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Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

https://doi.org/10.1038/nature06604
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/exnr.1998.6846openalex-snapshot
Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation
inferredcites →https://doi.org/10.1016/j.cell.2006.06.021openalex-snapshot
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
inferredcites →https://doi.org/10.1016/j.cell.2006.06.025openalex-snapshot
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
inferredcites →https://doi.org/10.1016/j.molcel.2006.03.005openalex-snapshot
Growth Factor Withdrawal and Apoptosis: The Middle Game
inferredcites →https://doi.org/10.1016/s0092-8674(00)81167-8openalex-snapshot
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
inferredcites →https://doi.org/10.1016/s0092-8674(03)00851-1openalex-snapshot
HtrA2/Omi, a Sheep in Wolf's Clothing
inferredcites →https://doi.org/10.1016/s0161-5890(03)00047-6openalex-snapshot
Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis
inferredcites →https://doi.org/10.1016/s0896-6273(00)80173-7openalex-snapshot
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development
inferredcites →https://doi.org/10.1016/s1097-2765(00)00136-2openalex-snapshot
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
inferredcites →https://doi.org/10.1038/377591a0openalex-snapshot
Cytokine receptor signalling
inferredcites →https://doi.org/10.1038/nature02052openalex-snapshot
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
inferredcites →https://doi.org/10.1038/ncb1644openalex-snapshot
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
inferredcites →https://doi.org/10.1038/ng1940openalex-snapshot
HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)
inferredcites →https://doi.org/10.1038/nsb795openalex-snapshot
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
inferredcites →https://doi.org/10.1038/sj.onc.1206792openalex-snapshot
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
inferredcites →https://doi.org/10.1073/pnas.0406837101openalex-snapshot
Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
inferredcites →https://doi.org/10.1074/jbc.m311578200openalex-snapshot
Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover
inferredcites →https://doi.org/10.1074/jbc.m406006200openalex-snapshot
Regulation of HAX-1 Anti-apoptotic Protein by Omi/HtrA2 Protease during Cell Death
inferredcites →https://doi.org/10.1080/080352501750315663openalex-snapshot
Infantile genetic agranulocytosis, morbus Kostmann: Presentation of six cases from the original "Kostmann family" and a review
inferredcites →https://doi.org/10.1083/jcb.139.5.1281openalex-snapshot
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
inferredcites →https://doi.org/10.1093/emboj/18.9.2330openalex-snapshot
Conformation of the Bax C‐terminus regulates subcellular location and cell death
inferredcites →https://doi.org/10.1101/gad.14.16.2060openalex-snapshot
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
inferredcites →https://doi.org/10.1128/jvi.76.2.802-816.2002openalex-snapshot
K15 Protein of Kaposi’s Sarcoma-Associated Herpesvirus Is Latently Expressed and Binds to HAX-1, a Protein with Antiapoptotic Function
inferredcites →https://doi.org/10.1128/mcb.24.22.9848-9862.2004openalex-snapshot
Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice
inferredcites →https://doi.org/10.1523/jneurosci.18-04-01428.1998openalex-snapshot
Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice
inferredcites →https://doi.org/10.3324/haematol.11973openalex-snapshot
Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency
inferredcites →https://doi.org/10.4049/jimmunol.158.6.2736openalex-snapshot
HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3209877openalex-extracted
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inferred← citeshttps://doi.org/10.1002/2211-5463.70131openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9780470015902.a0021576openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ajmg.a.33748openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/eji.200940221openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/ijch.202300153openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jcp.22638openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jimd.70025openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/pbc.22131openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/pbc.24964openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/stem.2543openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-319-61421-2_10openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-981-10-2513-6_1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10875-016-0358-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11064-011-0641-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11262-024-02081-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-382219-2.00570-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-822227-0.00005-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-7020-3147-2.00016-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-1-4557-5414-4.00007-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-3-437-23256-5.16001-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/bs.ircmb.2018.05.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.abb.2017.04.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ajhg.2014.12.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.arr.2014.12.010openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbabio.2009.07.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbabio.2012.05.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbagen.2009.06.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2008.07.