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Multiple roles for separase auto-cleavage during the G2/M transition
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/0092-8674(95)90142-6openalex-snapshot
Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
inferredcites →https://doi.org/10.1016/j.cub.2004.09.049openalex-snapshot
Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles
inferredcites →https://doi.org/10.1016/j.molcel.2005.05.022openalex-snapshot
Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation
inferredcites →https://doi.org/10.1016/s0014-5793(02)03238-6openalex-snapshot
Anaphase specific auto‐cleavage of separase
inferredcites →https://doi.org/10.1016/s0092-8674(00)00130-6openalex-snapshot
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
inferredcites →https://doi.org/10.1016/s0092-8674(01)00340-3openalex-snapshot
Securin Is Required for Chromosomal Stability in Human Cells
inferredcites →https://doi.org/10.1016/s0092-8674(01)00603-1openalex-snapshot
Dual Inhibition of Sister Chromatid Separation at Metaphase
inferredcites →https://doi.org/10.1016/s0092-8674(02)00618-9openalex-snapshot
Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase
inferredcites →https://doi.org/10.1016/s0092-8674(03)00642-1openalex-snapshot
Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells
inferredcites →https://doi.org/10.1016/s0960-9822(02)01073-4openalex-snapshot
Regulation of Human Separase by Securin Binding and Autocleavage
inferredcites →https://doi.org/10.1016/s0960-9822(98)70156-3openalex-snapshot
Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
inferredcites →https://doi.org/10.1016/s1534-5807(04)00128-5openalex-snapshot
A Role for the FEAR Pathway in Nuclear Positioning during Anaphase
inferredcites →https://doi.org/10.1038/342039a0openalex-snapshot
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
inferredcites →https://doi.org/10.1038/nature02767openalex-snapshot
Cell cycle regulation of central spindle assembly
inferredcites →https://doi.org/10.1038/nature02803openalex-snapshot
Separase-mediated cleavage of cohesin at interphase is required for DNA repair
inferredcites →https://doi.org/10.1038/nbt0702-735openalex-snapshot
Targeted transgene insertion into human chromosomes by adeno-associated virus vectors
inferredcites →https://doi.org/10.1038/ncb1208openalex-snapshot
The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments
inferredcites →https://doi.org/10.1038/ncb940openalex-snapshot
A non-proteolytic function of separase links the onset of anaphase to mitotic exit
inferredcites →https://doi.org/10.1038/ng1060openalex-snapshot
A molecular signature of metastasis in primary solid tumors
inferredcites →https://doi.org/10.1038/nsmb935openalex-snapshot
Domain structure of separase and its binding to securin as determined by EM
inferredcites →https://doi.org/10.1073/pnas.0307700101openalex-snapshot
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF β-TrCP
inferredcites →https://doi.org/10.1073/pnas.0730733100openalex-snapshot
Processing, localization, and requirement of human separase for normal anaphase progression
inferredcites →https://doi.org/10.1073/pnas.94.6.2545openalex-snapshot
DNA methylation and genetic instability in colorectal cancer cells
inferredcites →https://doi.org/10.1074/jbc.m313681200openalex-snapshot
Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis
inferredcites →https://doi.org/10.1083/jcb.200208092openalex-snapshot
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
inferredcites →https://doi.org/10.1093/nar/gnh009openalex-snapshot
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses
inferredcites →https://doi.org/10.1101/gad.242202openalex-snapshot
Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function
inferredcites →https://doi.org/10.1126/science.1074757openalex-snapshot
Segregating Sister Genomes: The Molecular Biology of Chromosome Separation
inferredcites →https://doi.org/10.1126/science.1091936openalex-snapshot
Separase Regulates INCENP-Aurora B Anaphase Spindle Function Through Cdc14
inferredcites →https://doi.org/10.1126/science.277.5331.1501openalex-snapshot
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
inferredcites →https://doi.org/10.1126/science.281.5376.533openalex-snapshot
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors
inferredcites →https://doi.org/10.1126/science.285.5426.418openalex-snapshot
Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis
inferredcites →https://doi.org/10.1210/me.11.4.433openalex-snapshot
Isolation and Characterization of a Pituitary Tumor-Transforming Gene (PTTG)
