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A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods

https://doi.org/10.1038/aps.2017.55

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/med.21317openalex-snapshot

Harnessing Allostery: A Novel Approach to Drug Discovery

inferredcites →https://doi.org/10.1002/prot.20232openalex-snapshot

Is allostery an intrinsic property of all dynamic proteins?

inferredcites →https://doi.org/10.1006/abbi.1996.0036openalex-snapshot

Protein Kinase CK2: Biphasic Kinetics with Peptide Substrates

inferredcites →https://doi.org/10.1006/bbrc.1995.1024openalex-snapshot

Mapping the Residues of Protein Kinase CK2 Implicated in Substrate Recognition: Mutagenesis of Conserved Basic Residues in the α-Subunit

inferredcites →https://doi.org/10.1006/bbrc.1995.1354openalex-snapshot

Halogenated Benzimidazoles and Benzotriazoles as Selective Inhibitors of Protein Kinases CK-I and CK-II from Saccharomyces Cerevisiae and Other Sources

inferredcites →https://doi.org/10.1007/s00018-009-9151-1openalex-snapshot

Protein Kinase CK2 in Health and Disease

inferredcites →https://doi.org/10.1007/s00018-009-9154-yopenalex-snapshot

Protein Kinase CK2 in Health and Disease

inferredcites →https://doi.org/10.1007/s11010-011-0960-9openalex-snapshot

A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase

inferredcites →https://doi.org/10.1016/0014-5793(94)01190-7openalex-snapshot

Substrate recognition by casein kinase‐II: The role of histidine‐160

inferredcites →https://doi.org/10.1016/j.ajhg.2016.02.006openalex-snapshot

Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis

inferredcites →https://doi.org/10.1016/j.ajhg.2016.09.020openalex-snapshot

Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

inferredcites →https://doi.org/10.1016/j.bbapap.2007.08.017openalex-snapshot

Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

inferredcites →https://doi.org/10.1016/j.bbapap.2009.07.018openalex-snapshot

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

inferredcites →https://doi.org/10.1016/j.ccr.2013.03.021openalex-snapshot

Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions

inferredcites →https://doi.org/10.1016/j.ccr.2014.07.027openalex-snapshot

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

inferredcites →https://doi.org/10.1016/j.celrep.2013.03.027openalex-snapshot

The Protein Interaction Landscape of the Human CMGC Kinase Group

inferredcites →https://doi.org/10.1016/j.chembiol.2007.12.012openalex-snapshot

The CK2α/CK2β Interface of Human Protein Kinase CK2 Harbors a Binding Pocket for Small Molecules

inferredcites →https://doi.org/10.1016/j.drudis.2012.11.009openalex-snapshot

αC helix displacement as a general approach for allosteric modulation of protein kinases

inferredcites →https://doi.org/10.1016/j.febslet.2010.11.019openalex-snapshot

Structural basis of CX-4945 binding to human protein kinase CK2

inferredcites →https://doi.org/10.1016/j.jmb.2003.12.068openalex-snapshot

Allosteric Inhibition Through Core Disruption

inferredcites →https://doi.org/10.1016/j.jmb.2007.04.068openalex-snapshot

Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2α and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases

inferredcites →https://doi.org/10.1016/j.tips.2014.03.006openalex-snapshot

Unraveling structural mechanisms of allosteric drug action

inferredcites →https://doi.org/10.1016/s0026-895x(25)08527-xopenalex-snapshot

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis.

inferredcites →https://doi.org/10.1016/s0092-8674(04)00206-5openalex-snapshot

The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks

inferredcites →https://doi.org/10.1021/bi2008382openalex-snapshot

Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer

inferredcites →https://doi.org/10.1021/jm030827eopenalex-snapshot

Discovery of a Potent and Selective Protein Kinase CK2 Inhibitor by High-Throughput Docking

inferredcites →https://doi.org/10.1021/jm101251qopenalex-snapshot

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

inferredcites →https://doi.org/10.1038/nature13001openalex-snapshot

The ensemble nature of allostery

inferredcites →https://doi.org/10.1038/nchembio.208openalex-snapshot

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

inferredcites →https://doi.org/10.1038/sj.embor.7400115openalex-snapshot

Protein kinase CK2: a new view of an old molecular complex

inferredcites →https://doi.org/10.1038/sj.onc.1204411openalex-snapshot

Protein kinase CK2 in mammary gland tumorigenesis

inferredcites →https://doi.org/10.1042/bj20021469openalex-snapshot

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

inferredcites →https://doi.org/10.1073/pnas.1102376108openalex-snapshot

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

inferredcites →https://doi.org/10.1073/pnas.1209309109openalex-snapshot

Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites

inferredcites →https://doi.org/10.1073/pnas.1417811112openalex-snapshot

Discovery of multiple hidden allosteric sites by combining Markov state models and experiments

