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Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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UCSF Chimera—A visualization system for exploratory research and analysis
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Comparative Protein Modelling by Satisfaction of Spatial Restraints
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Beta-myosin Heavy Chain Gene Mutations and Hypertrophic Cardiomyopathy in Austrian Children
inferredcites →https://doi.org/10.1007/s00018-012-1002-9openalex-snapshot
Nonmuscle myosin-2: mix and match
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Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.1007/s00109-005-0635-7openalex-snapshot
Prevalence of cardiac beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.1007/s00439-013-1358-4openalex-snapshot
The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine
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A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
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Purification of cytoplasmic actin by affinity chromatography using the C-terminal half of gelsolin
inferredcites →https://doi.org/10.1016/j.cell.2012.05.037openalex-snapshot
Structure of the Rigor Actin-Tropomyosin-Myosin Complex
inferredcites →https://doi.org/10.1016/j.devcel.2015.03.025openalex-snapshot
How Actin Initiates the Motor Activity of Myosin
inferredcites →https://doi.org/10.1016/j.febslet.2014.11.007openalex-snapshot
Crystal structure of the rigor‐like human non‐muscle myosin‐2 motor domain
inferredcites →https://doi.org/10.1016/j.jacc.2004.04.039openalex-snapshot
Comprehensive Analysis of the Beta-Myosin Heavy Chain Gene in 389 Unrelated Patients With Hypertrophic Cardiomyopathy
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SPARX, a new environment for Cryo-EM image processing
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Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions
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RELION: Implementation of a Bayesian approach to cryo-EM structure determination
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iMODFIT: Efficient and robust flexible fitting based on vibrational analysis in internal coordinates
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Novel mutations in sarcomeric protein genes in dilated cardiomyopathy
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Enhanced stimulation of myosin subfragment 1 ATPase activity by addition of negatively charged residues to the yeast actin NH2 terminus.
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Accurate determination of local defocus and specimen tilt in electron microscopy
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Stabilization of the Actomyosin Complex by Negative Charges on Myosin
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Functional Roles of Ionic and Hydrophobic Surface Loops in Smooth Muscle Myosin: Their Interactions with Actin
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Mechanism of adenosine triphosphate hydrolysis by actomyosin
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Functional Homodimers and Heterodimers of Recombinant Smooth Muscle Tropomyosin
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Mutational Analysis of the Role of the N Terminus of Actin in Actomyosin Interactions. Comparison with Other Mutant Actins and Implications for the Cross-Bridge Cycle
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X-ray Structures of the MgADP, MgATPγS, and MgAMPPNP Complexes of the Dictyostelium discoideum Myosin Motor Domain,
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The Sequence of the Myosin 50−20K Loop Affects Myosin's Affinity for Actin throughout the Actin−Myosin ATPase Cycle and Its Maximum ATPase Activity
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Functional Characterization of the Secondary Actin Binding Site of Myosin II
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Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy
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Molecular structure of F-actin and location of surface binding sites
inferredcites →https://doi.org/10.1038/368567a0openalex-snapshot
Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin
inferredcites →https://doi.org/10.1038/msb.2011.75openalex-snapshot
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
inferredcites →https://doi.org/10.1038/nature01927openalex-snapshot
A structural state of the myosin V motor without bound nucleotide
inferredcites →https://doi.org/10.1038/nature02005openalex-snapshot
Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide
inferredcites →https://doi.org/10.1038/nature03216openalex-snapshot
Recognition of transmembrane helices by the endoplasmic reticulum translocon
inferredcites →https://doi.org/10.1038/nature07485openalex-snapshot
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
inferredcites →https://doi.org/10.1038/nature14033openalex-snapshot
Structure of the F-actin–tropomyosin complex
inferredcites →https://doi.org/10.1038/ng1775openalex-snapshot
Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome
inferredcites →https://doi.org/10.1038/nmeth.2115openalex-snapshot
Prevention of overfitting in cryo-EM structure determination
inferredcites →https://doi.org/10.1038/nmeth.2472openalex-snapshot
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
inferredcites →https://doi.org/10.1038/nmeth.2727openalex-snapshot
Quantifying the local resolution of cryo-EM density maps
inferredcites →https://doi.org/10.1038/nsmb.2216openalex-snapshot
A novel actin binding site of myosin required for effective muscle contraction
inferredcites →https://doi.org/10.1038/sj.emboj.7600458openalex-snapshot
Three myosin V structures delineate essential features of chemo‐mechanical transduction
inferredcites →https://doi.org/10.1056/nejm200012073432304openalex-snapshot
Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy
inferredcites →https://doi.org/10.1073/pnas.0601595103openalex-snapshot
Toward understanding actin activation of myosin ATPase: The role of myosin surface loops
inferredcites →https://doi.org/10.1073/pnas.0802286105openalex-snapshot
Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR
inferredcites →https://doi.org/10.1073/pnas.1514859112openalex-snapshot
Direct real-time detection of the structural and biochemical events in the myosin power stroke
inferredcites →https://doi.org/10.1073/pnas.88.17.7711openalex-snapshot
Site-directed mutations of Dictyostelium actin: disruption of a negative charge cluster at the N terminus.
