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Are isothiocyanates potential anti-cancer drugs?
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0010(20000515)80:7<967::aid-jsfa597>3.0.co;2-vopenalex-snapshot
The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods
inferredcites →https://doi.org/10.1002/biof.552210106openalex-snapshot
Benzyl isothiocyanate modifies expression of the G2/M arrest‐related genes
inferredcites →https://doi.org/10.1002/jcb.240590825openalex-snapshot
Chemoprevention by isothiocyanates
inferredcites →https://doi.org/10.1006/abio.2001.5030openalex-snapshot
High-Performance Liquid Chromatography-Based Determination of Total Isothiocyanate Levels in Human Plasma: Application to Studies with 2-Phenethyl Isothiocyanate
inferredcites →https://doi.org/10.1007/978-94-011-4221-2_5openalex-snapshot
Myrosinase: gene family evolution and herbivore defense in Brassicaceae
inferredcites →https://doi.org/10.1007/s11095-007-9370-9openalex-snapshot
Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression
inferredcites →https://doi.org/10.1007/s12272-001-2158-2openalex-snapshot
Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cells
inferredcites →https://doi.org/10.1016/0278-6915(88)90042-7openalex-snapshot
Chemical and biological properties of indole glucosinolates (glucobrassicins): A review
inferredcites →https://doi.org/10.1016/0278-6915(96)00124-xopenalex-snapshot
Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate
inferredcites →https://doi.org/10.1016/0304-3835(80)90060-9openalex-snapshot
Alterations in glycoproteins and lipids in azaserine-induced acinar cell carcinoma of rat pancreas
inferredcites →https://doi.org/10.1016/0304-3835(93)90018-5openalex-snapshot
Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats
inferredcites →https://doi.org/10.1016/0378-4347(87)80020-8openalex-snapshot
Determination of N-acetyl-S-(N-alkylthiocarbamoyl)-l-cysteine, a principal metabolite of alkyl isothiocyanates, in rat urine
inferredcites →https://doi.org/10.1016/j.ccr.2006.08.009openalex-snapshot
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
inferredcites →https://doi.org/10.1016/j.fct.2004.06.009openalex-snapshot
Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21
inferredcites →https://doi.org/10.1016/j.ygyno.2006.03.002openalex-snapshot
Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: Role of caspase and MAPK activation
inferredcites →https://doi.org/10.1016/s0006-2952(00)00319-1openalex-snapshot
Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro
inferredcites →https://doi.org/10.1016/s0006-2952(00)00526-8openalex-snapshot
Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro11Abbreviations: BSO, l-buthionine sulphoximine; DNP-SG, S-2,4-dinitrophenylglutathione; DTT, dithiothreitol; GST, glutathione S-transferase; HL60,…
inferredcites →https://doi.org/10.1016/s0009-2797(96)03745-3openalex-snapshot
A review of mechanisms underlying anticarcinogenicity by brassica vegetables
inferredcites →https://doi.org/10.1016/s0304-3835(00)00619-4openalex-snapshot
Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate
inferredcites →https://doi.org/10.1016/s0304-3835(96)04556-9openalex-snapshot
Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate
inferredcites →https://doi.org/10.1021/np800233qopenalex-snapshot
Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo
inferredcites →https://doi.org/10.1023/a:1006380021658openalex-snapshot
Myrosinase: gene family evolution and herbivore defense in Brassicaceae
inferredcites →https://doi.org/10.1042/bst0240806openalex-snapshot
Chemoprotection against cancer by isothiocyanates and glucosinolates
inferredcites →https://doi.org/10.1054/bjoc.2000.1636openalex-snapshot
Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK
inferredcites →https://doi.org/10.1080/10408398209527361openalex-snapshot
Glucosinolates and their breakdown products in food and food plants
inferredcites →https://doi.org/10.1093/carcin/10.9.1757openalex-snapshot
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates
inferredcites →https://doi.org/10.1093/carcin/14.6.1167openalex-snapshot
Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice
inferredcites →https://doi.org/10.1093/carcin/16.10.2423openalex-snapshot
Altered expression of cyclins and c-fos in R6 cells that overproduce PKCε
inferredcites →https://doi.org/10.1093/carcin/17.11.2423openalex-snapshot
Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study
inferredcites →https://doi.org/10.1093/carcin/23.7.1155openalex-snapshot
Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions
inferredcites →https://doi.org/10.1093/carcin/23.9.1433openalex-snapshot
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
inferredcites →https://doi.org/10.1093/carcin/24.3.517openalex-snapshot
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats
inferredcites →https://doi.org/10.1093/carcin/8.12.1971openalex-snapshot
Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice
inferredcites →https://doi.org/10.1093/carcin/bgg023openalex-snapshot
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis
inferredcites →https://doi.org/10.1093/carcin/bgg092openalex-snapshot
The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells
inferredcites →https://doi.org/10.1093/carcin/bgi251openalex-snapshot
ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells
inferredcites →https://doi.org/10.1093/jn/136.11.2728openalex-snapshot
Benzyl Isothiocyanate-Induced DNA Damage Causes G2/M Cell Cycle Arrest and Apoptosis in Human Pancreatic Cancer Cells
inferredcites →https://doi.org/10.1093/jnci/58.2.395openalex-snapshot
Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds2
inferredcites →https://doi.org/10.1097/00001813-199304000-00021openalex-snapshot
Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase
inferredcites →https://doi.org/10.1111/j.1753-4887.2008.00065.xopenalex-snapshot
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1326openalex-snapshot
A Novel Mechanism of Chemoprotection by Sulforaphane
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3645openalex-snapshot
Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0340openalex-snapshot
The Role of Protein Binding in Induction of Apoptosis by Phenethyl Isothiocyanate and Sulforaphane in Human Non–Small Lung Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0392openalex-snapshot
Phenethyl Isothiocyanate, a Cancer Chemopreventive Constituent of Cruciferous Vegetables, Inhibits Cap-Dependent Translation by Regulating the Level and Phosphorylation of 4E-BP1
inferredcites →https://doi.org/10.1158/1055-9965.epi-08-0710openalex-snapshot
Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review
inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0494openalex-snapshot
Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines
inferredcites →https://doi.org/10.1177/153537020422900817openalex-snapshot
Dietary Organic Isothiocyanates are Cytotoxic in Human Breast Cancer MCF-7 and Mammary Epithelial MCF-12A Cell Lines
inferredcites →https://doi.org/10.1182/blood-2008-04-149815openalex-snapshot
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
inferredcites →https://doi.org/10.1289/ehp.97105s4955openalex-snapshot
Approaches to Chemoprevention of Lung Cancer Based on Carcinogens in Tobacco Smoke
inferredcites →https://doi.org/10.2174/092986708783503168openalex-snapshot
Chemoprevention of Cancer by Isothiocyanates and Anthocyanins: Mechanisms of Action and Structure-Activity Relationship
inferredcites →https://doi.org/10.2174/138920008785821675openalex-snapshot
Interaction of the Isothiocyanate Sulforaphane with Drug Disposition and Metabolism: Pharmacological and Toxicological Implications
inferredcites →https://doi.org/10.3892/ijo.28.5.1287openalex-snapshot
Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells
inferredcites →https://doi.org/10.3892/or.18.5.1263openalex-snapshot
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non–small cell lung cancer cells via endoplasmic reticulum stress‐mediated degradation of Mcl‐1
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The Role of Cruciferous Vegetables and Isothiocyanates for Lung Cancer Prevention: Current Status, Challenges, and Future Research Directions
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PEITC Induces DNA Damage and Inhibits DNA Repair‐Associated Proteins in Human Retinoblastoma Cells In Vitro
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Exosomal miR16 induced by allyl isothiocyanate (AITC) inhibits tumor growth in cervical cancer via modulation of apoptotic and inflammatory pathways
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A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1
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Inhibition of crosstalk between Bcr-Abl and PKC signaling by PEITC, augments imatinib sensitivity in chronic myelogenous leukemia cells
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Evaporation of allyl isothiocyanate from clay minerals and organoclays
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Natural compounds and combination therapy in colorectal cancer treatment
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Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes
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Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells
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In vitro and in vivo biotransformation of glucosinolates from mashua (Tropaeolum tuberosum) by lactic acid bacteria
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Capparis spinosa L. as a potential source of nutrition and its health benefits in foods: A comprehensive review of its phytochemistry, bioactivities, safety, and application
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Protective effects of Sulforaphene on kidney damage and gut dysbiosis in high-fat diet plus streptozotocin-induced diabetic mice
