin
inferred← citeshttps://doi.org/10.1002/med.20242openalex-snapshot
Drugs that target dynamic microtubules: A new molecular perspective
inferred← citeshttps://doi.org/10.1002/nadc.19960440209openalex-snapshot
Biochemie und Molekulargenetik 1995
inferred← citeshttps://doi.org/10.1002/pauz.200400109openalex-snapshot
Wirkmechanismus der Taxane: Angriff auf die mitotische Spindel
inferred← citeshttps://doi.org/10.1002/pro.2808openalex-snapshot
An electron microscopy journey in the study of microtubule structure and dynamics
inferred← citeshttps://doi.org/10.1002/prot.340230405openalex-snapshot
Toward understanding the structure and interactions of microtubules and motor proteins
inferred← citeshttps://doi.org/10.1002/qsar.200330837openalex-snapshot
Epothilones: Quantitative Structure Activity Relations Studied by Support Vector Machines and Artificial Neural Networks
inferred← citeshttps://doi.org/10.1002/qua.21712openalex-snapshot
Theoretical study on the reactive sites and intramolecular interactions in taxol and its four analogues
inferred← citeshttps://doi.org/10.1006/bbrc.1997.6437openalex-snapshot
Studies on the Intracellular Localization of Acetyl-CoA Carboxylase
inferred← citeshttps://doi.org/10.1006/bbrc.1997.6688openalex-snapshot
Taxol Inhibits Opioid Binding on T47D Human Breast Cancer Cells
inferred← citeshttps://doi.org/10.1006/bbrc.1998.8409openalex-snapshot
Structural Significance of the Benzoyl Group at the C-3′-N Position of Paclitaxel for Nitric Oxide and Tumor Necrosis Factor Production by Murine Macrophages
inferred← citeshttps://doi.org/10.1006/bbrc.2000.3707openalex-snapshot
Identification of a Novel Taxol-Sensitive Kinase Activity Associated with the Cytoskeleton
inferred← citeshttps://doi.org/10.1006/jmbi.1996.0322openalex-snapshot
Microtubule Minus Ends can be Labelled with a Phage Display Antibody Specific to Alpha-Tubulin
inferred← citeshttps://doi.org/10.1006/jmbi.1996.0757openalex-snapshot
Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry
inferred← citeshttps://doi.org/10.1006/jmbi.2001.5262openalex-snapshot
Isolation and characterization of gap junctions from tissue culture cells
inferred← citeshttps://doi.org/10.1006/jsbi.1997.3840openalex-snapshot
Three-Dimensional Cryoelectron Microscopy of 16-Protofilament Microtubules: Structure, Polarity, and Interaction with Motor Proteins
inferred← citeshttps://doi.org/10.1006/jsbi.1997.3841openalex-snapshot
Visualizing the Secondary Structure of Tubulin: Three-Dimensional Map at 4 Å
inferred← citeshttps://doi.org/10.1006/jsbi.1997.3851openalex-snapshot
Three Different Approaches for Calculating the Three-Dimensional Structure of Microtubules Decorated with Kinesin Motor Domains
inferred← citeshttps://doi.org/10.1006/jsbi.1999.4162openalex-snapshot
Visualizing a New Binding Site of ncd-Motor Domain on Tubulin
inferred← citeshttps://doi.org/10.1007/128_2008_12openalex-snapshot
The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels
inferred← citeshttps://doi.org/10.1007/128_2008_24openalex-snapshot
The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography
inferred← citeshttps://doi.org/10.1007/978-1-4020-8843-8_16openalex-snapshot
Dinitroaniline Interactions with Tubulin: Genetic and Computational Approaches to Define the Mechanisms of Action and Resistance
inferred← citeshttps://doi.org/10.1007/978-1-4419-7216-3_13openalex-snapshot
New Insights into Tubulin Binders
inferred← citeshttps://doi.org/10.1007/978-1-61779-788-0_11openalex-snapshot
Microtubules as a Target in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-3-319-02159-1_4openalex-snapshot
Towards an Atomistic Structure of a De Novo Designed Peptide Fibre
inferred← citeshttps://doi.org/10.1007/978-3-319-53082-6_2openalex-snapshot
Microtubule Targeting Agents in Cancer Therapy: Elucidating the Underlying Molecular Mechanisms