inferredcites →https://doi.org/10.1074/jbc.274.53.37840openalex-snapshot
Deletion of the Myopathy Loop of Dictyostelium Myosin II and Its Impact on Motor Functions
inferredcites →https://doi.org/10.1074/jbc.m001966200openalex-snapshot
Insertion or Deletion of a Single Residue in the Strut Sequence of Dictyostelium Myosin II Abolishes Strong Binding to Actin
inferredcites →https://doi.org/10.1074/jbc.m006930200openalex-snapshot
Two Conserved Lysines at the 50/20-kDa Junction of Myosin Are Necessary for Triggering Actin Activation
inferredcites →https://doi.org/10.1074/jbc.m110.212290openalex-snapshot
Comparative Kinetic and Functional Characterization of the Motor Domains of Human Nonmuscle Myosin-2C Isoforms
inferredcites →https://doi.org/10.1074/jbc.m114.606665openalex-snapshot
Structural Model of Weak Binding Actomyosin in the Prepowerstroke State
inferredcites →https://doi.org/10.1086/302623openalex-snapshot
The Origins of Hypertrophic Cardiomyopathy–Causing Mutations in Two South African Subpopulations: A Unique Profile of Both Independent and Founder Events
inferredcites →https://doi.org/10.1089/109065703321560895openalex-snapshot
Utility of Genetic Screening in Hypertrophic Cardiomyopathy: Prevalence and Significance of Novel and Double (Homozygous and Heterozygous) β -Myosin Mutations
inferredcites →https://doi.org/10.1093/eurheartj/ehi193openalex-snapshot
Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene
inferredcites →https://doi.org/10.1093/hmg/2.10.1731openalex-snapshot
Identification of a new missense mutation at Arg403, a CpG mutation hotspot, in exon 13 of the β-myosin heavy chain gene in hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.1093/nar/gks375openalex-snapshot
H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations
inferredcites →https://doi.org/10.1093/nar/gku989openalex-snapshot
UniProt: a hub for protein information
inferredcites →https://doi.org/10.1107/s0907444909042073openalex-snapshot
MolProbity : all-atom structure validation for macromolecular crystallography
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1107/s0907444910045749openalex-snapshot
Overview of the CCP 4 suite and current developments
inferredcites →https://doi.org/10.1107/s1399004714016241openalex-snapshot
Conformation-independent structural comparison of macromolecules withProSMART
inferredcites →https://doi.org/10.1107/s1399004714021683openalex-snapshot
Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions
inferredcites →https://doi.org/10.1126/science.164.3886.1356openalex-snapshot
The Mechanism of Muscular Contraction
inferredcites →https://doi.org/10.1126/science.8316858openalex-snapshot
Structure of the actin-myosin complex and its implications for muscle contraction
inferredcites →https://doi.org/10.1136/heart.89.10.1179openalex-snapshot
Mutations of the β myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis
inferredcites →https://doi.org/10.1136/jcp.2004.021642openalex-snapshot
Denaturing high performance liquid chromatography: high throughput mutation screening in familial hypertrophic cardiomyopathy and SNP genotyping in motor neurone disease
inferredcites →https://doi.org/10.1146/annurev.biophys.050708.133751openalex-snapshot
Structural and Functional Insights into the Myosin Motor Mechanism
inferredcites →https://doi.org/10.1161/01.cir.0000066323.15244.54openalex-snapshot
Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1161/01.cir.86.2.345openalex-snapshot
Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation.
inferredcites →https://doi.org/10.1161/01.res.84.4.475openalex-snapshot
Altered Crossbridge Kinetics in the αMHC 403/+ Mouse Model of Familial Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1172/jci116530openalex-snapshot
Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.
inferredcites →https://doi.org/10.1172/jci116900openalex-snapshot
Familial hypertrophic cardiomyopathy. Microsatellite haplotyping and identification of a hot spot for mutations in the beta-myosin heavy chain gene.
inferredcites →https://doi.org/10.1172/jci117795openalex-snapshot
Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy.
