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Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1098-1128(200103)21:2<129::aid-med1003>3.0.co;2-hopenalex-snapshot
Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
inferredcites →https://doi.org/10.1016/j.ccr.2010.03.021openalex-snapshot
TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer
inferredcites →https://doi.org/10.1016/j.jneumeth.2009.07.029openalex-snapshot
Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery
inferredcites →https://doi.org/10.1016/j.neuroscience.2008.07.007openalex-snapshot
NF-κB signaling in cerebral ischemia
inferredcites →https://doi.org/10.1016/j.tips.2005.07.006openalex-snapshot
Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage
inferredcites →https://doi.org/10.1016/s0168-0102(03)00184-6openalex-snapshot
Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils
inferredcites →https://doi.org/10.1038/8432openalex-snapshot
NF-κB is activated and promotes cell death in focal cerebral ischemia
inferredcites →https://doi.org/10.1038/cdd.2009.107openalex-snapshot
Apoptosis and glutathione: beyond an antioxidant
inferredcites →https://doi.org/10.1038/cdd.2010.47openalex-snapshot
Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation
inferredcites →https://doi.org/10.1038/jcbfm.2009.47openalex-snapshot
Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion
inferredcites →https://doi.org/10.1038/ni1255openalex-snapshot
Essential function for the kinase TAK1 in innate and adaptive immune responses
inferredcites →https://doi.org/10.1038/nm1323openalex-snapshot
IKK mediates ischemia-induced neuronal death
inferredcites →https://doi.org/10.1038/nm911openalex-snapshot
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
inferredcites →https://doi.org/10.1038/onc.2008.184openalex-snapshot
IKK/NF-κB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors
inferredcites →https://doi.org/10.1038/sj.cdd.4401865openalex-snapshot
The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
inferredcites →https://doi.org/10.1038/sj.jcbfm.9600369openalex-snapshot
Cyclooxygenase-2 Does Not Contribute to Postischemic Production of Reactive Oxygen Species
inferredcites →https://doi.org/10.1073/pnas.0704908104openalex-snapshot
Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
inferredcites →https://doi.org/10.1074/jbc.m207453200openalex-snapshot
A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase
inferredcites →https://doi.org/10.1074/jbc.m506172200openalex-snapshot
NF-κB Regulates Phagocytic NADPH Oxidase by Inducing the Expression of gp91
inferredcites →https://doi.org/10.1074/jbc.m603384200openalex-snapshot
TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m804513200openalex-snapshot
TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity
inferredcites →https://doi.org/10.1084/jem.20080297openalex-snapshot
TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice
inferredcites →https://doi.org/10.1097/00004647-200206000-00001openalex-snapshot
Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury
inferredcites →https://doi.org/10.1101/gad.1360605openalex-snapshot
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
inferredcites →https://doi.org/10.1111/j.1365-2826.2008.01717.xopenalex-snapshot
Genetic Dissection of Glucocorticoid Receptor Function in the Mouse Brain
inferredcites →https://doi.org/10.1124/jpet.110.165829openalex-snapshot
Inhibition of IκB Kinase-β Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity
inferredcites →https://doi.org/10.1126/science.270.5244.2008openalex-snapshot
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction
inferredcites →https://doi.org/10.1128/mcb.26.10.3785-3797.2006openalex-snapshot
Direct Interaction and Reciprocal Regulation between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth
inferredcites →https://doi.org/10.1146/annurev.pharmtox.48.113006.094606openalex-snapshot
Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response
inferredcites →https://doi.org/10.1159/000068332openalex-snapshot
Tamoxifen, a Selective Estrogen Receptor Modulator, Reduces Ischemic Damage Caused by Middle Cerebral Artery Occlusion in the Ovariectomized Female Rat
inferredcites →https://doi.org/10.1159/000118039openalex-snapshot
Improving Outcome after Stroke: Overcoming the Translational Roadblock