inferredcites →https://doi.org/10.1074/jbc.m001870200openalex-snapshot

The Allosteric Regulation of Pyruvate Kinase

inferredcites →https://doi.org/10.1074/jbc.m004257200openalex-snapshot

The Replacement of ATP by the Competitive Inhibitor Emodin Induces Conformational Modifications in the Catalytic Site of Protein Kinase CK2

inferredcites →https://doi.org/10.1074/mcp.m110.004390openalex-snapshot

Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

inferredcites →https://doi.org/10.1093/bioinformatics/btm404openalex-snapshot

Clustal W and Clustal X version 2.0

inferredcites →https://doi.org/10.1093/bioinformatics/btt399openalex-snapshot

Allosite: a method for predicting allosteric sites

inferredcites →https://doi.org/10.1093/nar/28.1.235openalex-snapshot

The Protein Data Bank

inferredcites →https://doi.org/10.1093/nar/gkt284openalex-snapshot

MCPath: Monte Carlo path generation approach to predict likely allosteric pathways and functional residues

inferredcites →https://doi.org/10.1093/nar/gkv902openalex-snapshot

ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

inferredcites →https://doi.org/10.1096/fj.02-0473revopenalex-snapshot

One‐thousand‐and‐one substrates of protein kinase CK2?

inferredcites →https://doi.org/10.1186/2050-6511-14-36openalex-snapshot

Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2

inferredcites →https://doi.org/10.1186/2050-6511-14-s1-o37openalex-snapshot

Nitric oxide regulated cyclic di-GMP signaling

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9780470027318.a9614openalex-snapshot

Methods Applied for the Allosteric Site Revelation

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Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration

inferred← citeshttps://doi.org/10.1002/minf.201800089openalex-snapshot

Structure‐based Discovery of Novel CK2α‐Binding Cyclic Peptides with Anti‐cancer Activity

inferred← citeshttps://doi.org/10.1002/wcms.1585openalex-snapshot

Along the allostery stream: Recent advances in computational methods for allosteric drug discovery

inferred← citeshttps://doi.org/10.1016/b978-0-323-96121-9.00004-8openalex-snapshot

Casein kinase (CK) inhibitors

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117675openalex-snapshot

Identification and characterization of broad-spectrum cathelicidin family antimicrobial peptides from the pygmy sperm whale Kogia breviceps

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Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.07.018openalex-snapshot

Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α

inferred← citeshttps://doi.org/10.1016/j.jare.2024.11.021openalex-snapshot

Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.10.004openalex-snapshot

Negative allosteric modulator of Group Ⅰ mGluRs: Recent advances and therapeutic perspective for neuropathic pain

inferred← citeshttps://doi.org/10.1021/acs.accounts.8b00570openalex-snapshot

Allosteric Methods and Their Applications: Facilitating the Discovery of Allosteric Drugs and the Investigation of Allosteric Mechanisms

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c03783openalex-snapshot

Probing Allosteric Kinase Modulators as Next Game-Changers in Fighting Neurodegeneration

inferred← citeshttps://doi.org/10.1021/acschembio.2c00626openalex-snapshot

Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin

inferred← citeshttps://doi.org/10.1021/acsomega.3c10478openalex-snapshot

Recent Advances in the Discovery of CK2 Inhibitors

inferred← citeshttps://doi.org/10.1080/07391102.2021.2024449openalex-snapshot

Lead optimization, pharmacophore development and scaffold design of protein kinase CK2 inhibitors as potential COVID-19 therapeutics

inferred← citeshttps://doi.org/10.1093/nar/gky374openalex-snapshot

AlloFinder: a strategy for allosteric modulator discovery and allosterome analyses

inferred← citeshttps://doi.org/10.1136/svn-2019-000323openalex-snapshot

Big data and artificial intelligence discover novel drugs targeting proteins without 3D structure and overcome the undruggable targets

inferred← citeshttps://doi.org/10.3389/fonc.2020.00893openalex-snapshot

Protein Kinase CK2 in Cancer Energetics

inferred← citeshttps://doi.org/10.3390/ijms19010111openalex-snapshot

Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies

inferred← citeshttps://doi.org/10.3390/molecules25010237openalex-snapshot

Identification and Biological Evaluation of CK2 Allosteric Fragments through Structure-Based Virtual Screening

inferred← citeshttps://doi.org/10.3390/molecules25040870openalex-snapshot

Recent Advances in the Discovery of CK2 Allosteric Inhibitors: From Traditional Screening to Structure-Based Design

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Serine/Threonine Protein Kinases as Attractive Targets for Anti-Cancer Drugs—An Innovative Approach to Ligand Tuning Using Combined Quantum Chemical Calculations, Molecular Docking, Molecular Dynamic Simulations, and Network-like Similarity Graphs

inferred← citeshttps://doi.org/10.3892/etm.2021.10359openalex-snapshot

Long non‑coding RNA B3GALT5‑AS1 contributes to the progression of gastric cancer via interacting with CSNK2A1

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