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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

https://doi.org/10.1038/ncomms10199
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201000620openalex-snapshot
The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain
inferredcites →https://doi.org/10.1002/anie.201409135openalex-snapshot
Structure and Mechanism of an Aspartimide‐Dependent Peptide Ligase in Human Legumain
inferredcites →https://doi.org/10.1002/bip.21422openalex-snapshot
Circular proteins and mechanisms of cyclization
inferredcites →https://doi.org/10.1002/bip.22284openalex-snapshot
Cyclotides as grafting frameworks for protein engineering and drug design applications
inferredcites →https://doi.org/10.1002/cbic.201300034openalex-snapshot
Cyclization of the Antimicrobial Peptide Gomesin with Native Chemical Ligation: Influences on Stability and Bioactivity
inferredcites →https://doi.org/10.1006/abbi.1993.1274openalex-snapshot
The Two Cysteine Endopeptidases of Legume Seeds: Purification and Characterization by Use of Specific Fluorometric Assays
inferredcites →https://doi.org/10.1006/abio.1998.3014openalex-snapshot
Use of a Fluorescence Plate Reader for Measuring Kinetic Parameters with Inner Filter Effect Correction
inferredcites →https://doi.org/10.1016/j.actatropica.2008.11.003openalex-snapshot
Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms
inferredcites →https://doi.org/10.1016/j.chembiol.2014.10.015openalex-snapshot
Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in α-Amanitin Biosynthesis
inferredcites →https://doi.org/10.1016/j.chembiol.2015.04.010openalex-snapshot
Peptide Macrocyclization by a Bifunctional Endoprotease
inferredcites →https://doi.org/10.1016/j.febslet.2004.10.034openalex-snapshot
Capped acyclic permutants of the circular protein kalata B1
inferredcites →https://doi.org/10.1016/j.febslet.2014.10.020openalex-snapshot
Backbone cyclization of a recombinant cystine‐knot peptide by engineered Sortase A
inferredcites →https://doi.org/10.1016/s0014-5793(99)00286-0openalex-snapshot
Vacuolar processing enzyme is self‐catalytically activated by sequential removal of the C‐terminal and N‐terminal propeptides
inferredcites →https://doi.org/10.1016/s0021-9258(18)53726-1openalex-snapshot
Asparaginyl endopeptidase of jack bean seeds. Purification, characterization, and high utility in protein sequence analysis.
inferredcites →https://doi.org/10.1016/s0022-2836(05)80360-2openalex-snapshot
Basic Local Alignment Search Tool
inferredcites →https://doi.org/10.1021/bi800223yopenalex-snapshot
Cyclotides: Natural, Circular Plant Peptides that Possess Significant Activity against Gastrointestinal Nematode Parasites of Sheep
inferredcites →https://doi.org/10.1021/ja1067806openalex-snapshot
Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
inferredcites →https://doi.org/10.1021/ja8092168openalex-snapshot
Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates
inferredcites →https://doi.org/10.1021/jf800302fopenalex-snapshot
Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice Pest Pomacea canaliculata (Golden Apple Snail)
inferredcites →https://doi.org/10.1038/nature02240openalex-snapshot
Immune recognition of a human renal cancer antigen through post-translational protein splicing
inferredcites →https://doi.org/10.1038/nchembio.1586openalex-snapshot
Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis
inferredcites →https://doi.org/10.1038/nchembio.542openalex-snapshot
Albumins and their processing machinery are hijacked for cyclic peptides in sunflower
inferredcites →https://doi.org/10.1038/nsmb.2340openalex-snapshot
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
inferredcites →https://doi.org/10.1042/bj3200865openalex-snapshot
Post-translational peptide bond formation during concanavalin A processing in vitro
inferredcites →https://doi.org/10.1042/bj3350111openalex-snapshot
Cloning and expression of mouse legumain, a lysosomal endopeptidase
inferredcites →https://doi.org/10.1046/j.1365-313x.1997.12040819.xopenalex-snapshot
Expression and activation of the vacuolar processing enzyme in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1073/pnas.0504613102openalex-snapshot
Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII
inferredcites →https://doi.org/10.1073/pnas.1300686110openalex-snapshot
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
inferredcites →https://doi.org/10.1073/pnas.191366898openalex-snapshot
Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis
inferredcites →https://doi.org/10.1074/jbc.272.12.8090openalex-snapshot
Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase
inferredcites →https://doi.org/10.1074/jbc.m112.347823openalex-snapshot
Insights into Processing and Cyclization Events Associated with Biosynthesis of the Cyclic Peptide Kalata B1
inferredcites →https://doi.org/10.1074/jbc.m112.437947openalex-snapshot
The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme
inferredcites →https://doi.org/10.1074/jbc.m705185200openalex-snapshot
An Asparaginyl Endopeptidase Mediates in Vivo Protein Backbone Cyclization
inferredcites →https://doi.org/10.1074/jbc.m808762200openalex-snapshot
Rapid Optimization of a Peptide Inhibitor of Malaria Parasite Invasion by Comprehensive N-Methyl Scanning
inferredcites →https://doi.org/10.1093/bioinformatics/btl158openalex-snapshot
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
inferredcites →https://doi.org/10.1093/bioinformatics/btm091openalex-snapshot
Enhancements and modifications of primer design program Primer3
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/bts094openalex-snapshot
Oases:robustde novoRNA-seq assembly across the dynamic range of expression levels
inferredcites →https://doi.org/10.1093/pcp/pcf035openalex-snapshot
Activation of Arabidopsis Vacuolar Processing Enzyme by Self-Catalytic Removal of an Auto-Inhibitory Domain of the C-Terminal Propeptide
inferredcites →https://doi.org/10.1105/tpc.10.3.343openalex-snapshot
The Role of Proteolysis in the Processing and Assembly of 11S Seed Globulins
inferredcites →https://doi.org/10.1107/s1744309111048020openalex-snapshot
Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile
inferredcites →https://doi.org/10.1110/ps.04618904openalex-snapshot
An efficient system for high‐level expression and easy purification of authentic recombinant proteins
inferredcites →https://doi.org/10.1111/j.1365-313x.2007.03357.xopenalex-snapshot
Biosynthesis of circular proteins in plants
inferredcites →https://doi.org/10.1126/science.1099859openalex-snapshot
A Plant Vacuolar Protease, VPE, Mediates Virus-Induced Hypersensitive Cell Death
inferredcites →https://doi.org/10.1126/science.285.5428.760openalex-snapshot
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
inferredcites →https://doi.org/10.1128/iai.73.10.6981-6989.2005openalex-snapshot
Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1
inferredcites →https://doi.org/10.1186/1471-2164-11-111openalex-snapshot
Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis
inferredcites →https://doi.org/10.3390/toxins4020139openalex-snapshot
Host-Defense Activities of Cyclotides

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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An overview of acyclotides: Past, present and future
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Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis
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Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming
inferred← citeshttps://doi.org/10.1002/1873-3468.12640openalex-snapshot
Segmental isotopic labeling of a single‐domain globular protein without any refolding step by an asparaginyl endopeptidase
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On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation
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Omniligase‐1: A Powerful Tool for Peptide Head‐to‐Tail Cyclization
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Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
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Der Sonnenblumen‐Trypsin‐Inhibitor 1 (SFTI‐1) in der Chemie und Biologie
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Improved Asparaginyl‐Ligase‐Catalyzed Transpeptidation via Selective Nucleophile Quenching
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Nγ‐Hydroxyasparagine: A Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases
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Enzymatic C‐to‐C Protein Ligation
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Efficient Multiple Domain Ligation for Proteins Using Asparaginyl Endopeptidase by Selection of Appropriate Ligation Sites Based on Steric Hindrance
inferred← citeshttps://doi.org/10.1002/anie.201601564openalex-snapshot
Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics
inferred← citeshttps://doi.org/10.1002/anie.202006919openalex-snapshot
Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology
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Improved Asparaginyl‐Ligase‐Catalyzed Transpeptidation via Selective Nucleophile Quenching
inferred← citeshttps://doi.org/10.1002/anie.202108125openalex-snapshot
Nγ‐Hydroxyasparagine: A Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases
inferred← citeshttps://doi.org/10.1002/anie.202116672openalex-snapshot
Enzymatic C‐to‐C Protein Ligation
inferred← citeshttps://doi.org/10.1002/anie.202214412openalex-snapshot
Efficient Multiple Domain Ligation for Proteins Using Asparaginyl Endopeptidase by Selection of Appropriate Ligation Sites Based on Steric Hindrance
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Unveiling the diversity of cyclotides by combining peptidome and transcriptome analysis
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Cyclic peptide oral bioavailability: Lessons from the past
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The N‐terminal pro‐domain of the kalata B1 cyclotide precursor is intrinsically unstructured
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Cyclotides: Overview and Biotechnological Applications
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Efficient Enzymatic Cyclization of Disulfide‐Rich Peptides by Using Peptide Ligases
inferred← citeshttps://doi.org/10.1002/cbic.202000398openalex-snapshot
Site‐Selective Peptide Macrocyclization
inferred← citeshttps://doi.org/10.1002/cbic.202000634openalex-snapshot
Cysteine‐Rich Peptides: Hyperstable Scaffolds for Protein Engineering
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Asparaginyl Ligases: New Enzymes for the Protein Engineer's Toolbox
inferred← citeshttps://doi.org/10.1002/cbic.202300372openalex-snapshot
Promiscuous Enzymes for Residue‐Specific Peptide and Protein Late‐Stage Functionalization
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Reading and Writing the Ubiquitin Code Using Genetic Code Expansion
inferred← citeshttps://doi.org/10.1002/cbic.202400591openalex-snapshot
Recombinant Production of The Cyclotide Kalata B1 by Conditional Split Inteins
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Protein N‐Terminal Modification: Recent Advances in Chemical and Enzymatic Strategies
inferred← citeshttps://doi.org/10.1002/chem.71730openalex-snapshot
C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
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A Self‐Adjuvanting Vaccine Platform: Optimization of Site‐Specific Sortase A Mediated Conjugation of Toll‐Like Receptor 2 Ligands onto the Carboxyl or Amino terminus of Recombinant Protein Antigens
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Cyclisation of Disulfide‐Rich Conotoxins in Drug Design Applications
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Display Technologies for Expanding the Pharmaceutical Applications of Cyclotides
inferred← citeshttps://doi.org/10.1002/med.21639openalex-snapshot
A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies
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Exploring and exploiting plant cyclic peptides for drug discovery and development
inferred← citeshttps://doi.org/10.1002/pld3.42openalex-snapshot
A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch
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Positional scanning and computational modeling reveal determinants of legumain transpeptidase activity
inferred← citeshttps://doi.org/10.1002/psc.3570openalex-snapshot
Cyclotides: The next generation in biopesticide development for eco‐friendly agriculture
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Development and applications of enzymatic peptide and protein ligation
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Cyclotides Versus Acyclotides: Discovery, Characterization and Their Potential in Cancer Therapy
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Engineering Mesoporous Silica Nanoparticles for Targeted and Controlled Delivery of Cyclic Peptides
inferred← citeshttps://doi.org/10.1007/978-1-0716-1689-5_7openalex-snapshot
Scalable and Efficient In Planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics
inferred← citeshttps://doi.org/10.1007/978-1-0716-2079-3_4openalex-snapshot
Production of Functional Plant Legumain Proteases Using the Leishmania tarentolae Expression System
