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Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications

https://doi.org/10.1038/mp.2018.2

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Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes

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The Mesolimbic Dopamine Reward Circuit in Depression

inferredcites →https://doi.org/10.1016/j.biopsych.2008.05.034openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.biopsych.2008.08.029openalex-snapshot

Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression

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Tractography-Activation Models Applied to Subcallosal Cingulate Deep Brain Stimulation

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Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

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Deep Brain Stimulation Modulates Gamma Oscillations and Theta–Gamma Coupling in Treatment Resistant Depression

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Prelimbic Stimulation Ameliorates Depressive-Like Behaviors and Increases Regional BDNF Expression in a Novel Drug-Resistant Animal Model of Depression

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High frequency stimulation of the infralimbic cortex induces morphological changes in rat hippocampal neurons

inferredcites →https://doi.org/10.1016/j.brs.2017.01.581openalex-snapshot

Deep brain stimulation to the medial forebrain bundle for depression- long-term outcomes and a novel data analysis strategy

inferredcites →https://doi.org/10.1016/j.brs.2017.10.003openalex-snapshot

Effect of Deep Brain Stimulation of the ventromedial prefrontal cortex on the noradrenergic system in rats

inferredcites →https://doi.org/10.1016/j.brs.2017.11.008openalex-snapshot

Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice

inferredcites →https://doi.org/10.1016/j.clinph.2003.12.024openalex-snapshot

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Electrocortical and behavioral responses elicited by acute electrical stimulation of inferior thalamic peduncle and nucleus reticularis thalami in a patient with major depression disorder

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Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation

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What is the meaning of treatment resistant/refractory major depression (TRD)? A systematic review of current randomized trials

inferredcites →https://doi.org/10.1016/j.euroneuro.2014.05.006openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.expneurol.2010.06.022openalex-snapshot

Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin

inferredcites →https://doi.org/10.1016/j.expneurol.2013.08.017openalex-snapshot

Antidepressant effects after short-term and chronic stimulation of the subgenual cingulate gyrus in treatment-resistant depression

inferredcites →https://doi.org/10.1016/j.expneurol.2015.03.023openalex-snapshot

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal–prefrontal coherence

inferredcites →https://doi.org/10.1016/j.expneurol.2016.05.016openalex-snapshot

Electrical stimulation of the vmPFC serves as a remote control to affect VTA activity and improve depressive-like behavior

inferredcites →https://doi.org/10.1016/j.jad.2013.10.043openalex-snapshot

Treatment-resistant depression: Definitions, review of the evidence, and algorithmic approach

inferredcites →https://doi.org/10.1016/j.jad.2014.02.016openalex-snapshot

Effectiveness and acceptability of deep brain stimulation (DBS) of the subgenual cingulate cortex for treatment-resistant depression: A systematic review and exploratory meta-analysis

inferredcites →https://doi.org/10.1016/j.jad.2014.03.007openalex-snapshot

Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats

inferredcites →https://doi.org/10.1016/j.jad.2014.10.035openalex-snapshot

Immediate cerebral metabolic changes induced by discontinuation of deep brain stimulation of subcallosal cingulate gyrus in treatment-resistant depression

inferredcites →https://doi.org/10.1016/j.jad.2016.01.022openalex-snapshot

Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression

inferredcites →https://doi.org/10.1016/j.jad.2016.05.064openalex-snapshot

Deep brain stimulation of the medial forebrain bundle: Distinctive responses in resistant depression

inferredcites →https://doi.org/10.1016/j.jad.2017.03.074openalex-snapshot

Increased dopamine receptor expression and anti-depressant response following deep brain stimulation of the medial forebrain bundle

inferredcites →https://doi.org/10.1016/j.jad.2017.11.024openalex-snapshot

Deep brain stimulation of the subcallosal cingulate gyrus in patients with treatment-resistant depression: A double-blinded randomized controlled study and long-term follow-up in eight patients

inferredcites →https://doi.org/10.1016/j.jneumeth.2011.04.034openalex-snapshot

Unilateral deep brain stimulation in the nucleus accumbens core does not affect local monoamine release

inferredcites →https://doi.org/10.1016/j.jocn.2013.12.020openalex-snapshot

Neuropsychological and psychiatric assessments following bilateral deep brain stimulation of the subthalamic nucleus in Japanese patients with Parkinson’s disease

