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Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gcc.20355openalex-snapshot
Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia
inferredcites →https://doi.org/10.1016/j.cell.2013.10.026openalex-snapshot
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
inferredcites →https://doi.org/10.1016/j.cell.2013.10.047openalex-snapshot
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
inferredcites →https://doi.org/10.1016/j.celrep.2014.05.048openalex-snapshot
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
inferredcites →https://doi.org/10.1016/j.molcel.2012.10.015openalex-snapshot
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
inferredcites →https://doi.org/10.1038/cr.2014.3openalex-snapshot
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
inferredcites →https://doi.org/10.1038/nature11112openalex-snapshot
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
inferredcites →https://doi.org/10.1038/nature12730openalex-snapshot
N6-methyladenosine-dependent regulation of messenger RNA stability
inferredcites →https://doi.org/10.1038/ncb2902openalex-snapshot
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
inferredcites →https://doi.org/10.1038/nchembio.1432openalex-snapshot
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
inferredcites →https://doi.org/10.1038/nchembio.1654openalex-snapshot
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
inferredcites →https://doi.org/10.1038/nchembio.687openalex-snapshot
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
inferredcites →https://doi.org/10.1038/nrg3724openalex-snapshot
Gene expression regulation mediated through reversible m6A RNA methylation
inferredcites →https://doi.org/10.1073/pnas.1412742111openalex-snapshot
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
inferredcites →https://doi.org/10.1074/jbc.m110.180182openalex-snapshot
Alternatively Expressed Domains of AU-rich Element RNA-binding Protein 1 (AUF1) Regulate RNA-binding Affinity, RNA-induced Protein Oligomerization, and the Local Conformation of Bound RNA Ligands

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4673415openalex-extracted
GAS5 Regulated by m6A Demethylase FTO Suppresses Cell Growth via IGF2BP2/QKI Axis in Breast Cancer
inferred← citeshttps://doi.org/10.1002/1878-0261.12898openalex-snapshot
METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
inferred← citeshttps://doi.org/10.1002/bip.23403openalex-snapshot
Mechanisms of epitranscriptomic gene regulation
inferred← citeshttps://doi.org/10.1002/bmb.21854openalex-snapshot
A primer for junior trainees: Recognition of RNA modifications by RNA ‐binding proteins
inferred← citeshttps://doi.org/10.1002/cmdc.202200549openalex-snapshot
Peptides Targeting RNA m6A Methylations Influence the Viability of Cancer Cells
inferred← citeshttps://doi.org/10.1002/cti2.1393openalex-snapshot
YTHDF2 promotes temozolomide resistance in glioblastoma by activation of the Akt and NF‐κB signalling pathways via inhibiting EPHB3 and TNFAIP3
inferred← citeshttps://doi.org/10.1002/ibra.70000openalex-snapshot
Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders
inferred← citeshttps://doi.org/10.1002/jcp.28014openalex-snapshot
A dynamic reversible RNA N6‐methyladenosine modification: current status and perspectives
inferred← citeshttps://doi.org/10.1002/jcp.30136openalex-snapshot
The momentous role of N6‐methyladenosine in lung cancer
inferred← citeshttps://doi.org/10.1002/jcp.30652openalex-snapshot
RNA N6‐methyladenosine in nonocular and ocular disease
inferred← citeshttps://doi.org/10.1002/jez.2681openalex-snapshot
mRNA m6A methylation in wood frog brain is maintained during freezing and anoxia
inferred← citeshttps://doi.org/10.1002/mc.70036openalex-snapshot
miR‐150‐5p Regulates Merkel Cell Carcinoma Progression by Targeting FTO That Stabilizes CTNNB1 via m6A Modification
inferred← citeshttps://doi.org/10.1002/wrna.1489openalex-snapshot
RNA methylation in nuclear pre‐mRNA processing
inferred← citeshttps://doi.org/10.1002/wrna.1691openalex-snapshot
RNA nucleotide methylation: 2021 update
inferred← citeshttps://doi.org/10.1002/wrna.1783openalex-snapshot
3′‐end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players