inferred← citeshttps://doi.org/10.1007/978-3-642-41787-0_10openalex-snapshot
Plant Compounds Acting on the Cytoskeleton
inferred← citeshttps://doi.org/10.1007/978-3-662-03458-3_1openalex-snapshot
Mechanism of Resistance to Fungicides
inferred← citeshttps://doi.org/10.1007/bfb0105454openalex-snapshot
Dynamic instability and oscillations of microtubules
inferred← citeshttps://doi.org/10.1007/s00018-017-2476-2openalex-snapshot
Regulation of end-binding protein EB1 in the control of microtubule dynamics
inferred← citeshttps://doi.org/10.1007/s00044-012-0445-8openalex-snapshot
Pharmacophore model generation for microtubule-stabilizing anti-mitotic agents (MSAAs) against ovarian cancer
inferred← citeshttps://doi.org/10.1007/s00044-019-02352-2openalex-snapshot
An overview of tubulin modulators deposited in protein data bank
inferred← citeshttps://doi.org/10.1007/s002490050001openalex-snapshot
Imaging microtubules and kinesin decorated microtubules using tapping mode atomic force microscopy in fluids
inferred← citeshttps://doi.org/10.1007/s002490050153openalex-snapshot
New insights into microtubule structure and function from the atomic model of tubulin
inferred← citeshttps://doi.org/10.1007/s00280-010-1256-6openalex-snapshot
A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer
inferred← citeshttps://doi.org/10.1007/s00709-016-1060-1openalex-snapshot
Novel mutations involving βI-, βIIA-, or βIVB-tubulin isotypes with functional resemblance to βIII-tubulin in breast cancer
inferred← citeshttps://doi.org/10.1007/s00894-011-1083-7openalex-snapshot
Molecular dynamics simulation and density functional theory studies on the active pocket for the binding of paclitaxel to tubulin
inferred← citeshttps://doi.org/10.1007/s00894-022-05428-wopenalex-snapshot
Xanthatin and 8-epi-xanthatin as new potential colchicine binding site inhibitors: a computational study
inferred← citeshttps://doi.org/10.1007/s10549-010-0824-0openalex-snapshot
Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer
inferred← citeshttps://doi.org/10.1007/s10616-018-0227-3openalex-snapshot
Cytotoxic, tubulin-interfering and proapoptotic activities of 4′-methylthio-trans-stilbene derivatives, analogues of trans-resveratrol
inferred← citeshttps://doi.org/10.1007/s10637-011-9765-7openalex-snapshot
Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma
inferred← citeshttps://doi.org/10.1007/s11101-013-9302-8openalex-snapshot
Deciphering the molecular mechanisms of anti-tubulin plant derived drugs
inferred← citeshttps://doi.org/10.1007/s12026-022-09307-7openalex-snapshot
Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity
inferred← citeshttps://doi.org/10.1007/s12640-018-9929-8openalex-snapshot
Differential Morphological and Biochemical Recovery from Chemotherapy-Induced Peripheral Neuropathy Following Paclitaxel, Ixabepilone, or Eribulin Treatment in Mouse Sciatic Nerves
inferred← citeshttps://doi.org/10.1016/0027-5107(96)00025-5openalex-snapshot
Genetic toxicology of mitotic spindle inhibitors used as anticancer drugs
inferred← citeshttps://doi.org/10.1016/0962-8924(96)10024-6openalex-snapshot
Getting to the heart of β-tubulin
inferred← citeshttps://doi.org/10.1016/b978-0-12-374920-8.00119-3openalex-snapshot
1.15 Analysis of 2-D Crystals of Membrane Proteins by Electron Microscopy
inferred← citeshttps://doi.org/10.1016/b978-0-12-397924-7.00003-0openalex-snapshot
Quantitative Analysis of Microtubule Self-assembly Kinetics and Tip Structure
inferred← citeshttps://doi.org/10.1016/b978-0-12-802173-6.00011-3openalex-snapshot
Microtubule Stabilization
inferred← citeshttps://doi.org/10.1016/b978-0-12-821277-6.00002-7openalex-snapshot
Epothilones A and B: The 16-Membered Natural Macrolides as a Fascinating Template for Antibreast Cancer Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-443-23585-6.00005-4openalex-snapshot
