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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Autoreactivity in Human IgG+ Memory B Cells
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Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
inferredcites →https://doi.org/10.1016/j.jim.2008.11.012openalex-snapshot
A method for identification of HIV gp140 binding memory B cells in human blood
inferredcites →https://doi.org/10.1038/31405openalex-snapshot
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
inferredcites →https://doi.org/10.1038/449029aopenalex-snapshot
Allied responses
inferredcites →https://doi.org/10.1038/5568openalex-snapshot
Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys
inferredcites →https://doi.org/10.1038/nature01470openalex-snapshot
Antibody neutralization and escape by HIV-1
inferredcites →https://doi.org/10.1038/nature05580openalex-snapshot
Structural definition of a conserved neutralization epitope on HIV-1 gp120
inferredcites →https://doi.org/10.1038/nm1244openalex-snapshot
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
inferredcites →https://doi.org/10.1038/nm1624openalex-snapshot
Broad HIV-1 neutralization mediated by CD4-binding site antibodies
inferredcites →https://doi.org/10.1038/nri1307openalex-snapshot
Identifying epitopes of HIV-1 that induce protective antibodies
inferredcites →https://doi.org/10.1038/nrmicro1819openalex-snapshot
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
inferredcites →https://doi.org/10.1073/pnas.0308527100openalex-snapshot
Structural basis of tyrosine sulfation and V H -gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
inferredcites →https://doi.org/10.1073/pnas.0803644105openalex-snapshot
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors
inferredcites →https://doi.org/10.1073/pnas.88.22.10134openalex-snapshot
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.
inferredcites →https://doi.org/10.1089/aid.1994.10.359openalex-snapshot
Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization
inferredcites →https://doi.org/10.1126/science.1086907openalex-snapshot
Predominant Autoantibody Production by Early Human B Cell Precursors
inferredcites →https://doi.org/10.1128/jvi.64.12.5701-5707.1990openalex-snapshot
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding
inferredcites →https://doi.org/10.1128/jvi.65.11.6188-6193.1991openalex-snapshot
Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody
inferredcites →https://doi.org/10.1128/jvi.65.9.4832-4838.1991openalex-snapshot
Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies
inferredcites →https://doi.org/10.1128/jvi.66.12.7538-7542.1992openalex-snapshot
Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody
inferredcites →https://doi.org/10.1128/jvi.67.11.6642-6647.1993openalex-snapshot
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
inferredcites →https://doi.org/10.1128/jvi.67.7.3978-3988.1993openalex-snapshot
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
inferredcites →https://doi.org/10.1128/jvi.70.2.1100-1108.1996openalex-snapshot
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
inferredcites →https://doi.org/10.1128/jvi.73.5.4009-4018.1999openalex-snapshot
Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies
inferredcites →https://doi.org/10.1128/jvi.74.12.5716-5725.2000openalex-snapshot
Characterization of Stable, Soluble Trimers Containing Complete Ectodomains of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins
inferredcites →https://doi.org/10.1128/jvi.75.22.10892-10905.2001openalex-snapshot
Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
inferredcites →https://doi.org/10.1128/jvi.77.1.642-658.2003openalex-snapshot
Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
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Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/978-3-030-32459-9_21openalex-snapshot
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VRC01 antibody protects against vaginal and rectal transmission of human immunodeficiency virus 1 in hu-BLT mice
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ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants
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A Blueprint for HIV Vaccine Discovery
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VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage
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Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning
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Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller
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Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases
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Human B cell memory
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High throughput cellular screens to interrogate the human T and B cell repertoires
inferred← citeshttps://doi.org/10.1016/j.coi.2013.09.011openalex-snapshot
Spontaneous activation of RNA-sensing pathways in autoimmune disease
inferred← citeshttps://doi.org/10.1016/j.coi.2014.02.010openalex-snapshot
Clonal and cellular dynamics in germinal centers
inferred← citeshttps://doi.org/10.1016/j.coi.2017.03.002openalex-snapshot
Role of germinal centers for the induction of broadly-reactive memory B cells
inferred← citeshttps://doi.org/10.1016/j.coi.2020.03.013openalex-snapshot
Innovations in structure-based antigen design and immune monitoring for next generation vaccines
inferred← citeshttps://doi.org/10.1016/j.coisb.2020.10.002openalex-snapshot
Antigen discovery tools for adaptive immune receptor repertoire research
inferred← citeshttps://doi.org/10.1016/j.coviro.2011.07.005openalex-snapshot
No acquisition: A new ambition for HIV vaccine development?
inferred← citeshttps://doi.org/10.1016/j.coviro.2015.04.002openalex-snapshot
Strategies to guide the antibody affinity maturation process
inferred← citeshttps://doi.org/10.1016/j.coviro.2022.101211openalex-snapshot
Broadly neutralizing antibodies against HIV-1 and concepts for application
inferred← citeshttps://doi.org/10.1016/j.crimmu.2021.03.002openalex-snapshot
Hybridoma technology: is it still useful?