inferredcites →https://doi.org/10.1242/jcs.108.2.621openalex-snapshot
Mutation of the predicted p34cdc2 phosphorylation sites in numa impair the assembly of the mitotic spindle and block mitosis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/jcb.25835openalex-snapshot
Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene
inferred← citeshttps://doi.org/10.1002/jcp.29038openalex-snapshot
Factors, mechanisms and implications of chromatin condensation and chromosomal structural maintenance through the cell cycle
inferred← citeshttps://doi.org/10.1007/978-1-60327-993-2_2openalex-snapshot
Functional Dissection of Mitotic Regulators Through Gene Targeting in Human Somatic Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-58971-4_4openalex-snapshot
Structure and Function of the Separase-Securin Complex
inferred← citeshttps://doi.org/10.1007/s00412-012-0375-8openalex-snapshot
A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression
inferred← citeshttps://doi.org/10.1016/b978-0-12-381978-9.10084-8openalex-snapshot
Vitamin D Effects on Differentiation and Cell Cycle
inferred← citeshttps://doi.org/10.1016/b978-0-12-809963-6.00096-1openalex-snapshot
Effects of Vitamin D Derivatives on Differentiation, Cell Cycle, and Apoptosis in Hematological Malignancies
inferred← citeshttps://doi.org/10.1016/b978-0-323-91338-6.00036-7openalex-snapshot
Antiproliferative and immunoregulatory actions of vitamin D derivatives on hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.12.037openalex-snapshot
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression
inferred← citeshttps://doi.org/10.1016/j.cell.2006.03.038openalex-snapshot
Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111723openalex-snapshot
Autocleavage of Separase Suppresses its Premature Activation by Promoting Binding to Cyclin B1
inferred← citeshttps://doi.org/10.1016/j.cub.2010.01.001openalex-snapshot
Cell Cycle: The Art of Multi-Tasking
inferred← citeshttps://doi.org/10.1016/j.devcel.2009.07.015openalex-snapshot
Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells
inferred← citeshttps://doi.org/10.1016/j.gene.2009.09.003openalex-snapshot
Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades
inferred← citeshttps://doi.org/10.1016/j.isci.2019.07.018openalex-snapshot
A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis
inferred← citeshttps://doi.org/10.1016/j.jsb.2006.04.003openalex-snapshot
Cdc48 is required for the stability of Cut1/separase in mitotic anaphase
inferred← citeshttps://doi.org/10.1016/j.molcel.2007.02.003openalex-snapshot
Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells
inferred← citeshttps://doi.org/10.1016/j.molcel.2011.03.031openalex-snapshot
Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation
inferred← citeshttps://doi.org/10.1016/j.sbi.2018.01.012openalex-snapshot
Structural biology of the separase–securin complex with crucial roles in chromosome segregation
inferred← citeshttps://doi.org/10.1016/j.tcb.2016.07.008openalex-snapshot
Time To Split Up: Dynamics of Chromosome Separation
inferred← citeshttps://doi.org/10.1016/j.urolonc.2025.09.007openalex-snapshot
Exploring the tumor-promoting function and prognostic value of ESPL1 in prostate adenocarcinoma
inferred← citeshttps://doi.org/10.1038/nature08550openalex-snapshot
Cohesin acetylation speeds the replication fork
inferred← citeshttps://doi.org/10.1038/nprot.2007.408openalex-snapshot
Genetic knockouts and knockins in human somatic cells
inferred← citeshttps://doi.org/10.1073/pnas.0701140104openalex-snapshot
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
inferred← citeshttps://doi.org/10.1073/pnas.0712083105openalex-snapshot
A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes
inferred← citeshttps://doi.org/10.1074/jbc.m512714200openalex-snapshot
Inhibition of S/G2 Phase CDK4 Reduces Mitotic Fidelity
inferred← citeshttps://doi.org/10.1074/jbc.m702545200openalex-snapshot
Protein Phosphatase 2A and Separase Form a Complex Regulated by Separase Autocleavage
inferred← citeshttps://doi.org/10.1074/jbc.m706748200openalex-snapshot
Phosphorylation-dependent Binding of Cyclin B1 to a Cdc6-like Domain of Human Separase
inferred← citeshttps://doi.org/10.1080/15384101.2017.1363936openalex-snapshot
Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking
inferred← citeshttps://doi.org/10.1083/jcb.200506119openalex-snapshot
Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression
inferred← citeshttps://doi.org/10.1083/jcb.200511126openalex-snapshot
The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase
inferred← citeshttps://doi.org/10.1083/jcb.200609088openalex-snapshot