inferredcites →https://doi.org/10.1016/j.jpsychires.2009.12.010openalex-snapshot

Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats

inferredcites →https://doi.org/10.1016/j.jpsychires.2015.05.012openalex-snapshot

Acute high frequency stimulation of the prefrontal cortex or nucleus accumbens does not increase hippocampal neurogenesis in rats

inferredcites →https://doi.org/10.1016/j.jpsychires.2016.06.016openalex-snapshot

Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression

inferredcites →https://doi.org/10.1016/j.jpsychires.2017.09.026openalex-snapshot

One year double blind study of high vs low frequency subcallosal cingulate stimulation for depression

inferredcites →https://doi.org/10.1016/j.mehy.2007.03.021openalex-snapshot

Deep brain stimulation of the lateral habenula in treatment resistant major depression

inferredcites →https://doi.org/10.1016/j.mehy.2013.07.014openalex-snapshot

One ring to rule them all? – Temporospatial specificity of deep brain stimulation for treatment-resistant depression

inferredcites →https://doi.org/10.1016/j.mehy.2014.04.007openalex-snapshot

Treatment of depression with deep brain stimulation works by altering in specific ways the conscious perception of the core symptoms of sadness or anhedonia, not by modulating network circuitry

inferredcites →https://doi.org/10.1016/j.nbd.2014.08.007openalex-snapshot

Deep brain stimulation in rats: Different targets induce similar antidepressant-like effects but influence different circuits

inferredcites →https://doi.org/10.1016/j.nbd.2015.07.010openalex-snapshot

The combined depletion of monoamines alters the effectiveness of subthalamic deep brain stimulation

inferredcites →https://doi.org/10.1016/j.neubiorev.2007.07.004openalex-snapshot

Anatomy and physiology of the basal ganglia: Implications for DBS in psychiatry

inferredcites →https://doi.org/10.1016/j.neubiorev.2010.12.009openalex-snapshot

Cross-species affective functions of the medial forebrain bundle—Implications for the treatment of affective pain and depression in humans

inferredcites →https://doi.org/10.1016/j.neubiorev.2012.06.001openalex-snapshot

Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

inferredcites →https://doi.org/10.1016/j.neubiorev.2015.03.015openalex-snapshot

Deep brain stimulation for psychiatric disorders: Are nucleus accumbens and medial forebrain bundle two branches of the same tree?

inferredcites →https://doi.org/10.1016/j.neuroimage.2012.10.013openalex-snapshot

Nucleus accumbens, thalamus and insula connectivity during incentive anticipation in typical adults and adolescents

inferredcites →https://doi.org/10.1016/j.neuroimage.2015.10.049openalex-snapshot

Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature

inferredcites →https://doi.org/10.1016/j.neuron.2005.02.014openalex-snapshot

Deep brain stimulation for treatment-resistant depression.

inferredcites →https://doi.org/10.1016/j.neuropharm.2010.10.006openalex-snapshot

Electrical stimulation of the lateral habenula produces an inhibitory effect on sucrose self-administration

inferredcites →https://doi.org/10.1016/j.neuropharm.2016.04.020openalex-snapshot

Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex

inferredcites →https://doi.org/10.1016/j.parkreldis.2015.10.252openalex-snapshot

The combined depletion of monoamines alters the effectiveness of subthalamic deep brain stimulation

inferredcites →https://doi.org/10.1016/j.pnpbp.2012.07.019openalex-snapshot

Deep brain stimulation in treatment-resistant depression in mice: Comparison with the CRF1 antagonist, SSR125543

inferredcites →https://doi.org/10.1016/j.pnpbp.2014.12.003openalex-snapshot

The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: A review of published data

inferredcites →https://doi.org/10.1016/j.pnpbp.2017.11.012openalex-snapshot

A systematic review and meta-analysis of deep brain stimulation in treatment-resistant depression