inferred← citeshttps://doi.org/10.1007/978-1-0716-2489-0_13openalex-snapshot
PAL-Mediated Ligation for Protein and Cell-Surface Modification
inferred← citeshttps://doi.org/10.1007/978-1-0716-4562-8_10openalex-snapshot
Diol as a New Pantetheine Surrogate for Chemoenzymatic Synthesis of Cyclic Peptides via Nonribosomal Peptide Cyclases
inferred← citeshttps://doi.org/10.1007/978-1-4939-9546-2_12openalex-snapshot
In Vitro and In Planta Cyclization of Target Peptides Using an Asparaginyl Endopeptidase from Oldenlandia affinis
inferred← citeshttps://doi.org/10.1007/978-1-4939-9546-2_6openalex-snapshot
Butelase 1-Mediated Ligation of Peptides and Proteins
inferred← citeshttps://doi.org/10.1007/978-3-319-76822-9_4openalex-snapshot
Biosynthesis of the Amanita Cyclic Peptide Toxins
inferred← citeshttps://doi.org/10.1007/s00203-024-04122-0openalex-snapshot
Characterization of cyclotides Mra30 and cycloviolacin O17 derived from Viola dalatensis Gadnep
inferred← citeshttps://doi.org/10.1007/s00425-016-2562-yopenalex-snapshot
Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense
inferred← citeshttps://doi.org/10.1007/s00425-020-03505-zopenalex-snapshot
Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme
inferred← citeshttps://doi.org/10.1007/s00726-016-2333-xopenalex-snapshot
Natural structural diversity within a conserved cyclic peptide scaffold
inferred← citeshttps://doi.org/10.1007/s00726-023-03271-8openalex-snapshot
Insights into the synthesis strategies of plant-derived cyclotides
inferred← citeshttps://doi.org/10.1007/s10858-018-0175-4openalex-snapshot
Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation
inferred← citeshttps://doi.org/10.1007/s10858-022-00409-wopenalex-snapshot
Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1
inferred← citeshttps://doi.org/10.1007/s10989-021-10320-xopenalex-snapshot
Butelase-1 as the Prototypical Peptide Asparaginyl Ligase and Its Applications: A Review
inferred← citeshttps://doi.org/10.1007/s10989-021-10336-3openalex-snapshot
Development of ULYSSIS, a Tool for the Biosynthesis of Cyclotides and Cyclic Knottins
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Cyclotides as sustainable biopesticides: structure, function and agricultural potential
inferred← citeshttps://doi.org/10.1007/s11105-024-01462-5openalex-snapshot
Proximity Labelling Confirms the Involvement of Papain-Like Cysteine Proteases and Chaperones in Cyclotide Biosynthesis
inferred← citeshttps://doi.org/10.1007/s11248-023-00341-1openalex-snapshot
Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis
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Peptide asparaginyl ligases—renegade peptide bond makers
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Different Strategies for the Biosynthesis of Bioactive Peptide Using Bioengineering Technology in Pichia pastoris: A Review
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LC-MS/MS identification and structural characterization of isolated cyclotides from precursor sequences of Viola odorata L. petiole tissue using computational approach
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Stabilization of Proteins by Covalent Cyclization
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Expression und Untersuchung von Pflanzenproteinen mit Leishmania tarentolae
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Progress toward sourcing plants for new bioconjugation tools: a screening evaluation of a model peptide ligase using a synthetic precursor
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Design and applications of cyclic peptides
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Enzymatic bioconjugation to nanoparticles
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Protocols for measuring the stability and cytotoxicity of cyclotides
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Preparing recombinant “Split AEP” for protein labeling
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AEP-mediated backbone cyclization of cyclotides—A chemoenzymatic method for cyclotide production
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Surface sieving coordinated IMAC material for purification of His-tagged proteins
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Make it or break it: Plant AEPs on stage in biotechnology
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Insights into post-translational modification enzymes from RiPPs: A toolkit for applications in peptide synthesis