inferred← citeshttps://doi.org/10.1016/j.crmeth.2023.100509openalex-snapshot
Increasing sensitivity of antibody-antigen interactions using photo-cross-linking
inferred← citeshttps://doi.org/10.1016/j.drudis.2011.08.013openalex-snapshot
HIV vaccine: hopes and hurdles
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.05.029openalex-snapshot
HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
inferred← citeshttps://doi.org/10.1016/j.eimc.2011.01.006openalex-snapshot
Inmunopatogenia de la infección por el virus de la inmunodeficiencia humana
inferred← citeshttps://doi.org/10.1016/j.febslet.2013.11.005openalex-snapshot
Profiling the IgOme: Meeting the challenge
inferred← citeshttps://doi.org/10.1016/j.humimm.2021.10.007openalex-snapshot
Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients
inferred← citeshttps://doi.org/10.1016/j.idc.2014.08.004openalex-snapshot
Human Immunodeficiency Virus Vaccines
inferred← citeshttps://doi.org/10.1016/j.imlet.2012.08.002openalex-snapshot
Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution
inferred← citeshttps://doi.org/10.1016/j.imlet.2017.06.001openalex-snapshot
Human IgG repertoire of malaria antigen-immunized human immune system (HIS) mice
inferred← citeshttps://doi.org/10.1016/j.imlet.2021.11.001openalex-snapshot
Mechanisms underpinning poor antibody responses to vaccines in ageing
inferred← citeshttps://doi.org/10.1016/j.immuni.2010.09.011openalex-snapshot
Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination
inferred← citeshttps://doi.org/10.1016/j.immuni.2010.10.008openalex-snapshot
From Vaccines to Memory and Back
inferred← citeshttps://doi.org/10.1016/j.immuni.2012.08.012openalex-snapshot
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
inferred← citeshttps://doi.org/10.1016/j.immuni.2014.04.009openalex-snapshot
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.08.016openalex-snapshot
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.04.014openalex-snapshot
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.09.001openalex-snapshot
Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus
inferred← citeshttps://doi.org/10.1016/j.immuni.2020.10.005openalex-snapshot
Polyreactive Broadly Neutralizing B Cells are Selected to Provide Defense Against Pandemic Threat Influenza Viruses
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.03.023openalex-snapshot
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.07.008openalex-snapshot
Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
inferred← citeshttps://doi.org/10.1016/j.immuni.2021.12.003openalex-snapshot
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
inferred← citeshttps://doi.org/10.1016/j.immuni.2022.07.020openalex-snapshot
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
inferred← citeshttps://doi.org/10.1016/j.it.2014.02.010openalex-snapshot
Emerging concepts on T follicular helper cell dynamics in HIV infection
inferred← citeshttps://doi.org/10.1016/j.it.2014.04.005openalex-snapshot
Studying the antibody repertoire after vaccination: practical applications
inferred← citeshttps://doi.org/10.1016/j.it.2014.08.007openalex-snapshot
Antibody B cell responses in HIV-1 infection
inferred← citeshttps://doi.org/10.1016/j.it.2014.09.004openalex-snapshot
Characterizing immune repertoires by high throughput sequencing: strategies and applications
inferred← citeshttps://doi.org/10.1016/j.it.2016.01.007openalex-snapshot
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies
inferred← citeshttps://doi.org/10.1016/j.jaci.2012.04.006openalex-snapshot
Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100745openalex-snapshot
50 Years of structural immunology
inferred← citeshttps://doi.org/10.1016/j.jdermsci.2023.04.006openalex-snapshot
Targeting the elevated IFN-γ in vitiligo patients by human anti- IFN-γ monoclonal antibody hampers direct cytotoxicity in melanocyte
inferred← citeshttps://doi.org/10.1016/j.jim.2009.08.009openalex-snapshot
Cloning and expression of murine Ig genes from single B cells
inferred← citeshttps://doi.org/10.1016/j.jim.2011.05.010openalex-snapshot
Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes
inferred← citeshttps://doi.org/10.1016/j.jim.2012.09.003openalex-snapshot
Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells
inferred← citeshttps://doi.org/10.1016/j.jim.2013.09.003openalex-snapshot
Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160ΔcBaL
inferred← citeshttps://doi.org/10.1016/j.jim.2014.11.003openalex-snapshot
Vaccine-induced plasmablast responses in rhesus macaques: Phenotypic characterization and a source for generating antigen-specific monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jim.2015.01.011openalex-snapshot
Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient
inferred← citeshttps://doi.org/10.1016/j.jim.2015.04.010openalex-snapshot
Efficient generation of human IgA monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jim.2016.02.020openalex-snapshot
An antigen-specific, four-color, B-cell FluoroSpot assay utilizing tagged antigens for detection
inferred← citeshttps://doi.org/10.1016/j.jim.2016.09.001openalex-snapshot