inferredcites →https://doi.org/10.1172/jci7956openalex-snapshot
A transgenic rabbit model for human hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.7554/elife.03665openalex-snapshot
Beam-induced motion correction for sub-megadalton cryo-EM particles
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The MYO 6 interactome: selective motor‐cargo complexes for diverse cellular processes
inferred← citeshttps://doi.org/10.1002/2211-5463.12876openalex-snapshot
Cardiac troponin and tropomyosin bind to F‐actin cooperatively, as revealed by fluorescence microscopy
inferred← citeshttps://doi.org/10.1002/agt2.70265openalex-snapshot
Tissue‐Specific Extraction and Structural Elucidation of Actin‐Tropomyosin‐Myosin Complexes from Human and Rodent
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Kryo‐Elektronenmikroskopie als Methode für die strukturbasierte Wirkstoffentwicklung
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Electron Cryo‐microscopy as a Tool for Structure‐Based Drug Development
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Advances in Structural Biology and the Application to Biological Filament Systems
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An ionic–chemical–mechanical model for muscle contraction
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K eeping the focus on biophysics and actin filaments in Nagoya: A report of the 2016 “now in actin” symposium
inferred← citeshttps://doi.org/10.1002/cm.21440openalex-snapshot
Distinct sites in tropomyosin specify shared and isoform‐specific regulation of myosins II and V
inferred← citeshttps://doi.org/10.1002/cm.21757openalex-snapshot
Actin's C‐terminus coordinates actin structural changes and functions
inferred← citeshttps://doi.org/10.1002/cm.21852openalex-snapshot
Biochemical characterization of cardiac α‐actin mutations A21V and D26N implicated in hypertrophic cardiomyopathy
inferred← citeshttps://doi.org/10.1002/pro.3054openalex-snapshot
While the revolution will not be crystallized, biochemistry reigns supreme
inferred← citeshttps://doi.org/10.1002/prot.25404openalex-snapshot
Simultaneous refinement of inaccurate local regions and overall structure in the CASP12 protein model refinement experiment
inferred← citeshttps://doi.org/10.1002/prot.25707openalex-snapshot
Molecular dynamics simulation of tropomyosin bound to actins/myosin in the closed and open states
inferred← citeshttps://doi.org/10.1007/978-3-030-03526-6_3openalex-snapshot
Actin-Myosin Biochemistry and Structure
inferred← citeshttps://doi.org/10.1007/978-3-030-03526-6_4openalex-snapshot
Models for Fully-Activated Muscle
inferred← citeshttps://doi.org/10.1007/978-3-030-38062-5_4openalex-snapshot
The Structure of Acto-Myosin
inferred← citeshttps://doi.org/10.1007/978-3-030-38062-5_5openalex-snapshot
Small Molecule Effectors of Myosin Function
inferred← citeshttps://doi.org/10.1007/978-3-030-38062-5_9openalex-snapshot
How Actin Tracks Affect Myosin Motors
inferred← citeshttps://doi.org/10.1007/978-3-662-56086-0_5openalex-snapshot
Das Bewegungsorgan Skelettmuskulatur
inferred← citeshttps://doi.org/10.1007/978-4-431-56550-5_5openalex-snapshot
Remodeling of Actin Filaments by Drebrin A and Its Implications
inferred← citeshttps://doi.org/10.1007/978-981-13-2200-6_4openalex-snapshot
Complementary Use of Electron Cryomicroscopy and X-Ray Crystallography: Structural Studies of Actin and Actomyosin Filaments
inferred← citeshttps://doi.org/10.1007/s00018-021-03971-yopenalex-snapshot
Alpha and beta myosin isoforms and human atrial and ventricular contraction
inferred← citeshttps://doi.org/10.1007/s00018-024-05264-6openalex-snapshot
Structure, regulation, and mechanisms of nonmuscle myosin-2
inferred← citeshttps://doi.org/10.1007/s00109-018-1640-yopenalex-snapshot
Electron cryomicroscopy as a powerful tool in biomedical research
inferred← citeshttps://doi.org/10.1007/s10974-019-09514-0openalex-snapshot
Actin–tropomyosin distribution in non-muscle cells
inferred← citeshttps://doi.org/10.1007/s10974-019-09537-7openalex-snapshot
After the revolution: how is Cryo-EM contributing to muscle research?
