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Signalling through the lipid products of phosphoinositide-3-OH kinase
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00414.xopenalex-snapshot
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3‐kinase.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb01014.xopenalex-snapshot
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.
inferredcites →https://doi.org/10.1016/0092-8674(95)90036-5openalex-snapshot
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
inferredcites →https://doi.org/10.1016/0092-8674(95)90044-6openalex-snapshot
Antigenic variation in malaria
inferredcites →https://doi.org/10.1016/0092-8674(95)90195-7openalex-snapshot
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
inferredcites →https://doi.org/10.1016/0092-8674(95)90363-1openalex-snapshot
GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more
inferredcites →https://doi.org/10.1016/0092-8674(95)90534-0openalex-snapshot
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
inferredcites →https://doi.org/10.1016/s0021-9258(18)31643-0openalex-snapshot
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.
inferredcites →https://doi.org/10.1016/s0021-9258(18)54107-7openalex-snapshot
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.
inferredcites →https://doi.org/10.1016/s0092-8674(00)80095-1openalex-snapshot
αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule
inferredcites →https://doi.org/10.1016/s0092-8674(00)81883-8openalex-snapshot
PI3K: Downstream AKTion Blocks Apoptosis
inferredcites →https://doi.org/10.1016/s0960-9822(00)00087-7openalex-snapshot
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
inferredcites →https://doi.org/10.1016/s0960-9822(06)00122-9openalex-snapshot
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
inferredcites →https://doi.org/10.1016/s0960-9822(95)00080-7openalex-snapshot
PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase
inferredcites →https://doi.org/10.1016/s0960-9822(96)00749-xopenalex-snapshot
Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
inferredcites →https://doi.org/10.1021/bi961878zopenalex-snapshot
Lipid Products of Phosphoinositide 3-Kinase Bind Human Profilin with High Affinity
inferredcites →https://doi.org/10.1038/332644a0openalex-snapshot
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
inferredcites →https://doi.org/10.1038/334353a0openalex-snapshot
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
inferredcites →https://doi.org/10.1038/370527a0openalex-snapshot
Phosphatidylinositol-3-OH kinase direct target of Ras
inferredcites →https://doi.org/10.1038/376599a0openalex-snapshot
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
inferredcites →https://doi.org/10.1038/378584a0openalex-snapshot
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
inferredcites →https://doi.org/10.1038/382536a0openalex-snapshot
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
inferredcites →https://doi.org/10.1038/384481a0openalex-snapshot
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
inferredcites →https://doi.org/10.1042/bj3030021openalex-snapshot
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
inferredcites →https://doi.org/10.1046/j.1471-4159.1996.67010220.xopenalex-snapshot
Stimulation of an Insulin Receptor Activates and Down‐Regulates the Ca2+‐Independent Protein Kinase C, Apl II, Through a Wortmannin‐Sensitive Signaling Pathway in Aplysia
inferredcites →https://doi.org/10.1073/pnas.93.1.151openalex-snapshot
Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.
inferredcites →https://doi.org/10.1073/pnas.93.15.7639openalex-snapshot
Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.
inferredcites →https://doi.org/10.1073/pnas.93.23.13327openalex-snapshot
Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin
inferredcites →https://doi.org/10.1074/jbc.270.38.22412openalex-snapshot
Activation of PRK1 by Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate
inferredcites →https://doi.org/10.1074/jbc.270.49.29525openalex-snapshot
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase
inferredcites →https://doi.org/10.1074/jbc.271.31.18859openalex-snapshot
Identification and Cloning of Centaurin-α
inferredcites →https://doi.org/10.1074/jbc.271.36.21920openalex-snapshot
Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation
inferredcites →https://doi.org/10.1074/jbc.271.48.30303openalex-snapshot
Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity
inferredcites →https://doi.org/10.1074/jbc.271.51.32986openalex-snapshot
D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate
inferredcites →https://doi.org/10.1074/jbc.272.1.466openalex-snapshot
Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic Peptide
inferredcites →https://doi.org/10.1074/jbc.272.10.6393openalex-snapshot
