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Classification of 5-HT1A receptor agonists and antagonists using GA-SVM method

https://doi.org/10.1038/aps.2011.112

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The 5-HT1A receptor and its ligands: structure and function

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1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), α1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics

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Structure–intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity

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Novel class of arylpiperazines containing N-acylated amino acids: Their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation

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Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors

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3,4-Dihydro-2H-benzoxazinones are 5-HT1A receptor antagonists with potent 5-HT reuptake inhibitory activity

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1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands

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Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs

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8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: Potent, selective, orally bioavailable 5-HT1 receptor ligands

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3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors

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6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors

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Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

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Synthesis and 5-HT1A, 5-HT2A receptor activity of new β-tetralonohydantoins

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Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity, Part 1

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Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: Part 2☆

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Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. part 3

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5-HT1A receptor function in major depressive disorder

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Important messages in the ‘post’: recent discoveries in 5-HT neurone feedback control

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Molecular, pharmacological and functional diversity of 5-HT receptors

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New 5-HT1A receptor agonists possessing 1,4-Benzoxazepine scaffold exhibit highly potent anti-ischemic effects

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QSAR Study on the Affinity of Some Arylpiperazines towards the 5-HT1A/α1-Adrenergic Receptor Using the E-State Index

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Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics

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Traditional topological indexes vs electronic, geometrical, and combined molecular descriptors in QSAR/QSPR research

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Quantum-Chemical Descriptors in QSAR/QSPR Studies

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A 3 dimensional model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogs of 8-hydroxy-2-(dipropylamino)tetralin

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New Arylpiperazine 5-HT1AReceptor Ligands Containing the Pyrimido[2,1-f]purine Fragment: Synthesis, in Vitro, and in Vivo Pharmacological Evaluation

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Indolebutylamines as Selective 5-HT1A Agonists

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Synthesis and in Vivo Validation of [ O -Methyl- 11 C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2 H -[1,2,4]triazine-3,5-dione: A Novel 5-HT 1A Receptor Agonist Positron Emission Tomography Ligand

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Synthesis and Biological Evaluation of Novel Compounds within a Class of 3-Aminochroman Derivatives with Dual 5-HT1AReceptor and Serotonin Transporter Affinity

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N-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands

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Discovery of Potent, Orally Bioavailable, Selective 5-HT1A/B/D Receptor Antagonists

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Synthesis of New Arylpiperazinylalkylthiobenzimidazole, Benzothiazole, or Benzoxazole Derivatives as Potent and Selective 5-HT1A Serotonin Receptor Ligands

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Discovery of Innovative Small Molecule Therapeutics

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Synthesis and Characterization of Environment-Sensitive Fluorescent Ligands for Human 5-HT1A Receptors with 1-Arylpiperazine Structure

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G-Protein Coupled Receptors: Models, Mutagenesis, and Drug Design

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Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

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Using support vector regression coupled with the genetic algorithm for predicting acute toxicity to the fathead minnow

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SUBTYPES OF SEROTONIN RECEPTORS AND ANXIOLYTIC DRUGS: MODEL SYSTEMS FOR THE STUDY OF 5-HT RECEPTORS

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Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties

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Subtypes of Receptors for Serotonin

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A method of comparing the areas under receiver operating characteristic curves derived from the same cases.

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Receiver-Operating Characteristic Analysis for Evaluating Diagnostic Tests and Predictive Models

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Acteoside protects endothelial cells against free radical-induced oxidative stress

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SAR Study of 1-Aryl-4-(phenylarylmethyl)piperazines as Ligands for Both Dopamine D2 and Serotonin 5-HT1A Receptors Showing Varying Degrees of (Ant)agonism. Selection of a Potential Atypical Antipsychotic

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Serotonin Receptor and Transporter Ligands - Current Status

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Arylpiperazine Derivatives Acting at 5-HT1A Receptors

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Derivatives as 5HT1A Receptor Ligands-Past and Present

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Pharmacophore Models for Metabotropic 5-HT Receptor Ligands

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