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Universal allosteric mechanism for Gα activation by GPCRs
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
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UCSF Chimera—A visualization system for exploratory research and analysis
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MUSTANG: A multiple structural alignment algorithm
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Classification and evolution of P-loop GTPases and related ATPases
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Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family
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Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system
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Inference of Macromolecular Assemblies from Crystalline State
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Conformational Flexibility and Structural Dynamics in GPCR-Mediated G Protein Activation: A Perspective
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A Million Peptide Motifs for the Molecular Biologist
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Evolution of protein structures and interactions from the perspective of residue contact networks
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Analyzing and visualizing residue networks of protein structures
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Basic Local Alignment Search Tool
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Receptor Molecular Biology
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Structural basis of function in heterotrimeric G proteins
inferredcites →https://doi.org/10.1021/bi025514kopenalex-snapshot
Disruption of the α5 Helix of Transducin Impairs Rhodopsin-Catalyzed Nucleotide Exchange
inferredcites →https://doi.org/10.1038/28548openalex-snapshot
The structural basis of the activation of Ras by Sos
inferredcites →https://doi.org/10.1038/363276a0openalex-snapshot
NMR structure of a receptor-bound G-protein peptide
inferredcites →https://doi.org/10.1038/366654a0openalex-snapshot
The 2.2 Å crystal structure of transducin-α complexed with GTPγS
inferredcites →https://doi.org/10.1038/371164a0openalex-snapshot
Rapid GDP release from Gsα in patients with gain and loss of endocrine function
inferredcites →https://doi.org/10.1038/msb4100063openalex-snapshot
Residues crucial for maintaining short paths in network communication mediate signaling in proteins
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Crystal structure of opsin in its G-protein-interacting conformation
inferredcites →https://doi.org/10.1038/nature09789openalex-snapshot
Crystal structure of metarhodopsin II
inferredcites →https://doi.org/10.1038/nature09795openalex-snapshot
The structural basis of agonist-induced activation in constitutively active rhodopsin
inferredcites →https://doi.org/10.1038/nature10361openalex-snapshot
Crystal structure of the β2 adrenergic receptor–Gs protein complex
inferredcites →https://doi.org/10.1038/nature10488openalex-snapshot
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
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AAA+ proteins: have engine, will work
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Heterotrimeric G protein activation by G-protein-coupled receptors
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Evolutionarily conserved networks of residues mediate allosteric communication in proteins
inferredcites →https://doi.org/10.1038/nsmb.2705openalex-snapshot
Energetic analysis of the rhodopsin–G-protein complex links the α5 helix to GDP release
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Probing Gαi1 protein activation at single–amino acid resolution
inferredcites →https://doi.org/10.1038/nsmb1129openalex-snapshot
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
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Probing the mechanism of rhodopsin-catalyzed transducin activation
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Mutations Affecting G-Protein Subunit α 11 in Hypercalcemia and Hypocalcemia
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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
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Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
inferredcites →https://doi.org/10.1073/pnas.1114089108openalex-snapshot
Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II
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α Helix Content of G Protein α Subunit Is Decreased upon Activation by Receptor Mimetics
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Rapid Activation of Transducin by Mutations Distant from the Nucleotide-binding Site
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Crystal Structures of the Scaffolding Protein LGN Reveal the General Mechanism by Which GoLoco Binding Motifs Inhibit the Release of GDP from Gαi
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Structural Basis of G Protein-coupled Receptor-Gi Protein Interaction
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Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling
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Structural Determinants Underlying the Temperature-sensitive Nature of a Gα Mutant in Asymmetric Cell Division of Caenorhabditis elegans
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The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
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PCMA: fast and accurate multiple sequence alignment based on profile consistency
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IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
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Bio3d: an R package for the comparative analysis of protein structures
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inferredcites →https://doi.org/10.1093/nar/gkh340openalex-snapshot
MUSCLE: multiple sequence alignment with high accuracy and high throughput
inferredcites →https://doi.org/10.1093/nar/gkh429openalex-snapshot
STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins
inferredcites →https://doi.org/10.1093/nar/gkn180openalex-snapshot
Phylogeny.fr: robust phylogenetic analysis for the non-specialist
inferredcites →https://doi.org/10.1093/nar/gkq1238openalex-snapshot
OMA 2011: orthology inference among 1000 complete genomes
inferredcites →https://doi.org/10.1093/nar/gks1258openalex-snapshot
SIFTS: Structure Integration with Function, Taxonomy and Sequences resource
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COSMIC: exploring the world's knowledge of somatic mutations in human cancer
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New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
inferredcites →https://doi.org/10.1101/gr.073585.107openalex-snapshot
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
inferredcites →https://doi.org/10.1107/s1744309107003363openalex-snapshot
Crystallization and preliminary X-ray crystallographic analysis of the receptor-uncoupled mutant of Gαi1
inferredcites →https://doi.org/10.1110/ps.03259908openalex-snapshot
Allostery and cooperativity revisited
inferredcites →https://doi.org/10.1126/science.1062023openalex-snapshot
The Guanine Nucleotide-Binding Switch in Three Dimensions
inferredcites →https://doi.org/10.1126/science.2406906openalex-snapshot
Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins
inferredcites →https://doi.org/10.1186/1471-2105-14-217openalex-snapshot
RCytoscape: tools for exploratory network analysis
inferredcites →https://doi.org/10.1186/1471-2105-7-439openalex-snapshot
TreeDyn: towards dynamic graphics and annotations for analyses of trees
inferredcites →https://doi.org/10.1186/gm13openalex-snapshot
The Human Gene Mutation Database: 2008 update
inferredcites →https://doi.org/10.1210/jc.2014-1029openalex-snapshot
Autosomal Dominant Hypoparathyroidism Caused by Germline Mutation inGNA11: Phenotypic and Molecular Characterization
inferredcites →https://doi.org/10.1371/journal.pone.0071711openalex-snapshot
Mutationmapper: A Tool to Aid the Mapping of Protein Mutation Data
inferredcites →https://doi.org/10.1371/journal.pone.0078878openalex-snapshot
AAscan, PCRdesign and MutantChecker: A Suite of Programs for Primer Design and Sequence Analysis for High-Throughput Scanning Mutagenesis
inferredcites →https://doi.org/10.1371/journal.pone.0098714openalex-snapshot
Crystallization Scale Preparation of a Stable GPCR Signaling Complex between Constitutively Active Rhodopsin and G-Protein
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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A Universal Allosteric Mechanism for G Protein Activation
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inferred← citeshttps://doi.org/10.1016/j.sbi.2016.11.005openalex-snapshot
Mechanistic insights into GPCR–G protein interactions
inferred← citeshttps://doi.org/10.1016/j.sbi.2017.04.010openalex-snapshot
Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces
inferred← citeshttps://doi.org/10.1016/j.sbi.2019.03.017openalex-snapshot
Molecular switches in GPCRs
inferred← citeshttps://doi.org/10.1016/j.sbi.2020.04.008openalex-snapshot
Structural features of activated GPCR signaling complexes
inferred← citeshttps://doi.org/10.1016/j.sbi.2021.03.013openalex-snapshot
The conformational transition during G protein–coupled receptor (GPCR) and G protein interaction
inferred← citeshttps://doi.org/10.1016/j.sbi.2023.102574openalex-snapshot
New insights into GPCR coupling and dimerisation from cryo-EM structures
inferred← citeshttps://doi.org/10.1016/j.str.2016.03.008openalex-snapshot
Identifying Allosteric Hotspots with Dynamics: Application to Inter- and Intra-species Conservation
inferred← citeshttps://doi.org/10.1016/j.str.2019.04.013openalex-snapshot
Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A
inferred← citeshttps://doi.org/10.1016/j.str.2025.07.020openalex-snapshot
Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs
inferred← citeshttps://doi.org/10.1016/j.tibs.2018.11.011openalex-snapshot
New Binding Sites, New Opportunities for GPCR Drug Discovery
inferred← citeshttps://doi.org/10.1016/j.tibs.2019.10.010openalex-snapshot
Do All Roads Lead to Rome in G-Protein Activation?
