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Putting the brakes on innate immunity: a regulatory role for CD200?
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/s1074-7613(00)00023-6openalex-snapshot
Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function
inferredcites →https://doi.org/10.1016/s1074-7613(00)80149-1openalex-snapshot
Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
inferredcites →https://doi.org/10.1016/s1286-4579(00)00294-xopenalex-snapshot
Human inhibitory and activating Ig-like receptors which modulate the function of myeloid cells
inferredcites →https://doi.org/10.1038/334260a0openalex-snapshot
Deactivation of macrophages by transforming growth factor-β
inferredcites →https://doi.org/10.1083/jcb.122.1.243openalex-snapshot
Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin)
inferredcites →https://doi.org/10.1126/science.282.5388.480openalex-snapshot
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
inferredcites →https://doi.org/10.1126/science.288.5473.2051openalex-snapshot
Role of CD47 as a Marker of Self on Red Blood Cells
inferredcites →https://doi.org/10.1126/science.290.5489.84openalex-snapshot
Immune Inhibitory Receptors
inferredcites →https://doi.org/10.1126/science.290.5497.1768openalex-snapshot
Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)
inferredcites →https://doi.org/10.1146/annurev.immunol.15.1.323openalex-snapshot
NITRIC OXIDE AND MACROPHAGE FUNCTION
inferredcites →https://doi.org/10.1172/jci113241openalex-snapshot
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4645518openalex-extracted
The Association Betwen Expression of Cd200 on B Lymphocytes and the Count of Eosinophils and Basophils in Atopic Dermatitis Patients with and Without Dupilumab Therapy – Pilot Study
inferred← citeshttps://doi.org/10.1002/eji.200425273openalex-snapshot
Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3‐kinase‐mediated intracellular signaling
inferred← citeshttps://doi.org/10.1002/eji.201847861openalex-snapshot
CD200R1 regulates eosinophilia during pulmonary fungal infection in mice
inferred← citeshttps://doi.org/10.1002/glia.10051openalex-snapshot
Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray
inferred← citeshttps://doi.org/10.1002/glia.20611openalex-snapshot
Myelin‐phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
inferred← citeshttps://doi.org/10.1002/jnr.23922openalex-snapshot
Reduction of CD200 expression in glioma cells enhances microglia activation and tumor growth
inferred← citeshttps://doi.org/10.1002/stem.2611openalex-snapshot
Mesenchymal Stem Cells Modulate Differentiation of Myeloid Progenitor Cells During Inflammation
inferred← citeshttps://doi.org/10.1007/978-1-4614-0809-3_18openalex-snapshot
Immunomodulatory Functions of Cancer Stem Cells
inferred← citeshttps://doi.org/10.1007/978-3-319-54090-0_13openalex-snapshot
Activation of Macrophages in Response to Biomaterials
inferred← citeshttps://doi.org/10.1007/s11481-007-9075-1openalex-snapshot
CD200–CD200R Regulation of Microglia Activation in the Pathogenesis of Parkinson’s Disease
inferred← citeshttps://doi.org/10.1007/s11825-017-0132-8openalex-snapshot
Mikroglia und Immuntherapien bei degenerativen Netzhauterkrankungen
inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.10.067openalex-snapshot
Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells
inferred← citeshttps://doi.org/10.1016/j.chom.2010.08.005openalex-snapshot
Immune Inhibitory Ligand CD200 Induction by TLRs and NLRs Limits Macrophage Activation to Protect the Host from Meningococcal Septicemia
inferred← citeshttps://doi.org/10.1016/j.cyto.2008.07.100openalex-snapshot
59 Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2011.01.032openalex-snapshot
Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK
inferred← citeshttps://doi.org/10.1016/j.imbio.2004.04.007openalex-snapshot
Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells
inferred← citeshttps://doi.org/10.1016/j.imlet.2012.04.017openalex-snapshot
Characterization and functionality of the CD200–CD200R system during mesenchymal stromal cell interactions with T-lymphocytes
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112023openalex-snapshot
The association between expression of CD200 on B lymphocytes and the count of eosinophils and basophils in atopic dermatitis patients with and without dupilumab therapy – Pilot study
inferred← citeshttps://doi.org/10.1016/j.it.2008.07.005openalex-snapshot
Cancer stem cells, CD200 and immunoevasion
inferred← citeshttps://doi.org/10.1016/j.jcyt.2014.10.001openalex-snapshot
Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells
inferred← citeshttps://doi.org/10.1016/j.jri.2015.05.005openalex-snapshot
The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks’ gestation
inferred← citeshttps://doi.org/10.1016/j.jri.2016.04.288openalex-snapshot
The importance of being a regulatory T cell in pregnancy
inferred← citeshttps://doi.org/10.1016/j.molimm.2005.04.014openalex-snapshot
Cloning and characterization of the human CD200 promoter region
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2018.05.006openalex-snapshot
Retinal microglia – A key player in healthy and diseased retina
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2014.11.004openalex-snapshot
Retinal microglia: Just bystander or target for therapy?