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2012.05.019openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2017.01.016openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119191openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2023.119538openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamcr.2023.119587openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamem.2013.03.025openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamem.2013.05.012openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbamem.2019.183034openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.02.075openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.07.037openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.biochi.2024.06.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cell.2016.02.009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.04.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.coi.2009.09.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.drudis.2014.01.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envpol.2020.115090openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.exphem.2014.10.010openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.exphem.2026.105418openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.expneurol.2021.113642openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.febslet.2013.10.031openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.febslet.2014.05.042openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.gene.2022.146263openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.hoc.2009.01.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.hoc.2012.10.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.hoc.2012.10.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.hoc.2012.11.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.jns.2020.116928openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.mito.2021.03.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.molcel.2009.11.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.mrl.2024.200141openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.mrrev.2023.108476openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.nbd.2015.11.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ncrna.2024.01.009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.neulet.2012.12.009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.neuroscience.2014.03.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.prp.2023.154457openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.rechem.2026.103765openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.semcdb.2008.10.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.semcdb.2009.12.011openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.07.034openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tice.2018.07.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tplants.2018.02.010openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.trecan.2015.09.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.yjmcc.2012.08.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.yjmcc.2014.10.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.yjmcc.2017.11.014openalex-snapshot
HAX-1 regulates SERCA2a oxidation and degradation
inferred← citeshttps://doi.org/10.1016/j.ymthe.2024.10.031openalex-snapshot
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inferred← citeshttps://doi.org/10.1017/s1462399410001456openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/bi300368bopenalex-snapshot
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inferred← citeshttps://doi.org/10.1021/bi301087copenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/cdd.2008.166openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/cdd.2009.110openalex-snapshot
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis
inferred← citeshttps://doi.org/10.1038/cdd.2009.23openalex-snapshot
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
inferred← citeshttps://doi.org/10.1038/cdd.2010.55openalex-snapshot
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1038/cdd.2013.39openalex-snapshot
Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-β (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation
inferred← citeshttps://doi.org/10.1038/cmi.2015.018openalex-snapshot
HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis
inferred← citeshttps://doi.org/10.1038/cmi.2015.18openalex-snapshot
HAX1 deletion impairs BCR internalization and leads to delayed BCR-mediated apoptosis
inferred← citeshttps://doi.org/10.1038/jcbfm.2013.138openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/jcbfm.2013.139openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/nature06872openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/nature08146openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/ncb3488openalex-snapshot
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis
inferred← citeshttps://doi.org/10.1038/ng.278openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/ng.3709openalex-snapshot
The genomic landscape of core-binding factor acute myeloid leukemias
inferred← citeshttps://doi.org/10.1038/ni0508-465openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/nm.2958openalex-snapshot
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF–triggered granulopoiesis
inferred← citeshttps://doi.org/10.1038/nm.3740openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/nrm3065openalex-snapshot
HTRA proteases: regulated proteolysis in protein quality control
inferred← citeshttps://doi.org/10.1038/nrm3984openalex-snapshot
New roles for mitochondrial proteases in health, ageing and disease
inferred← citeshttps://doi.org/10.1038/s41419-022-04748-2openalex-snapshot
Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance
inferred← citeshttps://doi.org/10.1038/s41419-025-08035-8openalex-snapshot
PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson’s disease
inferred← citeshttps://doi.org/10.1038/s41467-021-22003-8openalex-snapshot