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inferred← citeshttps://doi.org/10.1007/978-3-030-14792-1_14openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-981-13-7342-8_4openalex-snapshot
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
inferred← citeshttps://doi.org/10.1007/978-981-99-7471-9_7openalex-snapshot
N6-Methyladenosine RNA Modification in Normal and Malignant Hematopoiesis
inferred← citeshttps://doi.org/10.1007/s00395-023-00986-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00432-022-04134-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00439-026-02818-5openalex-snapshot
Human YTHDC2 mutations disturb RNA homeostasis of oocytes and early embryos
inferred← citeshttps://doi.org/10.1007/s10528-024-10725-5openalex-snapshot
Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis
inferred← citeshttps://doi.org/10.1007/s10529-018-2632-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10565-024-09951-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11033-018-4471-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11033-019-04655-4openalex-snapshot
Functions of RNA N6-methyladenosine modification in cancer progression
inferred← citeshttps://doi.org/10.1007/s11033-026-12270-3openalex-snapshot
A novel method for the identification and quantification of N6-methyladenosine motifs in RNA transcripts
inferred← citeshttps://doi.org/10.1007/s11262-022-01889-6openalex-snapshot
Overexpression of m6A-factors METTL3, ALKBH5, and YTHDC1 alters HPV16 mRNA splicing
inferred← citeshttps://doi.org/10.1007/s11427-020-1909-6openalex-snapshot
YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock
inferred← citeshttps://doi.org/10.1007/s11427-023-2535-xopenalex-snapshot
PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress
inferred← citeshttps://doi.org/10.1007/s11427-024-2674-2openalex-snapshot
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation
inferred← citeshttps://doi.org/10.1007/s11427-024-2848-xopenalex-snapshot
m6A-REFII: an antibody-independent tool for in situ visualizing cellular specific RNA m6A compatible with protein immunofluorescence staining
inferred← citeshttps://doi.org/10.1007/s12016-025-09041-6openalex-snapshot
The Role of M6A Modification in Autoimmunity: Emerging Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.1007/s12032-023-02121-7openalex-snapshot
SETD2 controls m6A modification of transcriptome and regulates the molecular oncogenesis of glioma
inferred← citeshttps://doi.org/10.1007/s12033-018-00149-zopenalex-snapshot
Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins
inferred← citeshttps://doi.org/10.1007/s12033-020-00269-5openalex-snapshot
m6A RNA Methylation: Ramifications for Gene Expression and Human Health
inferred← citeshttps://doi.org/10.1007/s12035-018-1138-1openalex-snapshot
m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
inferred← citeshttps://doi.org/10.1007/s12104-020-09974-3openalex-snapshot
1H, 13C and 15N resonance assignment of the YTH domain of YTHDC2
inferred← citeshttps://doi.org/10.1007/s12672-024-01051-8openalex-snapshot
GAS5 regulated by FTO-mediated m6A modification suppresses cell proliferation via the IGF2BP2/QKI axis in breast cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-802389-1.00008-3openalex-snapshot
Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers
inferred← citeshttps://doi.org/10.1016/b978-0-12-823937-7.00011-0openalex-snapshot
Novel mechanisms for gene regulation: Chemical tags on RNA molecules
inferred← citeshttps://doi.org/10.1016/bs.adgen.2025.02.005openalex-snapshot
Understanding the link between regulatory RNA regions and genomic variation in coeliac disease
inferred← citeshttps://doi.org/10.1016/bs.ai.2022.08.002openalex-snapshot
RNA methylation in immune cells
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.12.006openalex-snapshot
Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.01.003openalex-snapshot
Detailed resume of RNA m6A demethylases
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102717openalex-snapshot
Mechanistic insights into stem cell fate regulation via RNA methylation
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2018.10.006openalex-snapshot
m6A-mediated translation regulation
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2018.12.008openalex-snapshot
Readers of the m6A epitranscriptomic code
