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The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity

https://doi.org/10.1038/ijo.2013.209

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Murine models for pharmacological studies of the metabolic syndrome

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Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

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Inhibition of Adipogenesis by Wnt Signaling

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Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis

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Disruption of the c/ebpα Gene in Adult Mouse liver

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Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism

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The Wnt Signaling Pathway in Bipolar Disorder

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Indirubin derivative E804 inhibits angiogenesis

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Mechanical Strain Inhibits Adipogenesis in Mesenchymal Stem Cells by Stimulating a Durable β-Catenin Signal

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Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility

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Wnt signal transduction pathways

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Indirubin-3'-oxime suppresses human cholangiocarcinoma through cell-cycle arrest and apoptosis

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Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors

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WDR76 mediates obesity and hepatic steatosis via HRas destabilization

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The role of the oxime group in the excited state deactivation processes of indirubin

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Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity

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Behavior of adipocytes in the mammary niche during pregnancy and lactation

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Treatment with indigo plant (Polygonum tinctorium Lour) improves serum lipid profiles in Wistar rats fed a high-fat diet

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Additional file 1 of Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

inferred← citeshttps://doi.org/10.6084/m9.figshare.11992239openalex-snapshot

Additional file 2 of Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

inferred← citeshttps://doi.org/10.6084/m9.figshare.11992245openalex-snapshot

Additional file 3 of Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

inferred← citeshttps://doi.org/10.6084/m9.figshare.11992248openalex-snapshot

Additional file 4 of Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

inferred← citeshttps://doi.org/10.6084/m9.figshare.11992254openalex-snapshot

Additional file 5 of Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning

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