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1
inferred← citeshttps://doi.org/10.1038/s41467-025-60670-zopenalex-snapshot
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy
inferred← citeshttps://doi.org/10.1038/s41586-022-04414-9openalex-snapshot
Mechanism-based traps enable protease and hydrolase substrate discovery
inferred← citeshttps://doi.org/10.1038/s42255-026-01566-0openalex-snapshot
Hypoxia rescues complex 1-associated disease caused by proteostatic defects
inferred← citeshttps://doi.org/10.1038/srep06565openalex-snapshot
Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL
inferred← citeshttps://doi.org/10.1042/bcj20190569openalex-snapshot
Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2
inferred← citeshttps://doi.org/10.1042/bsr20203094openalex-snapshot
The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing
inferred← citeshttps://doi.org/10.1053/j.seminhematol.2012.04.007openalex-snapshot
Discovery and Development of Second-Generation Proteasome Inhibitors
inferred← citeshttps://doi.org/10.1073/pnas.0801146105openalex-snapshot
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
inferred← citeshttps://doi.org/10.1073/pnas.0906998106openalex-snapshot
The anti-apoptotic protein HAX-1 is a regulator of cardiac function
inferred← citeshttps://doi.org/10.1073/pnas.1508760112openalex-snapshot
HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart
inferred← citeshttps://doi.org/10.1073/pnas.1811938116openalex-snapshot
PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome
inferred← citeshttps://doi.org/10.1074/jbc.m109.027912openalex-snapshot
Nα-Tosyl-l-phenylalanine Chloromethyl Ketone Induces Caspase-dependent Apoptosis in Transformed Human B Cell Lines with Transcriptional Down-regulation of Anti-apoptotic HS1-associated Protein X-1
inferred← citeshttps://doi.org/10.1074/jbc.m109.086587openalex-snapshot
Deregulation of Mitochondrial Membrane Potential by Mitochondrial Insertion of Granzyme B and Direct Hax-1 Cleavage
inferred← citeshttps://doi.org/10.1074/jbc.m111.310482openalex-snapshot
Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate
inferred← citeshttps://doi.org/10.1074/jbc.m112.357509openalex-snapshot
Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5
inferred← citeshttps://doi.org/10.1074/jbc.m112.438127openalex-snapshot
Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease
inferred← citeshttps://doi.org/10.1074/jbc.m113.536151openalex-snapshot
Competition through Dimerization between Antiapoptotic and Proapoptotic HS-1-associated Protein X-1 (Hax-1)
inferred← citeshttps://doi.org/10.1074/jbc.r112.422378openalex-snapshot
Structure and Mechanism of Rhomboid Protease
inferred← citeshttps://doi.org/10.1074/jbc.ra117.000128openalex-snapshot
The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart
inferred← citeshttps://doi.org/10.1074/jbc.ra119.012361openalex-snapshot
Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export
inferred← citeshttps://doi.org/10.1080/08830180902995645openalex-snapshot
Neutropenia and Primary Immunodeficiency Diseases
inferred← citeshttps://doi.org/10.1083/jcb.201010143openalex-snapshot
Hax1 regulates neutrophil adhesion and motility through RhoA
inferred← citeshttps://doi.org/10.1083/jcb.202305087openalex-snapshot
CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
inferred← citeshttps://doi.org/10.1089/ars.2014.6199openalex-snapshot
Mitochondrial Protein Quality Control: The Mechanisms Guarding Mitochondrial Health
inferred← citeshttps://doi.org/10.1089/ars.2022.0124openalex-snapshot
Molecular Determinants of Mitochondrial Shape and Function and Their Role in Glaucoma
inferred← citeshttps://doi.org/10.1091/mbc.e12-04-0281openalex-snapshot
Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast
inferred← citeshttps://doi.org/10.1091/mbc.e19-05-0304openalex-snapshot
HAX1 impact on collective cell migration, cell adhesion, and cell shape is linked to the regulation of actomyosin contractility
inferred← citeshttps://doi.org/10.1093/hmg/ddac005openalex-snapshot
Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1
inferred← citeshttps://doi.org/10.1093/hmg/ddr077openalex-snapshot
Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease
inferred← citeshttps://doi.org/10.1093/hmg/ddz306openalex-snapshot
Frataxin deficiency in Friedreich’s ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival
inferred← citeshttps://doi.org/10.1093/jxb/ers012openalex-snapshot
An Arabidopsis rhomboid protease has roles in the chloroplast and in flower development
inferred← citeshttps://doi.org/10.1093/pcp/pcaf038openalex-snapshot
Mitochondrial proteases and their roles in mitophagy in plants, animals, and yeast
inferred← citeshttps://doi.org/10.1097/aci.0000000000000014openalex-snapshot
Pathogenic mechanisms and clinical implications of congenital neutropenia syndromes
inferred← citeshttps://doi.org/10.1097/moh.0b013e32831c83f3openalex-snapshot
Mitochondrial defects lie at the basis of neutropenia in Barth syndrome
inferred← citeshttps://doi.org/10.1097/mop.0b013e32834262f8openalex-snapshot
Genetic etiologies of severe congenital neutropenia
inferred← citeshttps://doi.org/10.1098/rsob.220274openalex-snapshot
Mitochondrial biology and dysfunction in secondary mitochondrial disease
inferred← citeshttps://doi.org/10.1099/vir.0.022897-0openalex-snapshot
The classical swine fever virus N-terminal protease Npro binds to cellular HAX-1
inferred← citeshttps://doi.org/10.1101/2024.06.03.597104openalex-snapshot
Direct prediction of intermolecular interactions driven by disordered regions
inferred← citeshttps://doi.org/10.1111/apa.16005openalex-snapshot
Kostmann disease and other forms of severe congenital neutropenia
inferred← citeshttps://doi.org/10.1111/bjh.18477openalex-snapshot
Truncated CSF3 receptors induce pro‐inflammatory responses in severe congenital neutropenia
inferred← citeshttps://doi.org/10.1111/bph.15844openalex-snapshot