Regulation of AP-3 Function by Inositides
inferredcites →https://doi.org/10.1074/jbc.272.10.6465openalex-snapshot
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C
inferredcites →https://doi.org/10.1074/jbc.272.13.8474openalex-snapshot
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity
inferredcites →https://doi.org/10.1093/emboj/16.9.2240openalex-snapshot
Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes
inferredcites →https://doi.org/10.1126/science.275.5298.394openalex-snapshot
Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ
inferredcites →https://doi.org/10.1126/science.275.5300.665openalex-snapshot
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
inferredcites →https://doi.org/10.1126/science.275.5308.1927openalex-snapshot
Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains
inferredcites →https://doi.org/10.1126/science.8303278openalex-snapshot
Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites
inferredcites →https://doi.org/10.1126/science.8385367openalex-snapshot
Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting
inferredcites →https://doi.org/10.1128/mcb.16.8.4117openalex-snapshot
Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways
inferredcites →https://doi.org/10.1128/mcb.17.1.190openalex-snapshot
Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes
inferredcites →https://doi.org/10.1128/mcb.17.1.338openalex-snapshot
A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/(sici)1097-4644(19990615)73:4<533::aid-jcb11>3.0.co;2-yopenalex-snapshot
Malignant astrocytoma cell attachment and migration to various matrix proteins is differentially sensitive to phosphoinositide 3-OH kinase inhibitors
inferred← citeshttps://doi.org/10.1002/(sici)1521-1878(199805)20:5<423::aid-bies9>3.0.co;2-oopenalex-snapshot
Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic
inferred← citeshttps://doi.org/10.1002/(sici)1521-1878(199905)21:5<422::aid-bies9>3.0.co;2-#openalex-snapshot
Signaling pathways in phagocytosis
inferred← citeshttps://doi.org/10.1002/(sici)1521-4141(199803)28:03<1005::aid-immu1005>3.0.co;2-oopenalex-snapshot
CD16-mediated activation of phosphatidylinositol-3 kinase (Pl-3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc, pp36 and p85 Pl-3K subunit
inferred← citeshttps://doi.org/10.1002/(sici)1521-4141(199810)28:10<3003::aid-immu3003>3.0.co;2-wopenalex-snapshot
CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase
inferred← citeshttps://doi.org/10.1002/(sici)1521-4141(199810)28:10<3183::aid-immu3183>3.0.co;2-aopenalex-snapshot
Ligands of CD4 inhibit the association of phospholipase Cγ1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity
inferred← citeshttps://doi.org/10.1002/(sici)1521-4141(199911)29:11<3507::aid-immu3507>3.0.co;2-9openalex-snapshot
CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP
inferred← citeshttps://doi.org/10.1002/0471203076.emm0744openalex-snapshot
Pleckstrin Homology ( PH ) Domains
inferred← citeshttps://doi.org/10.1002/047120918x.emb0752openalex-snapshot
Inositol Lipids and Phosphates
inferred← citeshttps://doi.org/10.1002/047120918x.emb1121openalex-snapshot
Phosphatidylinositol Kinases
inferred← citeshttps://doi.org/10.1002/1097-0061(200007)16:10<933::aid-yea591>3.0.co;2-copenalex-snapshot
A phosphatidylinositol 3-kinase ofCandida albicans: molecular cloning and characterization
inferred← citeshttps://doi.org/10.1002/1097-4547(20001215)62:6<799::aid-jnr6>3.0.co;2-1openalex-snapshot
Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells
inferred← citeshttps://doi.org/10.1002/1521-4141(200112)31:12<3612::aid-immu3612>3.0.co;2-jopenalex-snapshot
Role of phosphoinositide 3-kinase in TCR-signaled regulation of CD8-mediated adhesion to class I MHC protein
inferred← citeshttps://doi.org/10.1002/1521-4141(200202)32:2<486::aid-immu486>3.0.co;2-uopenalex-snapshot
Cytokine-mediated inhibition of apoptosis in non-transformed T cells and neutrophils can be dissociated from protein kinase B activation
inferred← citeshttps://doi.org/10.1002/9780470747919.ch24openalex-snapshot
Apical Recycling of Canalicular ABC Transporters
inferred← citeshttps://doi.org/10.1002/9781119289470.ch3openalex-snapshot
Ethylene Signal Transduction During Fruit Ripening and Senescence
inferred← citeshttps://doi.org/10.1002/art.10314openalex-snapshot
Necessary role of phosphatidylinositol 3‐kinase in transforming growth factor β–mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts
inferred← citeshttps://doi.org/10.1002/bjs.4449openalex-snapshot
Interleukin 7 induces the growth of breast cancer cells through a wortmannin-sensitive pathway
inferred← citeshttps://doi.org/10.1002/brb3.23openalex-snapshot
Genetic association of the Phosphoinositide‐3 kinase in schizophrenia and bipolar disorder and interaction with a BDNF gene polymorphism