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2019.02.010openalex-snapshot
RNA modifications in gene expression control
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2019.07.003openalex-snapshot
Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189299openalex-snapshot
Emerging importance of m6A modification in liver cancer and its potential therapeutic role
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.08.107openalex-snapshot
Crystal structure of human YTHDC2 YTH domain
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116576openalex-snapshot
Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108760openalex-snapshot
Structure and function of reader proteins that recognize methylated RNA residues
inferred← citeshttps://doi.org/10.1016/j.bjorl.2025.101578openalex-snapshot
Transcriptomic analysis reveals the function of m6A regulators in aged cochlea
inferred← citeshttps://doi.org/10.1016/j.bmc.2023.117373openalex-snapshot
Targeting m6A binding protein YTHDFs for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.brainres.2021.147766openalex-snapshot
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.11.006openalex-snapshot
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.cbpa.2015.10.024openalex-snapshot
RNA epigenetics — chemical messages for posttranscriptional gene regulation
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.04.019openalex-snapshot
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
inferred← citeshttps://doi.org/10.1016/j.cell.2017.05.045openalex-snapshot
Dynamic RNA Modifications in Gene Expression Regulation
inferred← citeshttps://doi.org/10.1016/j.cell.2019.06.013openalex-snapshot
Deciphering the “m6A Code” via Antibody-Independent Quantitative Profiling
inferred← citeshttps://doi.org/10.1016/j.cell.2024.11.007openalex-snapshot
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
inferred← citeshttps://doi.org/10.1016/j.cell.2025.04.020openalex-snapshot
m6A alters ribosome dynamics to initiate mRNA degradation
inferred← citeshttps://doi.org/10.1016/j.cellsig.2023.110751openalex-snapshot
FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.03.028openalex-snapshot
FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108120openalex-snapshot
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110861openalex-snapshot
UPF1 promotes rapid degradation of m6A-containing RNAs
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.118087openalex-snapshot
ZNF121 recruits YTHDF2 to modulate mRNA stability
inferred← citeshttps://doi.org/10.1016/j.chembiol.2023.12.004openalex-snapshot
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.06.003openalex-snapshot
The physiological and pathological roles of RNA modifications in T cells
inferred← citeshttps://doi.org/10.1016/j.cophys.2022.100561openalex-snapshot
m6A RNA methylation: a dynamic regulator of cardiac muscle and extracellular matrix
inferred← citeshttps://doi.org/10.1016/j.crtox.2025.100262openalex-snapshot
Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation
inferred← citeshttps://doi.org/10.1016/j.csbj.2023.06.018openalex-snapshot
Characterization of epitranscriptome reader proteins experimentally and in silico : Current knowledge and future perspectives beyond the YTH domain
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2022.04.004openalex-snapshot
The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.dnarep.2024.103697openalex-snapshot
The roles of TonEBP in the DNA damage response: From DNA damage bypass to R-loop resolution
inferred← citeshttps://doi.org/10.1016/j.drup.2024.101200openalex-snapshot
YTHDF2-mediated m6A modification of ONECUT2 promotes stemness and oxaliplatin resistance in gastric cancer through transcriptionally activating TFPI
inferred← citeshttps://doi.org/10.1016/j.ejcb.2022.151239openalex-snapshot
The impact of RNA modifications on the biology of DNA virus infection
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116526openalex-snapshot
Small molecules that regulate the N6-methyladenosine RNA modification as potential anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.gendis.2023.01.032openalex-snapshot
The essential roles of m6A modification in osteogenesis and common bone diseases
inferred← citeshttps://doi.org/10.1016/j.gendis.2023.04.038openalex-snapshot