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Human metabolic fate of glucosinolates from kailan-hybrid broccoli. Differences between raw and microwaved consumption
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Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K
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Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome
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Therapeutic potential of isothiocyanates by targeting the NRF2 pathway
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Exploring the spectral and nonlinear optical properties of phenyl isothiocyanate through density functional theory and molecular docking studies: A comprehensive analysis of a potent biologically active phytochemical
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Inhibition of DNA oxidative damage and antimutagenic activity by dichloromethane extract of Brassica rapa var. rapa L. seeds
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Nanoemulsion-based nanoplatform as a new PEITC nano - delivery system to pancreatic cancer cells
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Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells
inferred← citeshttps://doi.org/10.1016/j.jff.2018.11.004openalex-snapshot
Dietary natural products and lung cancer: Effects and mechanisms of action
inferred← citeshttps://doi.org/10.1016/j.jff.2020.104270openalex-snapshot
Glucosinolate-rich hydrolyzed extract from Moringa oleifera leaves decreased the production of TNF-α and IL-1β cytokines and induced ROS and apoptosis in human colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.matpr.2021.12.401openalex-snapshot
A comparative study of bacterial activity of allyl isothiocyanate, phenyl isothiocyanate, and 2- (4- hydroxy phenyl) ethyl isothiocyanate using density functional theory
inferred← citeshttps://doi.org/10.1016/j.maturitas.2016.08.004openalex-snapshot
Cancer chemoprevention by dietary phytochemicals: Epidemiological evidence
inferred← citeshttps://doi.org/10.1016/j.nut.2019.110563openalex-snapshot
Targeting hallmarks of cancer with a food-system–based approach
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107107openalex-snapshot
Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
inferred← citeshttps://doi.org/10.1016/j.phymed.2017.03.007openalex-snapshot
Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.poly.2024.117364openalex-snapshot
Structure characterization, DNA binding, molecular docking and antitumor activity of manganese isothiocyanate complex with neocuproine ligand
inferred← citeshttps://doi.org/10.1016/j.postharvbio.2023.112292openalex-snapshot
Optimal allyl isothiocyanate concentration on Botrytis cinerea during the postharvest storage of blackberries and mechanism of blackberry color changes at high concentration of allyl isothiocyanate
inferred← citeshttps://doi.org/10.1016/j.prmcm.2022.100123openalex-snapshot
Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective
inferred← citeshttps://doi.org/10.1016/j.reactfunctpolym.2024.106062openalex-snapshot
Synthesis and chemical recycling investigations of polythioureas
inferred← citeshttps://doi.org/10.1016/j.saa.2023.123408openalex-snapshot
Unravelling the molecular interactions of phenyl isothiocyanate and benzoyl isothiocyanate with human lysozyme: Biophysical and computational analyses
inferred← citeshttps://doi.org/10.1016/j.sciaf.2023.e01558openalex-snapshot
Traditional processing techniques impacted the bioactivities of selected local consumed foods
inferred← citeshttps://doi.org/10.1016/j.scienta.2018.02.061openalex-snapshot
Influence of blue/red vs. white LED light treatments on biomass, shoot morphology, and quality parameters of hydroponically grown kale
inferred← citeshttps://doi.org/10.1016/j.taap.2018.10.020openalex-snapshot
The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells
inferred← citeshttps://doi.org/10.1016/j.tetlet.2016.10.059openalex-snapshot
Synthesis of sterically hindered allyl thiocyanates: kinetic and DFT studies of their rearrangement
inferred← citeshttps://doi.org/10.1016/j.ultsonch.2016.08.026openalex-snapshot
Formulation and physiochemical study of α-tocopherol based oil in water nanoemulsion stabilized with non toxic, biodegradable surfactant: Sodium stearoyl lactate
inferred← citeshttps://doi.org/10.1017/s0007114511002315openalex-snapshot
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates
inferred← citeshttps://doi.org/10.1021/acs.jafc.7b03628openalex-snapshot
Enhancement Of Glucosinolate and Isothiocyanate Profiles in Brassicaceae Crops: Addressing Challenges in Breeding for Cultivation, Storage, and Consumer-Related Traits
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01698openalex-snapshot
Development of Isoselenocyanate Compounds’ Syntheses and Biological Applications