inferred← citeshttps://doi.org/10.1002/cbic.200900545openalex-snapshot
5‐Stabilized Phosphatidylinositol 3,4,5‐Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration
inferred← citeshttps://doi.org/10.1002/cmdc.202100731openalex-snapshot
Recent Advances in Dual BRD4‐Kinase Inhibitors Based on Polypharmacology
inferred← citeshttps://doi.org/10.1002/cncr.21476openalex-snapshot
Akt activation correlates with adverse outcome in tongue cancer
inferred← citeshttps://doi.org/10.1002/cphy.c110018openalex-snapshot
Motility, Survival, and Proliferation
inferred← citeshttps://doi.org/10.1002/ddr.1157openalex-snapshot
Role of p‐21‐activated kinases in cell survival and apoptotic pathways
inferred← citeshttps://doi.org/10.1002/ddr.22058openalex-snapshot
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of PI3K/AKT/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1002/eji.201242371openalex-snapshot
Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)‐bisphosphate regulates B ‐cell activation and autoantibody production
inferred← citeshttps://doi.org/10.1002/ejoc.201200726openalex-snapshot
Versatile Synthesis of 1‐O‐(ω‐Aminolauryl)‐I(4,5)P2
inferred← citeshttps://doi.org/10.1002/hep.510270519openalex-snapshot
Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes
inferred← citeshttps://doi.org/10.1002/ijc.10147openalex-snapshot
Dysregulation of phosphatidylinositol 3‐kinase and downstream effectors in human breast cancer
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2012.tb00408.xopenalex-snapshot
Motility, Survival, and Proliferation
inferred← citeshttps://doi.org/10.1002/jbm.a.34608openalex-snapshot
Promotive effect of insulin‐like growth factor‐1 for epithelial sealing to titanium implants
inferred← citeshttps://doi.org/10.1002/jcb.20185openalex-snapshot
Involvement of phosphoinositide 3‐kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: Application of a gene‐trap mutagenesis
inferred← citeshttps://doi.org/10.1002/jcb.21279openalex-snapshot
PI‐3K/Akt signal pathway plays a crucial role in arsenite‐induced cell proliferation of human keratinocytes through induction of cyclin D1
inferred← citeshttps://doi.org/10.1002/jcp.10082openalex-snapshot
Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK‐dependent manner in normal rat kidney cells
inferred← citeshttps://doi.org/10.1002/jcp.1117openalex-snapshot
Role of protein kinase Cδ in transmitting hypoxia signal to HSF and HIF‐1
inferred← citeshttps://doi.org/10.1002/jcp.20478openalex-snapshot
The class II phosphoinositide 3‐kinase PI3K‐C2β regulates cell migration by a PtdIns(3)P dependent mechanism
inferred← citeshttps://doi.org/10.1002/jcp.20507openalex-snapshot
The N‐terminus of phosphoinositide 3‐kinase‐C2β regulates lipid kinase activity and binding to clathrin
inferred← citeshttps://doi.org/10.1002/jcp.20592openalex-snapshot
Regulation of Ang2 release by PTEN/PI3‐kinase/Akt in lung microvascular endothelial cells
inferred← citeshttps://doi.org/10.1002/jcp.20696openalex-snapshot
Regulation of phosphatidylinositol 3‐kinase (PI3K)/Akt and nuclear factor‐kappa B signaling pathways in dystrophin‐deficient skeletal muscle in response to mechanical stretch
inferred← citeshttps://doi.org/10.1002/jcp.23038openalex-snapshot
PI3K: A potential therapeutic target for cancer
inferred← citeshttps://doi.org/10.1002/jcp.24146openalex-snapshot
MEK/ERK pathway mediates PKC activation‐induced recruitment of PKCζ and MMP‐9 to podosomes
inferred← citeshttps://doi.org/10.1002/jlb.65.3.321openalex-snapshot
Multiple roles for PI 3-kinase in the regulation of PLCγ activity and Ca2+ mobilization in antigen-stimulated mast cells
inferred← citeshttps://doi.org/10.1002/jmv.2189openalex-snapshot
Human cytomegalovirus hyperimmune globulin not only neutralizes HCMV infectivity, but also inhibits HCMV‐induced intracellular NF‐κB, Sp1, and PI3‐K signaling pathways
inferred← citeshttps://doi.org/10.1002/jnr.20174openalex-snapshot
Performance in long‐term memory tasks is augmented by a phosphorylated growth factor receptor fragment
inferred← citeshttps://doi.org/10.1002/jnr.21406openalex-snapshot
Activation of phosphoinositide‐3 kinase/Akt pathway by FeSO4 in rat cerebral cortex synaptic endings
inferred← citeshttps://doi.org/10.1002/lipd.12135openalex-snapshot
Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3‐L1 Adipocytes
inferred← citeshttps://doi.org/10.1002/mrd.20150openalex-snapshot
Phosphatidylinositol 3‐kinase and Akt participate in the FSH‐induced meiotic maturation of mouse oocytes
inferred← citeshttps://doi.org/10.1002/mrd.20663openalex-snapshot
Phosphatidylinositol 3‐kinase pathway regulates sperm viability but not capacitation on boar spermatozoa
inferred← citeshttps://doi.org/10.1002/nbm.1186openalex-snapshot
Myo ‐Inositol: a marker of reactive astrogliosis in glial tumors?
