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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment
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Different Effects of Glucose Starvation on Expression and Stability of VEGF mRNA Isoforms in Murine Ovarian Cancer Cells
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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
inferredcites →https://doi.org/10.1016/j.chembiol.2004.06.006openalex-snapshot
Visualizing a Correlation between siRNA Localization, Cellular Uptake, and RNAi in Living Cells
inferredcites →https://doi.org/10.1016/j.immuni.2005.06.008openalex-snapshot
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
inferredcites →https://doi.org/10.1016/j.immuni.2005.12.012openalex-snapshot
Double-Stranded RNA-Mediated TLR3 Activation Is Enhanced by CD14
inferredcites →https://doi.org/10.1016/j.molimm.2007.04.021openalex-snapshot
C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission
inferredcites →https://doi.org/10.1016/j.ymthe.2005.11.002openalex-snapshot
Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo
inferredcites →https://doi.org/10.1016/s0092-8674(01)00547-5openalex-snapshot
ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway
inferredcites →https://doi.org/10.1016/s0092-8674(02)00908-xopenalex-snapshot
Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi
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Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
inferredcites →https://doi.org/10.1038/35099560openalex-snapshot
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
inferredcites →https://doi.org/10.1038/nature01889openalex-snapshot
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
inferredcites →https://doi.org/10.1038/nbt1038openalex-snapshot
Lack of interferon response in animals to naked siRNAs
inferredcites →https://doi.org/10.1038/nbt1081openalex-snapshot
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
inferredcites →https://doi.org/10.1038/nbt1101openalex-snapshot
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
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Expression profiling reveals off-target gene regulation by RNAi
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Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
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Activation of the interferon system by short-interfering RNAs
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The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
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Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
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Drusen complement components C3a and C5a promote choroidal neovascularization
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The molecular structure of the Toll-like receptor 3 ligand-binding domain
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inferredcites →https://doi.org/10.1073/pnas.0603245103openalex-snapshot
The dsRNA binding site of human Toll-like receptor 3
inferredcites →https://doi.org/10.1073/pnas.95.16.9349openalex-snapshot
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
inferredcites →https://doi.org/10.1074/jbc.m610946200openalex-snapshot
Biochemical and Functional Analyses of the Human Toll-like Receptor 3 Ectodomain
inferredcites →https://doi.org/10.1074/jbc.m700209200openalex-snapshot
Effects of Single Nucleotide Polymorphisms on Toll-like Receptor 3 Activity and Expression in Cultured Cells
inferredcites →https://doi.org/10.1093/jnci/87.8.581openalex-snapshot
Inhibition of Angiogenesis In Vivo by Interleukin 12
inferredcites →https://doi.org/10.1126/science.1087262openalex-snapshot
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
inferredcites →https://doi.org/10.1126/science.1115253openalex-snapshot
Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain
inferredcites →https://doi.org/10.1126/science.8009221openalex-snapshot
Functional Role of Type I and Type II Interferons in Antiviral Defense
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3612openalex-snapshot
Signal Transducer and Activator of Transcription 1 Activation in Endothelial Cells Is a Negative Regulator of Angiogenesis
inferredcites →https://doi.org/10.1167/iovs.06-0598openalex-snapshot
Unique Gene Expression Profiles of Donor-Matched Human Retinal and Choroidal Vascular Endothelial Cells
inferredcites →https://doi.org/10.1172/jci26316openalex-snapshot
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
inferredcites →https://doi.org/10.1172/jci27597openalex-snapshot
Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice
inferredcites →https://doi.org/10.1172/jci28349openalex-snapshot
Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling
inferredcites →https://doi.org/10.1523/jneurosci.4290-06.2007openalex-snapshot
Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals
inferredcites →https://doi.org/10.2353/ajpath.2007.061237openalex-snapshot
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inferredcites →https://doi.org/10.4049/jimmunol.172.11.6545openalex-snapshot
Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3
inferredcites →https://doi.org/10.4049/jimmunol.176.7.4147openalex-snapshot
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TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules
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inferred← citeshttps://doi.org/10.1007/978-3-319-48683-3_1openalex-snapshot
Emerging Themes in Drug Resistance
inferred← citeshttps://doi.org/10.1007/978-3-540-77148-7_2openalex-snapshot
siRNA/RNAi: Ein neuer Therapieansatz?