inferred← citeshttps://doi.org/10.1021/acschemneuro.6b00041openalex-snapshot
Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe
inferred← citeshttps://doi.org/10.1021/acschemneuro.7b00003openalex-snapshot
Human Cannabinoid Receptor 2 Ligand-Interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose
inferred← citeshttps://doi.org/10.1021/acsfoodscitech.3c00040openalex-snapshot
Brassicaceae Microgreens: Phytochemical Compositions, Influences of Growing Practices, Postharvest Technology, Health, and Food Applications
inferred← citeshttps://doi.org/10.1021/jf204193vopenalex-snapshot
Benzyl Isothiocyanate (BITC) Induces G2/M Phase Arrest and Apoptosis in Human Melanoma A375.S2 Cells through Reactive Oxygen Species (ROS) and both Mitochondria-Dependent and Death Receptor-Mediated Multiple Signaling Pathways
inferred← citeshttps://doi.org/10.1021/jf501096xopenalex-snapshot
Glucosinolates, Myrosinase Hydrolysis Products, and Flavonols Found in Rocket ( Eruca sativa and Diplotaxis tenuifolia )
inferred← citeshttps://doi.org/10.1038/aps.2016.146openalex-snapshot
Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmic reticulum stress-mediated mechanism
inferred← citeshttps://doi.org/10.1038/s41401-023-01178-4openalex-snapshot
Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
inferred← citeshttps://doi.org/10.1038/s41420-024-02225-7openalex-snapshot
Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis
inferred← citeshttps://doi.org/10.1038/s41467-023-39800-yopenalex-snapshot
The allotetraploid horseradish genome provides insights into subgenome diversification and formation of critical traits
inferred← citeshttps://doi.org/10.1038/srep10306openalex-snapshot
Pre-diagnostic cruciferous vegetables intake and lung cancer survival among Chinese women
inferred← citeshttps://doi.org/10.1038/srep10835openalex-snapshot
The radish genome and comprehensive gene expression profile of tuberous root formation and development
inferred← citeshttps://doi.org/10.1038/srep40569openalex-snapshot
Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
inferred← citeshttps://doi.org/10.1039/9781837674046-00161openalex-snapshot
Bioactive Organosulfides: Dietary Sources and Health Benefits
inferred← citeshttps://doi.org/10.1039/bk9781837675036-00173openalex-snapshot
Differential Biological Effects of a Single Natural Product Depending on the Site of Action
inferred← citeshttps://doi.org/10.1039/c1fo10114eopenalex-snapshot
Mechanisms of action of isothiocyanates in cancer chemoprevention: an update
inferred← citeshttps://doi.org/10.1039/c2fo30192jopenalex-snapshot
Characterisation of taste-active extracts from raw Brassica oleracea vegetables
inferred← citeshttps://doi.org/10.1039/c8fo01914bopenalex-snapshot
Synergistic chemopreventive effect of allyl isothiocyanate and sulforaphane on non-small cell lung carcinoma cells
inferred← citeshttps://doi.org/10.1039/c8ra08162jopenalex-snapshot
Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives
inferred← citeshttps://doi.org/10.1039/c9fd00087aopenalex-snapshot
Synthesis and characterisation of isothiocyanate functionalised silicon nanoparticles and their uptake in cultured colonic cells
inferred← citeshttps://doi.org/10.1039/c9nj00563copenalex-snapshot
Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria
inferred← citeshttps://doi.org/10.1074/jbc.m111.308049openalex-snapshot
Transthiocarbamoylation of Proteins by Thiolated Isothiocyanates
inferred← citeshttps://doi.org/10.1080/01635581.2013.767366openalex-snapshot
Targeting Heat Shock Proteins by Phenethyl Isothiocyanate Results in Cell-Cycle Arrest and Apoptosis of Human Breast Cancer Cells
inferred← citeshttps://doi.org/10.1080/01635581.2014.868912openalex-snapshot
Benzyl Isothiocyanate Inhibits HNSCC Cell Migration and Invasion, and Sensitizes HNSCC Cells to Cisplatin
inferred← citeshttps://doi.org/10.1080/07352689.2022.2158270openalex-snapshot
Selenium Exerts an Intriguing Alteration of Primary and Secondary Plant Metabolites: Advances, Challenges, and Prospects
inferred← citeshttps://doi.org/10.1080/10408398.2021.1971944openalex-snapshot
The retention and bioavailability of phytochemicals in the manufacturing of baked snacks
inferred← citeshttps://doi.org/10.1080/10408398.2023.2195493openalex-snapshot
Anticancer activity of broccoli, its organosulfur and polyphenolic compounds
inferred← citeshttps://doi.org/10.1080/1061186x.2025.2600679openalex-snapshot
Multi-pathway therapeutics in colorectal cancer: targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal
inferred← citeshttps://doi.org/10.1080/10942912.2022.2135531openalex-snapshot
Recent updates and perspectives of fermented healthy super food sauerkraut: a review
inferred← citeshttps://doi.org/10.1080/14786419.2017.1392953openalex-snapshot
Screening and identification of major phytochemical compounds in seeds, sprouts and leaves of Tuscan black kale Brassica oleracea (L.) ssp acephala (DC) var. sabellica L.