inferred← citeshttps://doi.org/10.1002/ptr.4931openalex-snapshot
Caffeoylserotonin Protects Human Keratinocyte HaCaT Cells against H2O2‐Induced Oxidative Stress and Apoptosis through Upregulation of HO‐1 Expression via Activation of the PI3K/Akt/Nrf2 Pathway
inferred← citeshttps://doi.org/10.1002/rnc.6049openalex-snapshot
Enhanced chemotaxis through spatially regulated absolute concentration robustness
inferred← citeshttps://doi.org/10.1002/slct.202401366openalex-snapshot
Unveiling the Therapeutic Potential of Quinazolinone Derivatives in Cancer Treatment: A Comprehensive Exploration
inferred← citeshttps://doi.org/10.1006/abbi.1998.0796openalex-snapshot
Probing the Phosphoinositide Binding Site of the Clathrin Assembly Protein AP-2 with Photoaffinity Labels
inferred← citeshttps://doi.org/10.1006/abbi.2000.2199openalex-snapshot
Ligation of the α2M* Signaling Receptor Regulates Synthesis of Cytosolic Phospholipase A2
inferred← citeshttps://doi.org/10.1006/abio.2000.4525openalex-snapshot
Biotinylated Phosphatidylinositol 3,4,5-Trisphosphate as Affinity Ligand
inferred← citeshttps://doi.org/10.1006/abio.2001.5449openalex-snapshot
A Straightforward Method for Analysis of Highly Phosphorylated Inositols in Blood Cells by High-Performance Liquid Chromatography
inferred← citeshttps://doi.org/10.1006/bbrc.1998.8134openalex-snapshot
Protein Kinase C Modulates the Insulin-Stimulated Increase in Akt1 and Akt3 Activity in 3T3-L1 Adipocytes
inferred← citeshttps://doi.org/10.1006/bbrc.1998.8564openalex-snapshot
Molecular Cloning of Multiple Isoforms of Synaptojanin 2 and Assignment of the Gene to Mouse Chromosome 17A2-3.1
inferred← citeshttps://doi.org/10.1006/bbrc.1998.8606openalex-snapshot
Multiple Isoforms of the Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI3-Kinase) Are Expressed in Neurons in the Rat Brain
inferred← citeshttps://doi.org/10.1006/bbrc.1998.9444openalex-snapshot
Stimulation of Mitogenesis by a Cell-Permeable PI 3-Kinase Binding Peptide
inferred← citeshttps://doi.org/10.1006/bbrc.1999.0888openalex-snapshot
Molecular Cloning of Rat SH2-Containing Inositol Phosphatase 2 (SHIP2) and Its Role in the Regulation of Insulin Signaling
inferred← citeshttps://doi.org/10.1006/bbrc.1999.1065openalex-snapshot
Molecular Cloning and Functional Characterization of a Human Homologue of Centaurin-α
inferred← citeshttps://doi.org/10.1006/bbrc.1999.1150openalex-snapshot
Mouse Phosphoinositide 3-Kinase p110α Gene: Cloning, Structural Organization, and Localization to Chromosome 3 Band B
inferred← citeshttps://doi.org/10.1006/bbrc.1999.1347openalex-snapshot
Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes
inferred← citeshttps://doi.org/10.1006/bbrc.2000.2417openalex-snapshot
FYVE-DSP1, a Dual-Specificity Protein Phosphatase Containing an FYVE Domain
inferred← citeshttps://doi.org/10.1006/bbrc.2000.2806openalex-snapshot
Constitutive Cellular Expression of PI 3-Kinase Is Distinct from Transient Expression
inferred← citeshttps://doi.org/10.1006/bbrc.2001.5967openalex-snapshot
Pancreastatin, a Chromogranin-A-Derived Peptide, Inhibits Insulin-Stimulated Glycogen Synthesis by Activating GSK-3 in Rat Adipocytes
inferred← citeshttps://doi.org/10.1006/bbrc.2002.6504openalex-snapshot
Phosphorylation of Fanconi Anemia Protein, FANCA, Is Regulated by Akt Kinase
inferred← citeshttps://doi.org/10.1006/excr.1999.4693openalex-snapshot
Role of PI 3-Kinase in Angiopoietin-1-Mediated Migration and Attachment-Dependent Survival of Endothelial Cells
inferred← citeshttps://doi.org/10.1006/excr.2001.5272openalex-snapshot
MIP-1α Induces Activation of Phosphatidylinositol-3 Kinase That Associates with Pyk-2 and Is Necessary for B-Cell Migration
inferred← citeshttps://doi.org/10.1006/exer.2001.1076openalex-snapshot
Regulation of Lacrimal Gland Secretion by Neurotransmitters and the EGF Family of Growth Factors
inferred← citeshttps://doi.org/10.1006/gyno.2002.6692openalex-snapshot
Specific Keynote: Molecular Therapeutics in Ovarian Cancer
inferred← citeshttps://doi.org/10.1006/jmbi.1997.1562openalex-snapshot
Solution structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase 1 1Edited by P. E. Wright