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Cognitive functioning after deep brain stimulation in subcallosal cingulate gyrus for treatment-resistant depression: An exploratory study

inferredcites →https://doi.org/10.1016/j.wneu.2012.01.054openalex-snapshot

Minimally Invasive Posterior Atlantoaxial Fusion: A Cadaveric and Clinical Feasibility Study

inferredcites →https://doi.org/10.1016/j.wneu.2012.07.010openalex-snapshot

Electrical Stimulation of the Inferior Thalamic Peduncle in the Treatment of Major Depression and Obsessive Compulsive Disorders

inferredcites →https://doi.org/10.1016/j.wneu.2012.10.068openalex-snapshot

Deep Brain Stimulation for Treatment-Resistant Depression

inferredcites →https://doi.org/10.1016/j.wneu.2012.11.074openalex-snapshot

Practical Considerations in the Development and Refinement of Subcallosal Cingulate White Matter Deep Brain Stimulation for Treatment-Resistant Depression

inferredcites →https://doi.org/10.1016/j.ypsy.2011.08.041openalex-snapshot

Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6Years

inferredcites →https://doi.org/10.1016/s0079-6123(00)26027-5openalex-snapshot

Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression

inferredcites →https://doi.org/10.1016/s0306-4522(01)00379-7openalex-snapshot

Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation

inferredcites →https://doi.org/10.1016/s2215-0366(17)30371-1openalex-snapshot

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial

inferredcites →https://doi.org/10.1017/neu.2014.22openalex-snapshot

Exploratory meta-analysis on deep brain stimulation in treatment-resistant depression

inferredcites →https://doi.org/10.1017/s0033291717000113openalex-snapshot

Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression

inferredcites →https://doi.org/10.1017/s1092852900013754openalex-snapshot

The Subgenual Anterior Cingulate Cortex in Mood Disorders

inferredcites →https://doi.org/10.1017/s1092852900016710openalex-snapshot

The Lateral Habenula:No Longer Neglected

inferredcites →https://doi.org/10.1017/s1461145711001088openalex-snapshot

Deep brain stimulation of the subcallosal cingulate gyrus: further evidence in treatment-resistant major depression

inferredcites →https://doi.org/10.1038/mp.2013.63openalex-snapshot

Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs

inferredcites →https://doi.org/10.1038/mp.2014.2openalex-snapshot

Different patterns of local field potentials from limbic DBS targets in patients with major depressive and obsessive compulsive disorder

inferredcites →https://doi.org/10.1038/mp.2015.92openalex-snapshot

Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder

inferredcites →https://doi.org/10.1038/mp.2017.59openalex-snapshot

A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression

inferredcites →https://doi.org/10.1038/nature09742openalex-snapshot

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

inferredcites →https://doi.org/10.1038/nn.2647openalex-snapshot

Animal models of neuropsychiatric disorders

inferredcites →https://doi.org/10.1038/nn.2956openalex-snapshot

Cross-species studies of orbitofrontal cortex and value-based decision-making

inferredcites →https://doi.org/10.1038/npp.2012.23openalex-snapshot

Frontal Theta Cordance Predicts 6-Month Antidepressant Response to Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Pilot Study

inferredcites →https://doi.org/10.1038/npp.2012.44openalex-snapshot

Long-Term Effects of Nucleus Accumbens Deep Brain Stimulation in Treatment-Resistant Depression: Evidence for Sustained Efficacy

inferredcites →https://doi.org/10.1038/npp.2013.21openalex-snapshot

Behavioral and Neurobiological Effects of Deep Brain Stimulation in a Mouse Model of High Anxiety- and Depression-Like Behavior

inferredcites →https://doi.org/10.1038/npp.2013.330openalex-snapshot

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

inferredcites →https://doi.org/10.1038/npp.2014.28openalex-snapshot

Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook

inferredcites →https://doi.org/10.1038/sj.npp.1301408openalex-snapshot

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

inferredcites →https://doi.org/10.1038/tp.2014.105openalex-snapshot

Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression

inferredcites →https://doi.org/10.1038/tp.2015.166openalex-snapshot

Neuroplasticity-dependent and -independent mechanisms of chronic deep brain stimulation in stressed rats

inferredcites →https://doi.org/10.1038/tp.2015.24openalex-snapshot

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

inferredcites →https://doi.org/10.1038/tp.2016.84openalex-snapshot

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

inferredcites →https://doi.org/10.1038/tp.2017.66openalex-snapshot

Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up

inferredcites →https://doi.org/10.1046/j.1471-4159.1995.65031407.xopenalex-snapshot

Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area

inferredcites →https://doi.org/10.1056/nejmoa052963openalex-snapshot

Bupropion-SR, Sertraline, or Venlafaxine-XR after Failure of SSRIs for Depression

inferredcites →https://doi.org/10.1080/03007995.2016.1277201openalex-snapshot

Comparative efficacy and tolerability of pharmacological and somatic interventions in adult patients with treatment-resistant depression: a systematic review and network meta-analysis

inferredcites →https://doi.org/10.1093/cercor/bhm167openalex-snapshot

Anatomical Connectivity of the Subgenual Cingulate Region Targeted with Deep Brain Stimulation for Treatment-Resistant Depression

inferredcites →https://doi.org/10.1093/cercor/bhv133openalex-snapshot

Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex

inferredcites →https://doi.org/10.1097/adm.0b013e318240acf5openalex-snapshot

Reversible Increase in Smoking After Withdrawal of Ventral Capsule/Ventral Striatum Deep Brain Stimulation in a Depressed Smoker

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Neuropsychological Impact of Cg25 Deep Brain Stimulation for Treatment-Resistant Depression

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Differences in gray matter volumes of subcortical nuclei between major depressive disorder with and without persistent depressive disorder

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Temporal interference stimulation (TIS) for major depressive disorder: right lingual gyrus as a predictor

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Remotely controlled drug release in deep brain regions of non-human primates

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A case of treatment-resistant bipolar depression and comorbid OCD treated with deep brain stimulation of the medial forebrain bundle: 5 years follow-up results

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inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106069openalex-snapshot

Deep brain stimulation in the lateral habenula reverses local neuronal hyperactivity and ameliorates depression-like behaviors in rats

inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107293openalex-snapshot

Inhibition of the LHb glutamatergic pathway ameliorates depressive-like behaviors in a 6-hydroxydopamine-induced Parkinson's disease mouse model

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.08.013openalex-snapshot

The anatomy of pain and suffering in the brain and its clinical implications

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2024.105583openalex-snapshot

Distinctive intrinsic functional connectivity alterations of anterior cingulate cortex subdivisions in major depressive disorder: A systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1016/j.neuint.2018.10.002openalex-snapshot

Behavioral response to imipramine under chronic mild stress corresponds with increase of mRNA encoding somatostatin receptors sst2 and sst4 expression in medial habenular nucleus

inferred← citeshttps://doi.org/10.1016/j.neulet.2020.135428openalex-snapshot

Relationship between white matter microstructure and work hours

inferred← citeshttps://doi.org/10.1016/j.neures.2020.01.002openalex-snapshot

Oscillotherapeutics – Time-targeted interventions in epilepsy and beyond

inferred← citeshttps://doi.org/10.1016/j.neuroimage.2021.118848openalex-snapshot

High-resolution virtual brain modeling personalizes deep brain stimulation for treatment-resistant depression: Spatiotemporal response characteristics following stimulation of neural fiber pathways

inferred← citeshttps://doi.org/10.1016/j.neurom.2022.05.005openalex-snapshot

Investigating Deep Brain Stimulation of the Habenula: A Review of Clinical Studies

inferred← citeshttps://doi.org/10.1016/j.neurom.2023.03.011openalex-snapshot

Deep Brain Stimulation of the Medial Forebrain Bundle for Treatment-Resistant Depression: A Systematic Review Focused on the Long-Term Antidepressive Effect

inferred← citeshttps://doi.org/10.1016/j.neurom.2026.04.021openalex-snapshot

The Amelioration of Depression-Like Behaviors in Mice by Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Is Associated With Neuroinflammation

inferred← citeshttps://doi.org/10.1016/j.neuron.2019.11.012openalex-snapshot

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.07.052openalex-snapshot

Deep brain stimulation targeted at lateral hypothalamus-medial forebrain bundle reverses depressive-like symptoms and related cognitive deficits in rat: Role of serotoninergic system

inferred← citeshttps://doi.org/10.1016/j.nicl.2021.102758openalex-snapshot

Multiscale neural modeling of resting-state fMRI reveals executive-limbic malfunction as a core mechanism in major depressive disorder

