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Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

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What this work says

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inferred← citeshttps://doi.org/10.1007/s00284-021-02535-4openalex-snapshot

An Analysis of Biosynthesis Gene Clusters and Bioactivity of Marine Bacterial Symbionts

inferred← citeshttps://doi.org/10.1007/s00294-009-0236-zopenalex-snapshot

A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa

inferred← citeshttps://doi.org/10.1007/s00294-010-0288-0openalex-snapshot

Identification of a hybrid PKS–NRPS required for the biosynthesis of NG-391 in Metarhizium robertsii

inferred← citeshttps://doi.org/10.1007/s00294-011-0362-2openalex-snapshot

Genetic transformation of Diaporthe phaseolorum, an endophytic fungus found in mangrove forests, mediated by Agrobacterium tumefaciens

inferred← citeshttps://doi.org/10.1007/s00294-013-0396-8openalex-snapshot

Species diversity of culturable endophytic fungi from Brazilian mangrove forests

inferred← citeshttps://doi.org/10.1007/s10142-016-0506-zopenalex-snapshot

Genomic and functional features of the biosurfactant producing Bacillus sp. AM13

inferred← citeshttps://doi.org/10.1007/s10295-010-0849-8openalex-snapshot

Do we need new antibiotics? The search for new targets and new compounds

inferred← citeshttps://doi.org/10.1007/s10295-013-1361-8openalex-snapshot

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor

inferred← citeshttps://doi.org/10.1007/s10295-013-1366-3openalex-snapshot

Strategies for mining fungal natural products

inferred← citeshttps://doi.org/10.1007/s10295-013-1379-yopenalex-snapshot

Genome mining of Streptomyces ambofaciens

inferred← citeshttps://doi.org/10.1007/s10295-013-1386-zopenalex-snapshot

Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans

inferred← citeshttps://doi.org/10.1007/s10295-015-1666-xopenalex-snapshot

Metabolic profiling as a tool for prioritizing antimicrobial compounds

inferred← citeshttps://doi.org/10.1007/s10295-019-02250-xopenalex-snapshot

Apc.LaeA and Apc.VeA of the velvet complex govern secondary metabolism and morphological development in the echinocandin-producing fungusAspergillus pachycristatus

inferred← citeshttps://doi.org/10.1007/s10529-010-0473-8openalex-snapshot

Aspergillus as a multi-purpose cell factory: current status and perspectives

inferred← citeshttps://doi.org/10.1007/s10529-012-0919-2openalex-snapshot

Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics

inferred← citeshttps://doi.org/10.1007/s11101-009-9127-7openalex-snapshot

Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria

inferred← citeshttps://doi.org/10.1007/s11101-018-9590-0openalex-snapshot

The current status on secondary metabolites produced by plant pathogenic Colletotrichum species

inferred← citeshttps://doi.org/10.1007/s11101-019-09608-0openalex-snapshot

Recent approaches on the genomic analysis of the phytopathogenic fungus Colletotrichum spp.

inferred← citeshttps://doi.org/10.1007/s11101-020-09684-7openalex-snapshot

Natural products development under epigenetic modulation in fungi

inferred← citeshttps://doi.org/10.1007/s11274-023-03649-6openalex-snapshot

Molecular regulation of fungal secondary metabolism

inferred← citeshttps://doi.org/10.1007/s11427-022-2175-0openalex-snapshot

Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products

inferred← citeshttps://doi.org/10.1007/s11696-023-02832-1openalex-snapshot

One-pot Biginelli synthesis of novel series of 2-oxo/thioxo/imino-1,2,3,4-tetrahydropyrimidine based on 4-hydroxy-2-pyridone

inferred← citeshttps://doi.org/10.1007/s12275-011-1009-1openalex-snapshot

Transcriptional regulatory elements in fungal secondary metabolism

inferred← citeshttps://doi.org/10.1007/s13199-023-00928-6openalex-snapshot

Bioprospecting potentials of endophytic microbes in the sustainable biotechnological applications

inferred← citeshttps://doi.org/10.1007/s13225-012-0191-8openalex-snapshot

Endophytes and associated marine derived fungi—ecological and chemical perspectives

inferred← citeshttps://doi.org/10.1007/s13659-021-00306-zopenalex-snapshot

Naturally Occurring Terpenes: A Promising Class of Organic Molecules to Address Influenza Pandemics

inferred← citeshttps://doi.org/10.1007/s13659-026-00607-1openalex-snapshot

Pyridone alkaloids from an Antarctic endolichenic Tolypocladium sp.