inferred← citeshttps://doi.org/10.1080/17415993.2024.2370528openalex-snapshot
Cyclization of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-dione with isothiocyanates: a simple one-pot synthesis of novel 4-oxo-2-phenyl-4 H -chromene-3-carbothioamides and 2-phenyl-3-(2-thioxo-2 H -1,3,5,4-thiadiazaphosphinin-6-yl)-4-oxo-4 H -chromenes
inferred← citeshttps://doi.org/10.1080/17415993.2026.2651242openalex-snapshot
Comprehensive review on the synthesis of isothiocyanates via desulfurization
inferred← citeshttps://doi.org/10.1080/17460441.2016.1245289openalex-snapshot
Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target
inferred← citeshttps://doi.org/10.1080/19476337.2025.2467410openalex-snapshot
The therapeutic potential of red radish microgreens in modulating inflammation and cancer pathways
inferred← citeshttps://doi.org/10.1089/jmf.2016.3869openalex-snapshot
Ethanol Extract of Brassica rapa ssp . pekinensis Suppresses Tumor Necrosis Factor- α -Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells
inferred← citeshttps://doi.org/10.1093/nutrit/nuae131openalex-snapshot
Unveiling the Effects of Cruciferous Vegetable Intake on Different Cancers: A Systematic Review and Dose–Response Meta-analysis
inferred← citeshttps://doi.org/10.1093/nutrit/nuaf009openalex-snapshot
Therapeutic Potential of Phytochemicals as Adjuvants in Head and Neck Cancer
inferred← citeshttps://doi.org/10.1104/pp.114.251892openalex-snapshot
Involvement of the Electrophilic Isothiocyanate Sulforaphane in Arabidopsis Local Defense Responses
inferred← citeshttps://doi.org/10.1111/cbdd.12826openalex-snapshot
Structure‐based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1
inferred← citeshttps://doi.org/10.1111/ijfs.16088openalex-snapshot
Impact of cold storage followed by drying of mashua tuber (Tropaeolum tuberosum) on the glucosinolate content and their transformation products
inferred← citeshttps://doi.org/10.1111/jipb.12705openalex-snapshot
Biotechnological approaches in glucosinolate production
inferred← citeshttps://doi.org/10.1128/aem.00478-18openalex-snapshot
Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria
inferred← citeshttps://doi.org/10.1155/2021/5516450openalex-snapshot
A Narrative Review on Therapeutic Potentials of Watercress in Human Disorders
inferred← citeshttps://doi.org/10.1155/bmri/5076755openalex-snapshot
Synthesis, Characterization, Antimicrobial Activity, Docking, and In Silico ADMET Analysis of Some New 2,3‐Dihydrobenzo[b][1,4]thiazepine Derivatives
inferred← citeshttps://doi.org/10.1177/1082013217741798openalex-snapshot
Quality characteristics of sauerkraut fermented by using a Lactobacillus paracasei starter culture grown in tofu whey
inferred← citeshttps://doi.org/10.1186/1471-2407-10-269openalex-snapshot
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1186/s12906-020-2856-2openalex-snapshot
Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
inferred← citeshttps://doi.org/10.1186/s13071-016-1616-0openalex-snapshot
Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections
inferred← citeshttps://doi.org/10.1208/s12248-014-9610-yopenalex-snapshot
Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
inferred← citeshttps://doi.org/10.1271/bbb.100840openalex-snapshot
Inhibition of Premature Death by Isothiocyanates through Immune Restoration in LP-BM5 Leukemia Retrovirus-Infected C57BL/6 Mice
inferred← citeshttps://doi.org/10.12998/wjcc.v10.i10.2990openalex-snapshot
Targeting metabolism: A potential strategy for hematological cancer therapy
inferred← citeshttps://doi.org/10.1371/journal.pone.0053240openalex-snapshot
The MAPK Pathway Signals Telomerase Modulation in Response to Isothiocyanate-Induced DNA Damage of Human Liver Cancer Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0083538openalex-snapshot
Fermented Wheat Powder Induces the Antioxidant and Detoxifying System in Primary Rat Hepatocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0093335openalex-snapshot
