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Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/humu.9452openalex-snapshot
Somatic mutations ofGUCY2F,EPHA3, andNTRK3 in human cancers
inferredcites →https://doi.org/10.1006/meth.2001.1262openalex-snapshot
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
inferredcites →https://doi.org/10.1007/s00268-001-0243-9openalex-snapshot
Re‐study of Gastric Cancer: Analysis of Outcome
inferredcites →https://doi.org/10.1007/s00384-010-0903-zopenalex-snapshot
Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with β-catenin
inferredcites →https://doi.org/10.1007/s00535-006-1975-yopenalex-snapshot
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer
inferredcites →https://doi.org/10.1007/s00535-012-0549-4openalex-snapshot
Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival
inferredcites →https://doi.org/10.1007/s10555-006-7886-9openalex-snapshot
Matrix metalloproteinases and tumor metastasis
inferredcites →https://doi.org/10.1016/j.stem.2009.11.013openalex-snapshot
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
inferredcites →https://doi.org/10.1038/bjc.1996.374openalex-snapshot
Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma
inferredcites →https://doi.org/10.1038/nature06196openalex-snapshot
Identification of stem cells in small intestine and colon by marker gene Lgr5
inferredcites →https://doi.org/10.1038/nature10337openalex-snapshot
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
inferredcites →https://doi.org/10.1046/j.1365-2559.2001.01306.xopenalex-snapshot
Expression of MMP‐2 is associated with progression and lymph node metastasis of gastric carcinoma
inferredcites →https://doi.org/10.1053/j.gastro.2006.08.039openalex-snapshot
The Intestinal Wnt/TCF Signature
inferredcites →https://doi.org/10.1053/jhep.2003.50029openalex-snapshot
Overexpression of Orphan G–Protein-Coupled Receptor, Gpr49 , in Human Hepatocellular Carcinomas With β–Catenin Mutations
inferredcites →https://doi.org/10.1073/pnas.0805706105openalex-snapshot
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
inferredcites →https://doi.org/10.1093/hmg/ddn286openalex-snapshot
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice
inferredcites →https://doi.org/10.1101/sqb.2008.72.003openalex-snapshot
Very Long-term Self-renewal of Small Intestine, Colon, and Hair Follicles from Cycling Lgr5+ve Stem Cells
inferredcites →https://doi.org/10.1111/j.1349-7006.2010.01571.xopenalex-snapshot
Overexpression of leucine‐rich repeat‐containing G protein‐coupled receptor 5 in colorectal cancer
inferredcites →https://doi.org/10.1111/j.1442-2050.2009.00979.xopenalex-snapshot
Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma
inferredcites →https://doi.org/10.1159/000081726openalex-snapshot
Deregulation of Collagen Metabolism in Human Stomach Cancer
inferredcites →https://doi.org/10.1159/000139127openalex-snapshot
Clinical Significance of Insulin-Like Growth Factor Type 1 Receptor and Epidermal Growth Factor Receptor in Patients with Advanced Gastric Cancer
inferredcites →https://doi.org/10.1186/2045-824x-3-28openalex-snapshot
Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion
inferredcites →https://doi.org/10.1245/s10434-010-1373-9openalex-snapshot
Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum
inferredcites →https://doi.org/10.14670/hh-23.917openalex-snapshot
Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer.