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2021.110346openalex-snapshot

Characterization of brain functional connectivity in treatment-resistant depression

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2023.110865openalex-snapshot

Unilateral anterior capsulotomy combined with deep brain stimulation for Parkinson's disease psychosis and motor dysfunctions

inferred← citeshttps://doi.org/10.1016/j.psiq.2026.100912openalex-snapshot

Estimulación cerebral profunda en el núcleo accumbens y cápsula interna para depresión resistente al tratamiento: ¿una opción efectiva y definitiva? A propósito de un caso

inferred← citeshttps://doi.org/10.1016/j.tem.2021.10.005openalex-snapshot

The menace of obesity to depression and anxiety prevalence

inferred← citeshttps://doi.org/10.1016/j.wneu.2019.08.094openalex-snapshot

Network Basis of Seizures Induced by Deep Brain Stimulation: Literature Review and Connectivity Analysis

inferred← citeshttps://doi.org/10.1016/j.ynstr.2021.100370openalex-snapshot

Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

inferred← citeshttps://doi.org/10.1016/j.ynstr.2023.100566openalex-snapshot

Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway

inferred← citeshttps://doi.org/10.1016/j.ynstr.2025.100745openalex-snapshot

Deep brain stimulation changes locus coeruleus responses to social stress from activation to inhibition

inferred← citeshttps://doi.org/10.1016/s2215-0366(19)30476-6openalex-snapshot

Putting deep brain stimulation for depression in a wider perspective

inferred← citeshttps://doi.org/10.1016/s2215-0366(20)30187-5openalex-snapshot

Neuromodulation for major depressive disorder: innovative measures to capture efficacy and outcomes

inferred← citeshttps://doi.org/10.1021/acschemneuro.3c00727openalex-snapshot

SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats

inferred← citeshttps://doi.org/10.1024/1661-8157/a004047openalex-snapshot

Der Stellenwert der tiefen Hirnstimulation bei der schwer behandelbaren sowie therapierefraktären Depression

inferred← citeshttps://doi.org/10.1038/s41380-020-00953-7openalex-snapshot

miR-323a regulates ERBB4 and is involved in depression

inferred← citeshttps://doi.org/10.1038/s41380-021-01381-xopenalex-snapshot

A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

inferred← citeshttps://doi.org/10.1038/s41380-023-02181-1openalex-snapshot

Functional brain network features specify DBS outcome for patients with treatment resistant depression

inferred← citeshttps://doi.org/10.1038/s41380-023-02217-6openalex-snapshot

Changes in cerebral connectivity and brain tissue pulsations with the antidepressant response to an equimolar mixture of oxygen and nitrous oxide: an MRI and ultrasound study

inferred← citeshttps://doi.org/10.1038/s41380-023-02262-1openalex-snapshot

Effects of deep brain stimulation on cognitive functioning in treatment-resistant depression: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1038/s41380-024-02540-6openalex-snapshot

Social experience in adolescence shapes prefrontal cortex structure and function in adulthood

inferred← citeshttps://doi.org/10.1038/s41380-025-03013-0openalex-snapshot

Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders

inferred← citeshttps://doi.org/10.1038/s41386-024-01894-3openalex-snapshot

A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response

inferred← citeshttps://doi.org/10.1038/s41398-018-0254-zopenalex-snapshot

Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex—a relevant mechanism in the pathophysiology and treatment of depression?

inferred← citeshttps://doi.org/10.1038/s41398-021-01321-xopenalex-snapshot

Data-driven parcellation and graph theory analyses to study adolescent mood and anxiety symptoms

inferred← citeshttps://doi.org/10.1038/s41398-022-01818-zopenalex-snapshot

Bilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features

inferred← citeshttps://doi.org/10.1038/s41398-023-02712-yopenalex-snapshot

Normalized affective responsiveness following deep brain stimulation of the medial forebrain bundle in depression

inferred← citeshttps://doi.org/10.1038/s41398-025-03758-wopenalex-snapshot

Symptom-specific alterations in subregional intrinsic connectivity of anterior cingulate cortex in major depressive disorder

inferred← citeshttps://doi.org/10.1038/s41398-026-03986-8openalex-snapshot

Identification of common spontaneous brain activity alterations across psychiatric disorders