Microtubule-stabilizing compounds as antiprostate cancer agents
inferred← citeshttps://doi.org/10.1016/b978-1-60805-865-5.50004-6openalex-snapshot
Recent advances in the discovery and development of protein- protein interaction modulators by virtual screening
inferred← citeshttps://doi.org/10.1016/j.bbadis.2004.07.002openalex-snapshot
Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death
inferred← citeshttps://doi.org/10.1016/j.bbagen.2016.09.011openalex-snapshot
Paclitaxel suppresses Tau-mediated microtubule bundling in a concentration-dependent manner
inferred← citeshttps://doi.org/10.1016/j.bbalip.2013.12.013openalex-snapshot
Evolving concepts in cancer therapy through targeting sphingolipid metabolism
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.08.125openalex-snapshot
Structure of 4′-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.02.064openalex-snapshot
Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2017.06.034openalex-snapshot
Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.12.029openalex-snapshot
Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors
inferred← citeshttps://doi.org/10.1016/j.bpj.2012.01.045openalex-snapshot
Spectral Analysis Methods for the Robust Measurement of the Flexural Rigidity of Biopolymers
inferred← citeshttps://doi.org/10.1016/j.bpj.2025.12.029openalex-snapshot
Regulation of microtubule radial structure by competition between Tau and paclitaxel: Binding and x-ray scattering studies
inferred← citeshttps://doi.org/10.1016/j.brainres.2012.10.022openalex-snapshot
Non-taxoid site microtubule-stabilizing drugs work independently of tau overexpression in mouse N2a neuroblastoma cells
inferred← citeshttps://doi.org/10.1016/j.cbi.2019.108906openalex-snapshot
Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.05.009openalex-snapshot
Retracted: Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.chembiol.2013.01.014openalex-snapshot
The Binding Sites of Microtubule-Stabilizing Agents
inferred← citeshttps://doi.org/10.1016/j.cis.2015.11.002openalex-snapshot
The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure
inferred← citeshttps://doi.org/10.1016/j.cmonc.2012.06.001openalex-snapshot
Balancing the efficacy and safety of ixabepilone: optimizing treatment in metastatic breast cancer
inferred← citeshttps://doi.org/10.1016/j.cocis.2018.01.010openalex-snapshot
From electron crystallography of 2D crystals to MicroED of 3D crystals
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2006.02.062openalex-snapshot
Direct electron transfer of hemoglobin on DDAB/SWNTs film modified Au electrode and its interaction with Taxol
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.12.001openalex-snapshot
Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective
inferred← citeshttps://doi.org/10.1016/j.ejca.2009.07.015openalex-snapshot
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejcb.2020.151075openalex-snapshot
Microtubule-targeting agents and their impact on cancer treatment
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114466openalex-snapshot
Discovery of (2-(pyrrolidin-1-yl)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone as a novel potent tubulin depolymerizing and vascular disrupting agent
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116649openalex-snapshot
Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118245openalex-snapshot
Structure-based design and synthesis of 3-substituted-1,2,4-triazolo[1,5-a]pyrimidines as dual vinca/gatorbulin-site ligands for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118849openalex-snapshot
Structure-based design and synthesis of KX-01 analogs as potent antitumor agents targeting the tubulin colchicine binding site