inferredcites →https://doi.org/10.2353/ajpath.2008.071091openalex-snapshot
G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation
inferredcites →https://doi.org/10.3748/wjg.v12.i18.2941openalex-snapshot
Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma
inferredcites →https://doi.org/10.3748/wjg.v16.i13.1644openalex-snapshot
Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma
inferredcites →https://doi.org/10.3892/ijo.30.2.437openalex-snapshot
Expression of p-STAT3 in human gastric carcinoma: Significant correlation in tumour invasion and prognosis
inferredcites →https://doi.org/10.4161/cbt.5.4.2521openalex-snapshot
Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors
inferredcites →https://doi.org/10.5114/wo.2013.34618openalex-snapshot
Clinicopathological significance of platelet-derived growth factor B, platelet-derived growth factor recpertor-β, and E-cadherin expression in gastric carcinoma
inferredcites →https://doi.org/10.5812/ircmj.4032openalex-snapshot
Abnormal Expression of E-Cadherin in Gastric Adenocarcinoma, and Its Correlation With Tumor Histopathology and Helicobacter Pylori Infection
inferredcites →https://doi.org/10.6004/jnccn.2010.0033openalex-snapshot
Gastric Cancer: A Primer on the Epidemiology and Biology of the Disease and an Overview of the Medical Management of Advanced Disease
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4671653openalex-extracted
Diagnostic Gene and Immune Infiltration Analysis of Colorectal Cancer Based on Bioinformatics and Machine Learning
inferred← citeshttps://doi.org/10.1002/jcb.27867openalex-snapshot
RSPO2 enhances cell invasion and migration via the WNT/β‐catenin pathway in human gastric cancer
inferred← citeshttps://doi.org/10.1002/path.5186openalex-snapshot
LGR5 promotes tumorigenicity and invasion of glioblastoma stem‐like cells and is a potential therapeutic target for a subset of glioblastoma patients
inferred← citeshttps://doi.org/10.1007/s10120-015-0543-7openalex-snapshot
Prognostic significance of leucine-rich-repeat-containing G-protein-coupled receptor 5, an intestinal stem cell marker, in gastric carcinomas
inferred← citeshttps://doi.org/10.1007/s10120-017-0748-zopenalex-snapshot
Toward early detection of Helicobacter pylori-associated gastric cancer
inferred← citeshttps://doi.org/10.1007/s12015-024-10747-xopenalex-snapshot
Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
inferred← citeshttps://doi.org/10.1007/s13277-015-4346-6openalex-snapshot
MicroRNAs as biomarkers and prospective therapeutic targets in colon and pancreatic cancers
inferred← citeshttps://doi.org/10.1016/b978-0-323-85563-1.00014-9openalex-snapshot
Stomach corpus stem cells in homeostasis, tissue repair, and cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.09.163openalex-snapshot
FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.09.073openalex-snapshot
Identification and validation of LGR5-binding peptide for molecular imaging of gastric cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117486openalex-snapshot
Application of hydrogels for targeting cancer stem cells in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.clinre.2015.07.009openalex-snapshot
The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.10.006openalex-snapshot
Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108315openalex-snapshot
Refining the Correa cascade: Gastric stem cell plasticity, niche remodelling, and parallel pathways to neoplasia
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00275openalex-snapshot
Evaluation of Anti-LGR5 Antibodies by ImmunoPET for Imaging Colorectal Tumors and Development of Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00259openalex-snapshot
Development of Fluorogenic Substrates of α- l -Fucosidase Useful for Inhibitor Screening and Gene-expression Profiling
inferred← citeshttps://doi.org/10.1021/acsnano.5c02321openalex-snapshot
Advances in Nanomedicine for Targeting Cancer Stem Cells and Overcoming Therapeutic Resistance
inferred← citeshttps://doi.org/10.1038/cr.2016.47openalex-snapshot
Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice
inferred← citeshttps://doi.org/10.1038/onc.2015.129openalex-snapshot
Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling
inferred← citeshttps://doi.org/10.1038/srep08654openalex-snapshot
Characterization of LGR5 stem cells in colorectal adenomas and carcinomas
inferred← citeshttps://doi.org/10.1053/j.gastro.2015.09.004openalex-snapshot
Pathobiology of Helicobacter pylori–Induced Gastric Cancer
inferred← citeshttps://doi.org/10.1053/j.gastro.2020.10.047openalex-snapshot
Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer
inferred← citeshttps://doi.org/10.1080/14796694.2025.2577629openalex-snapshot
Vasculogenic mimicry in human cancers associated with chronic high-risk human papillomavirus infection
inferred← citeshttps://doi.org/10.1101/604850openalex-snapshot
Dynamic changes in the urine proteome in two ovarian cancer rat models
inferred← citeshttps://doi.org/10.1111/pin.12451openalex-snapshot
Distribution of Lgr5‐positive cancer cells in intramucosal gastric signet‐ring cell carcinoma
inferred← citeshttps://doi.org/10.1136/jim-2018-000934openalex-snapshot
Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis
inferred← citeshttps://doi.org/10.1142/s0192415x18500593openalex-snapshot
Effects of Celastrus orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions
inferred← citeshttps://doi.org/10.1155/2019/8154926openalex-snapshot
Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively Treated Gastric Carcinomas and Correlation with Therapy Response
inferred← citeshttps://doi.org/10.1155/2023/6675265openalex-snapshot
miR-21 Targets ASPP2 to Inhibit Apoptosis via CHOP-Mediated Signaling in Helicobacter pylori-Infected Gastric Cancer Cells
inferred← citeshttps://doi.org/10.1158/0008-5472.can-17-2581openalex-snapshot
Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-16-0114openalex-snapshot
LGR5-Targeted Antibody–Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-16-0472openalex-snapshot
Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1
inferred← citeshttps://doi.org/10.1177/1758835918794628openalex-snapshot
Towards precision medicine: linking genetic and cellular heterogeneity in gastric cancer
inferred← citeshttps://doi.org/10.1186/s12885-021-07913-6openalex-snapshot
LGR5 expression is associated with prognosis in poorly differentiated gastric adenocarcinoma
inferred← citeshttps://doi.org/10.1186/s12935-021-01840-zopenalex-snapshot
Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1186/s12967-025-06851-2openalex-snapshot
G protein-coupled receptors: pivotal hubs in gastric cancer malignancy—from multidimensional crosstalk to precision therapeutics
inferred← citeshttps://doi.org/10.1186/s13046-018-0864-6openalex-snapshot
LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients
inferred← citeshttps://doi.org/10.1186/s13287-017-0548-8openalex-snapshot
Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-β/catenin signaling pathway
inferred← citeshttps://doi.org/10.1293/tox.2018-0062openalex-snapshot
Evaluation of a biomarker for the diagnosis of pancreas cancer using an animal model
inferred← citeshttps://doi.org/10.18632/oncotarget.11384openalex-snapshot
Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study
inferred← citeshttps://doi.org/10.21037/atm-20-3986openalex-snapshot
Which is the optimal management for locally advanced gastric cancer patients with TRG 0 and 1 after R0 resection?