inferred← citeshttps://doi.org/10.1007/s10974-019-09543-9openalex-snapshot
Monitoring the myosin crossbridge cycle in contracting muscle: steps towards ‘Muscle—the Movie’
inferred← citeshttps://doi.org/10.1007/s12551-017-0274-6openalex-snapshot
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
inferred← citeshttps://doi.org/10.1007/s12551-020-00717-1openalex-snapshot
Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers
inferred← citeshttps://doi.org/10.1007/s12551-020-00721-5openalex-snapshot
Disease mutations in striated muscle myosins
inferred← citeshttps://doi.org/10.1007/s41048-016-0032-5openalex-snapshot
Thermodynamic aspects of ATP hydrolysis of actomyosin complex
inferred← citeshttps://doi.org/10.1016/b978-0-443-18829-9.00006-2openalex-snapshot
Interpretation of cellular tomograms
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2021.02.017openalex-snapshot
Cancer type-specific alterations in actin genes: Worth a closer look?
inferred← citeshttps://doi.org/10.1016/j.abb.2016.12.004openalex-snapshot
Molecular mechanisms of deregulation of the thin filament associated with the R167H and K168E substitutions in tropomyosin Tpm1.1
inferred← citeshttps://doi.org/10.1016/j.abb.2018.03.002openalex-snapshot
The primary cause of muscle disfunction associated with substitutions E240K and R244G in tropomyosin is aberrant behavior of tropomyosin and response of actin and myosin during ATPase cycle
inferred← citeshttps://doi.org/10.1016/j.abb.2018.11.002openalex-snapshot
Cleavage of loops 1 and 2 in skeletal muscle heavy meromyosin (HMM) leads to a decreased function
inferred← citeshttps://doi.org/10.1016/j.bbagen.2022.130132openalex-snapshot
Mechanisms of the modulation of actin-myosin interactions by A1-type myosin light chains
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.172openalex-snapshot
Structural and dynamical characteristics of tropomyosin epitopes as the major allergens in shrimp
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.03.010openalex-snapshot
C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.151089openalex-snapshot
New strokes to the portrait of inactivated actin
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.04.053openalex-snapshot
Switching Muscles On and Off in Steps: The McKillop-Geeves Three-State Model of Muscle Regulation
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.09.037openalex-snapshot
Regulation of Contraction by the Thick Filaments in Skeletal Muscle
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.11.3812openalex-snapshot
Tropomyosins Regulate the Severing Activity of Gelsolin in Isoform-Dependent and Independent Manners
inferred← citeshttps://doi.org/10.1016/j.bpj.2019.04.042openalex-snapshot
Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label
inferred← citeshttps://doi.org/10.1016/j.bpj.2020.07.006openalex-snapshot
Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments
inferred← citeshttps://doi.org/10.1016/j.cdev.2021.203760openalex-snapshot
Mechanobiology of muscle and myofibril morphogenesis
inferred← citeshttps://doi.org/10.1016/j.ceb.2020.08.011openalex-snapshot
Mythical origins of the actin cytoskeleton
inferred← citeshttps://doi.org/10.1016/j.ceb.2024.102419openalex-snapshot
Actin filament dynamics at barbed ends: New structures, new insights
inferred← citeshttps://doi.org/10.1016/j.cell.2021.02.047openalex-snapshot
The molecular basis for sarcomere organization in vertebrate skeletal muscle
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Structural basis of membrane skeleton organization in red blood cells
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Hybrid method for representing ions in implicit solvation calculations
inferred← citeshttps://doi.org/10.1016/j.cub.2019.03.022openalex-snapshot
Nonmuscle myosin-2 isoforms
inferred← citeshttps://doi.org/10.1016/j.ejcb.2022.151224openalex-snapshot
Capturing actin assemblies in cells using in situ cryo-electron tomography
inferred← citeshttps://doi.org/10.1016/j.ejcb.2024.151460openalex-snapshot
Cryo-EM structures of cardiac muscle α-actin mutants M305L and A331P give insights into the structural mechanisms of hypertrophic cardiomyopathy
inferred← citeshttps://doi.org/10.1016/j.ejcb.2026.151577openalex-snapshot
Non-muscle actinopathy-associated loss-of-function actin variants modulate cytoskeletal reorganization
inferred← citeshttps://doi.org/10.1016/j.foodchem.2021.129655openalex-snapshot
Phosphorylation of myosin regulatory light chain at Ser17 regulates actomyosin dissociation
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107773openalex-snapshot
Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activity
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100938openalex-snapshot
Challenges in sample preparation and structure determination of amyloids by cryo-EM
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107925openalex-snapshot
Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110351openalex-snapshot
Bacterial genome-encoded ParMs
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111446openalex-snapshot
Actin’s functional “switch”: Constraining C-terminal conformational flexibility disrupts functionally important communication networks
inferred← citeshttps://doi.org/10.1016/j.jmb.2019.11.013openalex-snapshot
X-ray Crystallographic and Molecular Dynamic Analyses of Drosophila melanogaster Embryonic Muscle Myosin Define Domains Responsible for Isoform-Specific Properties
inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167879openalex-snapshot
Cryo-Electron Microscopy Reveals Cardiac Myosin Binding Protein-C M-Domain Interactions with the Thin Filament
inferred← citeshttps://doi.org/10.1016/j.jsb.2017.10.003openalex-snapshot
The structure of the actin-smooth muscle myosin motor domain complex in the rigor state
inferred← citeshttps://doi.org/10.1016/j.jsb.2023.107995openalex-snapshot
Double-headed binding of myosin II to F-actin shows the effect of strain on head structure
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Resolution advances in cryo-EM enable application to drug discovery
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Single particle cryo-EM — an optimal tool to study cytoskeletal proteins
inferred← citeshttps://doi.org/10.1016/j.sbi.2022.102391openalex-snapshot
Cryo-electron microscopy analysis of myosin at work and at rest
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Towards a structural understanding of the remodeling of the actin cytoskeleton
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N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament
inferred← citeshttps://doi.org/10.1016/j.str.2020.01.014openalex-snapshot
Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments
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A Global Ramachandran Score Identifies Protein Structures with Unlikely Stereochemistry
inferred← citeshttps://doi.org/10.1016/j.str.2020.09.013openalex-snapshot
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex
inferred← citeshttps://doi.org/10.1016/j.tcb.2024.12.009openalex-snapshot
Structural insights into actin filament turnover
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How Myosin Generates Force on Actin Filaments
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ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview
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Mechanical regulation of myofibroblast phenoconversion and collagen contraction
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2025.05.005openalex-snapshot
The role of the troponin T interactions with actin in regulation of cardiac thin filament revealed by the troponin T pathogenic variant Ile79Asn
inferred← citeshttps://doi.org/10.1017/s003358352300001xopenalex-snapshot
Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling
inferred← citeshttps://doi.org/10.1017/s1431927621009880openalex-snapshot
The molecular basis for sarcomere organization in vertebrate skeletal muscle
inferred← citeshttps://doi.org/10.1021/acs.chemrev.9b00264openalex-snapshot
Force Generation by Myosin Motors: A Structural Perspective
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00503openalex-snapshot
Medicinal Chemistry and Use of Myosin II Inhibitor (S)-Blebbistatin and Its Derivatives
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b10003openalex-snapshot
Dielectric Allostery of Protein: Response of Myosin to ATP Binding
inferred← citeshttps://doi.org/10.1021/acs.jpclett.8b00958openalex-snapshot
Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin As Revealed by All-Atom Steered Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1038/ncomms13969openalex-snapshot
Structure of actomyosin rigour complex at 5.2 Å resolution and insights into the ATPase cycle mechanism
inferred← citeshttps://doi.org/10.1038/nrd.2018.77openalex-snapshot
Cryo-EM in drug discovery: achievements, limitations and prospects
inferred← citeshttps://doi.org/10.1038/nsmb.3408openalex-snapshot
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
inferred← citeshttps://doi.org/10.1038/s41467-017-01367-wopenalex-snapshot
Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
inferred← citeshttps://doi.org/10.1038/s41467-017-02357-8openalex-snapshot
Catastrophic disassembly of actin filaments via Mical-mediated oxidation
inferred← citeshttps://doi.org/10.1038/s41467-018-04290-wopenalex-snapshot
Structural basis for cofilin binding and actin filament disassembly
inferred← citeshttps://doi.org/10.1038/s41467-018-06713-0openalex-snapshot
Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia
inferred← citeshttps://doi.org/10.1038/s41467-019-10779-9openalex-snapshot
The structure of a 15-stranded actin-like filament from Clostridium botulinum
inferred← citeshttps://doi.org/10.1038/s41467-019-11120-0openalex-snapshot
Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism
inferred← citeshttps://doi.org/10.1038/s41467-019-14008-1openalex-snapshot
Cardiac muscle thin filament structures reveal calcium regulatory mechanism
inferred← citeshttps://doi.org/10.1038/s41467-020-19513-2openalex-snapshot
TranSPHIRE: automated and feedback-optimized on-the-fly processing for cryo-EM
inferred← citeshttps://doi.org/10.1038/s41467-021-22093-4openalex-snapshot
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity
inferred← citeshttps://doi.org/10.1038/s41467-021-24049-0openalex-snapshot
Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
inferred← citeshttps://doi.org/10.1038/s41467-024-49427-2openalex-snapshot
The DIAPH3 linker specifies a β-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow
inferred← citeshttps://doi.org/10.1038/s41467-026-74543-6openalex-snapshot
Structural mechanisms of drebrin-mediated F-actin network modulation
inferred← citeshttps://doi.org/10.1038/s41467-026-74674-wopenalex-snapshot
Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
inferred← citeshttps://doi.org/10.1038/s41569-022-00677-xopenalex-snapshot
Electron microscopy of cardiac 3D nanodynamics: form, function, future
inferred← citeshttps://doi.org/10.1038/s41586-022-05241-8openalex-snapshot
Structural basis of actin filament assembly and aging
inferred← citeshttps://doi.org/10.1038/s41586-025-08876-5openalex-snapshot
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM
inferred← citeshttps://doi.org/10.1038/s41586-026-10398-7openalex-snapshot
Myosin forces remodel F-actin for mechanosensitive protein recognition
inferred← citeshttps://doi.org/10.1038/s41588-021-00886-zopenalex-snapshot
Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome
inferred← citeshttps://doi.org/10.1038/s41592-022-01690-1openalex-snapshot
Parallel cryo electron tomography on in situ lamellae
inferred← citeshttps://doi.org/10.1038/s41594-018-0074-0openalex-snapshot
Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM
inferred← citeshttps://doi.org/10.1038/s41598-017-11984-6openalex-snapshot
Kinetic adaptation of human Myo19 for active mitochondrial transport to growing filopodia tips
inferred← citeshttps://doi.org/10.1038/s41598-018-24953-4openalex-snapshot
Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells
inferred← citeshttps://doi.org/10.1038/s41684-024-01377-4openalex-snapshot
The pig as an optimal animal model for cardiovascular research
inferred← citeshttps://doi.org/10.1038/s42004-024-01243-xopenalex-snapshot
High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations
inferred← citeshttps://doi.org/10.1039/c9ra05072hopenalex-snapshot
A model for the chemomechanical coupling of myosin-V molecular motors
inferred← citeshttps://doi.org/10.1042/bst20220221openalex-snapshot
Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM
inferred← citeshttps://doi.org/10.1063/1.5004809openalex-snapshot
Long-range coupling between ATP-binding and lever-arm regions in myosin via dielectric allostery
inferred← citeshttps://doi.org/10.1063/5.0078166openalex-snapshot
Molecular mechanisms of cardiac actomyosin transforming from rigor state to post-rigor state
inferred← citeshttps://doi.org/10.1073/pnas.1700868114openalex-snapshot
Ca 2+ -induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy
inferred← citeshttps://doi.org/10.1073/pnas.1707506114openalex-snapshot
Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability
inferred← citeshttps://doi.org/10.1073/pnas.1711512115openalex-snapshot
An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics
inferred← citeshttps://doi.org/10.1073/pnas.1715836115openalex-snapshot
Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain
inferred← citeshttps://doi.org/10.1073/pnas.1718316115openalex-snapshot
High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing
inferred← citeshttps://doi.org/10.1073/pnas.1802967115openalex-snapshot
Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels
inferred← citeshttps://doi.org/10.1073/pnas.1806394115openalex-snapshot
Structural evidence for the roles of divalent cations in actin polymerization and activation of ATP hydrolysis
inferred← citeshttps://doi.org/10.1073/pnas.1807028115openalex-snapshot
Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides
inferred← citeshttps://doi.org/10.1073/pnas.1900799116openalex-snapshot
Nucleotide-dependent conformational changes in the actin filament: Subtler than expected
inferred← citeshttps://doi.org/10.1073/pnas.2024288118openalex-snapshot
The structure of the native cardiac thin filament at systolic Ca 2+ levels
inferred← citeshttps://doi.org/10.1073/pnas.2120962119openalex-snapshot
Discovery of ultrafast myosin, its amino acid sequence, and structural features
inferred← citeshttps://doi.org/10.1073/pnas.2205370119openalex-snapshot
Structural mechanism for bidirectional actin cross-linking by T-plastin
inferred← citeshttps://doi.org/10.1073/pnas.2215836120openalex-snapshot
Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation
inferred← citeshttps://doi.org/10.1074/jbc.m117.806521openalex-snapshot
Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous β-actin in vitro
inferred← citeshttps://doi.org/10.1074/jbc.m117.810119openalex-snapshot
The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step
inferred← citeshttps://doi.org/10.1074/jbc.ra120.015863openalex-snapshot
Myosin and gelsolin cooperate in actin filament severing and actomyosin motor activity
inferred← citeshttps://doi.org/10.1080/19420889.2016.1242538openalex-snapshot
Structural complexity of filaments formed from the actin and tubulin folds
inferred← citeshttps://doi.org/10.1080/19490976.2026.2709265openalex-snapshot
The role of adhesins of Fusobacterium nucleatum in colorectal cancer – a structural perspective
inferred← citeshttps://doi.org/10.1083/jcb.202006151openalex-snapshot
Lysine acetylation of cytoskeletal proteins: Emergence of an actin code
inferred← citeshttps://doi.org/10.1083/jcb.202409067openalex-snapshot
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation
inferred← citeshttps://doi.org/10.1083/jcb.202409192openalex-snapshot
Structure of the F-tractin–F-actin complex
inferred← citeshttps://doi.org/10.1085/jgp.201812210openalex-snapshot
Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels
inferred← citeshttps://doi.org/10.1085/jgp.202012778openalex-snapshot
Analysis methods and quality criteria for investigating muscle physiology using x-ray diffraction
inferred← citeshttps://doi.org/10.1085/jgp.202213267openalex-snapshot
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
inferred← citeshttps://doi.org/10.1085/jgp.202213274openalex-snapshot
Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation
inferred← citeshttps://doi.org/10.1085/jgp.202413538openalex-snapshot
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
inferred← citeshttps://doi.org/10.1088/1674-1056/27/6/066803openalex-snapshot
Cryo-ET bridges the gap between cell biology and structural biophysics
inferred← citeshttps://doi.org/10.1091/mbc.e18-12-0815openalex-snapshot
Tropomyosin isoforms differentially tune actin filament length and disassembly
inferred← citeshttps://doi.org/10.1096/fj.202301604ropenalex-snapshot
Mechanochemical consequences of myopathy‐linked mutations in Tpm2.2 on striated muscle contractility
inferred← citeshttps://doi.org/10.1098/rsif.2020.0029openalex-snapshot
Dynamics of ATP-dependent and ATP-independent steppings of myosin-V on actin: catch-bond characteristics
inferred← citeshttps://doi.org/10.1101/2020.02.16.951269openalex-snapshot
Structure of the Lifeact–F-actin complex
inferred← citeshttps://doi.org/10.1101/2020.09.13.295386openalex-snapshot
Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ET
inferred← citeshttps://doi.org/10.1101/2021.04.20.440673openalex-snapshot
Modeling myosin with interacting linkages
inferred← citeshttps://doi.org/10.1101/2021.09.08.459548openalex-snapshot
Mechanoaccumulation of non-muscle myosin IIB during mitosis requires its translocation activity
inferred← citeshttps://doi.org/10.1101/2021.10.06.463400openalex-snapshot
Structure of the thin filament in native skeletal muscles reveals its interaction with nebulin and two distinct conformations of myosin
inferred← citeshttps://doi.org/10.1101/2021.10.25.465733openalex-snapshot
IntAct: a non-disruptive internal tagging strategy to study actin isoform organization and function
inferred← citeshttps://doi.org/10.1101/2022.11.22.517348openalex-snapshot
Structure and function of Plasmodium actin II in the parasite mosquito stages
inferred← citeshttps://doi.org/10.1101/2023.08.30.554051openalex-snapshot
Dynamic coordination of the lever-arm swing of human myosin II in thick filaments on actin
inferred← citeshttps://doi.org/10.1101/2023.09.10.557040openalex-snapshot
The non–muscle actinopathy–associated mutation E334Q in cytoskeletal γ– actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins
inferred← citeshttps://doi.org/10.1101/2024.01.05.574365openalex-snapshot
Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM
inferred← citeshttps://doi.org/10.1101/2024.06.12.598685openalex-snapshot
Structure and physiological investigation of arginylated actin
inferred← citeshttps://doi.org/10.1101/2024.08.15.608188openalex-snapshot
Myosin forces elicit an F-actin structural landscape that mediates mechanosensitive protein recognition
inferred← citeshttps://doi.org/10.1101/303909openalex-snapshot
Thrombocytopenia Microcephaly Syndrome - a novel phenotype associated with ACTB mutations
inferred← citeshttps://doi.org/10.1101/458257openalex-snapshot
High-resolution models of actin-bound myosin from EPR of a bifunctional spin label
inferred← citeshttps://doi.org/10.1105/tpc.18.00973openalex-snapshot
Cryo-EM Structure of Actin Filaments from Zea mays Pollen
inferred← citeshttps://doi.org/10.1107/s205979831700225xopenalex-snapshot
`Atomic resolution': a badly abused term in structural biology