inferred← citeshttps://doi.org/10.1016/j.tibs.2022.03.009openalex-snapshot
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
inferred← citeshttps://doi.org/10.1016/j.tips.2018.01.002openalex-snapshot
Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors
inferred← citeshttps://doi.org/10.1016/j.tips.2018.02.005openalex-snapshot
Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways
inferred← citeshttps://doi.org/10.1016/j.tips.2025.07.003openalex-snapshot
Mutated G proteins as drug targets
inferred← citeshttps://doi.org/10.1021/acs.biochem.3c00029openalex-snapshot
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00779openalex-snapshot
G Protein Selectivity in Dopamine Receptors is Determined before GDP Release
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b01087openalex-snapshot
A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist
inferred← citeshttps://doi.org/10.1021/acs.jcim.0c00432openalex-snapshot
GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β2 Adrenergic Receptor
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c00118openalex-snapshot
Ligand-Dependent Modulation of the Dynamics of Intracellular Loops Dictates Functional Selectivity of 5-HT2AR
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c00417openalex-snapshot
Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c01481openalex-snapshot
Biased Signaling in Mutated Variants of β 2 -Adrenergic Receptor: Insights from Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1021/acs.jcim.6c00203openalex-snapshot
Protein Frustration Reveals Orthosteric and Allosteric Active Sites in GPCR:G Protein Complexes
inferred← citeshttps://doi.org/10.1021/acs.jctc.1c01243openalex-snapshot
Computation of the Protein Conformational Transition Pathway on Ligand Binding by Linear Response-Driven Molecular Dynamics
inferred← citeshttps://doi.org/10.1021/acs.jctc.6b00813openalex-snapshot
Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm
inferred← citeshttps://doi.org/10.1021/acs.jpcb.0c10985openalex-snapshot
Molecular Dynamics Simulations for the Determination of the Characteristic Structural Differences between Inactive and Active States of Wild Type and Mutants of the Orexin2 Receptor
inferred← citeshttps://doi.org/10.1021/acs.jpcb.3c07028openalex-snapshot
G Protein Activation Occurs via a Largely Universal Mechanism
inferred← citeshttps://doi.org/10.1021/acs.jpcb.9b04867openalex-snapshot
Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors
inferred← citeshttps://doi.org/10.1021/acscatal.7b04263openalex-snapshot
Unraveling Allosteric Mechanisms of Enzymatic Catalysis with an Evolutionary Analysis of Residue–Residue Contact Dynamical Changes
inferred← citeshttps://doi.org/10.1021/acscentsci.3c00063openalex-snapshot
Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling
inferred← citeshttps://doi.org/10.1021/acschembio.0c00867openalex-snapshot
Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52
inferred← citeshttps://doi.org/10.1021/acsptsci.1c00239openalex-snapshot
Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants
inferred← citeshttps://doi.org/10.1021/acsptsci.5c00102openalex-snapshot
Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors
inferred← citeshttps://doi.org/10.1021/acsptsci.8b00017openalex-snapshot
Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination
inferred← citeshttps://doi.org/10.1021/acsptsci.8b00026openalex-snapshot
Rules of Engagement: GPCRs and G Proteins
inferred← citeshttps://doi.org/10.1021/acsptsci.9b00054openalex-snapshot
Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors
inferred← citeshttps://doi.org/10.1021/jacs.4c14293openalex-snapshot
CXC Chemokine Ligand 12 Facilitates Gi Protein Binding to CXC Chemokine Receptor 4 by Stabilizing Packing of the Proline–Isoleucine–Phenylalanine Motif: Insights from Automated Path Searching
inferred← citeshttps://doi.org/10.1021/jacs.9b03193openalex-snapshot
GTP Hydrolysis Without an Active Site Base: A Unifying Mechanism for Ras and Related GTPases
inferred← citeshttps://doi.org/10.1021/jacsau.6c00851openalex-snapshot
Landscape of G Protein-Coupled Receptor Function from Structure Networks
inferred← citeshttps://doi.org/10.1038/nature18966openalex-snapshot
Structure of the adenosine A2A receptor bound to an engineered G protein
inferred← citeshttps://doi.org/10.1038/nature19107openalex-snapshot
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
inferred← citeshttps://doi.org/10.1038/nature22070openalex-snapshot
Selectivity determinants of GPCR–G-protein binding
inferred← citeshttps://doi.org/10.1038/nature22354openalex-snapshot
Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