The budding yeast PP2ACdc55 protein phosphatase prevents the onset of anaphase in response to morphogenetic defects
inferred← citeshttps://doi.org/10.1083/jcb.202602088openalex-snapshot
Chromosome segregation synchrony in S. pombe is noise limited and arises without positive feedback
inferred← citeshttps://doi.org/10.1093/carcin/bgm019openalex-snapshot
A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy
inferred← citeshttps://doi.org/10.1093/molbev/msaf195openalex-snapshot
Polyploid Formation Through Disrupting Mitotic Sister Chromatid Separation of Spermatogonia based on espl1 Heterozygous Knockout in Fish
inferred← citeshttps://doi.org/10.1093/nar/gkag841openalex-snapshot
Lamin B1-dependent regulation of human separase in mitosis
inferred← citeshttps://doi.org/10.1101/069906openalex-snapshot
Separase Protease Activity is Required for Cytokinesis in addition to Chromosome Segregation
inferred← citeshttps://doi.org/10.1101/2019.12.15.876763openalex-snapshot
Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression
inferred← citeshttps://doi.org/10.1101/gad.1724308openalex-snapshot
The cohesin complex and its roles in chromosome biology
inferred← citeshttps://doi.org/10.1104/pp.109.140699openalex-snapshot
Arabidopsis Separase Functions beyond the Removal of Sister Chromatid Cohesion during Meiosis
inferred← citeshttps://doi.org/10.1105/tpc.105.036913openalex-snapshot
Arabidopsis Separase AESP Is Essential for Embryo Development and the Release of Cohesin during Meiosis
inferred← citeshttps://doi.org/10.1111/brv.12321openalex-snapshot
Biology and insights into the role of cohesin protease separase in human malignancies
inferred← citeshttps://doi.org/10.1111/j.1365-2184.2008.00540.xopenalex-snapshot
Effect of separase depletion on ionizing radiation‐induced cell cycle checkpoints and survival in human lung cancer cell lines
inferred← citeshttps://doi.org/10.1111/j.1365-2443.2007.01093.xopenalex-snapshot
Sister chromatid cohesion: the cohesin cleavage model does not ring true
inferred← citeshttps://doi.org/10.1111/j.1365-2958.2009.06611.xopenalex-snapshot
Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei
inferred← citeshttps://doi.org/10.1111/j.1399-3054.2011.01550.xopenalex-snapshot
Separases: biochemistry and function
inferred← citeshttps://doi.org/10.1155/2020/4625123openalex-snapshot
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer
inferred← citeshttps://doi.org/10.1186/s13062-018-0210-0openalex-snapshot
Conservation of the separase regulatory domain
inferred← citeshttps://doi.org/10.1242/dev.041939openalex-snapshot
A conditional mutation in Arabidopsis thaliana separase induces chromosome non-disjunction, aberrant morphogenesis and cyclin B1;1 stability
inferred← citeshttps://doi.org/10.1242/jcs.029132openalex-snapshot
Chromosome cohesion – rings, knots, orcs and fellowship
inferred← citeshttps://doi.org/10.1242/jcs.03083openalex-snapshot
Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007029openalex-snapshot
Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset
inferred← citeshttps://doi.org/10.1371/journal.pone.0125382openalex-snapshot
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans
inferred← citeshttps://doi.org/10.2741/3189openalex-snapshot
Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces Cerevisiae
inferred← citeshttps://doi.org/10.3390/bios14040192openalex-snapshot
Live Cell Monitoring of Separase Activity, a Key Enzymatic Reaction for Chromosome Segregation, with Chimeric FRET-Based Molecular Sensor upon Cell Cycle Progression
inferred← citeshttps://doi.org/10.3390/ijms24054604openalex-snapshot
Separase and Roads to Disengage Sister Chromatids during Anaphase
inferred← citeshttps://doi.org/10.4161/cc.4.11.2143openalex-snapshot
Anaphase Promoting Complex or Cyclosome?
inferred← citeshttps://doi.org/10.4161/cc.6.14.4501openalex-snapshot
Polo Kinase and Cytokinesis Initiation in Mammalian Cells: Harnessing the Awesome Power of Chemical Genetics
inferred← citeshttps://doi.org/10.4161/cc.7.9.5792openalex-snapshot
The nucleolar phosphataseCdc14Bis dispensable for chromosome segregation and mitotic exit in human cells
inferred← citeshttps://doi.org/10.4161/cc.8.17.9403openalex-snapshot
Chromosome cohesion and the spindle checkpoint
inferred← citeshttps://doi.org/10.4161/cc.9.9.11523openalex-snapshot
Determinants of Rad21 localization at the centrosome in human cells
inferred← citeshttps://doi.org/10.70675/8a35d253z2bc1z4f60za910za75252660eadopenalex-snapshot
Implications de la lamine B1 dans la stabilité des télomères et la mitose
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