Targeting mitochondrial proteases for therapy of acute myeloid leukaemia
inferred← citeshttps://doi.org/10.1111/cas.13082openalex-snapshot
Establishment of MAGEC 2‐knockout cells and functional investigation of MAGEC 2 in tumor cells
inferred← citeshttps://doi.org/10.1111/febs.12066openalex-snapshot
HAX ‐1 is a nucleocytoplasmic shuttling protein with a possible role in m RNA processing
inferred← citeshttps://doi.org/10.1111/febs.16912openalex-snapshot
NOD1 cooperates with HAX ‐1 to promote cell migration in a RIPK2‐ and NF‐ĸB ‐independent manner
inferred← citeshttps://doi.org/10.1111/febs.17328openalex-snapshot
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation
inferred← citeshttps://doi.org/10.1111/j.1365-2141.2008.07425.xopenalex-snapshot
Clinical implications of ELA2‐, HAX1‐, and G‐CSF‐receptor (CSF3R) mutations in severe congenital neutropenia
inferred← citeshttps://doi.org/10.1111/j.1365-2141.2008.07493.xopenalex-snapshot
Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds
inferred← citeshttps://doi.org/10.1111/j.1365-2141.2010.08361.xopenalex-snapshot
Recent advances in the understanding of genetic defects of neutrophil number and function
inferred← citeshttps://doi.org/10.1111/j.1399-3054.2011.01533.xopenalex-snapshot
Deg proteases and their role in protein quality control and processing in different subcellular compartments of the plant cell
inferred← citeshttps://doi.org/10.1111/j.1460-9568.2008.06323.xopenalex-snapshot
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington’s disease
inferred← citeshttps://doi.org/10.1111/j.1471-4159.2011.07253.xopenalex-snapshot
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
inferred← citeshttps://doi.org/10.1111/j.1582-4934.2009.00892.xopenalex-snapshot
Mitochondrial accumulation of APP and Aβ: significance for Alzheimer disease pathogenesis
inferred← citeshttps://doi.org/10.1111/j.1600-0854.2011.01219.xopenalex-snapshot
Intramembrane Proteolysis in Regulated Protein Trafficking
inferred← citeshttps://doi.org/10.1111/nph.13174openalex-snapshot
Differential evolution of members of the rhomboid gene family with conservative and divergent patterns
inferred← citeshttps://doi.org/10.1126/science.adq8381openalex-snapshot
Sequence-based prediction of intermolecular interactions driven by disordered regions
inferred← citeshttps://doi.org/10.1126/scisignal.2002946openalex-snapshot
The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation
inferred← citeshttps://doi.org/10.1128/jvi.02030-20openalex-snapshot
A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability
inferred← citeshttps://doi.org/10.1136/jmg.2008.058297openalex-snapshot
Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene
inferred← citeshttps://doi.org/10.1146/annurev-immunol-030409-101259openalex-snapshot
Genetic Defects in Severe Congenital Neutropenia: Emerging Insights into Life and Death of Human Neutrophil Granulocytes
inferred← citeshttps://doi.org/10.1146/annurev.genet.42.110807.091628openalex-snapshot
Rhomboid Proteases and their Biological Functions
inferred← citeshttps://doi.org/10.1152/physrev.00002.2017openalex-snapshot
Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance
inferred← citeshttps://doi.org/10.1155/2016/4587691openalex-snapshot
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
inferred← citeshttps://doi.org/10.1155/2018/3586132openalex-snapshot
Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells
inferred← citeshttps://doi.org/10.1155/2022/1092107openalex-snapshot
Knockdown of Long Noncoding RNA 01124 Inhibits the Malignant Behaviors of Colon Cancer Cells via miR-654-5p/HAX-1
inferred← citeshttps://doi.org/10.1158/1078-0432.22442163openalex-snapshot
Supplementary Data from Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
inferred← citeshttps://doi.org/10.1158/1078-0432.22442163.v1openalex-snapshot
Supplementary Data from Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-10-1950openalex-snapshot
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
inferred← citeshttps://doi.org/10.1161/circresaha.112.279935openalex-snapshot
Novel Role of HAX-1 in Ischemic Injury Protection Involvement of Heat Shock Protein 90
inferred← citeshttps://doi.org/10.1172/jci153153openalex-snapshot
HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation
inferred← citeshttps://doi.org/10.1177/1010428317692228openalex-snapshot
Chemoresistance is associated with overexpression of HAX-1, inhibition of which resensitizes drug-resistant breast cancer cells to chemotherapy
inferred← citeshttps://doi.org/10.1182/asheducation-2009.1.344openalex-snapshot
Congenital neutropenia
inferred← citeshttps://doi.org/10.1182/asheducation-2016.1.33openalex-snapshot
Children with rare diseases of neutrophil granulocytes: from therapeutic orphans to pioneers of individualized medicine
inferred← citeshttps://doi.org/10.1182/asheducation-2017.1.172openalex-snapshot
New monogenic disorders identify more pathways to neutropenia: from the clinic to next-generation sequencing
inferred← citeshttps://doi.org/10.1182/blood-2007-11-120667openalex-snapshot
Novel HAX1 mutations in patients with severe congenital neutropenia reveal isoform-dependent genotype-phenotype associations
inferred← citeshttps://doi.org/10.1182/blood-2010-01-234120openalex-snapshot
G-CSF and its receptor in myeloid malignancy
inferred← citeshttps://doi.org/10.1182/blood-2010-10-311704openalex-snapshot
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane
inferred← citeshttps://doi.org/10.1182/bloodadvances.2016003798openalex-snapshot
Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1182/bloodadvances.2023011656openalex-snapshot
A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation
inferred← citeshttps://doi.org/10.1186/1471-2121-13-20openalex-snapshot
Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence
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