Insights into the role of RNA m6A modification in the metabolic process and related diseases
inferred← citeshttps://doi.org/10.1016/j.gpb.2018.03.001openalex-snapshot
Structural Insights into N 6 -Methyladenosine (m 6 A) Modification in the Transcriptome
inferred← citeshttps://doi.org/10.1016/j.gpb.2018.04.002openalex-snapshot
YTH Domain: A Family of N 6 -Methyladenosine (m 6 A) Readers
inferred← citeshttps://doi.org/10.1016/j.gpb.2021.01.004openalex-snapshot
Global Profiling of the Lysine Crotonylome in Different Pluripotent States
inferred← citeshttps://doi.org/10.1016/j.indcrop.2026.123013openalex-snapshot
Sugarcane resistance to Xanthomonas albilineans was driven by m6A methylation-mediated defense reprogramming
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114441openalex-snapshot
TRIM8 enhances chondrocyte ferroptosis by inhibiting YTHDF2-m6A mediated SREBF2 mRNA degradation to promote OA progression
inferred← citeshttps://doi.org/10.1016/j.isci.2021.103046openalex-snapshot
DNA-guided photoactivatable probe-based chemical proteomics reveals the reader protein of mRNA methylation
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107838openalex-snapshot
ALKBH5-mediated m6A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression
inferred← citeshttps://doi.org/10.1016/j.it.2025.04.003openalex-snapshot
YTHDF2: a key RNA reader and antitumor target
inferred← citeshttps://doi.org/10.1016/j.jare.2021.10.001openalex-snapshot
Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113127openalex-snapshot
Methylation marks breast cancer metastasis: The roles of m6A-modified miRNAs and lncRNAs
inferred← citeshttps://doi.org/10.1016/j.jmb.2019.09.013openalex-snapshot
Detection of DNA Modifications by Sequence-Specific Transcription Factors
inferred← citeshttps://doi.org/10.1016/j.jmb.2020.04.021openalex-snapshot
RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein
inferred← citeshttps://doi.org/10.1016/j.jsb.2020.107572openalex-snapshot
The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108316openalex-snapshot
FTO-mediated m6A Demethylation of OTUB1 stabilizes SLC7A11 to alleviate Ferroptosis in cerebral ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.123355openalex-snapshot
The role and mechanism of m6A methylation in diabetic nephropathy
inferred← citeshttps://doi.org/10.1016/j.micpath.2025.108244openalex-snapshot
Epitranscriptomic control of viral infection: YTHDF2 at the crossroads of host–virus interactions
inferred← citeshttps://doi.org/10.1016/j.mmr.2026.100054openalex-snapshot
Downregulation of FTO aggravates osteoarthritis with obesity by erasing m6A methylation of PDP2
inferred← citeshttps://doi.org/10.1016/j.mod.2018.04.002openalex-snapshot
Emerging role of dynamic RNA modifications during animal development
inferred← citeshttps://doi.org/10.1016/j.molcel.2016.03.021openalex-snapshot
The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.molcel.2017.09.021openalex-snapshot
Regulation of m6A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.06.033openalex-snapshot
RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay
inferred← citeshttps://doi.org/10.1016/j.molcel.2020.03.011openalex-snapshot
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.02.034openalex-snapshot
The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.007openalex-snapshot
Longitudinal monitoring of cytoplasmic RBP-RNA interactions and transcriptome in living cells by engineered protein nanocages
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.033openalex-snapshot
SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.036openalex-snapshot
RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity
inferred← citeshttps://doi.org/10.1016/j.molp.2021.01.013openalex-snapshot
CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis
inferred← citeshttps://doi.org/10.1016/j.plantsci.2017.05.002openalex-snapshot
Functions of two Malus hupehensis (Pamp.) Rehd. YTPs (MhYTP1 and MhYTP2) in biotic- and abiotic-stress responses
inferred← citeshttps://doi.org/10.1016/j.plaphy.2022.04.031openalex-snapshot
Exploring epitranscriptomics for crop improvement and environmental stress tolerance
inferred← citeshttps://doi.org/10.1016/j.plaphy.2023.108255openalex-snapshot