inferred← citeshttps://doi.org/10.1007/s43393-022-00087-7openalex-snapshot

Optimization of citrinin production by endophytic Penicillium citrinum isolated from Ziziphus jujuba

inferred← citeshttps://doi.org/10.1016/b978-0-12-394382-8.00001-0openalex-snapshot

Heterologous Gene Expression in Filamentous Fungi

inferred← citeshttps://doi.org/10.1016/b978-0-12-394430-6.00010-8openalex-snapshot

Drug Discovery and Development via Synthetic Biology

inferred← citeshttps://doi.org/10.1016/b978-0-12-404634-4.00016-4openalex-snapshot

Regulatory Cross Talk and Microbial Induction of Fungal Secondary Metabolite Gene Clusters

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14637-2openalex-snapshot

Oxidative Modification Enzymes in Polyketide Biosynthetic Pathways

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14658-xopenalex-snapshot

Fraction Libraries and Genetics as Tools for Natural Product Research: Focus on Decalin-Containing Compounds

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14677-3openalex-snapshot

Fungal Polyketide-Nonribosomal Peptide Synthetases and Their Associated Natural Products

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14720-1openalex-snapshot

Microbial Co-Cultures as Source of Novel Drugs for Infections

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14721-3openalex-snapshot

Genome Mining in Fungi

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14732-8openalex-snapshot

Fungal Highly-Reducing Polyketide Synthases and Associated Natural Products

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14741-9openalex-snapshot

Engineering Saccharomyces cerevisiae for Fungal Natural Product Production

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14781-xopenalex-snapshot

Manipulating Biosynthesis of Plant Natural Products

inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.21072-8openalex-snapshot

The Biosynthesis of Fungal Secondary Metabolites: From Fundamentals to Biotechnological Applications

inferred← citeshttps://doi.org/10.1016/b978-0-12-818469-1.00025-0openalex-snapshot

Secondary metabolites and lytic tool box of trichoderma and their role in plant health

inferred← citeshttps://doi.org/10.1016/b978-0-12-821005-5.00015-6openalex-snapshot

Aspergillus terreus: Taxonomy, biology, and bioactive secondary metabolites with potential applications

inferred← citeshttps://doi.org/10.1016/b978-0-12-821006-2.00012-1openalex-snapshot

Fungal metabolites—A potential source of antiviral compounds

inferred← citeshttps://doi.org/10.1016/b978-0-12-822919-4.00001-6openalex-snapshot

Fungi endophytes for biofactory of secondary metabolites: Genomics and metabolism

inferred← citeshttps://doi.org/10.1016/b978-0-323-91245-7.00009-2openalex-snapshot

Endophytes and their secondary metabolites against human pathogenic MDR microbes

inferred← citeshttps://doi.org/10.1016/b978-0-443-18870-1.00005-6openalex-snapshot

Forest fungi: Secondary metabolism, regulation, function and drug discovery

inferred← citeshttps://doi.org/10.1016/b978-0-443-24738-5.00060-4openalex-snapshot

Antibiotics: Revitalizing Discovery and Production through Synthetic Biology

inferred← citeshttps://doi.org/10.1016/b978-0-444-63505-1.00035-xopenalex-snapshot

Secondary Metabolite Diversity of the Genus Aspergillus: Recent Advances

inferred← citeshttps://doi.org/10.1016/b978-008045382-8.00017-4openalex-snapshot

Fungal Type I Polyketides

inferred← citeshttps://doi.org/10.1016/b978-008045382-8.00046-0openalex-snapshot

Exploiting Genomics for New Natural Product Discovery in Prokaryotes

inferred← citeshttps://doi.org/10.1016/bs.adgen.2020.11.006openalex-snapshot

Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery

inferred← citeshttps://doi.org/10.1016/bs.mie.2025.04.003openalex-snapshot

Global genome mining in fungi using FunBGCeX

inferred← citeshttps://doi.org/10.1016/j.apsb.2017.12.005openalex-snapshot

Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals

inferred← citeshttps://doi.org/10.1016/j.aquatox.2011.04.001openalex-snapshot

On the origins and biosynthesis of tetrodotoxin

inferred← citeshttps://doi.org/10.1016/j.bcab.2018.09.025openalex-snapshot

Epigenetic modulations of mycoendophytes for novel bioactive molecules

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108798openalex-snapshot

Promoter engineering of filamentous fungi for novel natural product discovery

inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110054openalex-snapshot

Structually diverse polyketides from an endolicheic fungus Leotiomycetes sp.: discovery of polyene γ-lactone derivatives and antibacterial aspyridone analogues

inferred← citeshttps://doi.org/10.1016/j.biortech.2024.131703openalex-snapshot

Developing filamentous fungal chassis for natural product production

inferred← citeshttps://doi.org/10.1016/j.biortech.2026.134069openalex-snapshot

Sustainable biomanufacturing of alkaloids driven by biotechnology: applications, challenges and perspectives