inferred← citeshttps://doi.org/10.1006/jmbi.1999.3111openalex-snapshot
Crystal structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate
inferred← citeshttps://doi.org/10.1006/mcbr.1999.0124openalex-snapshot
The SH3 and BH Domains of the p85α Adapter Subunit Play a Critical Role in Regulating Class Ia Phosphoinositide 3-Kinase Function
inferred← citeshttps://doi.org/10.1006/mcbr.2000.0202openalex-snapshot
Phosphoinositide 3-Kinases and the Regulation of Vesicular Trafficking
inferred← citeshttps://doi.org/10.1006/mcne.1998.0733openalex-snapshot
GGF/Neuregulin Induces a Phenotypic Reversion of Oligodendrocytes
inferred← citeshttps://doi.org/10.1006/mvre.2001.2338openalex-snapshot
VEGF Increases Permeability of the Endothelial Cell Monolayer by Activation of PKB/akt, Endothelial Nitric-Oxide Synthase, and MAP Kinase Pathways
inferred← citeshttps://doi.org/10.1006/scbi.2000.0364openalex-snapshot
Towards a mechanistic understanding of tumor invasion—lessons from theα 6 β 4integrin
inferred← citeshttps://doi.org/10.1007/0-387-23752-6_33openalex-snapshot
The Role of the Phosphoinositide Pathway in Hormonal Regulation of the Epithelial Sodium Channel
inferred← citeshttps://doi.org/10.1007/0-387-26015-3_8openalex-snapshot
Organization of Signal Complexes by Lipids, Calcium, and Cyclic AMP
inferred← citeshttps://doi.org/10.1007/0-387-27600-9_1openalex-snapshot
Structure and Nomenclature of Inositol Phosphates, Phosphoinositides, and Glycosylphosphatidylinositols
inferred← citeshttps://doi.org/10.1007/3-540-65362-7_5openalex-snapshot
The insulin receptor and metabolic signaling
inferred← citeshttps://doi.org/10.1007/5584_2018_288openalex-snapshot
Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins
inferred← citeshttps://doi.org/10.1007/978-0-387-09568-4_2openalex-snapshot
Mouse Models of Intestinal Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-1513-9_9openalex-snapshot
Targeting the PI3K/Akt/mTOR Pathway in AIDS-Associated Malignancies
inferred← citeshttps://doi.org/10.1007/978-1-4419-9034-1_5openalex-snapshot
Cholestasis: An Intracellular “Traffic Jam”
inferred← citeshttps://doi.org/10.1007/978-1-4612-2154-8_15openalex-snapshot
Phosphoinositide-Derived Second Messengers in FcεRI Signaling: PI-3 Kinase Products Control Membrane Topography and the Translocation and Activation of PLC-γ1 in Antigen-Stimulated Mast Cells
inferred← citeshttps://doi.org/10.1007/978-1-4614-7512-5_9openalex-snapshot
Chemoattractant Receptor-G-Protein Coupling
inferred← citeshttps://doi.org/10.1007/978-1-4615-0193-0_76openalex-snapshot
The P21-Activated Protein Kinases (Paks) Receive And Integrate Messages From A Variety of Signaling Pathways
inferred← citeshttps://doi.org/10.1007/978-1-4615-4423-4_16openalex-snapshot
Stimulation of Mitogen-Activated Protein Kinases ERK-1 and ERK-2 by H2O2 in Vascular Smooth Muscle Cells
inferred← citeshttps://doi.org/10.1007/978-1-4615-4793-8_56openalex-snapshot
Functions of the P21-Activated Protein Kinases (Paks) in Neutrophils and their Regulation by Complex Lipids
inferred← citeshttps://doi.org/10.1007/978-1-4615-5647-3_14openalex-snapshot
Potential mechanism (S) involved in the regulation of glycogen synthesis by insulin
inferred← citeshttps://doi.org/10.1007/978-1-59259-298-2_6openalex-snapshot
Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation
inferred← citeshttps://doi.org/10.1007/978-1-59259-319-4_7openalex-snapshot
Life and Death Signaling Pathways in CVB3-Induced Myocarditis
inferred← citeshttps://doi.org/10.1007/978-1-59259-768-0_4openalex-snapshot
Modeling Human Colorectal Cancer in Mice for Chemoprevention Studies
inferred← citeshttps://doi.org/10.1007/978-1-59259-909-7_2openalex-snapshot
Tumor Necrosis Factor-α/Receptor Signaling Through the Akt Kinase
inferred← citeshttps://doi.org/10.1007/978-1-60327-538-5_2openalex-snapshot
Cell Membrane Receptors and Phospholipids
inferred← citeshttps://doi.org/10.1007/978-1-60761-543-9_7openalex-snapshot
Regulation and Function of Protein Kinase D Signaling
inferred← citeshttps://doi.org/10.1007/978-3-030-94004-1_7openalex-snapshot
Roles for 3’ Phosphoinositides in Macropinocytosis
inferred← citeshttps://doi.org/10.1007/978-3-0348-8225-5_1openalex-snapshot