inferred← citeshttps://doi.org/10.1007/978-3-540-79086-0_9openalex-snapshot
Nucleic Acids-Based Therapeutics in the Battle Against Pathogenic Viruses
inferred← citeshttps://doi.org/10.1007/978-3-642-12168-5_2openalex-snapshot
Selected Strategies for the Delivery of siRNA In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1007/978-3-642-12168-5_4openalex-snapshot
Strategies to Prevent siRNA-Triggered Cellular Toxicity
inferred← citeshttps://doi.org/10.1007/978-3-642-12168-5_8openalex-snapshot
RNAi Treatment of HIV-1 Infection
inferred← citeshttps://doi.org/10.1007/978-3-642-22054-8_8openalex-snapshot
Neue Therapieoptionen bei retinalen Erkrankungen: Was bringt die Zukunft?
inferred← citeshttps://doi.org/10.1007/978-90-481-2245-5_9openalex-snapshot
Engineering Cell Function by RNA Interference
inferred← citeshttps://doi.org/10.1007/978-981-13-6657-4_12openalex-snapshot
Periostin in Eye Diseases
inferred← citeshttps://doi.org/10.1007/978-981-15-2213-0_28openalex-snapshot
Gene Therapy for Choroidal Neovascularization
inferred← citeshttps://doi.org/10.1007/bf03657488openalex-snapshot
Targeting angiogenesis for cancer (gene) therapy
inferred← citeshttps://doi.org/10.1007/s00011-010-0208-2openalex-snapshot
Important aspects of Toll-like receptors, ligands and their signaling pathways
inferred← citeshttps://doi.org/10.1007/s00018-012-0953-1openalex-snapshot
Promoter-associated RNAs and promoter-targeted RNAs
inferred← citeshttps://doi.org/10.1007/s00018-012-1149-4openalex-snapshot
Multi-level regulation of cellular recognition of viral dsRNA
inferred← citeshttps://doi.org/10.1007/s00018-013-1502-2openalex-snapshot
Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
inferred← citeshttps://doi.org/10.1007/s00018-017-2651-5openalex-snapshot
Periostin in vitreoretinal diseases
inferred← citeshttps://doi.org/10.1007/s00018-017-2656-0openalex-snapshot
Evaluation and control of miRNA-like off-target repression for RNA interference
inferred← citeshttps://doi.org/10.1007/s00109-008-0417-0openalex-snapshot
Permanent silencing of NKG2A expression for cell-based therapeutics
inferred← citeshttps://doi.org/10.1007/s00109-008-0418-zopenalex-snapshot
Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors
inferred← citeshttps://doi.org/10.1007/s00109-010-0709-zopenalex-snapshot
Emerging therapeutic approaches in the management of retinal angiogenesis and edema
inferred← citeshttps://doi.org/10.1007/s00253-010-3065-6openalex-snapshot
The sense strand pre-cleaved RNA duplex mediates an efficient RNA interference with less off-target and immune response effects
inferred← citeshttps://doi.org/10.1007/s00262-008-0652-9openalex-snapshot
The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer
inferred← citeshttps://doi.org/10.1007/s00347-009-1969-2openalex-snapshot
Neue Aspekte in der Therapie der neovaskulären altersabhängigen Makuladegeneration
inferred← citeshttps://doi.org/10.1007/s00347-010-2230-8openalex-snapshot
siRNA bei Makuladegeneration
inferred← citeshttps://doi.org/10.1007/s00417-025-06837-2openalex-snapshot
Gene therapy in neovascular age related macular degeneration: an update
inferred← citeshttps://doi.org/10.1007/s00705-015-2674-xopenalex-snapshot
Activation of Toll-like receptor 3 inhibits Marek’s disease virus infection in chicken embryo fibroblast cells
inferred← citeshttps://doi.org/10.1007/s10059-011-0160-1openalex-snapshot
Selection and Optimization of Asymmetric siRNA Targeting the Human c-MET Gene
inferred← citeshttps://doi.org/10.1007/s10157-023-02329-xopenalex-snapshot
MiR-34a induces myofibroblast differentiation from renal fibroblasts
inferred← citeshttps://doi.org/10.1007/s10456-010-9173-1openalex-snapshot
Resequencing of the vascular endothelial growth factor promoter reveals haplotype structure and functional diversity
inferred← citeshttps://doi.org/10.1007/s10787-025-01913-9openalex-snapshot
Regulation of toll-like receptor signaling pathways in age-related eye disease: from mechanisms to targeted therapeutics
inferred← citeshttps://doi.org/10.1007/s11010-014-2040-4openalex-snapshot
Does toll-like receptor-3 (TLR-3) have any role in Indian AMD phenotype?