inferred← citeshttps://doi.org/10.1038/ncomms12344openalex-snapshot
Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
inferred← citeshttps://doi.org/10.1038/ncomms14335openalex-snapshot
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
inferred← citeshttps://doi.org/10.1038/ncomms15163openalex-snapshot
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
inferred← citeshttps://doi.org/10.1038/nsmb.3070openalex-snapshot
Probing Gαi1 protein activation at single–amino acid resolution
inferred← citeshttps://doi.org/10.1038/s41388-019-0895-2openalex-snapshot
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm
inferred← citeshttps://doi.org/10.1038/s41392-024-01803-6openalex-snapshot
G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery
inferred← citeshttps://doi.org/10.1038/s41401-022-00982-8openalex-snapshot
Function and structure of bradykinin receptor 2 for drug discovery
inferred← citeshttps://doi.org/10.1038/s41401-024-01385-7openalex-snapshot
Exploring the constitutive activation mechanism of the class A orphan GPR20
inferred← citeshttps://doi.org/10.1038/s41421-022-00403-4openalex-snapshot
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
inferred← citeshttps://doi.org/10.1038/s41421-023-00520-8openalex-snapshot
The activation mechanism and antibody binding mode for orphan GPR20
inferred← citeshttps://doi.org/10.1038/s41421-023-00627-yopenalex-snapshot
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways
inferred← citeshttps://doi.org/10.1038/s41421-024-00724-6openalex-snapshot
Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor
inferred← citeshttps://doi.org/10.1038/s41422-021-00552-3openalex-snapshot
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
inferred← citeshttps://doi.org/10.1038/s41422-021-00569-8openalex-snapshot
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide
inferred← citeshttps://doi.org/10.1038/s41467-017-02257-xopenalex-snapshot
Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
inferred← citeshttps://doi.org/10.1038/s41467-018-06002-wopenalex-snapshot
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
inferred← citeshttps://doi.org/10.1038/s41467-018-08171-0openalex-snapshot
Domain insertion permissibility-guided engineering of allostery in ion channels
inferred← citeshttps://doi.org/10.1038/s41467-019-10038-xopenalex-snapshot
Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
inferred← citeshttps://doi.org/10.1038/s41467-019-11088-xopenalex-snapshot
Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor
inferred← citeshttps://doi.org/10.1038/s41467-020-14943-4openalex-snapshot
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
inferred← citeshttps://doi.org/10.1038/s41467-021-25020-9openalex-snapshot
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
inferred← citeshttps://doi.org/10.1038/s41467-022-28399-1openalex-snapshot
Cryo-EM structures of human bradykinin receptor-Gq proteins complexes
inferred← citeshttps://doi.org/10.1038/s41467-022-29683-wopenalex-snapshot
Structural insights into the peptide selectivity and activation of human neuromedin U receptors
inferred← citeshttps://doi.org/10.1038/s41467-022-30595-yopenalex-snapshot
The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands
inferred← citeshttps://doi.org/10.1038/s41467-022-30601-3openalex-snapshot
Molecular mechanism of the wake-promoting agent TAK-925
inferred← citeshttps://doi.org/10.1038/s41467-022-31325-0openalex-snapshot
Structural basis for the activation and ligand recognition of the human oxytocin receptor
inferred← citeshttps://doi.org/10.1038/s41467-022-33121-2openalex-snapshot
Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist
inferred← citeshttps://doi.org/10.1038/s41467-022-34055-5openalex-snapshot
Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity
inferred← citeshttps://doi.org/10.1038/s41467-023-36182-zopenalex-snapshot
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
inferred← citeshttps://doi.org/10.1038/s41467-023-36911-4openalex-snapshot
Two-step structural changes in M3 muscarinic receptor activation rely on the coupled Gq protein cycle
inferred← citeshttps://doi.org/10.1038/s41467-023-39310-xopenalex-snapshot
Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
inferred← citeshttps://doi.org/10.1038/s41467-023-40045-yopenalex-snapshot
GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach
inferred← citeshttps://doi.org/10.1038/s41467-023-41646-3openalex-snapshot
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism
inferred← citeshttps://doi.org/10.1038/s41467-023-43922-8openalex-snapshot
Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity
inferred← citeshttps://doi.org/10.1038/s41467-023-44177-zopenalex-snapshot