inferred← citeshttps://doi.org/10.1038/s41467-022-28892-7openalex-snapshot

Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity

inferred← citeshttps://doi.org/10.1038/s41551-020-00666-wopenalex-snapshot

Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

inferred← citeshttps://doi.org/10.1038/s41562-022-01434-3openalex-snapshot

Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans

inferred← citeshttps://doi.org/10.1038/s41586-023-06541-3openalex-snapshot

Cingulate dynamics track depression recovery with deep brain stimulation

inferred← citeshttps://doi.org/10.1038/s41593-026-02281-5openalex-snapshot

Real-time brain-controlled selective hearing enhances speech perception in multi-talker environments

inferred← citeshttps://doi.org/10.1038/s41598-020-75641-1openalex-snapshot

Nasal respiration is necessary for ketamine-dependent high frequency network oscillations and behavioral hyperactivity in rats

inferred← citeshttps://doi.org/10.1038/s41598-026-49513-zopenalex-snapshot

Deep brain reconditioning stimulation suppresses tinnitus in a rat model

inferred← citeshttps://doi.org/10.1038/s44220-024-00286-2openalex-snapshot

Deep brain stimulation of habenula reduces depressive symptoms and modulates brain activities in treatment-resistant depression

inferred← citeshttps://doi.org/10.1055/s-0039-1692158openalex-snapshot

Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature

inferred← citeshttps://doi.org/10.1055/s-0042-1742582openalex-snapshot

Neuropsychiatric Treatments for Epilepsy: Nonpharmacological Approaches

inferred← citeshttps://doi.org/10.1073/pnas.2600016123openalex-snapshot

Assessment of diverse deep brain stimulation targets uncovers a common neural pathway for instantaneous antidepressant effects in rats

inferred← citeshttps://doi.org/10.1080/00029157.2023.2199811openalex-snapshot

Addressing global cognition and ineffective depressogenic discrimination strategies with clinical hypnosis

inferred← citeshttps://doi.org/10.1080/13651501.2021.2019789openalex-snapshot

Adjunctive vagus nerve stimulation for treatment-resistant depression: a preliminary study

inferred← citeshttps://doi.org/10.1080/14737175.2023.2289573openalex-snapshot

Current perspectives on tractography-guided deep brain stimulation for the treatment of mood disorders

inferred← citeshttps://doi.org/10.1080/17434440.2026.2717170openalex-snapshot

Use of neurostimulation in patients with treatment-resistant depression: current options and future directions

inferred← citeshttps://doi.org/10.1088/1741-2552/aad1a8openalex-snapshot

A control-theoretic system identification framework and a real-time closed-loop clinical simulation testbed for electrical brain stimulation

inferred← citeshttps://doi.org/10.1088/1741-2552/abc743openalex-snapshot

A compact stereotactic system for image-guided surgical intervention

inferred← citeshttps://doi.org/10.1088/1741-2552/ac17d7openalex-snapshot

Boundary element fast multipole method for modeling electrical brain stimulation with voltage and current electrodes

inferred← citeshttps://doi.org/10.1088/1741-2552/ac7005openalex-snapshot

Designing and validating a robust adaptive neuromodulation algorithm for closed-loop control of brain states

inferred← citeshttps://doi.org/10.1088/1741-2552/ad27efopenalex-snapshot

Noninvasive modulation of essential tremor with focused ultrasonic waves

inferred← citeshttps://doi.org/10.1089/neu.2022.0224openalex-snapshot

Involvement of Lateral Habenula Dysfunction in Repetitive Mild Traumatic Brain Injury–Induced Motivational Deficits

inferred← citeshttps://doi.org/10.1093/brain/awab284openalex-snapshot

Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression

inferred← citeshttps://doi.org/10.1093/brain/awac051openalex-snapshot

Optimization of closed-loop electrical stimulation enables robust cerebellar-directed seizure control

inferred← citeshttps://doi.org/10.1093/braincomms/fcad256openalex-snapshot

Effective connectivity between deep brain stimulation targets in individuals with treatment-resistant depression