inferred← citeshttps://doi.org/10.1107/s2059798321008810openalex-snapshot
On-grid and in-flow mixing for time-resolved cryo-EM
inferred← citeshttps://doi.org/10.1109/cisp-bmei.2017.8302304openalex-snapshot
Resolution determination method of a cryo-EM density map based on multi-scale spectral signal to noise analysis
inferred← citeshttps://doi.org/10.1111/cmi.13345openalex-snapshot
The multiple functions of actin in apicomplexan parasites
inferred← citeshttps://doi.org/10.1111/febs.14442openalex-snapshot
Interaction of isolated cross‐linked short actin oligomers with the skeletal muscle myosin motor domain
inferred← citeshttps://doi.org/10.1111/febs.17153openalex-snapshot
Structural and functional mechanisms of actin isoforms
inferred← citeshttps://doi.org/10.1111/febs.70018openalex-snapshot
Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome
inferred← citeshttps://doi.org/10.1111/febs.70263openalex-snapshot
Highly divergent apicomplexan cytoskeletons provide additional models for actin biology
inferred← citeshttps://doi.org/10.1113/jp289622openalex-snapshot
Mechanics of blunting of actin–myosin interaction dynamics by the actinopathy‐causing mutation E334Q in cytoskeletal γ‐actin
inferred← citeshttps://doi.org/10.1126/sciadv.abl4733openalex-snapshot
Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia
inferred← citeshttps://doi.org/10.1126/sciadv.aeg1209openalex-snapshot
The structure of the native cardiac crossbridge in the rigor state
inferred← citeshttps://doi.org/10.1126/science.abn1934openalex-snapshot
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin
inferred← citeshttps://doi.org/10.1134/s0006297919060014openalex-snapshot
Biological Role of Actin Isoforms in Mammalian Cells
inferred← citeshttps://doi.org/10.1134/s0026893318010193openalex-snapshot
Search for Functionally Significant Motifs and Amino Acid Residues of Actin
inferred← citeshttps://doi.org/10.1146/annurev-biochem-052521-042909openalex-snapshot
Structural Biochemistry of Muscle Contraction
inferred← citeshttps://doi.org/10.1146/annurev-cellbio-101223-022717openalex-snapshot
Structural Biophysics of Cytoskeletal Force Transduction
inferred← citeshttps://doi.org/10.1146/annurev-physiol-042222-022728openalex-snapshot
Regulating Striated Muscle Contraction: Through Thick and Thin
inferred← citeshttps://doi.org/10.1152/physrev.00014.2023openalex-snapshot
Mechanisms of myosin II force generation: insights from novel experimental techniques and approaches
inferred← citeshttps://doi.org/10.1165/rcmb.2023-0229ocopenalex-snapshot
Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development
inferred← citeshttps://doi.org/10.1186/s40543-025-00497-xopenalex-snapshot
Structural evidence of tropomyosin in purified smooth muscle thin filaments from chicken gizzard
inferred← citeshttps://doi.org/10.1242/jcs.205625openalex-snapshot
Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast
inferred← citeshttps://doi.org/10.1242/jcs.260540openalex-snapshot
Purification of human β- and γ-actin from budding yeast
inferred← citeshttps://doi.org/10.1371/journal.pbio.2005345openalex-snapshot
Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000315openalex-snapshot
Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000925openalex-snapshot
Structure of the Lifeact–F-actin complex
inferred← citeshttps://doi.org/10.1371/journal.pbio.3002551openalex-snapshot
IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010408openalex-snapshot
High-resolution structures of malaria parasite actomyosin and actin filaments
inferred← citeshttps://doi.org/10.1371/journal.ppat.1010779openalex-snapshot
Divergent Plasmodium actin residues are essential for filament localization, mosquito salivary gland invasion and malaria transmission
inferred← citeshttps://doi.org/10.1371/journal.ppat.1011174openalex-snapshot
Structure and function of Plasmodium actin II in the parasite mosquito stages
inferred← citeshttps://doi.org/10.1515/hsz-2020-0293openalex-snapshot
Targeting spectrin redox switches to regulate the mechanoproperties of red blood cells
inferred← citeshttps://doi.org/10.15252/embj.2021107982openalex-snapshot
Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
inferred← citeshttps://doi.org/10.17650/2313-805x-2017-4-1-8-16openalex-snapshot
Actin isoforms and neoplastic transformation
inferred← citeshttps://doi.org/10.2142/biophysico.bppb-v19.0025openalex-snapshot
Computational study of the impact of nucleotide variations on highly conserved proteins: In the case of actin
inferred← citeshttps://doi.org/10.2210/pdb6c1d/pdbopenalex-snapshot
High-Resolution Cryo-EM Structures of Actin-bound Myosin States Reveal the Mechanism of Myosin Force Sensing
inferred← citeshttps://doi.org/10.32657/10356/85724openalex-snapshot
Electron tomography of muscle cross- bridge by regulatory light chain labelling with APEX2
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