inferred← citeshttps://doi.org/10.2147/ott.s528050openalex-snapshot
Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis
inferred← citeshttps://doi.org/10.22074/cellj.2023.2010157.1396openalex-snapshot
Clinical Implications and Prognostic Value of Leucine-Rich G Protein-Coupled Receptor 5 Expression as A Cancer Stem Cell Marker in Malignancies: A Systematic Review and Meta-Analysis.
inferred← citeshttps://doi.org/10.2217/fon.15.27openalex-snapshot
Lgr5 Expression, Cancer Stem Cells and Pancreatic Cancer: Results from Biological and Computational Analyses
inferred← citeshttps://doi.org/10.29252/ibj.23.2.107openalex-snapshot
Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend
inferred← citeshttps://doi.org/10.3233/cbm-170383openalex-snapshot
Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas
inferred← citeshttps://doi.org/10.3389/fcimb.2018.00109openalex-snapshot
Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01741openalex-snapshot
Regulatory T Cells Promote Overexpression of Lgr5 on Gastric Cancer Cells via TGF-beta1 and Confer Poor Prognosis in Gastric Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01280openalex-snapshot
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
inferred← citeshttps://doi.org/10.3389/fonc.2021.701291openalex-snapshot
Targeting Glioblastoma Stem Cells: A Review on Biomarkers, Signal Pathways and Targeted Therapy
inferred← citeshttps://doi.org/10.3390/jpm12060929openalex-snapshot
Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer
inferred← citeshttps://doi.org/10.3748/wjg.v26.i43.6853openalex-snapshot
Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage II/III colorectal cancer: Cancer progression and prognosis
inferred← citeshttps://doi.org/10.3892/ol.2017.7207openalex-snapshot
Leucine‑rich repeat‑containing G protein‑coupled receptor 5 and CD133 expression is associated with tumor progression and resistance to preoperative chemoradiotherapy in low rectal cancer
inferred← citeshttps://doi.org/10.3892/ol.2020.11883openalex-snapshot
Functional roles of E3 ubiquitin ligases in gastric cancer (Review)
inferred← citeshttps://doi.org/10.4103/0366-6999.151114openalex-snapshot
G-protein Coupled Receptor 34 Knockdown Impairs the Proliferation and Migration of HGC-27 Gastric Cancer Cells In Vitro
inferred← citeshttps://doi.org/10.4103/mj.mj_5_23openalex-snapshot
Analysis of Correlation between the Important Helicobacter pylori Virulence Genes (CagA, SabA and Oip) and Gastric Epithelial Stem Cells (LGR5) in Patients with Gastric Disease
inferred← citeshttps://doi.org/10.4149/neo_2021_200714n726openalex-snapshot
The clinical and prognostic significance of LGR5 in GC: A meta-analysis of IHC assay and bioinformatics analysis
inferred← citeshttps://doi.org/10.5152/tjg.2021.20108openalex-snapshot
Co-Expression of LGR5 and CD133 Cancer Stem Cell Predicts a Poor Prognosis in Patients With Gastric Cancer
inferred← citeshttps://doi.org/10.5772/intechopen.69776openalex-snapshot
Impact of Stem Cell Genes in Gastric Cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.14131202openalex-snapshot
Additional file 1 of Clinical and prognostic significances of cancer stem cell markers in gastric cancer patients: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.63201/67mv-av4nopenalex-snapshot
Relationship of dietary knowledge and dietary practices of breast cancer prevention
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Comparison of metastatic castration-resistant prostate cancer in bone with other sites: clinical characteristics, molecular features and immune status
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