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2008.09.001openalex-snapshot

Developing Aspergillus as a host for heterologous expression

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.09.012openalex-snapshot

Production of recombinant proteins by filamentous fungi

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2014.03.001openalex-snapshot

Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2018.02.001openalex-snapshot

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107866openalex-snapshot

Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108117openalex-snapshot

Deciphering mechanisms of production of natural compounds using inducer-producer microbial consortia

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2024.108420openalex-snapshot

Interspecific cross-talk: The catalyst driving microbial biosynthesis of secondary metabolites

inferred← citeshttps://doi.org/10.1016/j.bmc.2008.11.025openalex-snapshot

A brief tour of myxobacterial secondary metabolism

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.04.004openalex-snapshot

An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii

inferred← citeshttps://doi.org/10.1016/j.bmc.2017.02.031openalex-snapshot

Biological evaluation of pyridone alkaloids on the endocannabinoid system

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.073openalex-snapshot

Functional expression of the Aspergillus flavus PKS–NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid

inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.02.091openalex-snapshot

Biomimetic conversion of (−)-fusoxypyridone and (−)-oxysporidinone to (−)-sambutoxin: Further evidence for the structure of the tricyclic pyridone alkaloid, (−)-fusoxypyridone

inferred← citeshttps://doi.org/10.1016/j.btre.2018.e00264openalex-snapshot

Functional redundancy in Echinocandin B in-cluster transcription factor ecdB of Emericella rugulosa NRRL 11440

inferred← citeshttps://doi.org/10.1016/j.cbpa.2010.03.036openalex-snapshot

Genetic chemistry: production of non-native compounds in yeast

inferred← citeshttps://doi.org/10.1016/j.cbpa.2010.10.011openalex-snapshot

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

inferred← citeshttps://doi.org/10.1016/j.cbpa.2010.10.020openalex-snapshot

Genomics-inspired discovery of natural products

inferred← citeshttps://doi.org/10.1016/j.cbpa.2011.05.018openalex-snapshot

Natural products as catalysts for innovation: a pharmaceutical industry perspective

inferred← citeshttps://doi.org/10.1016/j.cell.2014.06.034openalex-snapshot

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

inferred← citeshttps://doi.org/10.1016/j.chembiol.2008.05.010openalex-snapshot

Molecular Genetic Mining of the Aspergillus Secondary Metabolome: Discovery of the Emericellamide Biosynthetic Pathway

inferred← citeshttps://doi.org/10.1016/j.chembiol.2008.07.011openalex-snapshot

Biosynthesis of the Cyclooligomer Depsipeptide Beauvericin, a Virulence Factor of the Entomopathogenic Fungus Beauveria bassiana

inferred← citeshttps://doi.org/10.1016/j.chembiol.2010.03.015openalex-snapshot

Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum

inferred← citeshttps://doi.org/10.1016/j.chembiol.2010.12.011openalex-snapshot

Multifactorial Induction of an Orphan PKS-NRPS Gene Cluster in Aspergillus terreus

inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.12.018openalex-snapshot

Elucidation of Piericidin A1 Biosynthetic Locus Revealed a Thioesterase-Dependent Mechanism of α-Pyridone Ring Formation

inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.07.004openalex-snapshot

Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation

inferred← citeshttps://doi.org/10.1016/j.chembiol.2014.02.010openalex-snapshot

Synthetic Biology Tools for Bioprospecting of Natural Products in Eukaryotes

inferred← citeshttps://doi.org/10.1016/j.chembiol.2015.06.022openalex-snapshot

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols

inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.05.014openalex-snapshot

Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells

inferred← citeshttps://doi.org/10.1016/j.copbio.2008.10.012openalex-snapshot

Engineering natural products using combinatorial biosynthesis and biocatalysis

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