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans
inferred← citeshttps://doi.org/10.1038/s41467-024-50964-zopenalex-snapshot
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state
inferred← citeshttps://doi.org/10.1038/s41467-024-51993-4openalex-snapshot
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site
inferred← citeshttps://doi.org/10.1038/s41467-024-53161-0openalex-snapshot
Ligand-induced conformational changes in the β1-adrenergic receptor revealed by hydrogen-deuterium exchange mass spectrometry
inferred← citeshttps://doi.org/10.1038/s41467-024-53473-1openalex-snapshot
Structural insights into the agonist selectivity of the adenosine A3 receptor
inferred← citeshttps://doi.org/10.1038/s41467-024-54103-6openalex-snapshot
A non-canonical mechanism of GPCR activation
inferred← citeshttps://doi.org/10.1038/s41467-024-55466-6openalex-snapshot
Generic residue numbering of the GAIN domain of adhesion GPCRs
inferred← citeshttps://doi.org/10.1038/s41467-025-55901-2openalex-snapshot
Cryo-EM structure of an activated GPR4–Gs signaling complex
inferred← citeshttps://doi.org/10.1038/s41467-025-56434-4openalex-snapshot
Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex
inferred← citeshttps://doi.org/10.1038/s41467-025-64002-zopenalex-snapshot
Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1
inferred← citeshttps://doi.org/10.1038/s41467-025-66958-4openalex-snapshot
Temporally resolved and interpretable machine learning model of GPCR conformational transition
inferred← citeshttps://doi.org/10.1038/s41467-025-67629-0openalex-snapshot
Structure of the Gq-coupled adhesion receptor ADGRL4
inferred← citeshttps://doi.org/10.1038/s41467-026-77555-4openalex-snapshot
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins
inferred← citeshttps://doi.org/10.1038/s41580-018-0049-3openalex-snapshot
Mechanisms of signalling and biased agonism in G protein-coupled receptors
inferred← citeshttps://doi.org/10.1038/s41580-026-01030-7openalex-snapshot
Atomic, structural and molecular insights into GPCR ligand binding and signalling
inferred← citeshttps://doi.org/10.1038/s41586-018-0236-6openalex-snapshot
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
inferred← citeshttps://doi.org/10.1038/s41586-018-0241-9openalex-snapshot
Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go
inferred← citeshttps://doi.org/10.1038/s41586-020-03083-wopenalex-snapshot
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
inferred← citeshttps://doi.org/10.1038/s41586-020-2994-1openalex-snapshot
Structure of the class D GPCR Ste2 dimer coupled to two G proteins
inferred← citeshttps://doi.org/10.1038/s41586-021-03495-2openalex-snapshot
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
inferred← citeshttps://doi.org/10.1038/s41586-022-04498-3openalex-snapshot
Activation mechanism of the class D fungal GPCR dimer Ste2
inferred← citeshttps://doi.org/10.1038/s41586-022-04580-wopenalex-snapshot
Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1
inferred← citeshttps://doi.org/10.1038/s41586-022-05489-0openalex-snapshot
Molecular basis for selective activation of DREADD-based chemogenetics
inferred← citeshttps://doi.org/10.1038/s41586-023-06030-7openalex-snapshot
Ligand and G-protein selectivity in the κ-opioid receptor
inferred← citeshttps://doi.org/10.1038/s41586-024-07331-1openalex-snapshot
Promiscuous G-protein activation by the calcium-sensing receptor
inferred← citeshttps://doi.org/10.1038/s41586-025-09186-6openalex-snapshot
Allosteric modulation and biased signalling at free fatty acid receptor 2
inferred← citeshttps://doi.org/10.1038/s41586-025-10061-7openalex-snapshot
Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling
inferred← citeshttps://doi.org/10.1038/s41586-026-10228-wopenalex-snapshot
The dynamic basis of G-protein recognition and activation by a GPCR
inferred← citeshttps://doi.org/10.1038/s41589-018-0115-3openalex-snapshot
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
inferred← citeshttps://doi.org/10.1038/s41589-021-00841-3openalex-snapshot
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
inferred← citeshttps://doi.org/10.1038/s41589-022-01231-zopenalex-snapshot
The role of G protein conformation in receptor–G protein selectivity
inferred← citeshttps://doi.org/10.1038/s41589-024-01682-6openalex-snapshot
Balancing G protein selectivity and efficacy in the adenosine A2A receptor
inferred← citeshttps://doi.org/10.1038/s41589-025-01957-6openalex-snapshot
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R
inferred← citeshttps://doi.org/10.1038/s41591-025-03976-1openalex-snapshot
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
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