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Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds
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Cyclotides, a versatile ultrastable micro-protein scaffold for biotechnological applications
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Enzyme-mediated ligation technologies for peptides and proteins
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Cyclotides as drug design scaffolds
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Penicillin-binding protein-type thioesterases: An emerging family of non-ribosomal peptide cyclases with biocatalytic potentials
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A mini-review on the enzyme-mediated manipulation of proteins/peptides
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Recent advances in enzyme-mediated peptide ligation
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Site-specific protein labeling: Recent progress
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Enzyme-catalyzed peptide cyclization
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The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
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Engineering nanobodies for next-generation molecular imaging
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Emerging trends of receptor-mediated tumor targeting peptides: A review with perspective from molecular imaging modalities
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The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.102997openalex-snapshot
Consensus design and engineering of an efficient and high-yield peptide asparaginyl ligase for protein cyclization and ligation
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111301openalex-snapshot
Transcriptome-guided discovery and active-site gatekeeper engineering of a Viola arcuata asparaginyl ligase with superior catalytic performance
inferred← citeshttps://doi.org/10.1016/j.toxicon.2019.10.244openalex-snapshot
Cyclotides: Disulfide-rich peptide toxins in plants
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Advances in nanoscale engineering of cyclotides: Overcoming biological barriers toward precision therapeutics
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Modern strategies in nanobody engineering and functionalization: From discovery to biosensing application
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Merging the Passerini reaction with chemo-enzymatic synthesis for C-terminal peptide modification
inferred← citeshttps://doi.org/10.1016/j.xplc.2025.101315openalex-snapshot
Identification of a key peptide cyclase for novel cyclic peptide discovery in Pseudostellaria heterophylla
inferred← citeshttps://doi.org/10.1021/acs.accounts.7b00157openalex-snapshot
Cyclotides as Tools in Chemical Biology
inferred← citeshttps://doi.org/10.1021/acs.biochem.5c00808openalex-snapshot
Rational Design of Plant-Derived Protein Ligases with Altered Substrate Specificity
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b01139openalex-snapshot
Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00012openalex-snapshot
Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00114openalex-snapshot
Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00452openalex-snapshot
Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00551openalex-snapshot
Asparaginyl Endopeptidase-Mediated Protein C-Terminal Hydrazinolysis for the Synthesis of Bioconjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00029openalex-snapshot
Enzymatic Spin-Labeling of Protein N- and C-Termini for Electron Paramagnetic Resonance Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00037openalex-snapshot
OaAEP1 Ligase-Assisted Chemoenzymatic Synthesis of Full Cysteine-Rich Metal-Binding Cyanobacterial Metallothionein SmtA
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00026openalex-snapshot
Development of a Long-Acting Myeloid-Derived Growth Factor via Site-Specific PEGylation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6c00141openalex-snapshot
Orthogonal Acyl Acceptor Substrate Pairs and hQC Improve Sequential Ligation by Peptide Asparaginyl Ligases
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00478openalex-snapshot
Bioconjugation Approaches to Producing Subunit Vaccines Composed of Protein or Peptide Antigens and Covalently Attached Toll-Like Receptor Ligands
