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Culture pH Affects Expression Rates and Glycosylation of Recombinant Mouse Placental Lactogen Proteins by Chinese Hamster Ovary (CHO) Cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bit.260320803openalex-snapshot
A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH
inferredcites →https://doi.org/10.1002/jcp.1040820102openalex-snapshot
The effect of environmental pH on the growth of normal and malignant cells
inferredcites →https://doi.org/10.1002/jcp.1041500114openalex-snapshot
Effects of pH‐variations on the kinetics of growth and energy metabolism in cultured T‐lymphoma cells: A microcalorimetric study
inferredcites →https://doi.org/10.1002/mrm.1910060402openalex-snapshot
Comparison of intracellular pH measurements by 31P NMR and weak acid partitioning in Chinese hamster ovary fibroblasts
inferredcites →https://doi.org/10.1007/bf00369278openalex-snapshot
Growth inhibition of hybridoma cells by ammonium ion: correlation with effects on intracellular pH
inferredcites →https://doi.org/10.1007/bf01868588openalex-snapshot
Enhancement of Glucose transport in clone 9 cells by exposure to alkaline pH: Studies on potential mechanisms
inferredcites →https://doi.org/10.1016/0003-2697(79)90102-7openalex-snapshot
Use of endo- and exoglycosidases for structural studies of glycoconjugates
inferredcites →https://doi.org/10.1016/0006-2952(91)90322-vopenalex-snapshot
Relationships between energy level and insulin secretion in isolated rat islets of langerhans
inferredcites →https://doi.org/10.1016/0014-4827(87)90093-0openalex-snapshot
Relationship between cytoplasmic pH and proliferation during exponential growth and cellular quiescence
inferredcites →https://doi.org/10.1016/0014-5793(90)80061-mopenalex-snapshot
Stimulation of protein synthesis by raised extracellular pH in cardiac myocytes and perfused hearts
inferredcites →https://doi.org/10.1016/0141-0229(92)90137-dopenalex-snapshot
Relationship between hybridoma growth and monoclonal antibody production
inferredcites →https://doi.org/10.1016/0168-1656(90)90053-eopenalex-snapshot
The effect of pH on the toxicity of ammonia to a murine hybridoma
inferredcites →https://doi.org/10.1016/0168-1656(90)90054-fopenalex-snapshot
Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor: 1. Effects of physical and chemical environments
inferredcites →https://doi.org/10.1016/0168-1656(91)90298-aopenalex-snapshot
Monitoring of the production of monoclonal antibodies by hybridomas. Part II: Characterization and purification of acid proteases present in cell culture supernatant
inferredcites →https://doi.org/10.1016/0303-7207(90)90252-4openalex-snapshot
Biological activities of glycosylated and nonglycosylated porcine prolactin
inferredcites →https://doi.org/10.1016/0385-6380(88)90082-9openalex-snapshot
Large-scale production of Erythroid Differentiation Factor (EDF) by gene-engineered Chinese hamster ovary (CHO) cells in suspension culture
inferredcites →https://doi.org/10.1016/b978-0-408-02732-8.50065-1openalex-snapshot
Hybridoma culture for the continuous production of monoclonal antibodies; a fractionalized factorial design experiment for process optimization
inferredcites →https://doi.org/10.1016/s0021-9258(18)37982-1openalex-snapshot
Reduced extracellular pH reversibly inhibits oligomerization, intracellular transport, and processing of the influenza hemagglutinin in infected Madin-Darby canine kidney cells.
inferredcites →https://doi.org/10.1016/s0021-9258(18)69101-xopenalex-snapshot
Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors.