ECT12, an YTH-domain protein, is a potential mRNA m6A reader that affects abiotic stress responses by modulating mRNA stability in Arabidopsis
inferred← citeshttps://doi.org/10.1016/j.sbi.2017.05.011openalex-snapshot
Readers, writers and erasers of N6-methylated adenosine modification
inferred← citeshttps://doi.org/10.1016/j.sbi.2018.06.004openalex-snapshot
Detecting and interpreting DNA methylation marks
inferred← citeshttps://doi.org/10.1016/j.scienta.2017.04.018openalex-snapshot
Functional analysis of apple MhYTP1 and MhYTP2 genes in leaf senescence and fruit ripening
inferred← citeshttps://doi.org/10.1016/j.stem.2015.01.016openalex-snapshot
m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
inferred← citeshttps://doi.org/10.1016/j.tcb.2017.10.001openalex-snapshot
Reading m6A in the Transcriptome: m6A-Binding Proteins
inferred← citeshttps://doi.org/10.1016/j.tig.2016.09.006openalex-snapshot
Update: Mechanisms Underlying N 6 -Methyladenosine Modification of Eukaryotic mRNA
inferred← citeshttps://doi.org/10.1016/j.tig.2017.04.003openalex-snapshot
m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression
inferred← citeshttps://doi.org/10.1016/j.tig.2019.12.007openalex-snapshot
Molecular Mechanisms Driving mRNA Degradation by m6A Modification
inferred← citeshttps://doi.org/10.1016/j.tips.2023.03.004openalex-snapshot
The structure and function of YTHDF epitranscriptomic m6A readers
inferred← citeshttps://doi.org/10.1016/j.tplants.2021.12.007openalex-snapshot
An update on principles of m6A targeting
inferred← citeshttps://doi.org/10.1016/j.trecan.2022.02.010openalex-snapshot
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.xcrm.2026.103045openalex-snapshot
Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway
inferred← citeshttps://doi.org/10.1016/j.yexcr.2025.114667openalex-snapshot
K542 acetylation promotes YTHDF2 binding to m6A-modified mRNAs and fosters colorectal cancer progression
inferred← citeshttps://doi.org/10.1016/j.ygeno.2022.110542openalex-snapshot
Transcriptome-wide profiling of mRNA N6-methyladenosine modification in rice panicles and flag leaves
inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.12.012openalex-snapshot
FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner
inferred← citeshttps://doi.org/10.1016/s0021-9258(17)49932-7openalex-snapshot
The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c00588openalex-snapshot
Artificially Evolved Superbinder for Specific Recognition of N6-Methyladenine Base Modification in DNA and RNA
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01703openalex-snapshot
Identification of YTH Domain-Containing Proteins as the Readers for N 1-Methyladenosine in RNA
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b05500openalex-snapshot
A Reader-Based Assay for m6A Writers and Erasers
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b04505openalex-snapshot
YTHDF2 Binds to 5-Methylcytosine in RNA and Modulates the Maturation of Ribosomal RNA
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00949openalex-snapshot
RNA Modifications: Reversal Mechanisms and Cancer
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b01166openalex-snapshot
The m 6 A Writer: Rise of a Machine for Growing Tasks
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00367openalex-snapshot
Mono-(2-Ethylhexyl)phthalate Regulates Cholesterol Efflux via MicroRNAs Regulated m6A RNA Methylation
inferred← citeshttps://doi.org/10.1021/acs.jcim.4c00051openalex-snapshot
Pliability in the m6A-Binding Region Extends Druggability of YTH Domains
inferred← citeshttps://doi.org/10.1021/acs.jctc.0c01136openalex-snapshot
Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m6A) Recognition by the Reader Domain of YTHDC1
inferred← citeshttps://doi.org/10.1021/acs.jctc.9b00987openalex-snapshot
Flexible Binding of m 6 A Reader Protein YTHDC1 to Its Preferred RNA Motif
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01570openalex-snapshot
Small-Molecule Inhibitors Targeting RNA m6A Modifiers for Cancer Therapeutics: Latest Advances and Future Perspectives
inferred← citeshttps://doi.org/10.1021/acschembio.0c00841openalex-snapshot
m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells
inferred← citeshttps://doi.org/10.1021/acschembio.6b00268openalex-snapshot
ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin!