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.8b00244openalex-snapshot
Immobilization and Intracellular Delivery of Circular Proteins by Modifying a Genetically Incorporated Unnatural Amino Acid
inferred← citeshttps://doi.org/10.1021/acs.chemrev.9b00372openalex-snapshot
Subtiligase-Catalyzed Peptide Ligation
inferred← citeshttps://doi.org/10.1021/acs.chemrev.9b00402openalex-snapshot
Cyclotides: From Structure to Function
inferred← citeshttps://doi.org/10.1021/acs.chemrev.9b00450openalex-snapshot
Chemoenzymatic Semisynthesis of Proteins
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c01755openalex-snapshot
Enzymatic Properties of Recombinant Ligase Butelase-1 and Its Application in Cyclizing Food-Derived Angiotensin I-Converting Enzyme Inhibitory Peptides
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02379openalex-snapshot
Advances in Peptide-Based Chimeric Strategies for Targeted Protein Degradation
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c01065openalex-snapshot
In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.2c00674openalex-snapshot
Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.2c01158openalex-snapshot
Exploring the Limits of Cyanobactin Macrocyclase PatGmac: Cyclization of PawS-Derived Peptide Sunflower Trypsin Inhibitor-1 and Cyclotide Kalata B1
inferred← citeshttps://doi.org/10.1021/acs.joc.8b02032openalex-snapshot
Enzymatic On-Resin Peptide Cleavage and in Situ Cyclization One-Pot Strategy for the Synthesis of Cyclopeptide and Cyclotide
inferred← citeshttps://doi.org/10.1021/acs.joc.9b02524openalex-snapshot
Immobilized Peptide Asparaginyl Ligases Enhance Stability and Facilitate Macrocyclization and Site-Specific Ligation
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c00602openalex-snapshot
Asparaginyl Endopeptidase-Mediated Peptide Cyclization for Phage Display
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c01007openalex-snapshot
Improvement of Transpeptidative Protein Ligation via Selective Nucleophile Quenching using 2-Cyano-6-hydroxybenzothiazole
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c01205openalex-snapshot
Employing Broad Substrate Specificity of Omniligase to Generate Phage-Encoded Bicyclic Peptide Libraries for Ligand Discovery
inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.3c00059openalex-snapshot
Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis
inferred← citeshttps://doi.org/10.1021/acscatal.0c00623openalex-snapshot
Expanding the Chemical Space of Synthetic Cyclic Peptides Using a Promiscuous Macrocyclase from Prenylagaramide Biosynthesis
inferred← citeshttps://doi.org/10.1021/acscatal.0c02078openalex-snapshot
Turning an Asparaginyl Endopeptidase into a Peptide Ligase
inferred← citeshttps://doi.org/10.1021/acscatal.4c04145openalex-snapshot
Repurposing Amide Bond-Forming Enzymes for Non-native Protein Modification
inferred← citeshttps://doi.org/10.1021/acscatal.7b01505openalex-snapshot
Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
inferred← citeshttps://doi.org/10.1021/acscentsci.5c00408openalex-snapshot
Peptide and Protein Cyclization by a Promiscuous Graspetide Synthetase
inferred← citeshttps://doi.org/10.1021/acschembio.9b00996openalex-snapshot
Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00957openalex-snapshot
Small and Versatile Cyclotides as Anti-infective Agents
inferred← citeshttps://doi.org/10.1021/acsomega.4c09668openalex-snapshot
Transgenic Innovation: Harnessing Cyclotides as Next Generation Pesticides
inferred← citeshttps://doi.org/10.1021/acsomega.5c01401openalex-snapshot
Identification of Ginsentide-like Peptides from Cacao Beans with Oxidative Stress Protection
inferred← citeshttps://doi.org/10.1021/jacs.1c02638openalex-snapshot
pH-Controlled Protein Orthogonal Ligation Using Asparaginyl Peptide Ligases
inferred← citeshttps://doi.org/10.1021/jacs.1c08976openalex-snapshot
Enzymatic C-Terminal Protein Engineering with Amines
inferred← citeshttps://doi.org/10.1021/jacs.2c02191openalex-snapshot
Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase
inferred← citeshttps://doi.org/10.1021/jacs.2c13628openalex-snapshot
A Cascade Enzymatic Reaction Scheme for Irreversible Transpeptidative Protein Ligation
inferred← citeshttps://doi.org/10.1021/jacs.4c10689openalex-snapshot
Structural Basis of High-Precision Protein Ligation and Its Application
inferred← citeshttps://doi.org/10.1021/jacs.4c11964openalex-snapshot