inferredcites →https://doi.org/10.1016/s0021-9258(18)71502-0openalex-snapshot
Expression of Human Interleukin-2 in Recombinant Baby Hamster Kidney, Ltk−, and Chinese Hamster Ovary Cells
inferredcites →https://doi.org/10.1016/s0074-7696(08)62005-7openalex-snapshot
Proclactins of Pregnancy and Their Cellular Source
inferredcites →https://doi.org/10.1021/bi00338a028openalex-snapshot
Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F
inferredcites →https://doi.org/10.1021/bi00429a065openalex-snapshot
Clonal analysis of the glycosylation of immunoglobulin G secreted by murine hybridomas
inferredcites →https://doi.org/10.1021/bp00012a002openalex-snapshot
Growth, Metabolic, and Antibody Production Kinetics of Hybridoma Cell Culture: 2. Effects of Serum Concentration, Dissolved Oxygen Concentration, and Medium pH in a Batch Reactor
inferredcites →https://doi.org/10.1038/nbt0590-421openalex-snapshot
Environmental Effects on Protein Glycosylation
inferredcites →https://doi.org/10.1038/nbt1291-1347openalex-snapshot
The Oligosaccharides of Glycoproteins: Bioprocess Factors Affecting Oligosaccharide Structure and their Effect on Glycoprotein Properties
inferredcites →https://doi.org/10.1042/bj2720333openalex-snapshot
Recombinant human interferon-γ. Differences in glycosylation and proteolytic processing lead to heterogeneity in batch culture
inferredcites →https://doi.org/10.1042/bj2720407openalex-snapshot
Role of lysosomal and cytosolic pH in the regulation of macrophage lysosomal enzyme secretion
inferredcites →https://doi.org/10.1073/pnas.83.22.8496openalex-snapshot
Molecular cloning of mouse placental lactogen cDNA.
inferredcites →https://doi.org/10.1126/science.2424083openalex-snapshot
Large-Scale Cell Culture in Biotechnology
inferredcites →https://doi.org/10.1139/o86-091openalex-snapshot
Cultured Nb rat lymphoma cells in endocrine and cancer research
inferredcites →https://doi.org/10.1152/ajpcell.1991.260.2.c277openalex-snapshot
Abnormalities in protein synthesis and degradation induced by extracellular pH in BC3H1 myocytes
inferredcites →https://doi.org/10.1210/endo-120-6-2500openalex-snapshot
Purification and Partial Characterization of Two Prolactin-Like Glycoprotein Hormone Complexes from the Midpregnant Mouse Conceptus*
inferredcites →https://doi.org/10.1210/endo-123-3-1303openalex-snapshot
Glycosylation Selectively Alters the Biological Activity of Prolactin*
inferredcites →https://doi.org/10.1210/endo-123-6-2662openalex-snapshot
Biological, Immunological, and Binding Properties of Recombinant Mouse Placental Lactogen-I*
inferredcites →https://doi.org/10.1210/endo-125-5-2253openalex-snapshot
Mouse Placental Lactogen-I: RIA and Gestational Profile in Maternal Serum*
inferredcites →https://doi.org/10.1210/jcem-51-5-1058openalex-snapshot
A New Sensitive and Specific Bioassay for Lactogenic Hormones: Measurement of Prolactin and Growth Hormone in Human Serum*
inferredcites →https://doi.org/10.1210/mend-1-11-767openalex-snapshot
Molecular Cloning and Expression of Mouse Placental Lactogen I Complementary Deoxyribonucleic Acid
inferredcites →https://doi.org/10.1530/acta.0.1230218openalex-snapshot
Role of extracellular calcium and calmodulin in prolactin secretion induced by hyposmolarity, thyrotropin-releasing hormone, and high K+ in GH4C1 cells
inferredcites →https://doi.org/10.2307/3577466openalex-snapshot
Influence of Extracellular pH on Intracellular pH and Cell Energy Status: Relationship to Hyperthermic Sensitivity
inferredcites →https://doi.org/10.4049/jimmunol.138.1.276openalex-snapshot
Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Effect of bench-scale culture conditions on murine IgG heterogeneity
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Mapping of oxygen tension and cell distribution in a hollow-fiber bioreactor using magnetic resonance imaging
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Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions
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Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH
inferred← citeshttps://doi.org/10.1002/(sici)1097-0290(20000520)68:4<370::aid-bit2>3.0.co;2-kopenalex-snapshot
Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation
inferred← citeshttps://doi.org/10.1002/(sici)1097-0290(20000520)68:4<407::aid-bit6>3.0.co;2-sopenalex-snapshot
Modification of a recombinant GPI-anchored metalloproteinase for secretion alters the protein glycosylation
inferred← citeshttps://doi.org/10.1002/0471250570.spi009openalex-snapshot
Animal Cell Culture, Physiochemical Effects of p H
inferred← citeshttps://doi.org/10.1002/0471250589.ebt013openalex-snapshot
Ammonia Toxicity, Animal Cells
inferred← citeshttps://doi.org/10.1002/0471250589.ebt091openalex-snapshot
Expression Systems, mammalian cells
inferred← citeshttps://doi.org/10.1002/0471250589.ebt206openalex-snapshot
Suspension Culture, Animal Cells
inferred← citeshttps://doi.org/10.1002/1097-0290(20000805)69:3<242::aid-bit2>3.0.co;2-iopenalex-snapshot
A systematic approach to the validation of process control parameters for monoclonal antibody production in fed-batch culture of a murine myeloma
inferred← citeshttps://doi.org/10.1002/9780470054581.eib557openalex-snapshot
Suspension Culture, Animal Cells
inferred← citeshttps://doi.org/10.1002/9780470054581.eib637openalex-snapshot
Bioreactors, Cell Culture, Commercial Production
inferred← citeshttps://doi.org/10.1002/9780470054581.eib649openalex-snapshot
Protein Glycosylation: Analysis, Characterization, and Engineering
inferred← citeshttps://doi.org/10.1002/9781119378341.ch4openalex-snapshot
Bioreactors for Stem Cell and Mammalian Cell Cultivation
inferred← citeshttps://doi.org/10.1002/9783527626601.ch3openalex-snapshot
Mammalian Cell Lines and Glycosylation: A Case Study
inferred← citeshttps://doi.org/10.1002/9783527653096.ch19openalex-snapshot
Ensuring Quality and Efficiency of Bioprocesses by the Tailored Application of Process Analytical Technology and Quality by Design
inferred← citeshttps://doi.org/10.1002/9783527682423.ch22openalex-snapshot
Process Development and Manufacturing of Therapeutic Antibodies
inferred← citeshttps://doi.org/10.1002/9783527683321.ch12openalex-snapshot
Large Scale Suspension Culture of Mammalian Cells
inferred← citeshttps://doi.org/10.1002/biot.201400662openalex-snapshot
Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture
inferred← citeshttps://doi.org/10.1002/biot.70055openalex-snapshot
Transcriptomic Insights Into Serum‐Free Medium Adaptation and Temperature Reduction in Chinese Hamster Ovary Cell Cultures
inferred← citeshttps://doi.org/10.1002/bit.10144openalex-snapshot
Erythropoietin production from CHO cells grown by continuous culture in a fluidized‐bed bioreactor
inferred← citeshttps://doi.org/10.1002/bit.10366openalex-snapshot
Impact of cell culture process changes on endogenous retrovirus expression
inferred← citeshttps://doi.org/10.1002/bit.10443openalex-snapshot
Serum‐free suspension cultivation of PER.C6® cells and recombinant adenovirus production under different pH conditions
inferred← citeshttps://doi.org/10.1002/bit.10566openalex-snapshot
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.10673openalex-snapshot
Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti‐melanoma mouse IgG3 monoclonal antibody R24
inferred← citeshttps://doi.org/10.1002/bit.1165openalex-snapshot
The response of GS‐NS0 myeloma cells to pH shifts and pH perturbations
inferred← citeshttps://doi.org/10.1002/bit.20194openalex-snapshot
Process development for a recombinant Chinese hamster ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system
inferred← citeshttps://doi.org/10.1002/bit.20353openalex-snapshot
Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0°C
inferred← citeshttps://doi.org/10.1002/bit.20958openalex-snapshot
Process parameter shifting: Part II. Biphasic cultivation—A tool for enhancing the volumetric productivity of batch processes using Epo‐Fc expressing CHO cells
inferred← citeshttps://doi.org/10.1002/bit.21013openalex-snapshot
Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo‐Fc expressing CHO cells cultivated in controlled batch bioreactors
inferred← citeshttps://doi.org/10.1002/bit.21320openalex-snapshot
Comparisons of optical pH and dissolved oxygen sensors with traditional electrochemical probes during mammalian cell culture
inferred← citeshttps://doi.org/10.1002/bit.21816openalex-snapshot
Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon‐γ glycosylation during batch and fed‐batch cultures of CHO cells
inferred← citeshttps://doi.org/10.1002/bit.22006openalex-snapshot
Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells
inferred← citeshttps://doi.org/10.1002/bit.22348openalex-snapshot
Identification of cell culture conditions to control N‐glycosylation site‐occupancy of recombinant glycoproteins expressed in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.23200openalex-snapshot
Effects of cell culture conditions on antibody N ‐linked glycosylation—what affects high mannose 5 glycoform
inferred← citeshttps://doi.org/10.1002/bit.24834openalex-snapshot
Impact of cultivation conditions on N‐glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture
inferred← citeshttps://doi.org/10.1002/bit.25568openalex-snapshot
Understanding of altered N‐glycosylation‐related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting
inferred← citeshttps://doi.org/10.1002/bit.25620openalex-snapshot
A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture
inferred← citeshttps://doi.org/10.1002/bit.260430611openalex-snapshot
Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen‐I by chinese hamster ovary cells in a pH‐dependent manner
inferred← citeshttps://doi.org/10.1002/bit.260440207openalex-snapshot
Biochemistry of growth inhibition by ammonium ions in mammalian cells
inferred← citeshttps://doi.org/10.1002/bit.260440609openalex-snapshot
Characterization of a recombinant antibody produced in the course of a high yield fed‐batch process
inferred← citeshttps://doi.org/10.1002/bit.260460606openalex-snapshot
Effect of different cell culture conditions on the polypeptide integrity and N‐glycosylation of a recombinant model glycoprotein
inferred← citeshttps://doi.org/10.1002/bit.260480612openalex-snapshot
N ‐glycans of recombinant human interferon‐γ change during batch culture of chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.26339openalex-snapshot
Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion
inferred← citeshttps://doi.org/10.1002/btpr.1614openalex-snapshot
In situ pH maintenance for mammalian cell cultures in shake flasks and tissue culture flasks
inferred← citeshttps://doi.org/10.1002/btpr.1750openalex-snapshot
Application of a nonradioactive method of measuring protein synthesis in industrially relevant chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/btpr.1906openalex-snapshot
Control of galactosylated glycoforms distribution in cell culture system
inferred← citeshttps://doi.org/10.1002/btpr.2134openalex-snapshot
Application of multivariate analysis and mass transfer principles for refinement of a 3‐L bioreactor scale‐down model—when shake flasks mimic 15,000‐L bioreactors better
inferred← citeshttps://doi.org/10.1002/btpr.2429openalex-snapshot
Cell culture media supplementation of infrequently used sugars for the targeted shifting of protein glycosylation profiles
inferred← citeshttps://doi.org/10.1002/btpr.3076openalex-snapshot
A class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/btpr.348openalex-snapshot
Technological progresses in monoclonal antibody production systems
inferred← citeshttps://doi.org/10.1002/btpr.369openalex-snapshot
pH measurement and a rational and practical pH control strategy for high throughput cell culture system
inferred← citeshttps://doi.org/10.1002/btpr.470openalex-snapshot
Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns
inferred← citeshttps://doi.org/10.1002/btpr.503openalex-snapshot
Effect of surfactant pluronic F‐68 on CHO cell growth, metabolism, production, and glycosylation of human recombinant IFN‐γ in mild operating conditions
inferred← citeshttps://doi.org/10.1002/btpr.70080openalex-snapshot
Dynamic pH profiles drive higher cell‐specific and volumetric productivity
inferred← citeshttps://doi.org/10.1002/cjce.24242openalex-snapshot
A semi‐empirical mathematical model to specify the pH of bicarbonate‐buffered cell culture medium formulations
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Glycosylated and Phosphorylated Proteins—Expression in Yeast and Oocytes of Xenopus: Prospects and Challenges—Relevance to Expression of Thermostable Proteins
