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Fructus phyllanthi tannin fraction induces apoptosis and inhibits migration and invasion of human lung squamous carcinoma cells in vitro via MAPK/MMP pathways

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mc.22148openalex-snapshot
CRKL promotes lung cancer cell invasion through ERK‐MMP9 pathway
inferredcites →https://doi.org/10.1007/s00018-012-1115-1openalex-snapshot
Tumor cell migration in complex microenvironments
inferredcites →https://doi.org/10.1016/j.canlet.2012.09.025openalex-snapshot
Why does cancer therapy lack effective anti-metastasis drugs?
inferredcites →https://doi.org/10.1023/a:1023781114568openalex-snapshot
Role of MAP kinase in tumor progression and invasion
inferredcites →https://doi.org/10.1038/sj.onc.1210421openalex-snapshot
MAP kinase signalling pathways in cancer
inferredcites →https://doi.org/10.1097/00001813-200504000-00007openalex-snapshot
Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn.
inferredcites →https://doi.org/10.1128/iai.71.3.1497-1504.2003openalex-snapshot
Shiga Toxin 1 Triggers a Ribotoxic Stress Response Leading to p38 and JNK Activation and Induction of Apoptosis in Intestinal Epithelial Cells
inferredcites →https://doi.org/10.1136/tc.2007.022582openalex-snapshot
Comparison of aspects of smoking among the four histological types of lung cancer
inferredcites →https://doi.org/10.1155/2012/378415openalex-snapshot
Ethanol Extracts of Fruiting Bodies of Antrodia cinnamomea Suppress CL1-5 Human Lung Adenocarcinoma Cells Migration by Inhibiting Matrix Metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt Signaling Pathways
inferredcites →https://doi.org/10.1158/0008-5472.can-12-1033openalex-snapshot
TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
inferredcites →https://doi.org/10.1186/1471-2407-9-100openalex-snapshot
Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis
inferredcites →https://doi.org/10.1186/s13020-020-00404-zopenalex-snapshot
Protective effects of Ginkgo Biloba Dropping Pills against liver ischemia/reperfusion injury in mice
inferredcites →https://doi.org/10.1254/jphs.08236fpopenalex-snapshot
Quercetin Glucuronide Inhibits Cell Migration and Proliferation by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1003190openalex-snapshot
Genome-Wide Association Study Identifies a Novel Susceptibility Locus at 12q23.1 for Lung Squamous Cell Carcinoma in Han Chinese
inferredcites →https://doi.org/10.1371/journal.pone.0027444openalex-snapshot
Grape Proanthocyanidins Induce Apoptosis by Loss of Mitochondrial Membrane Potential of Human Non-Small Cell Lung Cancer Cells In Vitro and In Vivo
inferredcites →https://doi.org/10.17306/j.afs.2014.3.7openalex-snapshot
The structure, occurrence and biological activity of ellagitannins: a general review
inferredcites →https://doi.org/10.18632/oncotarget.1998openalex-snapshot
CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d
inferredcites →https://doi.org/10.2174/092986712803414196openalex-snapshot
Targeting Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1): Structure-Based Design of MKP-1 Inhibitors and Upregulators
inferredcites →https://doi.org/10.3892/mmr.2012.760openalex-snapshot
P-selectin-mediated platelet activation promotes adhesion of non-small cell lung carcinoma cells on vascular endothelial cells under flow
inferredcites →https://doi.org/10.4268/cjcmm20140706openalex-snapshot
HPLC-fingerprint-based quality evaluation on a Tibetan medicine Phyllanthus emblica and its tannin parts
inferredcites →https://doi.org/10.7314/apjcp.2013.14.11.6863openalex-snapshot
Suppression of Human Fibrosarcoma Cell Metastasis by Phyllanthus emblica Extract in Vitro

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112799zenodo-depositor-declared
An overview on the role of plant-derived tannins for the treatment of lung cancer
inferred← citeshttps://doi.org/10.1007/978-981-15-2361-8_16openalex-snapshot
Phytochemicals in the Prevention and Cure of Cancers
inferred← citeshttps://doi.org/10.1007/s00044-019-02358-wopenalex-snapshot
Viridicatol and viridicatin isolated from a shark-gill-derived fungus Penicilliumpolonicum AP2T1 as MMP-2 and MMP-9 inhibitors in HT1080 cells by MAPKs signaling pathway and docking studies
inferred← citeshttps://doi.org/10.1007/s41999-019-00212-1openalex-snapshot
The effects of different meditation exercises on sleep quality in older people: a network meta-analysis
inferred← citeshttps://doi.org/10.1016/j.bcab.2019.01.008openalex-snapshot