inferred← citeshttps://doi.org/10.1007/s11095-011-0604-5openalex-snapshot
RNA Interference and Cancer Therapy
inferred← citeshttps://doi.org/10.1007/s11095-011-0608-1openalex-snapshot
Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA
inferred← citeshttps://doi.org/10.1007/s11095-017-2134-2openalex-snapshot
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market
inferred← citeshttps://doi.org/10.1007/s11427-018-9438-yopenalex-snapshot
siRNA therapeutics: a clinical reality
inferred← citeshttps://doi.org/10.1007/s11515-010-0013-xopenalex-snapshot
Regulation of virus-triggered type I interferon signaling by cellular and viral proteins
inferred← citeshttps://doi.org/10.1007/s11523-012-0213-1openalex-snapshot
Targeting pattern recognition receptors in cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s12010-013-0098-1openalex-snapshot
RNA Interference—A Silent but an Efficient Therapeutic Tool
inferred← citeshttps://doi.org/10.1007/s12026-008-8053-xopenalex-snapshot
Innate immune recognition of nucleic acids
inferred← citeshttps://doi.org/10.1007/s12026-009-8146-1openalex-snapshot
Immune regulation in the retina
inferred← citeshttps://doi.org/10.1007/s12032-025-02939-3openalex-snapshot
Lipid nanoparticles: a promising tool for nucleic acid delivery in cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s12041-009-0068-0openalex-snapshot
Mediators of ocular angiogenesis
inferred← citeshttps://doi.org/10.1007/s13139-018-0550-9openalex-snapshot
Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
inferred← citeshttps://doi.org/10.1007/s13277-016-5093-zopenalex-snapshot
Poly (I:C) enhances the anti-tumor activity of canine parvovirus NS1 protein by inducing a potent anti-tumor immune response
inferred← citeshttps://doi.org/10.1007/s13346-012-0098-7openalex-snapshot
Clinical translation of RNAi-based treatments for respiratory diseases
inferred← citeshttps://doi.org/10.1007/s13346-013-0141-3openalex-snapshot
Liposomally encapsulated CDC20 siRNA inhibits both solid melanoma tumor growth and spontaneous growth of intravenously injected melanoma cells on mouse lung
inferred← citeshttps://doi.org/10.1007/s13346-013-0156-9openalex-snapshot
The application of RNAi-based treatments for inflammatory bowel disease
inferred← citeshttps://doi.org/10.1007/s13346-023-01361-4openalex-snapshot
Innate immune regulations and various siRNA modalities
inferred← citeshttps://doi.org/10.1007/s40005-016-0296-2openalex-snapshot
Polymers in the co-delivery of siRNA and anticancer drugs to treat multidrug-resistant tumors
inferred← citeshttps://doi.org/10.1007/s40259-022-00549-3openalex-snapshot
Therapeutic siRNA: State-of-the-Art and Future Perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-08-055294-1.00150-1openalex-snapshot
Delivery of Nucleic Acids and Gene Delivery
inferred← citeshttps://doi.org/10.1016/b978-0-08-088504-9.00342-1openalex-snapshot
RNA Interference (RNAi) Technology
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00340-5openalex-snapshot
Translational Implications of MicroRNAs in Clinical Diagnostics and Therapeutics
inferred← citeshttps://doi.org/10.1016/b978-0-12-374203-2.00126-3openalex-snapshot
Innate Immunity and Angiogenesis
inferred← citeshttps://doi.org/10.1016/b978-0-12-415795-8.00001-5openalex-snapshot
Toward a Durable Treatment of HIV-1 Infection Using RNA Interference
inferred← citeshttps://doi.org/10.1016/b978-0-12-814470-1.00003-4openalex-snapshot
Noncoding RNAs in Cardiovascular Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-816485-3.00008-8openalex-snapshot
Use of delivery technologies to mediate RNA degradation
inferred← citeshttps://doi.org/10.1016/b978-0-12-817846-1.00013-8openalex-snapshot
Therapeutic based on small interfering RNA (siRNA)
inferred← citeshttps://doi.org/10.1016/b978-0-12-822425-0.00074-9openalex-snapshot