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Analysis of Cell Growth in A Fixed Bed Bioreactor Using Magnetic Resonance Spectroscopy and Imaging
inferred← citeshttps://doi.org/10.1007/0-306-46860-3_2openalex-snapshot
Engineering Glycosylation in Animal Cells
inferred← citeshttps://doi.org/10.1007/0-306-47525-1_1openalex-snapshot
Analysis of Glycans of Recombinant Glycoproteins
inferred← citeshttps://doi.org/10.1007/0-306-47525-1_2openalex-snapshot
The Effect of Cell Culture Parameters on Protein Glycosylation
inferred← citeshttps://doi.org/10.1007/0-306-47525-1_5openalex-snapshot
Controlling Carbohydrates on Reconbinant Glycoproteins
inferred← citeshttps://doi.org/10.1007/1-4020-3103-3_129openalex-snapshot
Impact of Change in Fermentation Process pH and Dissolved Carbon Dioxide Concentration on Secreted Antibody Structure and Cell Physiology of a GS-NS0 Cell Line Expressing a Human Antibody
inferred← citeshttps://doi.org/10.1007/1-4020-3363-x_24openalex-snapshot
Production of Biologics from Animal Cell Cultures
inferred← citeshttps://doi.org/10.1007/978-1-4939-6972-2_14openalex-snapshot
Engineer Medium and Feed for Modulating N-Glycosylation of Recombinant Protein Production in CHO Cell Culture
inferred← citeshttps://doi.org/10.1007/978-1-59259-346-0_1openalex-snapshot
Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture
inferred← citeshttps://doi.org/10.1007/978-1-59745-399-8_16openalex-snapshot
Hollow Fiber Cell Culture
inferred← citeshttps://doi.org/10.1007/978-3-030-54630-4_13openalex-snapshot
Eukaryotic Expression Systems for Upstream Processing of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/978-3-319-10320-4_9openalex-snapshot
Glycosylation in Cell Culture
inferred← citeshttps://doi.org/10.1007/978-94-007-1257-7_12openalex-snapshot
The Role of Glycosylation in Therapeutic Antibodies
inferred← citeshttps://doi.org/10.1007/978-94-010-0369-8_27openalex-snapshot
Environmental Effects on Cell Physiology and Metabolism: Response to Elevated pC02
inferred← citeshttps://doi.org/10.1007/978-94-011-0437-1_64openalex-snapshot
The Role of Physiological Cell Parameters and Culture Conditions on Product Consistency and Glycosylation Pattern of Recombinant CHO Expressed Glycoproteins - Interferon Omega and Tissue Plasminogen Activator
inferred← citeshttps://doi.org/10.1007/978-94-011-5161-0_62openalex-snapshot
Effect of Ammonium Ion on Glycoform of Erythropoietin Produced by Recombinant CHO Cells Using Lectin-Blotting Technique
inferred← citeshttps://doi.org/10.1007/bf00762377openalex-snapshot
Diverse effects of essential (n?6 andn?3) fatty acids on cultured cells
inferred← citeshttps://doi.org/10.1007/bf02977719openalex-snapshot
Effect of low adapted temperature and medium composition on growth and erythropoietin (EPO) production by Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1007/s00216-014-8108-xopenalex-snapshot
Post-translational structural modifications of immunoglobulin G and their effect on biological activity
inferred← citeshttps://doi.org/10.1007/s00253-005-1980-8openalex-snapshot
Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals
inferred← citeshttps://doi.org/10.1007/s00253-007-0985-xopenalex-snapshot
Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor
inferred← citeshttps://doi.org/10.1007/s00253-011-3266-7openalex-snapshot
Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation
inferred← citeshttps://doi.org/10.1007/s00253-013-4849-2openalex-snapshot
Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C
inferred← citeshttps://doi.org/10.1007/s00253-016-7412-0openalex-snapshot
Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale
inferred← citeshttps://doi.org/10.1007/s00449-008-0247-zopenalex-snapshot
Significances of pH and temperature on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors
inferred← citeshttps://doi.org/10.1007/s00449-013-0998-zopenalex-snapshot
Application of dielectric spectroscopy for monitoring high cell density in monoclonal antibody producing CHO cell cultivations
inferred← citeshttps://doi.org/10.1007/s00449-018-1996-yopenalex-snapshot
pH excursions impact CHO cell culture performance and antibody N-linked glycosylation
inferred← citeshttps://doi.org/10.1007/s10295-004-0181-2openalex-snapshot