A comprehensive review on Phyllanthus derived natural products as potential chemotherapeutic and immunomodulators for a wide range of human diseases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113623openalex-snapshot
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115896openalex-snapshot
Therapeutic effects of Ilicifolius acid a in murine ulcerative colitis
inferred← citeshttps://doi.org/10.1016/j.jep.2017.07.001openalex-snapshot
Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.jtcms.2018.11.006openalex-snapshot
Anti-cancer activity of an ethyl-acetate extract of the fruits of Terminalia bellerica (Gaertn.) Roxb. through an apoptotic signaling pathway in vitro
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.08.016openalex-snapshot
Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155219openalex-snapshot
Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156576openalex-snapshot
Metabolism profiles of tannins in Phyllanthus emblica L. and its immunotherapeutic potential against hepatocellular carcinoma by re-educating tumor microenvironment
inferred← citeshttps://doi.org/10.1021/acschembio.9b00338openalex-snapshot
Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential
inferred← citeshttps://doi.org/10.1038/aps.2015.33openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41416-022-02089-7openalex-snapshot
Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies
inferred← citeshttps://doi.org/10.1038/s41598-019-55666-xopenalex-snapshot
Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1080/10496475.2024.2384023openalex-snapshot
Chromosomal Characterization of Five Medicinally Significant Phyllanthus Species in Bangladesh by DNA Base-Specific Fluorochrome Banding Technique
inferred← citeshttps://doi.org/10.1155/2016/7584952openalex-snapshot
The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review
inferred← citeshttps://doi.org/10.1155/2016/9205379openalex-snapshot
Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco‐2 Cell Monolayers
inferred← citeshttps://doi.org/10.1155/2021/6623791openalex-snapshot
Phytochemical Analysis Using UPLC-MSn Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of Phyllanthus emblica L. Habitat in Nepal
inferred← citeshttps://doi.org/10.1189/jlb.3a1115-510rropenalex-snapshot
Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation
inferred← citeshttps://doi.org/10.1590/1980-5373-mr-2018-0433openalex-snapshot
Intumescent Coatings Based on Tannins for Fire Protection
inferred← citeshttps://doi.org/10.2147/ott.s130255openalex-snapshot
Over-expression of ARHGAP18 suppressed cell proliferation, migration, invasion, and tumor growth in gastric cancer by restraining over-activation of MAPK signaling pathways
inferred← citeshttps://doi.org/10.2174/0929867323666151127201829openalex-snapshot
Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities
inferred← citeshttps://doi.org/10.26599/fmh.2026.9420091openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fcell.2021.743652openalex-snapshot
Comprehensive Genomic Characterization Analysis Identifies an Oncogenic Pseudogene RP11-3543B.1 in Human Gastric Cancer
inferred← citeshttps://doi.org/10.3389/fphar.2020.00976openalex-snapshot
Traditional Tibetan Medicine in Cancer Therapy by Targeting Apoptosis Pathways
inferred← citeshttps://doi.org/10.3389/fphar.2024.1438634openalex-snapshot
Antioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells
inferred← citeshttps://doi.org/10.3390/ijms221910827openalex-snapshot
Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment
inferred← citeshttps://doi.org/10.3390/molecules28217399openalex-snapshot
Phyllanthi Tannin Loaded Solid Lipid Nanoparticles for Lung Cancer Therapy: Preparation, Characterization, Pharmacodynamics and Safety Evaluation
inferred← citeshttps://doi.org/10.3892/mmr.2016.6077openalex-snapshot
Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma
inferred← citeshttps://doi.org/10.4314/tjpr.v16i12.13openalex-snapshot
Thymol inhibits cell migration and invasion by downregulating the activation of PI3K/AKT and ERK pathways in human colon cancer cells
inferred← citeshttps://doi.org/10.7150/jca.101050openalex-snapshot
HIF-1α Mediated Regulation of Glioblastoma Malignant Phenotypes through CD47 Protein: Understanding Functions and Mechanisms
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miR-1293 acts as a tumor promotor in lung adenocarcinoma via targeting phosphoglucomutase 5
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