inferred← citeshttps://doi.org/10.1016/j.smim.2009.01.005openalex-snapshot
Immune homeostasis in the respiratory tract and its impact on heterologous infection
inferred← citeshttps://doi.org/10.1016/j.stem.2025.03.008openalex-snapshot
A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models
inferred← citeshttps://doi.org/10.1016/j.str.2013.03.008openalex-snapshot
Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution
inferred← citeshttps://doi.org/10.1016/s0002-9440(10)64444-6openalex-snapshot
Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis
inferred← citeshttps://doi.org/10.1016/s0165-4608(02)00737-9openalex-snapshot
Molecular profiles of invasive mucinous and ductal carcinomas of the breast
inferred← citeshttps://doi.org/10.1016/s1471-4906(01)01930-5openalex-snapshot
Siglecs, sialic acids and innate immunity
inferred← citeshttps://doi.org/10.1016/s1471-4906(02)02223-8openalex-snapshot
CD200 and membrane protein interactions in the control of myeloid cells
inferred← citeshttps://doi.org/10.1038/ni.1637openalex-snapshot
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
inferred← citeshttps://doi.org/10.1038/ni846openalex-snapshot
CTLA-4–Ig regulates tryptophan catabolism in vivo
inferred← citeshttps://doi.org/10.1038/s41467-019-10156-6openalex-snapshot
CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
inferred← citeshttps://doi.org/10.1038/s41551-023-01133-yopenalex-snapshot
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts
inferred← citeshttps://doi.org/10.1038/s41577-019-0200-1openalex-snapshot
Engineering universal cells that evade immune detection
inferred← citeshttps://doi.org/10.1042/bst0370811openalex-snapshot
The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia
inferred← citeshttps://doi.org/10.1046/j.0019-2805.2001.01241.xopenalex-snapshot
Siglecs in the immune system
inferred← citeshttps://doi.org/10.1074/jbc.m502041200openalex-snapshot
Siglec-5 (CD170) Can Mediate Inhibitory Signaling in the Absence of Immunoreceptor Tyrosine-based Inhibitory Motif Phosphorylation
inferred← citeshttps://doi.org/10.1080/02713680490503778openalex-snapshot
CD200 maintains microglial potential to migrate in adult human retinal explant model
inferred← citeshttps://doi.org/10.1080/14767058.2019.1572741openalex-snapshot
Decreased expression of CD200 and CD200R1 by human decidual tissues in spontaneous early abortion
inferred← citeshttps://doi.org/10.1084/jem.194.8.1123openalex-snapshot
Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1097/ijg.0000000000000200openalex-snapshot
Retinal Microglia in Glaucoma
inferred← citeshttps://doi.org/10.1101/716571openalex-snapshot
Induction of long-term allogeneic cell acceptance and formation of immune privileged tissue in immunocompetent hosts
inferred← citeshttps://doi.org/10.1111/aji.12665openalex-snapshot
Changes in expression of the CD 200 tolerance‐signaling molecule and its receptor ( CD 200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis
inferred← citeshttps://doi.org/10.1111/aji.13655openalex-snapshot
Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA
inferred← citeshttps://doi.org/10.1111/j.0022-202x.2004.23461.xopenalex-snapshot
Expression of CD200 on Epithelial Cells of the Murine Hair Follicle: A Role in Tissue-Specific Immune Tolerance?