The effect of nitrogen source on yield and glycosylation of a human cystatin C mutant expressed in Pichia pastoris
inferred← citeshttps://doi.org/10.1007/s10529-005-3897-9openalex-snapshot
Controlled Growth of Chinese Hamster Ovary Cells and High Expression of Antibody-IL-2 Fusion Proteins by Temperature Manipulation
inferred← citeshttps://doi.org/10.1007/s10616-005-4537-xopenalex-snapshot
Optimisation of the Cellular Metabolism of Glycosylation for Recombinant Proteins Produced by Mammalian Cell Systems
inferred← citeshttps://doi.org/10.1007/s12257-010-0157-1openalex-snapshot
Increasing the productivity of TNFR-Fc in GS-CHO cells at reduced culture temperatures
inferred← citeshttps://doi.org/10.1007/s12257-026-00306-1openalex-snapshot
Purine precursor supplementation increases productivity of antibody-expressing Chinese Hamster Ovary cells by elevating intracellular ATP level
inferred← citeshttps://doi.org/10.1016/0141-0229(94)90149-xopenalex-snapshot
Glycosylation of recombinant proteins: Problems and prospects
inferred← citeshttps://doi.org/10.1016/0168-1656(95)00065-xopenalex-snapshot
Characterization of changes in the glycosylation pattern of recombinant proteins from BHK-21 cells due to different culture conditions
inferred← citeshttps://doi.org/10.1016/b978-0-7506-1845-8.50149-6openalex-snapshot
Culture pH and ammonia affect expression rates and glycosylation of recombinant mouse placental lactogen proteins by CHO cells
inferred← citeshttps://doi.org/10.1016/b978-044452114-9/50007-4openalex-snapshot
Bioreactor Engineering
inferred← citeshttps://doi.org/10.1016/j.ab.2008.12.015openalex-snapshot
Mass spectrometric quantification of neutral and sialylated N-glycans from a recombinant therapeutic glycoprotein produced in the two Chinese hamster ovary cell lines
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107831openalex-snapshot
Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108179openalex-snapshot
Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25512openalex-snapshot
Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2012.03.010openalex-snapshot
Application of computational fluid dynamics in tissue engineering
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2003.10.035openalex-snapshot
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.11.007openalex-snapshot
The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2014.05.024openalex-snapshot
Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.03.054openalex-snapshot
Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.06.019openalex-snapshot
High-density mammalian cell cultures in stirred-tank bioreactor without external pH control
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2017.01.016openalex-snapshot
A low redox potential affects monoclonal antibody assembly and glycosylation in cell culture
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.04.005openalex-snapshot
Assessment of fed-batch cultivation strategies for an inducible CHO cell line
inferred← citeshttps://doi.org/10.1016/j.ymben.2005.10.002openalex-snapshot
Effects of elevated ammonium on glycosylation gene expression in CHO cells
inferred← citeshttps://doi.org/10.1016/j.ymben.2006.11.003openalex-snapshot
Down-regulation of cold-inducible RNA-binding protein does not improve hypothermic growth of Chinese hamster ovary cells producing erythropoietin
inferred← citeshttps://doi.org/10.1016/j.ymben.2024.11.005openalex-snapshot
Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese Hamster Ovary (CHO) cell metabolism and N-linked glycosylation in the Fab and Fc regions of the produced IgG
inferred← citeshttps://doi.org/10.1016/s0015-0282(16)57686-9openalex-snapshot
Commentary—Tools of the Trade
inferred← citeshttps://doi.org/10.1016/s0021-9673(99)00978-4openalex-snapshot
3-Aminobenzamide and 3-aminobenzoic acid, tags for capillary electrophoresis of complex carbohydrates with laser-induced fluorescent detection
inferred← citeshttps://doi.org/10.1016/s0167-7799(96)10062-7openalex-snapshot
Effect of glycosylation on antibody function: implications for genetic engineering
inferred← citeshttps://doi.org/10.1016/s0304-4165(01)00145-3openalex-snapshot
The effect of pH on glucoamylase production, glycosylation and chemostat evolution of Aspergillus niger