A tale of protein kinase C and membrane lipid signaling
inferred← citeshttps://doi.org/10.1007/978-3-319-42118-6_3openalex-snapshot
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
inferred← citeshttps://doi.org/10.1007/978-3-540-28266-2_39openalex-snapshot
Mechanisms of Apoptosis Resistance In Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-3-540-33823-9_13openalex-snapshot
Protein Kinases as Potential Targets for the Treatment of Pathological Pain
inferred← citeshttps://doi.org/10.1007/978-3-540-34891-7_25openalex-snapshot
TRP Channels in Platelet Function
inferred← citeshttps://doi.org/10.1007/978-3-642-57066-7_2openalex-snapshot
The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins
inferred← citeshttps://doi.org/10.1007/978-3-642-57066-7_3openalex-snapshot
Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus
inferred← citeshttps://doi.org/10.1007/978-3-642-57066-7_7openalex-snapshot
Positive and Negative Signaling in B Lymphocytes
inferred← citeshttps://doi.org/10.1007/978-3-642-57282-1_2openalex-snapshot
Normal Cell Structure and Function
inferred← citeshttps://doi.org/10.1007/978-4-431-67897-7_50openalex-snapshot
No Differences Between Bipolar Patients and Normal Controls in Inositol Levels and Inositol Monophosphatase Activity in Postmortem Brain
inferred← citeshttps://doi.org/10.1007/978-94-007-3015-1_6openalex-snapshot
Phosphatidylinositol 4, 5 Bisphosphate and the Actin Cytoskeleton
inferred← citeshttps://doi.org/10.1007/978-94-007-6331-9_4openalex-snapshot
Phosphoinositides and PDZ Domain Scaffolds
inferred← citeshttps://doi.org/10.1007/bf02981954openalex-snapshot
Structural and Functional Hot Spots in Cytokine Receptors
inferred← citeshttps://doi.org/10.1007/bf03402094openalex-snapshot
Betulinic Acid-induced Mcl-1 Expression in Human Melanoma — Mode of Action and Functional Significance
inferred← citeshttps://doi.org/10.1007/pl00000645openalex-snapshot
Ras proteins in the control of the cell cycle and cell differentiation
inferred← citeshttps://doi.org/10.1007/s00011-017-1033-7openalex-snapshot
The α-cyclodextrin complex of the Moringa isothiocyanate suppresses lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells through Akt and p38 inhibition
inferred← citeshttps://doi.org/10.1007/s000110050364openalex-snapshot
Specific signaling pathways in the regulation of TNF-α mRNA synthesis and TNF-α secretion in RBL-2H3 mast cells stimulated through the high affinity IgE receptor
inferred← citeshttps://doi.org/10.1007/s001099900037openalex-snapshot
A light, rather than a heavy solution for hard working hearts
inferred← citeshttps://doi.org/10.1007/s001099900044openalex-snapshot
Erratum to: Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo
inferred← citeshttps://doi.org/10.1007/s001099900050openalex-snapshot
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling
inferred← citeshttps://doi.org/10.1007/s00125-004-1602-5openalex-snapshot
C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells
inferred← citeshttps://doi.org/10.1007/s00210-007-0211-5openalex-snapshot
The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons
inferred← citeshttps://doi.org/10.1007/s00268-003-7258-3openalex-snapshot
Acute Respiratory Distress Syndrome in the Septic Surgical Patient
inferred← citeshttps://doi.org/10.1007/s00280-004-0974-zopenalex-snapshot
Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma
inferred← citeshttps://doi.org/10.1007/s002800051123openalex-snapshot
Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase
inferred← citeshttps://doi.org/10.1007/s00292-011-1559-3openalex-snapshot
Chronische Herzinsuffizienz
inferred← citeshttps://doi.org/10.1007/s00395-011-0199-3openalex-snapshot
Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways
inferred← citeshttps://doi.org/10.1007/s00424-007-0286-3openalex-snapshot
Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases
inferred← citeshttps://doi.org/10.1007/s004240100542openalex-snapshot
Protein kinase C and phosphatidylinositol 3-kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule
inferred← citeshttps://doi.org/10.1007/s00436-003-0955-xopenalex-snapshot