inferredcites →https://doi.org/10.1161/atvbaha.108.163592openalex-snapshot
AP-1–Dependent Transcriptional Regulation of NADPH Oxidase in Human Aortic Smooth Muscle Cells
inferredcites →https://doi.org/10.1161/strokeaha.109.560250openalex-snapshot
Alternate Pathways Preserve Tumor Necrosis Factor-α Production After Nuclear Factor-κB Inhibition in Neonatal Cerebral Hypoxia–Ischemia
inferredcites →https://doi.org/10.1523/jneurosci.17-08-02746.1997openalex-snapshot
Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage
inferredcites →https://doi.org/10.1523/jneurosci.2675-04.2004openalex-snapshot
Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity
inferredcites →https://doi.org/10.1523/jneurosci.3670-06.2006openalex-snapshot
Bim and Noxa Are Candidates to Mediate the Deleterious Effect of the NF-κB Subunit RelA in Cerebral Ischemia
inferredcites →https://doi.org/10.1523/jneurosci.4407-08.2008openalex-snapshot
Hsp27 Protects against Ischemic Brain Injury via Attenuation of a Novel Stress-Response Cascade Upstream of Mitochondrial Cell Death Signaling
inferredcites →https://doi.org/10.1523/jneurosci.4468-06.2007openalex-snapshot
Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation
inferredcites →https://doi.org/10.4049/jimmunol.163.5.2858openalex-snapshot
Superoxide Attenuates Macrophage Apoptosis by NF-κB and AP-1 Activation That Promotes Cyclooxygenase-2 Expression
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/jlb.2a0220-401rrropenalex-snapshot
TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation
inferred← citeshttps://doi.org/10.1002/jnr.23207openalex-snapshot
Function of the master energy regulator adenosine monophosphate‐activated protein kinase in stroke
inferred← citeshttps://doi.org/10.1002/jnr.23306openalex-snapshot
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c‐Jun N‐terminal kinase in rats
inferred← citeshttps://doi.org/10.1007/s00109-020-01916-9openalex-snapshot
Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke
inferred← citeshttps://doi.org/10.1007/s00213-024-06565-1openalex-snapshot
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway
inferred← citeshttps://doi.org/10.1007/s10456-021-09787-5openalex-snapshot
TAK1 signaling is a potential therapeutic target for pathological angiogenesis
inferred← citeshttps://doi.org/10.1007/s10571-016-0397-5openalex-snapshot
Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage
inferred← citeshttps://doi.org/10.1007/s11033-014-3111-zopenalex-snapshot
Structural and functional in silico analysis of LRRK2 missense substitutions
inferred← citeshttps://doi.org/10.1007/s12035-016-9979-yopenalex-snapshot
Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity
inferred← citeshttps://doi.org/10.1007/s12192-016-0712-6openalex-snapshot
Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells
inferred← citeshttps://doi.org/10.1007/s12192-016-0728-yopenalex-snapshot
Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways
inferred← citeshttps://doi.org/10.1007/s12975-021-00948-8openalex-snapshot
Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner
inferred← citeshttps://doi.org/10.1007/s13197-020-04302-yopenalex-snapshot
Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IκBα/NF-κB
inferred← citeshttps://doi.org/10.1016/b978-0-12-821385-8.00013-5openalex-snapshot
Microglia and border-associated macrophages in the central nervous system
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2026.06.003openalex-snapshot
Autophagy and molecular chaperones in neurodegenerative disease
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165742openalex-snapshot
Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A > G variant alters the TGFβ-mediated α-SMA cytoskeleton assembly and autophagy
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.11.035openalex-snapshot
Structure-guided development of covalent TAK1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.brainres.2017.04.008openalex-snapshot
Poly-dimensional network comparative analysis reveals the pure pharmacological mechanism of baicalin in the targeted network of mouse cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.ejphar.2013.12.032openalex-snapshot
RETRACTED: Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade
inferred← citeshttps://doi.org/10.1016/j.expneurol.2012.05.019openalex-snapshot
Protection from cerebral ischemia by inhibition of TGFβ-activated kinase
inferred← citeshttps://doi.org/10.1016/j.expneurol.2012.09.010openalex-snapshot
TAK1 inhibition for treatment of cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115817openalex-snapshot
The TAK1-YAP Axis synergistically suppresses oxidative stress and apoptosis via a non-canonical signaling pathway: A neuroprotective mechanism in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29484openalex-snapshot
Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109980openalex-snapshot
Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105368openalex-snapshot
Ketogenic diet and calorie-restricted diet attenuate ischemic brain injury via UBR4 and downstream CamkⅡ/TAK1/JNK signaling
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105257openalex-snapshot
Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice
inferred← citeshttps://doi.org/10.1016/j.nbd.2025.106907openalex-snapshot
Molecular mechanism of PANoptosis and programmed cell death in neurological diseases
inferred← citeshttps://doi.org/10.1016/j.neulet.2013.05.045openalex-snapshot
An ASK1-p38 signalling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells
inferred← citeshttps://doi.org/10.1016/j.neulet.2016.04.017openalex-snapshot
Inhibition of spinal c-Jun-NH2-terminal kinase (JNK) improves locomotor activity of spinal cord injured rats
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.02.022openalex-snapshot
Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.02.018openalex-snapshot
Receptors, Channel Proteins, and Enzymes Involved in Microglia-mediated Neuroinflammation and Treatments by Targeting Microglia in Ischemic Stroke
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105103openalex-snapshot
Role of the neurovascular unit in the process of cerebral ischemic injury
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106617openalex-snapshot
TAK1 blockade as a therapy for retinal neovascularization
inferred← citeshttps://doi.org/10.1016/j.tips.2012.06.007openalex-snapshot
Targeting of TAK1 in inflammatory disorders and cancer
inferred← citeshttps://doi.org/10.1038/s41392-024-01977-zopenalex-snapshot
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
inferred← citeshttps://doi.org/10.1038/s41598-021-85279-2openalex-snapshot
A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity
inferred← citeshttps://doi.org/10.1038/srep00896openalex-snapshot
Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia
inferred← citeshttps://doi.org/10.1038/srep32893openalex-snapshot
Galectin-3 causes enteric neuronal loss in mice after left sided permanent middle cerebral artery occlusion, a model of stroke
inferred← citeshttps://doi.org/10.1039/d1sc06805aopenalex-snapshot
Simultaneous tracking of autophagy and oxidative stress during stroke with an ICT-TBET integrated ratiometric two-photon platform
inferred← citeshttps://doi.org/10.1073/pnas.1115635109openalex-snapshot
Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function
inferred← citeshttps://doi.org/10.1074/jbc.m115.636795openalex-snapshot
TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.1083/jcb.201404066openalex-snapshot
Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia
inferred← citeshttps://doi.org/10.1093/burnst/tkad016openalex-snapshot
Regulated necrosis pathways: a potential target for ischemic stroke
inferred← citeshttps://doi.org/10.1111/bph.13094openalex-snapshot
Involvement of neuronal TGF ‐ β activated kinase 1 in the development of tolerance to morphine‐induced antinociception in rat spinal cord
inferred← citeshttps://doi.org/10.1111/eci.12693openalex-snapshot
A positive correlation exists between neurotrauma and TGF ‐β1‐containing microglia in rats
inferred← citeshttps://doi.org/10.1111/imm.12434openalex-snapshot
Transforming growth factor‐β‐activated kinase 1 resistance limits glucocorticoid responsiveness to Toll‐like receptor 4‐mediated inflammation
inferred← citeshttps://doi.org/10.1111/j.1365-2990.2011.01236.xopenalex-snapshot
Review: Unchained maladie – a reassessment of the role of Ubb+1‐capped polyubiquitin chains in Alzheimer's disease
inferred← citeshttps://doi.org/10.1111/jnc.15546openalex-snapshot