inferred← citeshttps://doi.org/10.1093/braincomms/fcae210openalex-snapshot

Pain in Parkinson's disease: a neuroanatomy-based approach

inferred← citeshttps://doi.org/10.1093/neuros/nyy420openalex-snapshot

Double Blinded Randomized Trial of Subcutaneous Trigeminal Nerve Stimulation as Adjuvant Treatment for Major Unipolar Depressive Disorder

inferred← citeshttps://doi.org/10.1093/nsr/nwac212openalex-snapshot

Deep brain–machine interfaces: sensing and modulating the human deep brain

inferred← citeshttps://doi.org/10.1093/psyrad/kkae025openalex-snapshot

Effectiveness of non-invasive brain stimulation on depressive symptoms targeting prefrontal cortex in functional magnetic resonance imaging studies: a combined systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1097/md.0000000000026044openalex-snapshot

Efficacy and feasibility of deep brain stimulation for patients with depression

inferred← citeshttps://doi.org/10.1097/wnp.0000000000000961openalex-snapshot

70 Years of Human Cingulate Cortex Stimulation. Functions and Dysfunctions Through the Lens of Electrical Stimulation

inferred← citeshttps://doi.org/10.1097/wnr.0000000000002019openalex-snapshot

Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder

inferred← citeshttps://doi.org/10.1097/yco.0000000000000531openalex-snapshot

Inflammation and depression but where does the inflammation come from?

inferred← citeshttps://doi.org/10.1097/ypg.0000000000000332openalex-snapshot

Genetics of nonpharmacological treatments of depression

inferred← citeshttps://doi.org/10.1101/2020.03.08.980995openalex-snapshot

Anatomically precise relationship between specific amygdala connections and selective markers of mental well-being in humans

inferred← citeshttps://doi.org/10.1101/2020.05.19.104026openalex-snapshot

Medial Prefrontal Cortex Interacts with the Anteromedial Thalamus in Motivation and Dopaminergic Activity

inferred← citeshttps://doi.org/10.1101/2021.01.20.427537openalex-snapshot

The VTA-BLA-NAc circuit for sex reward inhibited by VTA GABAergic neurons under stress in male mice

inferred← citeshttps://doi.org/10.1101/2022.11.15.516581openalex-snapshot

Conscious perception and the role of the basal ganglia: preliminary findings from a deep brain stimulation study

inferred← citeshttps://doi.org/10.1101/2022.12.16.520788openalex-snapshot

Controlled delivery of ultrasound through the head for effective and safe therapies of the brain

inferred← citeshttps://doi.org/10.1101/2023.09.20.558632openalex-snapshot

Causal evidence of coherent theta rhythms in the modulation of multiregional brain communication

inferred← citeshttps://doi.org/10.1101/2023.10.13.562089openalex-snapshot

Immediate and Long-Term Electrophysiological Biomarkers of Antidepressant Behavioral Effects After Subanesthetic Ketamine and Medial Prefrontal Cortex Deep Brain Stimulation Treatment

inferred← citeshttps://doi.org/10.1101/2023.10.31.23297406openalex-snapshot

Cortical network mechanisms in subcallosal cingulate deep brain stimulation for depression

inferred← citeshttps://doi.org/10.1101/2024.03.01.582932openalex-snapshot

α7 nicotinic acetylcholine receptors are necessary for basal forebrain activation to increase expression of the nerve growth factor receptor TrkA

inferred← citeshttps://doi.org/10.1101/2024.12.12.24318914openalex-snapshot

Structural plasticity following deep brain stimulation of the internal capsule in treatment resistant depression

inferred← citeshttps://doi.org/10.1109/embc.2019.8856413openalex-snapshot

Resting-State Functional Connectivity in Popular Targets for Deep Brain Stimulation in the Treatment of Major Depression: An Application of a Graph Theory

inferred← citeshttps://doi.org/10.1109/embc58623.2025.11253515openalex-snapshot

Electrophysiological Changes of Multi-site Local Field Potentials after Deep Brain Stimulation in the Medial Prefrontal Cortex

inferred← citeshttps://doi.org/10.1109/jbhi.2025.3566057openalex-snapshot

A Habenula Neural Biomarker Simultaneously Tracks Weekly and Daily Symptom Variations During Deep Brain Stimulation Therapy for Depression