inferred← citeshttps://doi.org/10.1021/acschembio.9b00655openalex-snapshot
YTHDF2 Recognition of N 1 -Methyladenosine (m 1 A)-Modified RNA Is Associated with Transcript Destabilization
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00657openalex-snapshot
Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00303openalex-snapshot
Fragment Ligands of the m6A-RNA Reader YTHDF2
inferred← citeshttps://doi.org/10.1021/jacs.7b09213openalex-snapshot
RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome
inferred← citeshttps://doi.org/10.1021/jacsau.4c00754openalex-snapshot
Phenylpyrazoles as Inhibitors of the m6A RNA-Binding Protein YTHDF2
inferred← citeshttps://doi.org/10.1038/cr.2017.15openalex-snapshot
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
inferred← citeshttps://doi.org/10.1038/cr.2017.99openalex-snapshot
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
inferred← citeshttps://doi.org/10.1038/nature23883openalex-snapshot
m6A modulates haematopoietic stem and progenitor cell specification
inferred← citeshttps://doi.org/10.1038/ncomms10324openalex-snapshot
Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts
inferred← citeshttps://doi.org/10.1038/ncomms12626openalex-snapshot
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
inferred← citeshttps://doi.org/10.1038/nmicrobiol.2016.37openalex-snapshot
Viral cell biology: HIV RNA gets methylated
inferred← citeshttps://doi.org/10.1038/nrd.2018.71openalex-snapshot
RNA-modifying proteins as anticancer drug targets
inferred← citeshttps://doi.org/10.1038/nrm.2015.15openalex-snapshot
The regulation and functions of the nuclear RNA exosome complex
inferred← citeshttps://doi.org/10.1038/nrm.2016.132openalex-snapshot
Post-transcriptional gene regulation by mRNA modifications
inferred← citeshttps://doi.org/10.1038/s12276-023-00944-yopenalex-snapshot
The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
inferred← citeshttps://doi.org/10.1038/s12276-024-01330-yopenalex-snapshot
FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis
inferred← citeshttps://doi.org/10.1038/s41380-025-03013-0openalex-snapshot
Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders
inferred← citeshttps://doi.org/10.1038/s41380-026-03580-wopenalex-snapshot
Ythdf2/Setd1b regulatory axis is essential for cerebellar development through regulating epigenetic reprogramming
inferred← citeshttps://doi.org/10.1038/s41388-023-02675-wopenalex-snapshot
N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21cip1/waf1/CDK2-Cyclin E1 axis-mediated cell cycle transition
inferred← citeshttps://doi.org/10.1038/s41388-025-03315-1openalex-snapshot
The epigenetic landscape of brain metastasis
inferred← citeshttps://doi.org/10.1038/s41392-023-01316-8openalex-snapshot
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner
inferred← citeshttps://doi.org/10.1038/s41401-023-01214-3openalex-snapshot
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41416-022-02006-yopenalex-snapshot
YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation
inferred← citeshttps://doi.org/10.1038/s41418-024-01308-3openalex-snapshot
m6A demethylation of FOSL1 mRNA protects hepatoma cells against necrosis under glucose deprivation
inferred← citeshttps://doi.org/10.1038/s41419-020-2235-4openalex-snapshot
YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway
inferred← citeshttps://doi.org/10.1038/s41419-021-03625-8openalex-snapshot
Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
inferred← citeshttps://doi.org/10.1038/s41419-021-04156-yopenalex-snapshot
METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1
inferred← citeshttps://doi.org/10.1038/s41419-021-04484-zopenalex-snapshot
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA
inferred← citeshttps://doi.org/10.1038/s41420-022-00947-0openalex-snapshot
Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins
inferred← citeshttps://doi.org/10.1038/s41420-025-02680-wopenalex-snapshot
Emerging implications of N6-methyladenosine in prostate cancer progression and treatment