TBC1Domain Family Member 25 deficiency aggravates cerebral ischemia‐reperfusion injury via TAK1‐JNK/p38 pathway
inferred← citeshttps://doi.org/10.1152/ajprenal.00516.2019openalex-snapshot
TAK1 deficiency attenuates cisplatin-induced acute kidney injury
inferred← citeshttps://doi.org/10.1161/hypertensionaha.115.05430openalex-snapshot
Neuron-Specific Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke
inferred← citeshttps://doi.org/10.1161/jaha.119.014920openalex-snapshot
CARD3 Promotes Cerebral Ischemia‐Reperfusion Injury Via Activation of TAK1
inferred← citeshttps://doi.org/10.1161/strokeaha.119.028398openalex-snapshot
Transforming Growth Factor Beta-Activated Kinase 1–Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke
inferred← citeshttps://doi.org/10.1177/1753425916672313openalex-snapshot
Preclinical evaluation of drugs to block inflammation-driven preterm birth
inferred← citeshttps://doi.org/10.1186/1478-811x-12-6openalex-snapshot
A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.1186/s12974-017-0855-0openalex-snapshot
Microglia activation is essential for BMP7-mediated retinal reactive gliosis
inferred← citeshttps://doi.org/10.1186/s12974-018-1188-3openalex-snapshot
Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke
inferred← citeshttps://doi.org/10.1186/s12974-021-02226-8openalex-snapshot
TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.1242/jcs.180505openalex-snapshot
TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
inferred← citeshttps://doi.org/10.1371/journal.pone.0114044openalex-snapshot
Lipopolysaccharide-Induced Loss of Cultured Rat Myenteric Neurons - Role of AMP-Activated Protein Kinase
inferred← citeshttps://doi.org/10.14814/phy2.13181openalex-snapshot
Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease
inferred← citeshttps://doi.org/10.2147/nbhiv.s24914openalex-snapshot
HIV treatment: mechanisms of neurotoxicity and implications for targeted therapy
inferred← citeshttps://doi.org/10.2174/1871527320666210218084444openalex-snapshot
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2015.00166openalex-snapshot
Drugs to Block Cytokine Signaling for the Prevention and Treatment of Inflammation-Induced Preterm Birth
inferred← citeshttps://doi.org/10.3389/fimmu.2020.608976openalex-snapshot
TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1400544openalex-snapshot
Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons
inferred← citeshttps://doi.org/10.3389/fncel.2023.1191629openalex-snapshot
Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential
inferred← citeshttps://doi.org/10.3389/fphar.2017.00789openalex-snapshot
Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation
inferred← citeshttps://doi.org/10.3390/cells11142250openalex-snapshot
Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms and Pharmacological Opportunities
inferred← citeshttps://doi.org/10.3390/ijms18010205openalex-snapshot
Post-Translational Modifications of the TAK1-TAB Complex
inferred← citeshttps://doi.org/10.3892/mmr.2017.8024openalex-snapshot
NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats
inferred← citeshttps://doi.org/10.4103/1673-5374.331539openalex-snapshot
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies
inferred← citeshttps://doi.org/10.4103/pm.pm_398_19openalex-snapshot
Sandalwood oil neuroprotective effects on middle cerebral artery occlusion model of ischemic brain stroke
inferred← citeshttps://doi.org/10.5021/ad.22.210openalex-snapshot
Knockdown of CPEB1 and CPEB4 Inhibits Scar Formation via Modulation of TAK1 and SMAD Signaling
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544314openalex-snapshot
Additional file 1 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544317openalex-snapshot
Additional file 2 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544320openalex-snapshot
Additional file 3 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544323openalex-snapshot
Additional file 4 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544326openalex-snapshot
Additional file 5 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544329openalex-snapshot
Additional file 6 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.16544332openalex-snapshot
Additional file 7 of TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
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