inferred← citeshttps://doi.org/10.1016/s0958-1669(05)80032-1openalex-snapshot
Large-scale mammalian cell culture
inferred← citeshttps://doi.org/10.1021/bp00031a001openalex-snapshot
In Pursuit of the Optimal Fed‐Batch Process for Monoclonal Antibody Production
inferred← citeshttps://doi.org/10.1021/bp0101334openalex-snapshot
Effects of Ammonia and Glucosamine on the Heterogeneity of Erythropoietin Glycoforms
inferred← citeshttps://doi.org/10.1021/bp049761mopenalex-snapshot
Effect of Production Method and Gene Amplification on the Glycosylation Pattern of a Secreted Reporter Protein in CHO Cells
inferred← citeshttps://doi.org/10.1021/bp0498084openalex-snapshot
Production and Glycosylation of Recombinant β-Interferon in Suspension and Cytopore Microcarrier Cultures of CHO Cells
inferred← citeshttps://doi.org/10.1021/bp980050wopenalex-snapshot
Decreasing Extracellular pH Increases CD13 Receptor Surface Content and Alters the Metabolism of HL60 Cells Cultured in Stirred Tank Bioreactors
inferred← citeshttps://doi.org/10.1023/a:1007934216507openalex-snapshot
Effect of culture temperature on a recombinant CHO cell line producing a C-terminal α-amidating enzyme
inferred← citeshttps://doi.org/10.1023/a:1008039011960openalex-snapshot
Analysis of CHO-K1 cell growth in a fixed bed bioreactor using magnetic resonance spectroscopy and imaging
inferred← citeshttps://doi.org/10.1023/a:1008137712611openalex-snapshot
Enhanced erythropoietin heterogeneity in a CHO culture is caused by proteolytic degradation and can be eliminated by a high glutamine level
inferred← citeshttps://doi.org/10.1038/nbt0896-975openalex-snapshot
Getting the glycosylation right: Implications for the biotechnology industry
inferred← citeshttps://doi.org/10.1042/ba20070001openalex-snapshot
A semi‐empirical mathematical model useful for describing the relationship between carbon dioxide, pH, lactate and base in a bicarbonate‐buffered cell‐culture process
inferred← citeshttps://doi.org/10.1073/pnas.0806168105openalex-snapshot
GDP-mannose pyrophosphorylase is a genetic determinant of ammonium sensitivity in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1074/jbc.270.42.24810openalex-snapshot
N- and O-Glycosylation and Phosphorylation of the Bar Secretion Leader Derived from the Barrier Protease of Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1080/07328303.2011.605194openalex-snapshot
Quantitative MALDI-TOF-MS Using Stable-isotope Labeling: Application to the Analysis of N-glycans of Recombinant α-1 Antitrypsin Produced Using Different Culture Parameters
inferred← citeshttps://doi.org/10.1080/10408347.2025.2508868openalex-snapshot
Sialic Acids: Structural Diversity, Biological Roles, and Advances in Analytical Techniques
inferred← citeshttps://doi.org/10.1080/14789450.2021.1996231openalex-snapshot
Breast cancer glycan biomarkers: their link to tumour cell metabolism and their perspectives in clinical practice
inferred← citeshttps://doi.org/10.1080/19420862.2017.1405203openalex-snapshot
Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function
inferred← citeshttps://doi.org/10.1093/glycob/cwp079openalex-snapshot
Optimal and consistent protein glycosylation in mammalian cell culture
inferred← citeshttps://doi.org/10.1093/glycob/cwv097openalex-snapshot
Sialic acids in cancer biology and immunity
inferred← citeshttps://doi.org/10.1093/glycob/cwx108openalex-snapshot
Targeting sialic acid–Siglec interactions to reverse immune suppression in cancer
inferred← citeshttps://doi.org/10.1097/00002371-200011000-00008openalex-snapshot
Extracellular pH Affects the Proliferation of Cultured Human T Cells and Their Expression of the Interleukin-2 Receptor
inferred← citeshttps://doi.org/10.1111/j.1749-6632.1994.tb44388.xopenalex-snapshot
Cell Aggregation in a Chinese Hamster Ovary Cell Microcarrier Culture Affects the Expression Rate and N‐linked Glycosylation of Recombinant Mouse Placental Lactogen‐1a
inferred← citeshttps://doi.org/10.1128/9781555816827.ch48openalex-snapshot
Cell Culture Bioreactors: Controls, Measurements, and Scale-Down Model
inferred← citeshttps://doi.org/10.11606/t.87.2013.tde-06112013-105355openalex-snapshot
Desenvolvimento de processo de produção de fator VIII recombinante em biorreator.