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119244openalex-snapshot
Carborane-modified paclitaxel analogues: Position-dependent modulation of mitotic catastrophe and lysosomal function
inferred← citeshttps://doi.org/10.1016/j.expneurol.2007.11.001openalex-snapshot
Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells
inferred← citeshttps://doi.org/10.1016/j.expneurol.2019.113090openalex-snapshot
Analyzing chemotherapy-induced peripheral neuropathy in vivo using non-mammalian animal models
inferred← citeshttps://doi.org/10.1016/j.expneurol.2022.114258openalex-snapshot
Towards a mechanistic understanding of axon transport and endocytic changes underlying paclitaxel-induced peripheral neuropathy
inferred← citeshttps://doi.org/10.1016/j.ijpara.2015.03.010openalex-snapshot
Ivermectin binds to Haemonchus contortus tubulins and promotes stability of microtubules
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.07.046openalex-snapshot
Drug metabolites and their effects on the development of adverse reactions: Revisiting Lipinski’s Rule of Five
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104787openalex-snapshot
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113607openalex-snapshot
Tubulin C-terminal tails are pH sensors that regulate microtubule function
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120034openalex-snapshot
A review on the microtubule inhibitory effects of active ingredients extracted from TCMs and ethnic medicines in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.jmb.2012.05.040openalex-snapshot
Structural Studies of Ciliary Components
inferred← citeshttps://doi.org/10.1016/j.jmgm.2011.06.005openalex-snapshot
QM and QM/MD simulations of the Vinca alkaloids docked to tubulin
inferred← citeshttps://doi.org/10.1016/j.jneumeth.2020.109065openalex-snapshot
Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons
inferred← citeshttps://doi.org/10.1016/j.jsb.2013.10.006openalex-snapshot
Bayesian analysis of individual electron microscopy images: Towards structures of dynamic and heterogeneous biomolecular assemblies
inferred← citeshttps://doi.org/10.1016/j.mcn.2011.10.003openalex-snapshot
MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons
inferred← citeshttps://doi.org/10.1016/j.mee.2021.111512openalex-snapshot
Cyclic voltammetric biosensing of cellular ionic secretion based on silicon nanowires to detect the effect of paclitaxel on breast normal and cancer cells
inferred← citeshttps://doi.org/10.1016/j.molmed.2020.09.007openalex-snapshot
Predicting and Overcoming Taxane Chemoresistance
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.132723openalex-snapshot
Microtubules destabilizing agents binding sites in tubulin
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.08.016openalex-snapshot
The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions
inferred← citeshttps://doi.org/10.1016/j.pain.2006.01.037openalex-snapshot
Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107860openalex-snapshot
Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105585openalex-snapshot
Dichotomous role of microtubule associated protein tau as a biomarker of response to and a target for increasing efficacy of taxane treatment in cancers of epithelial origin
inferred← citeshttps://doi.org/10.1016/j.str.2022.11.006openalex-snapshot
Chemical modulation of microtubule structure through the laulimalide/peloruside site
inferred← citeshttps://doi.org/10.1016/j.taap.2021.115534openalex-snapshot
Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy
inferred← citeshttps://doi.org/10.1016/j.tet.2020.131660openalex-snapshot
A stereotetrad-centered approach toward pironetin: Dead ends, Detour, and evolution of the synthetic strategy
inferred← citeshttps://doi.org/10.1016/j.ultramic.2016.03.004openalex-snapshot