Refined protocol for generating monoclonal antibodies from single human and murine B cells
inferred← citeshttps://doi.org/10.1016/j.jim.2016.09.007openalex-snapshot
Rapid high-throughput cloning and stable expression of antibodies in HEK293 cells
inferred← citeshttps://doi.org/10.1016/j.jim.2018.07.007openalex-snapshot
Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus
inferred← citeshttps://doi.org/10.1016/j.jim.2019.112734openalex-snapshot
Isolation of single HIV-1 Envelope specific B cells and antibody cloning from immunized rhesus macaques
inferred← citeshttps://doi.org/10.1016/j.jim.2024.113747openalex-snapshot
Optimizing the method for expressing human monoclonal antibodies from a single peripheral blood cell from vaccinated donors
inferred← citeshttps://doi.org/10.1016/j.jmb.2012.11.010openalex-snapshot
Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast
inferred← citeshttps://doi.org/10.1016/j.jmgm.2015.08.003openalex-snapshot
Computational discovery of novel HIV-1 entry inhibitors based on potent and broad neutralizing antibody VRC01
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2015.11.006openalex-snapshot
Rituximab induces clonal expansion of IgG memory B-cells in patients with inflammatory central nervous system demyelination
inferred← citeshttps://doi.org/10.1016/j.jtbi.2010.11.009openalex-snapshot
Consequences of host heterogeneity, epitope immunodominance, and immune breadth for strain competition
inferred← citeshttps://doi.org/10.1016/j.jviromet.2012.07.011openalex-snapshot
Optimization and proficiency testing of a pseudovirus-based assay for detection of HIV-1 neutralizing antibody in China
inferred← citeshttps://doi.org/10.1016/j.jviromet.2013.01.016openalex-snapshot
Complete and repeatable inactivation of HIV-1 viral particles in suspension using a photo-labeled non-nucleoside reverse transcriptase inhibitor
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.04.011openalex-snapshot
A broad range of mutations in HIV-1 neutralizing human monoclonal antibodies specific for V2, V3, and the CD4 binding site
inferred← citeshttps://doi.org/10.1016/j.molimm.2015.12.002openalex-snapshot
Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations
inferred← citeshttps://doi.org/10.1016/j.molimm.2018.09.020openalex-snapshot
Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.molmed.2010.10.008openalex-snapshot
B cell responses to HIV-1 infection and vaccination: pathways to preventing infection
inferred← citeshttps://doi.org/10.1016/j.molmed.2019.01.007openalex-snapshot
Broadly Neutralizing Antibodies against HIV: Back to Blood
inferred← citeshttps://doi.org/10.1016/j.nbt.2011.03.014openalex-snapshot
Single B cell antibody technologies
inferred← citeshttps://doi.org/10.1016/j.sbi.2016.07.012openalex-snapshot
Engineering antibody therapeutics
inferred← citeshttps://doi.org/10.1016/j.sbi.2025.103104openalex-snapshot
Review: Membrane protein nanodiscs for antibody discovery
inferred← citeshttps://doi.org/10.1016/j.smim.2021.101475openalex-snapshot
Broadly neutralizing antibodies for HIV-1 prevention and therapy
inferred← citeshttps://doi.org/10.1016/j.smim.2024.101864openalex-snapshot
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
inferred← citeshttps://doi.org/10.1016/j.tibs.2014.02.010openalex-snapshot
Thermodynamic stability contributes to immunoglobulin specificity
inferred← citeshttps://doi.org/10.1016/j.tim.2012.08.011openalex-snapshot
HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design
inferred← citeshttps://doi.org/10.1016/j.tim.2013.06.004openalex-snapshot
Catching HIV ‘in the act’ with 3D electron microscopy
inferred← citeshttps://doi.org/10.1016/j.tips.2009.09.005openalex-snapshot
Elucidating the elite: mechanisms of control in HIV-1 infection
inferred← citeshttps://doi.org/10.1016/j.tube.2016.08.001openalex-snapshot
Antibodies and tuberculosis
inferred← citeshttps://doi.org/10.1016/j.vaccine.2009.08.028openalex-snapshot
HIV inactivation by cross-linking of photo-labeled anti-retroviral compounds with HIV reverse transcriptase
inferred← citeshttps://doi.org/10.1016/j.vaccine.2010.02.002openalex-snapshot
Emerging studies of human HIV-specific antibody repertoires
inferred← citeshttps://doi.org/10.1016/j.vaccine.2010.02.006openalex-snapshot
Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity
inferred← citeshttps://doi.org/10.1016/j.vaccine.2011.06.085openalex-snapshot
Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: A review
inferred← citeshttps://doi.org/10.1016/j.vaccine.2012.01.026openalex-snapshot
Prime boost vaccination approaches with different conjugates of a new HIV-1 gp41 epitope encompassing the membrane proximal external region induce neutralizing antibodies in mice
inferred← citeshttps://doi.org/10.1016/j.vaccine.2014.02.020openalex-snapshot
Profiling human antibody responses by integrated single-cell analysis
inferred← citeshttps://doi.org/10.1016/j.vaccine.2014.07.026openalex-snapshot
Vaccine focusing to cross-subtype HIV-1 gp120 variable loop epitopes
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