Involvement of signaling through protein kinase C and phosphatidylinositol 3-kinase in the excystation and metacystic development of Entamoeba invadens
inferred← citeshttps://doi.org/10.1007/s004360050539openalex-snapshot
Effects of fluorinated inositols on the phosphoinositide metabolism and the proliferation of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1007/s00705-008-0303-7openalex-snapshot
HSV immune complex (HSV-IgG: IC) and HSV-DNA elicit the production of angiogenic factor VEGF and MMP-9
inferred← citeshttps://doi.org/10.1007/s00705-016-2892-xopenalex-snapshot
Hepatitis C virus and its protein NS4B activate the cancer-related STAT3 pathway via the endoplasmic reticulum overload response
inferred← citeshttps://doi.org/10.1007/s00705-016-2908-6openalex-snapshot
Avian reovirus σA and σNS proteins activate the phosphatidylinositol 3-kinase-dependent Akt signalling pathway
inferred← citeshttps://doi.org/10.1007/s00774-005-0622-7openalex-snapshot
BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-κB activation
inferred← citeshttps://doi.org/10.1007/s00795-019-00226-5openalex-snapshot
Multiplex PCR analysis of apocrine lesions shows frequent PI3K–AKT pathway mutations in both benign and malignant apocrine breast tumors
inferred← citeshttps://doi.org/10.1007/s10456-009-9153-5openalex-snapshot
RETRACTED ARTICLE: PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation
inferred← citeshttps://doi.org/10.1007/s10456-011-9224-2openalex-snapshot
Retraction Note: PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation
inferred← citeshttps://doi.org/10.1007/s10495-013-0802-1openalex-snapshot
MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3K p110δ)
inferred← citeshttps://doi.org/10.1007/s10637-014-0152-zopenalex-snapshot
In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA
inferred← citeshttps://doi.org/10.1007/s10725-005-1434-4openalex-snapshot
Phosphatidylinositol 3-phosphate is required for abscisic acid-induced hydrogen peroxide production in rice leaves
inferred← citeshttps://doi.org/10.1007/s11010-007-9519-1openalex-snapshot
Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate β1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis
inferred← citeshttps://doi.org/10.1007/s11030-025-11138-1openalex-snapshot
Understanding the conformational dynamics of PI3Kα due to helical domain mutations: insights from Markov state model analysis
inferred← citeshttps://doi.org/10.1007/s11046-011-9456-0openalex-snapshot
Protein Profiling of the Dimorphic Pathogenic Fungus, Sporothrix schenckii
inferred← citeshttps://doi.org/10.1007/s11060-014-1606-zopenalex-snapshot
Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas
inferred← citeshttps://doi.org/10.1007/s11064-005-8804-1openalex-snapshot
p42IP4/Centaurin α1, a Brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding Protein: Membrane Trafficking Induced by Epidermal Growth Factor is Inhibited by Stimulation of Phospholipase C-coupled Thrombin Receptor
inferred← citeshttps://doi.org/10.1007/s11302-006-9021-3openalex-snapshot
Signal transduction events induced by extracellular guanosine 5′triphosphate in excitable cells
inferred← citeshttps://doi.org/10.1007/s11373-005-9016-zopenalex-snapshot
PI3-kinase is essential for ADP-stimulated integrin αIIbβ3-mediated platelet calcium oscillation, implications for P2Y receptor pathways in integrin αIIbβ3-initiated signaling cross-talks
inferred← citeshttps://doi.org/10.1007/s11468-025-02785-zopenalex-snapshot
SERS-Based Profiling of Cholesterol and Triglycerides in Blood Serum Samples of Lipid Metabolic Disorders Using PCA and PLSR
inferred← citeshttps://doi.org/10.1007/s11684-009-0067-9openalex-snapshot
Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells in vitro
inferred← citeshttps://doi.org/10.1007/s11696-026-04856-9openalex-snapshot
QSAR-based design and computational evaluation of thieno[2,3-d]pyrimidine derivatives as potential PI3Kα inhibitors
inferred← citeshttps://doi.org/10.1007/s12032-009-9408-4openalex-snapshot
Phosphorylated p27Kip1 on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro
inferred← citeshttps://doi.org/10.1007/s12154-009-0034-6openalex-snapshot
An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes?