Pterostilbene-Isothiocyanate Conjugate Suppresses Growth of Prostate Cancer Cells Irrespective of Androgen Receptor Status
inferred← citeshttps://doi.org/10.1371/journal.pone.0105710openalex-snapshot
Chemo-Predictive Assay for Targeting Cancer Stem-Like Cells in Patients Affected by Brain Tumors
inferred← citeshttps://doi.org/10.1371/journal.pone.0132151openalex-snapshot
Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites
inferred← citeshttps://doi.org/10.14264/uql.2016.283openalex-snapshot
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
inferred← citeshttps://doi.org/10.14739/2409-2932.2021.1.226726openalex-snapshot
Substituted (сycloalkylcarbonylthioureido)aryl-(benzyl-)carboxylic(sulfonic) acids: synthesis, antimicrobial and growth-regulating activity
inferred← citeshttps://doi.org/10.1515/cmble-2015-0007openalex-snapshot
Antioxidant effect of a fermented powder of Lady Joy bean in primary rat hepatocytes
inferred← citeshttps://doi.org/10.1517/17425255.2013.843668openalex-snapshot
Exploring the effects of isothiocyanates on chemotherapeutic drugs
inferred← citeshttps://doi.org/10.1590/1809-6891v23e-73601eopenalex-snapshot
Application of natural antioxidants in animal reproduction
inferred← citeshttps://doi.org/10.1590/1809-6891v23e-73601popenalex-snapshot
Aplicação de antioxidantes naturais na reprodução animal
inferred← citeshttps://doi.org/10.17508/cjfst.2021.13.2.04openalex-snapshot
Comparison of gastrointestinal stability of isothiocyanates from Tropaeolum Majus L. Altum using in vitro and ex vivo digestion methods
inferred← citeshttps://doi.org/10.17681/hsp.396016openalex-snapshot
Sulforaphane, Potential Mechanism of Action and Its Relationship with Diseases
inferred← citeshttps://doi.org/10.18063/ijb.v9i2.671openalex-snapshot
Preparation and characterization of 3D-printed antibacterial hydrogel with benzyl isothiocyanate
inferred← citeshttps://doi.org/10.18174/500666openalex-snapshot
Investigation of possible hazards and benefits of use of 'Ashkulebya' (Maerua subcordata (Gilg) DeWolf) as famine and/or potential functional food
inferred← citeshttps://doi.org/10.18632/oncotarget.17261openalex-snapshot
Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry
inferred← citeshttps://doi.org/10.18632/oncotarget.19213openalex-snapshot
Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity
inferred← citeshttps://doi.org/10.18632/oncotarget.3026openalex-snapshot
Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation
inferred← citeshttps://doi.org/10.20517/2394-4722.2020.61openalex-snapshot
Perspective on dietary isothiocyanates in the prevention, development and treatment of cancer
inferred← citeshttps://doi.org/10.20944/preprints202404.0601.v1openalex-snapshot
The number of health-promoting substances that all edible vascular plantscontain compared to the species-specific number of health-promoting substances of five Wild Edible Plants (WEPs)
inferred← citeshttps://doi.org/10.21595/jme.2018.20186openalex-snapshot
A passive diffusion model of fluorescein derivatives in an in vitro human brain microvascular endothelial cell (HBMEC) monolayer
inferred← citeshttps://doi.org/10.2174/0118756298328213240904051112openalex-snapshot
Synthetic Methods and Pharmacological Potentials of Isothiocyanate Derivatives
inferred← citeshttps://doi.org/10.2174/0929867325666180629153141openalex-snapshot
Impact of Natural Dietary Agents on Multiple Myeloma Prevention and Treatment: Molecular Insights and Potential for Clinical Translation
inferred← citeshttps://doi.org/10.2174/1570178615666181011145219openalex-snapshot
NSCLC Structure-activity Relationship (SAR) Study of Diisothiocyanates for Antiproliferative Activity on A549 Human Non-small Cell Lung Carcinoma (NSCLC)
inferred← citeshttps://doi.org/10.2174/187152012803833035openalex-snapshot
Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