inferred← citeshttps://doi.org/10.1038/s41467-018-05243-zopenalex-snapshot
A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
inferred← citeshttps://doi.org/10.1038/s41467-019-11232-7openalex-snapshot
m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis
inferred← citeshttps://doi.org/10.1038/s41467-020-20379-7openalex-snapshot
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
inferred← citeshttps://doi.org/10.1038/s41467-022-31358-5openalex-snapshot
Limited effects of m6A modification on mRNA partitioning into stress granules
inferred← citeshttps://doi.org/10.1038/s41467-023-40212-1openalex-snapshot
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis
inferred← citeshttps://doi.org/10.1038/s41467-023-42015-wopenalex-snapshot
YTHDF2 facilitates aggresome formation via UPF1 in an m6A-independent manner
inferred← citeshttps://doi.org/10.1038/s41467-024-53997-6openalex-snapshot
YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity
inferred← citeshttps://doi.org/10.1038/s41467-025-65542-0openalex-snapshot
Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2
inferred← citeshttps://doi.org/10.1038/s41580-019-0168-5openalex-snapshot
Reading, writing and erasing mRNA methylation
inferred← citeshttps://doi.org/10.1038/s41586-019-1374-1openalex-snapshot
m6A enhances the phase separation potential of mRNA
inferred← citeshttps://doi.org/10.1038/s41590-020-0650-4openalex-snapshot
The RNA modification N6-methyladenosine as a novel regulator of the immune system
inferred← citeshttps://doi.org/10.1038/s41594-023-01089-2openalex-snapshot
m6A governs length-dependent enrichment of mRNAs in stress granules
inferred← citeshttps://doi.org/10.1038/s44319-024-00310-7openalex-snapshot
Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication
inferred← citeshttps://doi.org/10.1039/d4cb00105bopenalex-snapshot
Discovery of a new inhibitor for YTH domain-containing m 6 A RNA readers
inferred← citeshttps://doi.org/10.1073/pnas.1812536116openalex-snapshot
RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation
inferred← citeshttps://doi.org/10.1073/pnas.2518250123openalex-snapshot
mRNA m 6 A modifications and the RNA-binding protein YTHDF1 affect translational control in both normal and pathological learning
inferred← citeshttps://doi.org/10.1074/jbc.m115.680389openalex-snapshot
Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010188openalex-snapshot
The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs
inferred← citeshttps://doi.org/10.1080/15384101.2017.1380125openalex-snapshot
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1080/15476286.2016.1201628openalex-snapshot
m6A: Signaling for mRNA splicing
inferred← citeshttps://doi.org/10.1080/15476286.2019.1630797openalex-snapshot
Effect of methylation of adenine N6 on kink turn structure depends on location
inferred← citeshttps://doi.org/10.1080/15476286.2020.1841458openalex-snapshot
FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway
inferred← citeshttps://doi.org/10.1080/15476286.2024.2399914openalex-snapshot
ECT2 peptide sequences outside the YTH domain regulate its m 6 A-RNA binding
inferred← citeshttps://doi.org/10.1080/1547691x.2022.2067916openalex-snapshot
Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients
inferred← citeshttps://doi.org/10.1080/15592294.2022.2158284openalex-snapshot
Analysis approaches for the identification and prediction of N 6 -methyladenosine sites
inferred← citeshttps://doi.org/10.1089/cell.2016.0041openalex-snapshot
m 6 A RNA Modification Determines Cell Fate by Regulating mRNA Degradation
inferred← citeshttps://doi.org/10.1093/bfgp/elaa025openalex-snapshot
Flipping the script: viral capitalization of RNA modifications
inferred← citeshttps://doi.org/10.1093/burnst/tkad023openalex-snapshot
The m6A reader YTHDF2 alleviates the inflammatory response by inhibiting IL-6R/JAK2/STAT1 pathway-mediated high-mobility group box-1 release
inferred← citeshttps://doi.org/10.1093/carcin/bgz152openalex-snapshot
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation
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