inferred← citeshttps://doi.org/10.1016/b978-0-08-102723-3.00170-0openalex-snapshot
New Drugs for Airway Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00077-2openalex-snapshot
The PIKK Family of Protein Kinases
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00129-7openalex-snapshot
Historical Overview
inferred← citeshttps://doi.org/10.1016/b978-0-12-800093-9.00014-4openalex-snapshot
Animal Models of Diabetic Cardiomyopathy
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.98578-7openalex-snapshot
Phosphatidylinositol Turnover and Receptors
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.99848-9openalex-snapshot
OBSOLETE: Signaling in Cardiac Physiology and Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-809657-4.99848-xopenalex-snapshot
Signaling in Cardiac Physiology and Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-816435-8.00012-2openalex-snapshot
PI3K/AKT Inhibitors as Sensitizing Agents for Cancer Chemotherapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-823292-7.00008-5openalex-snapshot
Selected molecular mechanisms of metal toxicity and carcinogenicity
inferred← citeshttps://doi.org/10.1016/b978-0-444-59453-2.00009-3openalex-snapshot
Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity
inferred← citeshttps://doi.org/10.1016/b978-012088561-9/50002-8openalex-snapshot
A SURVEY OF NOVEL MOLECULAR TARGETS FOR ANTICANCER DRUG DISCOVERY
inferred← citeshttps://doi.org/10.1016/b978-012124546-7/50454-xopenalex-snapshot
The PIKK Family of Protein Kinases
inferred← citeshttps://doi.org/10.1016/b978-012124546-7/50504-0openalex-snapshot
Historical Overview: Protein Kinase C, Phorbol Ester, and Lipid Mediators
inferred← citeshttps://doi.org/10.1016/b978-012304220-0/50017-0openalex-snapshot
Listeria monocytogenes
inferred← citeshttps://doi.org/10.1016/b978-012369413-3/50060-4openalex-snapshot
Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity
inferred← citeshttps://doi.org/10.1016/b978-012492543-4/50014-3openalex-snapshot
The Regulation of Enzymatic Activity and Metabolism
inferred← citeshttps://doi.org/10.1016/b978-1-4160-5583-9.00004-6openalex-snapshot
Insulin and Growth Factor Signaling Pathways
inferred← citeshttps://doi.org/10.1016/j.advenzreg.2003.11.015openalex-snapshot
Phosphoinositide 3-kinase γ mediates Jun kinase activation via its lipid-kinase activity
inferred← citeshttps://doi.org/10.1016/j.advenzreg.2007.11.015openalex-snapshot
Novel activation mechanism and physiological function of PIP5Kγ661
inferred← citeshttps://doi.org/10.1016/j.advenzreg.2009.10.016openalex-snapshot
Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells
inferred← citeshttps://doi.org/10.1016/j.amjoto.2014.11.002openalex-snapshot
Comprehensive network analysis of genes expressed in human oropharyngeal cancer
inferred← citeshttps://doi.org/10.1016/j.apsb.2016.07.006openalex-snapshot
Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbalip.2006.03.019openalex-snapshot
Live cell imaging of phosphoinositide dynamics with fluorescent protein domains
inferred← citeshttps://doi.org/10.1016/j.bbalip.2006.08.006openalex-snapshot
Lipid requirements for endocytosis in yeast
inferred← citeshttps://doi.org/10.1016/j.bbalip.2009.03.014openalex-snapshot
Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells
inferred← citeshttps://doi.org/10.1016/j.bbalip.2015.02.013openalex-snapshot
Polyphosphoinositide binding domains: Key to inositol lipid biology
inferred← citeshttps://doi.org/10.1016/j.bbalip.2025.159714openalex-snapshot
A retrospective on phosphatidylinositol transfer proteins (PITPs) – A fifty-year journey
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2004.09.028openalex-snapshot
Coupling actin and membrane dynamics during calcium-regulated exocytosis: a role for Rho and ARF GTPases
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.10.002openalex-snapshot
Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions
inferred← citeshttps://doi.org/10.1016/j.bbamem.2013.12.007openalex-snapshot
Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero- and sphingolipids in the kidney
inferred← citeshttps://doi.org/10.1016/j.bbcan.2007.10.003openalex-snapshot
FoxO tumor suppressors and BCR–ABL-induced leukemia: A matter of evasion of apoptosis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2012.04.008openalex-snapshot
The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
inferred← citeshttps://doi.org/10.1016/j.bbcan.2017.09.002openalex-snapshot
The roles of ubiquitin modifying enzymes in neoplastic disease
inferred← citeshttps://doi.org/10.1016/j.bbrc.2004.06.038openalex-snapshot
Inhibition of phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
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