inferred← citeshttps://doi.org/10.2174/1871520619666190930122137openalex-snapshot
Synthesis,In VitroEvaluation, Molecular Docking and DFT Studies of Some Phenyl Isothiocyanates as Anticancer Agents
inferred← citeshttps://doi.org/10.2174/1871520622666220425133936openalex-snapshot
Promising Role of Phytochemicals in the Prevention and Treatment of Cancer
inferred← citeshttps://doi.org/10.2174/1871530320999200818134942openalex-snapshot
Cancer Microbiome; Opportunities and Challenges
inferred← citeshttps://doi.org/10.2174/1874091x01812010046openalex-snapshot
Protective and Restorative Effects of Nutrients and Phytochemicals
inferred← citeshttps://doi.org/10.21806/aamm.2016.13.05openalex-snapshot
Holistic Health and the Exodus
inferred← citeshttps://doi.org/10.22034/apjcp.2018.19.6.1439openalex-snapshot
Apoptosis as a Mechanism of the Cancer Chemopreventive Activity of Glucosinolates: a Review
inferred← citeshttps://doi.org/10.2298/zmspn2345023wopenalex-snapshot
Chemical composition of moringa oleifera and cruciferous plants and their anti-inflammatory properties
inferred← citeshttps://doi.org/10.26479/2022.0801.03openalex-snapshot
Preventive Phytochemicals of Cancer, as Speed Breakers in Inflammatory Signaling
inferred← citeshttps://doi.org/10.29313/bcsms.v3i1.6638openalex-snapshot
Pengembangan Obat Kanker dari Daun Kelor (Moringa Oleifera)
inferred← citeshttps://doi.org/10.31428/10317/3148openalex-snapshot
Innovative minimal processing of mini broccoli for keeping quality and safety and enhancing bioactive compounds
inferred← citeshttps://doi.org/10.31883/pjfns/143574openalex-snapshot
Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential
inferred← citeshttps://doi.org/10.3389/fmicb.2020.591802openalex-snapshot
Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates
inferred← citeshttps://doi.org/10.3389/fnut.2021.721733openalex-snapshot
A Critical Review on Phytochemical Profile and Biological Effects of Turnip (Brassica rapa L.)
inferred← citeshttps://doi.org/10.3389/fnut.2021.778031openalex-snapshot
Pre-diagnosis Cruciferous Vegetables and Isothiocyanates Intake and Ovarian Cancer Survival: A Prospective Cohort Study
inferred← citeshttps://doi.org/10.3389/fnut.2022.884086openalex-snapshot
Volatile Flavor Compounds of Pugionium cornutum (L.) Gaertn. Before and After Different Dehydration Treatments
inferred← citeshttps://doi.org/10.3389/fnut.2024.1386083openalex-snapshot
Dietary isothiocyanates and anticancer agents: exploring synergism for improved cancer management
inferred← citeshttps://doi.org/10.3389/fonc.2015.00167openalex-snapshot
ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis
inferred← citeshttps://doi.org/10.3389/fonc.2023.1089115openalex-snapshot
Sulforaphane: An emergent anti-cancer stem cell agent
inferred← citeshttps://doi.org/10.3389/fphar.2021.613458openalex-snapshot
Chemopreventive Effects of Dietary Isothiocyanates in Animal Models of Gastric Cancer and Synergistic Anticancer Effects With Cisplatin in Human Gastric Cancer Cells
inferred← citeshttps://doi.org/10.3389/fphar.2022.1080977openalex-snapshot
Development and optimization of nanoparticles loaded with erucin, a dietary isothiocyanate isolated from Eruca sativa: Antioxidant and antiproliferative activities in ehrlich-ascites carcinoma cell line
inferred← citeshttps://doi.org/10.3389/fsufs.2022.1006573openalex-snapshot
Additive-induced pH determines bacterial community composition and metabolome in traditional mustard seed fermented products
inferred← citeshttps://doi.org/10.3390/antiox10020284openalex-snapshot
An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells
inferred← citeshttps://doi.org/10.3390/antiox8040106openalex-snapshot
The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents
inferred← citeshttps://doi.org/10.3390/bioengineering9090470openalex-snapshot
Anticancer Activity, Mechanism, and Delivery of Allyl Isothiocyanate
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