Designs for a quantum electron microscope
inferred← citeshttps://doi.org/10.1016/s0003-2670(01)00896-0openalex-snapshot
Studies on the interaction of paclitaxel with tubulin by an electrochemical method
inferred← citeshttps://doi.org/10.1016/s0006-3495(96)79809-0openalex-snapshot
Structural intermediates in the assembly of taxoid-induced microtubules and GDP-tubulin double rings: time-resolved X-ray scattering
inferred← citeshttps://doi.org/10.1016/s0006-3495(97)78682-xopenalex-snapshot
Divalent cation and ionic strength effects on Vinca alkaloid-induced tubulin self-association
inferred← citeshttps://doi.org/10.1016/s0006-3495(97)78782-4openalex-snapshot
Thermodynamic and structural analysis of microtubule assembly: the role of GTP hydrolysis
inferred← citeshttps://doi.org/10.1016/s0006-3495(98)77863-4openalex-snapshot
The Susceptibility of Pure Tubulin to High Magnetic Fields: A Magnetic Birefringence and X-Ray Fiber Diffraction Study
inferred← citeshttps://doi.org/10.1016/s0006-8993(00)02910-3openalex-snapshot
Description of a short-term Taxol®-induced nociceptive neuropathy in rats
inferred← citeshttps://doi.org/10.1016/s0014-5793(03)00181-9openalex-snapshot
Discodermolide interferes with the binding of tau protein to microtubules
inferred← citeshttps://doi.org/10.1016/s0014-5793(97)00159-2openalex-snapshot
Molecular mobility of nitroxyl‐labelled taxol during tubulin assembly
inferred← citeshttps://doi.org/10.1016/s0074-7696(08)62138-5openalex-snapshot
Multiple Forms of Tubulin: Different Gene Products and Covalent Modifications
inferred← citeshttps://doi.org/10.1016/s0076-6879(10)81001-8openalex-snapshot
Preparation of 2D Crystals of Membrane Proteins for High-Resolution Electron Crystallography Data Collection
inferred← citeshttps://doi.org/10.1016/s0076-6879(98)98023-5openalex-snapshot
[21] Photoaffinity labeling approach to map the taxol-binding site on the microtubule
inferred← citeshttps://doi.org/10.1016/s0091-679x(10)95016-4openalex-snapshot
Determination of Drug Binding to Microtubules In Vitro
inferred← citeshttps://doi.org/10.1016/s0091-679x(10)95017-6openalex-snapshot
Fluorescence Spectroscopic Methods to Analyze Drug–Tubulin Interactions
inferred← citeshttps://doi.org/10.1016/s0167-4838(99)00251-4openalex-snapshot
Interaction of taxol with human serum albumin
inferred← citeshttps://doi.org/10.1016/s0304-3991(00)00052-8openalex-snapshot
Parameters affecting specimen flatness of two-dimensional crystals for electron crystallography
inferred← citeshttps://doi.org/10.1016/s0304-3991(99)00039-xopenalex-snapshot
Cryo-electron crystallography of small and mosaic 2-D crystals: an assessment of a procedure for high-resolution data retrieval
inferred← citeshttps://doi.org/10.1016/s0306-3623(97)89716-9openalex-snapshot
The transport and binding of taxol
inferred← citeshttps://doi.org/10.1016/s0921-4410(03)21003-6openalex-snapshot
Tubulin-targeting agents
inferred← citeshttps://doi.org/10.1016/s0921-4410(04)22003-8openalex-snapshot
Tubulin-targeting agents
inferred← citeshttps://doi.org/10.1016/s0955-0674(97)80145-7openalex-snapshot
The structure of microtubule-motor complexes
inferred← citeshttps://doi.org/10.1016/s0955-0674(97)80146-9openalex-snapshot
Microtubule structure and dynamics
inferred← citeshttps://doi.org/10.1016/s0955-0674(98)80082-3openalex-snapshot
Tubulin and microtubule structure
inferred← citeshttps://doi.org/10.1016/s0959-440x(97)80032-2openalex-snapshot
Structure and dynamics of molecular motors
inferred← citeshttps://doi.org/10.1016/s0960-894x(97)00329-6openalex-snapshot
7-O-acylpaclitaxel analogues: potential probes to map the paclitaxel binding site
inferred← citeshttps://doi.org/10.1016/s0960-9822(95)00180-1openalex-snapshot
How does taxol stabilize microtubules?