Highly Efficient Transpeptidase-Catalyzed Isopeptide Ligation
inferred← citeshttps://doi.org/10.1021/jacs.5c04693openalex-snapshot
Asparaginyl Ligases with Engineered Substrate Specificity for Controlled, Sequential Transpeptidation Reactions
inferred← citeshttps://doi.org/10.1021/jacs.5c20426openalex-snapshot
Peptidyl Asparaginyl Ligase-Mediated Orthogonal Ligation at Non-Asx Peptide Bonds for d -Peptide Cyclization and Antibody Dual Labeling
inferred← citeshttps://doi.org/10.1021/jacs.5c23400openalex-snapshot
Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation
inferred← citeshttps://doi.org/10.1021/jacs.6b12637openalex-snapshot
Engineering a Catalytically Efficient Recombinant Protein Ligase
inferred← citeshttps://doi.org/10.1021/jacs.6b12872openalex-snapshot
Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products
inferred← citeshttps://doi.org/10.1021/jacs.7b13017openalex-snapshot
Macrocyclization of Interferon–Poly(α-amino acid) Conjugates Significantly Improves the Tumor Retention, Penetration, and Antitumor Efficacy
inferred← citeshttps://doi.org/10.1021/jacs.9b09166openalex-snapshot
Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase
inferred← citeshttps://doi.org/10.1021/jacsau.2c00617openalex-snapshot
Enzymatic Bioconjugation: A Perspective from the Pharmaceutical Industry
inferred← citeshttps://doi.org/10.1021/jacsau.3c00591openalex-snapshot
Intracellular Application of an Asparaginyl Endopeptidase for Producing Recombinant Head-to-Tail Cyclic Proteins
inferred← citeshttps://doi.org/10.1021/jacsau.5c01395openalex-snapshot
“Lys–Leu” Motif Empowers Expedient Oa AEP1-Catalyzed Generation of N-Terminal Cysteine Recombinant Proteins for Bioconjugation and Semisynthesis
inferred← citeshttps://doi.org/10.1038/nprot.2016.118openalex-snapshot
Butelase-mediated cyclization and ligation of peptides and proteins
inferred← citeshttps://doi.org/10.1038/s41467-018-04669-9openalex-snapshot
Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases
inferred← citeshttps://doi.org/10.1038/s41467-019-10696-xopenalex-snapshot
Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level
inferred← citeshttps://doi.org/10.1038/s41467-020-15418-2openalex-snapshot
A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
inferred← citeshttps://doi.org/10.1038/s41467-021-26812-9openalex-snapshot
A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes
inferred← citeshttps://doi.org/10.1038/s41467-023-42977-xopenalex-snapshot
C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule
inferred← citeshttps://doi.org/10.1038/s41467-024-48726-yopenalex-snapshot
Cell-free biosynthesis and engineering of ribosomally synthesized lanthipeptides
inferred← citeshttps://doi.org/10.1038/s41467-024-50742-xopenalex-snapshot
Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides
inferred← citeshttps://doi.org/10.1038/s41557-024-01520-1openalex-snapshot
Repurposing a plant peptide cyclase for targeted lysine acylation
inferred← citeshttps://doi.org/10.1038/s41570-023-00468-zopenalex-snapshot
Nature-inspired protein ligation and its applications
inferred← citeshttps://doi.org/10.1038/s41589-018-0039-yopenalex-snapshot
Designing macrocyclic disulfide-rich peptides for biotechnological applications
inferred← citeshttps://doi.org/10.1038/s41589-021-00892-6openalex-snapshot
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases
inferred← citeshttps://doi.org/10.1038/s41596-020-00483-0openalex-snapshot
Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
inferred← citeshttps://doi.org/10.1038/s41598-019-47273-7openalex-snapshot
A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
inferred← citeshttps://doi.org/10.1038/s41598-020-69452-7openalex-snapshot
Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis
inferred← citeshttps://doi.org/10.1038/s42004-023-00841-5openalex-snapshot
Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
inferred← citeshttps://doi.org/10.1038/s42004-024-01147-wopenalex-snapshot
Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides
inferred← citeshttps://doi.org/10.1038/s42004-024-01173-8openalex-snapshot
Design of a recombinant asparaginyl ligase for site-specific modification using efficient recognition and nucleophile motifs
inferred← citeshttps://doi.org/10.1038/s44383-026-00021-zopenalex-snapshot
Biotechnological approaches for producing therapeutic peptides in plants
inferred← citeshttps://doi.org/10.1039/9781837674541-00109openalex-snapshot