Nanoparticle and microparticle delivery in RNA-based cardiovascular disease treatment
inferred← citeshttps://doi.org/10.1016/b978-0-323-47674-4.00029-3openalex-snapshot
Gene Therapy in Oncology
inferred← citeshttps://doi.org/10.1016/b978-0-323-50878-0.00017-3openalex-snapshot
Nanoparticle-Mediated RNA Interference for Cancer Therapy
inferred← citeshttps://doi.org/10.1016/b978-0-323-85544-0.00002-2openalex-snapshot
siRNA polymer conjugates for the delivery of RNAi therapeutics for the treatment of Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/b978-0-323-85781-9.00004-xopenalex-snapshot
Delivery strategies for reprogramming tumor-associated macrophages
inferred← citeshttps://doi.org/10.1016/b978-0-444-63660-7.00010-3openalex-snapshot
Noncoding RNAs as Critical Players in Regulatory Accuracy, Redox Signaling, and Immune Cell Functions
inferred← citeshttps://doi.org/10.1016/b978-1-4557-0737-9.00067-9openalex-snapshot
Pharmacotherapy of Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/b978-84-8086-706-1.50015-8openalex-snapshot
Fármacos anti-VEGF en el edema macular diabético
inferred← citeshttps://doi.org/10.1016/j.abb.2023.109537openalex-snapshot
Untangling the complexity of heat shock protein 27 in cancer and metastasis
inferred← citeshttps://doi.org/10.1016/j.addr.2009.03.003openalex-snapshot
Lipid-based systemic delivery of siRNA
inferred← citeshttps://doi.org/10.1016/j.addr.2009.04.001openalex-snapshot
Delivery of RNA interference therapeutics using polycation-based nanoparticles
inferred← citeshttps://doi.org/10.1016/j.addr.2009.04.004openalex-snapshot
siRNA vs. shRNA: Similarities and differences
inferred← citeshttps://doi.org/10.1016/j.addr.2009.04.006openalex-snapshot
Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
inferred← citeshttps://doi.org/10.1016/j.addr.2009.04.018openalex-snapshot
siRNA delivery systems for cancer treatment
inferred← citeshttps://doi.org/10.1016/j.addr.2009.05.002openalex-snapshot
Small silencing RNAs: State-of-the-art
inferred← citeshttps://doi.org/10.1016/j.addr.2010.03.008openalex-snapshot
Engineering RNA for Targeted siRNA Delivery and Medical Application
inferred← citeshttps://doi.org/10.1016/j.addr.2010.07.005openalex-snapshot
Application of siRNA in targeting protein expression in kidney disease☆
inferred← citeshttps://doi.org/10.1016/j.addr.2011.01.006openalex-snapshot
RNA interference therapy via functionalized scaffolds
inferred← citeshttps://doi.org/10.1016/j.addr.2011.09.002openalex-snapshot
RNA therapeutics targeting osteoclast-mediated excessive bone resorption
inferred← citeshttps://doi.org/10.1016/j.addr.2011.09.003openalex-snapshot
Using drug-excipient interactions for siRNA delivery
inferred← citeshttps://doi.org/10.1016/j.addr.2012.06.013openalex-snapshot
Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles
inferred← citeshttps://doi.org/10.1016/j.addr.2012.07.004openalex-snapshot
Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions
inferred← citeshttps://doi.org/10.1016/j.addr.2015.10.015openalex-snapshot
Chemical and structural modifications of RNAi therapeutics
inferred← citeshttps://doi.org/10.1016/j.addr.2016.05.010openalex-snapshot
Delivery strategies and potential targets for siRNA in major cancer types
inferred← citeshttps://doi.org/10.1016/j.addr.2017.01.008openalex-snapshot
Angiogenesis regulation by nanocarriers bearing RNA interference
inferred← citeshttps://doi.org/10.1016/j.addr.2018.03.013openalex-snapshot
Controlled release technology for anti-angiogenesis treatment of posterior eye diseases: Current status and challenges
inferred← citeshttps://doi.org/10.1016/j.addr.2024.115215openalex-snapshot
Non-viral delivery of RNA for therapeutic T cell engineering
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