inferred← citeshttps://doi.org/10.1016/s0960-9822(95)00268-5openalex-snapshot
Motile Systems: Tubulin-based motility races ahead
inferred← citeshttps://doi.org/10.1016/s0969-2126(02)00827-4openalex-snapshot
Microtubule Structure at 8 Å Resolution
inferred← citeshttps://doi.org/10.1016/s1040-8428(02)00109-9openalex-snapshot
Weekly administration of paclitaxel: theoretical and clinical basis
inferred← citeshttps://doi.org/10.1016/s1067-5698(99)80004-2openalex-snapshot
Recent advances in the medicinal chemistry of taxoid anticancer agents
inferred← citeshttps://doi.org/10.1016/s1074-5521(01)00097-7openalex-snapshot
Effects of Novel Taxanes SB-T-1213 and IDN5109 on Tubulin Polymerization and Mitosis
inferred← citeshttps://doi.org/10.1016/s1074-5521(96)90129-5openalex-snapshot
Understanding and controlling the cell cycle with natural products
inferred← citeshttps://doi.org/10.1016/s1568-461x(01)80019-3openalex-snapshot
Chapter 15 Phytochrome as an algal photoreceptor
inferred← citeshttps://doi.org/10.1017/s1431927621000520openalex-snapshot
Minimizing Crinkling of Soft Specimens Using Holey Gold Films on Molybdenum Grids for Cryogenic Electron Microscopy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01837openalex-snapshot
Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00011openalex-snapshot
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01147openalex-snapshot
Ruthenocenyl and 1-Adamantyl Paclitaxel Analogs Disrupt the Balance between βIII- and βIVa-Tubulin and Inhibit the Growth and Invasiveness of Colon Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00574openalex-snapshot
Modulators of 14-3-3 Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01184openalex-snapshot
Exhaustive Repertoire of Druggable Cavities at Protein–Protein Interfaces of Known Three-Dimensional Structure
inferred← citeshttps://doi.org/10.1021/acs.langmuir.9b02208openalex-snapshot
Minireview - Microtubules and Tubulin Oligomers: Shape Transitions and Assembly by Intrinsically Disordered Protein Tau and Cationic Biomolecules
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.7b00624openalex-snapshot
Multicompartment Theranostic Nanoemulsions Stabilized by a Triphilic Semifluorinated Block Copolymer
inferred← citeshttps://doi.org/10.1021/acs.nanolett.4c04294openalex-snapshot
Visualizing the Submolecular Organization of αβ-Tubulin Subunits on the Microtubule Inner Surface Using Atomic Force Microscopy
inferred← citeshttps://doi.org/10.1021/acsnano.0c06945openalex-snapshot
All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin
inferred← citeshttps://doi.org/10.1021/acsomega.7b01784openalex-snapshot
Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents
inferred← citeshttps://doi.org/10.1021/acsomega.8b02475openalex-snapshot
Structural Changes in Tubulin Sheets Caused by Immobilization on Solid Supports
inferred← citeshttps://doi.org/10.1021/bi700753yopenalex-snapshot
Enhanced Microtubule Binding and Tubulin Assembly Properties of Conformationally Constrained Paclitaxel Derivatives
inferred← citeshttps://doi.org/10.1021/ct100374aopenalex-snapshot
Coarse-Grained Representations of Large Biomolecular Complexes from Low-Resolution Structural Data
inferred← citeshttps://doi.org/10.1021/ja805570fopenalex-snapshot
Functionalized Single-Walled Carbon Nanotubes as Rationally Designed Vehicles for Tumor-Targeted Drug Delivery
inferred← citeshttps://doi.org/10.1021/ja9633777openalex-snapshot
A Novel Approach to the Study of Solution Structures and Dynamic Behavior of Paclitaxel and Docetaxel Using Fluorine-Containing Analogs as Probes
inferred← citeshttps://doi.org/10.1021/jm030581dopenalex-snapshot
Synthesis and Anti-Tubulin Activity of a 3‘-(4-Azidophenyl)-3‘-dephenylpaclitaxel Photoaffinity Probe
inferred← citeshttps://doi.org/10.1021/jm200757gopenalex-snapshot
Identification and Biological Activities of New Taccalonolide Microtubule Stabilizers
inferred← citeshttps://doi.org/10.1021/jm301079zopenalex-snapshot
Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies
inferred← citeshttps://doi.org/10.1021/jm950796qopenalex-snapshot
NMR and Molecular Modeling Study of the Conformations of Taxol 2‘-Acetate in Chloroform and Aqueous Dimethyl Sulfoxide Solutions
inferred← citeshttps://doi.org/10.1021/jm970026+openalex-snapshot
Conformational Studies of Paclitaxel Analogs Modified at the C-2‘ Position in Hydrophobic and Hydrophilic Solvent Systems
inferred← citeshttps://doi.org/10.1021/jo000770topenalex-snapshot
Synthesis, Aggregation, and Binding Behavior of Synthetic Amphiphilic Receptors
inferred← citeshttps://doi.org/10.1021/np4002702openalex-snapshot
Enantioselective Effects of (+)- and (−)-Citronellal on Animal and Plant Microtubules
inferred← citeshttps://doi.org/10.1021/ol900709nopenalex-snapshot
A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation
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