Sustainable Approaches to Chemo-enzymatic Peptide Synthesis (CEPS)
inferred← citeshttps://doi.org/10.1039/c7cc02333bopenalex-snapshot
Pinpointing disulfide connectivities in cysteine-rich proteins
inferred← citeshttps://doi.org/10.1039/c7np00066aopenalex-snapshot
Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins
inferred← citeshttps://doi.org/10.1039/c9cc06748eopenalex-snapshot
Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity
inferred← citeshttps://doi.org/10.1039/d0cb00062kopenalex-snapshot
Harnessing cyclotides to design and develop novel peptide GPCR ligands
inferred← citeshttps://doi.org/10.1039/d0cs01148gopenalex-snapshot
Challenges in the use of sortase and other peptide ligases for site-specific protein modification
inferred← citeshttps://doi.org/10.1039/d0gc01366hopenalex-snapshot
An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides
inferred← citeshttps://doi.org/10.1039/d0np00027bopenalex-snapshot
New developments in RiPP discovery, enzymology and engineering
inferred← citeshttps://doi.org/10.1039/d0ra07204dopenalex-snapshot
Greening the synthesis of peptide therapeutics: an industrial perspective
inferred← citeshttps://doi.org/10.1039/d0sc02023kopenalex-snapshot
Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling
inferred← citeshttps://doi.org/10.1039/d1cb00045dopenalex-snapshot
Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins
inferred← citeshttps://doi.org/10.1039/d1cb00246eopenalex-snapshot
Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
inferred← citeshttps://doi.org/10.1039/d1cc01348copenalex-snapshot
A modular approach to enzymatic ligation of peptides and proteins with oligonucleotides
inferred← citeshttps://doi.org/10.1039/d1gc04387kopenalex-snapshot
Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges
inferred← citeshttps://doi.org/10.1039/d1ob00411eopenalex-snapshot
Approaches for peptide and protein cyclisation
inferred← citeshttps://doi.org/10.1039/d1ob00608hopenalex-snapshot
Asparaginyl endopeptidases: enzymology, applications and limitations
inferred← citeshttps://doi.org/10.1039/d1ra03763copenalex-snapshot
Characterization and application of natural and recombinant butelase-1 to improve industrial enzymes by end-to-end circularization
inferred← citeshttps://doi.org/10.1039/d3cc04919aopenalex-snapshot
Use of a head-to-tail peptide cyclase to prepare hybrid RiPPs
inferred← citeshttps://doi.org/10.1039/d3np00042gopenalex-snapshot
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides
inferred← citeshttps://doi.org/10.1039/d4cb00306copenalex-snapshot
Protein ligation for the assembly and study of nonribosomal peptide synthetase megaenzymes
inferred← citeshttps://doi.org/10.1039/d4fd00002aopenalex-snapshot
Towards controlling activity of a peptide asparaginyl ligase (PAL) by lumazine synthetase compartmentalization
inferred← citeshttps://doi.org/10.1039/d4ob01624fopenalex-snapshot
Generation of antibody–drug conjugates by proximity-driven acyl transfer and sortase-mediated ligation
inferred← citeshttps://doi.org/10.1039/d5cc05717eopenalex-snapshot
OaAEP1-dependent enzymatic protein ligation and immobilization for single-molecule force spectroscopy
inferred← citeshttps://doi.org/10.1039/d6sc04842kopenalex-snapshot
Constrained diffusion-enabled construction of a highly expressed and robust peptide asparaginyl ligase
inferred← citeshttps://doi.org/10.1042/bcj20180213openalex-snapshot
A structural perspective of plant antimicrobial peptides
inferred← citeshttps://doi.org/10.1042/bst20200001openalex-snapshot
Engineered peptide ligases for cell signaling and bioconjugation
inferred← citeshttps://doi.org/10.1042/bst20200881openalex-snapshot
Plant derived cyclic peptides
inferred← citeshttps://doi.org/10.1042/bst20200908openalex-snapshot
Plant asparaginyl endopeptidases and their structural determinants of function
inferred← citeshttps://doi.org/10.1055/s-0043-1775364openalex-snapshot
His-Tagging: Exploring Precise Chemical Modification of Histidine-Containing Bioactive Peptide Sequences
inferred← citeshttps://doi.org/10.1055/s-0043-1775459openalex-snapshot
Metabolite-Mediated Protein Macrocyclization
inferred← citeshttps://doi.org/10.1071/ch16589openalex-snapshot
Synthesis and Protein Engineering Applications of Cyclotides
inferred← citeshttps://doi.org/10.1073/pnas.1519960113openalex-snapshot
Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis
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