inferred← citeshttps://doi.org/10.1186/1472-6750-11-95openalex-snapshot
Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells
inferred← citeshttps://doi.org/10.1186/1475-2859-8-44openalex-snapshot
Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors
inferred← citeshttps://doi.org/10.1208/s12249-021-02170-zopenalex-snapshot
Sialic Acid Conjugated Chitosan Nanoparticles: Modulation to Target Tumour Cells and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1004062openalex-snapshot
Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells
inferred← citeshttps://doi.org/10.1385/mb:34:3:355openalex-snapshot
Living With Heterogeneities in Bioreactors: Understanding the Effects of Environmental Gradients on Cells
inferred← citeshttps://doi.org/10.18174/444363openalex-snapshot
Scale-down of CHO cell fed-batch cultures
inferred← citeshttps://doi.org/10.20944/preprints201811.0326.v1openalex-snapshot
Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture
inferred← citeshttps://doi.org/10.20944/preprints201811.0326.v2openalex-snapshot
Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture
inferred← citeshttps://doi.org/10.2225/vol16-issue3-fulltext-2openalex-snapshot
Advances in improving mammalian cells metabolism for recombinant protein production
inferred← citeshttps://doi.org/10.25560/15160openalex-snapshot
Assessment of the interactions between bioprocess conditions and protein glycosylation in antibody- producing mammalian cell cultures
inferred← citeshttps://doi.org/10.3109/07388551.2013.793649openalex-snapshot
Glycosylation: impact, control and improvement during therapeutic protein production
inferred← citeshttps://doi.org/10.3389/fbioe.2022.968294openalex-snapshot
A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
inferred← citeshttps://doi.org/10.3389/fsufs.2019.00043openalex-snapshot
Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture
inferred← citeshttps://doi.org/10.3390/pr8060637openalex-snapshot
A Reliable Automated Sampling System for On-Line and Real-Time Monitoring of CHO Cultures
inferred← citeshttps://doi.org/10.3929/ethz-a-005773994openalex-snapshot
A novel lobed Taylor-Couette bioreactor for the cultivation of shear sensitive cells and tissues
inferred← citeshttps://doi.org/10.4049/jimmunol.160.7.3393openalex-snapshot
Effect of C2-Associated Carbohydrate Structure on Ig Effector Function: Studies with Chimeric Mouse-Human IgG1 Antibodies in Glycosylation Mutants of Chinese Hamster Ovary Cells
inferred← citeshttps://doi.org/10.4155/bio-2017-0086openalex-snapshot
Investigation of O -Glycosylation Heterogeneity of Recombinant Coagulation Factor Ix Using LC–MS/MS
inferred← citeshttps://doi.org/10.4155/pbp.13.4openalex-snapshot
Applying quality by design to glycoprotein therapeutics: experimental and computational efforts of process control
inferred← citeshttps://doi.org/10.4155/pbp.15.25openalex-snapshot
Optimizing Chinese hamster ovary cell line development via targeted control of N-glycosylation
inferred← citeshttps://doi.org/10.5772/50261openalex-snapshot
Application of Quality by Design Paradigm to the Manufacture of Protein Therapeutics
inferred← citeshttps://doi.org/10.70675/a848a7b2z4ac9z4cd2z89b5z0c42807cd0d1openalex-snapshot
Approche méthodologique innovante pour le suivi en ligne de procédés de production d’anticorps par cellules animales : apport des techniques spectroscopiques in situ à la stratégie PAT
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