inferred← citeshttps://doi.org/10.1109/ner.2019.8716886openalex-snapshot

A scalable bonding technique for the development of next-generation brain-machine interfaces

inferred← citeshttps://doi.org/10.1109/tbcas.2025.3634251openalex-snapshot

A Neurostimulator for Deep Brain Stimulation With Wide Load Current and Impedance Adaptation Capability

inferred← citeshttps://doi.org/10.1109/tbme.2023.3313987openalex-snapshot

Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans

inferred← citeshttps://doi.org/10.1109/tmrb.2022.3145650openalex-snapshot

TinyLFP: A Tiny Local-Field-Potential Sensor

inferred← citeshttps://doi.org/10.1109/tnsre.2019.2913218openalex-snapshot

A Multiscale Dynamical Modeling and Identification Framework for Spike-Field Activity

inferred← citeshttps://doi.org/10.1111/ejn.14975openalex-snapshot

Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation: Focus on the medial forebrain bundle

inferred← citeshttps://doi.org/10.1111/ejn.15221openalex-snapshot

Brain circuit dysfunction in specific symptoms of depression

inferred← citeshttps://doi.org/10.1111/ejn.15507openalex-snapshot

Sensory stimulation via the visual, auditory, olfactory and gustatory systems can modulate mood and depression

inferred← citeshttps://doi.org/10.1111/jnc.14841openalex-snapshot

The role of adenosine receptors in mood and anxiety disorders

inferred← citeshttps://doi.org/10.1111/ner.13483openalex-snapshot

Biomarkers for Deep Brain Stimulation in Animal Models of Depression

inferred← citeshttps://doi.org/10.1111/pcn.13342openalex-snapshot

Toward recovery in schizophrenia: Current concepts, findings, and future research directions

inferred← citeshttps://doi.org/10.1117/1.nph.9.3.032207openalex-snapshot

High-precision neural stimulation through optoacoustic emitters

inferred← citeshttps://doi.org/10.1117/12.3013148openalex-snapshot

Post-traumatic stress disorder and neuromodulation methods in treating PTSD

inferred← citeshttps://doi.org/10.1136/jnnp-2019-321758openalex-snapshot

Long-term deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression

inferred← citeshttps://doi.org/10.1136/jnnp-2022-329702openalex-snapshot

Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-022423-014645openalex-snapshot

Apathy and Motivation: Biological Basis and Drug Treatment

inferred← citeshttps://doi.org/10.1159/000504860openalex-snapshot

Deep Brain Stimulation of the Medial Forebrain Bundle in a Rodent Model of Depression: Exploring Dopaminergic Mechanisms with Raclopride and Micro-PET

inferred← citeshttps://doi.org/10.1159/000509313openalex-snapshot

Deep Brain Stimulation of Nucleus Accumbens with Anterior Capsulotomy for Drug Addiction: A Case Report

inferred← citeshttps://doi.org/10.1172/jci163266openalex-snapshot

Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice

inferred← citeshttps://doi.org/10.1176/appi.books.9798894551920.lg51openalex-snapshot

Chapter 51. Deep Brain Stimulation

inferred← citeshttps://doi.org/10.1177/0271678x221074279openalex-snapshot

Molecular basis and clinical perspectives of deep brain stimulation for major depressive disorder

inferred← citeshttps://doi.org/10.1186/s12888-022-04221-6openalex-snapshot

Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder

inferred← citeshttps://doi.org/10.1186/s12888-023-04693-0openalex-snapshot

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

inferred← citeshttps://doi.org/10.1186/s12888-025-07681-8openalex-snapshot

Characteristics of resting-state EEG after deep brain stimulation in nucleus accumbens and anterior limb of internal capsule: a pilot study

inferred← citeshttps://doi.org/10.1186/s12916-025-04141-8openalex-snapshot

The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression

inferred← citeshttps://doi.org/10.1186/s12974-018-1377-0openalex-snapshot

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

inferred← citeshttps://doi.org/10.1186/s40337-023-00773-4openalex-snapshot

Eating disorder patients with and without PTSD treated in residential care: discharge and 6-month follow-up results

inferred← citeshttps://doi.org/10.12775/jehs.2023.13.05.002openalex-snapshot

Use of deep brain stimulation for treatment-resistant depression – review of main stimulation targets

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