inferred← citeshttps://doi.org/10.1111/j.1365-2567.2005.02161.xopenalex-snapshot
Multivalent recombinant proteins for probing functions of leucocyte surface proteins such as the CD200 receptor
inferred← citeshttps://doi.org/10.1128/jvi.79.10.6052-6067.2005openalex-snapshot
Myxoma Virus M141R Expresses a Viral CD200 (vOX-2) That Is Responsible for Down-Regulation of Macrophage and T-Cell Activation In Vivo
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-6506openalex-snapshot
A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis
inferred← citeshttps://doi.org/10.1182/blood-2003-09-3184openalex-snapshot
CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance
inferred← citeshttps://doi.org/10.1186/1742-2094-8-154openalex-snapshot
CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
inferred← citeshttps://doi.org/10.1189/jlb.0207114openalex-snapshot
Microglia activation in retinal degeneration
inferred← citeshttps://doi.org/10.1189/jlb.0705398openalex-snapshot
Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation
inferred← citeshttps://doi.org/10.12659/msm.913094openalex-snapshot
Role of CD200/CD200R Signaling Pathway in Regulation of CD4+T Cell Subsets During Thermal Ablation of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.2174/1381612826666200406083756openalex-snapshot
Cancer Stem Cells and Combination Therapies to Eradicate Them
inferred← citeshttps://doi.org/10.2217/17460794.1.4.471openalex-snapshot
Modulation of Immunity to Respiratory Viral Infection
inferred← citeshttps://doi.org/10.2353/ajpath.2007.070272openalex-snapshot
Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis
inferred← citeshttps://doi.org/10.3109/14767058.2013.785517openalex-snapshot
Amniotic fluid CD200 levels in pregnancies complicated by preterm prelabor rupture of the membranes
inferred← citeshttps://doi.org/10.3121/cmr.3.3.166openalex-snapshot
Immunoregulation of Dendritic Cells
inferred← citeshttps://doi.org/10.3389/bjbs.2023.11573openalex-snapshot
The Use of CD200 in the Differential Diagnosis of B-Cell Lymphoproliferative Disorders
inferred← citeshttps://doi.org/10.3389/fimmu.2022.825075openalex-snapshot
Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome
inferred← citeshttps://doi.org/10.3410/f.1000562.22304openalex-snapshot
Faculty Opinions recommendation of Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.
inferred← citeshttps://doi.org/10.4049/jimmunol.167.5.2547openalex-snapshot
Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-α: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation
inferred← citeshttps://doi.org/10.4049/jimmunol.170.9.4450openalex-snapshot
Decorin Reverses the Repressive Effect of Autocrine-Produced TGF-β on Mouse Macrophage Activation
inferred← citeshttps://doi.org/10.4049/jimmunol.171.6.3034openalex-snapshot
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200
inferred← citeshttps://doi.org/10.4049/jimmunol.172.10.5931openalex-snapshot
An Inhibitory Ig Superfamily Protein Expressed by Lymphocytes and APCs Is Also an Early Marker of Thymocyte Positive Selection
inferred← citeshttps://doi.org/10.4049/jimmunol.173.11.6786openalex-snapshot
Molecular Mechanisms of CD200 Inhibition of Mast Cell Activation
inferred← citeshttps://doi.org/10.4049/jimmunol.173.6.3748openalex-snapshot
Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement
inferred← citeshttps://doi.org/10.4049/jimmunol.175.4.2469openalex-snapshot
Recombinant CD200 Protein Does Not Bind Activating Proteins Closely Related to CD200 Receptor
inferred← citeshttps://doi.org/10.4049/jimmunol.175.7.4441openalex-snapshot
Down-Regulation of Basophil Function by Human CD200 and Human Herpesvirus-8 CD200
inferred← citeshttps://doi.org/10.4049/jimmunol.178.4.2141openalex-snapshot
NK3-Like NK Cells Are Involved in Protective Effect of Polyinosinic-Polycytidylic Acid on Type 1 Diabetes in Nonobese Diabetic Mice
inferred← citeshttps://doi.org/10.5772/32003openalex-snapshot
Analysis of the Impact of CD200 on Neurodegenerative Diseases
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