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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/3527608761openalex-snapshot
Fragment‐based Approaches in Drug Discovery
inferredcites →https://doi.org/10.1002/anie.200300626openalex-snapshot
A Planning Strategy for Diversity‐Oriented Synthesis
inferredcites →https://doi.org/10.1002/anie.200353466openalex-snapshot
Synthetic Strategy toward Skeletal Diversity via Solid‐Supported, Otherwise Unstable Reactive Intermediates
inferredcites →https://doi.org/10.1002/anie.200600350openalex-snapshot
Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
inferredcites →https://doi.org/10.1002/anie.200600497openalex-snapshot
Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions
inferredcites →https://doi.org/10.1002/anie.200700762openalex-snapshot
Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription‐Factor Inhibitor
inferredcites →https://doi.org/10.1002/anie.200703073openalex-snapshot
Towards the Optimal Screening Collection: A Synthesis Strategy
inferredcites →https://doi.org/10.1002/anie.200705415openalex-snapshot
Anti‐MRSA Agent Discovery Using Diversity‐Oriented Synthesis
inferredcites →https://doi.org/10.1002/anie.200804486openalex-snapshot
Synthesis of Natural‐Product‐Like Molecules with Over Eighty Distinct Scaffolds
inferredcites →https://doi.org/10.1002/anie.200805452openalex-snapshot
Synthesis of Unprecedented Scaffold Diversity
inferredcites →https://doi.org/10.1002/cbic.200800758openalex-snapshot
The State of the Art of Chemical Biology
inferredcites →https://doi.org/10.1007/3-540-37635-6_4openalex-snapshot
Diversity Oriented Synthesis: A Challenge for Synthetic Chemists
inferredcites →https://doi.org/10.1007/978-3-540-37635-4_4openalex-snapshot
Diversity Oriented Synthesis: A Challenge for Synthetic Chemists
inferredcites →https://doi.org/10.1007/s00018-007-7492-1openalex-snapshot
Biology-inspired synthesis of compound libraries
inferredcites →https://doi.org/10.1016/b0-08-045044-x/00114-0openalex-snapshot
Fragment-Based Approaches
inferredcites →https://doi.org/10.1016/j.cbpa.2005.03.004openalex-snapshot
Assessment of structural diversity in combinatorial synthesis
inferredcites →https://doi.org/10.1016/j.cbpa.2005.04.006openalex-snapshot
The principle of complementarity: chemical versus biological space
inferredcites →https://doi.org/10.1016/j.cbpa.2010.03.003openalex-snapshot
Recent advances in multicomponent reactions for diversity-oriented synthesis
inferredcites →https://doi.org/10.1016/j.cbpa.2010.03.018openalex-snapshot
Current strategies for diversity-oriented synthesis
inferredcites →https://doi.org/10.1016/j.drudis.2007.08.005openalex-snapshot
Integration of fragment screening and library design
inferredcites →https://doi.org/10.1016/j.sbi.2006.01.013openalex-snapshot
Can we rationally design promiscuous drugs?
inferredcites →https://doi.org/10.1016/j.tetlet.2009.02.034openalex-snapshot
Aziridines as intermediates in diversity-oriented syntheses of alkaloids
inferredcites →https://doi.org/10.1016/s1074-5521(02)00143-6openalex-snapshot
Teaching Target-Oriented and Diversity-Oriented Organic Synthesis at Harvard University
inferredcites →https://doi.org/10.1016/s1359-6446(03)02751-xopenalex-snapshot
Molecular diversity through sugar scaffolds
inferredcites →https://doi.org/10.1021/cc0601480openalex-snapshot
Diversity-Oriented Synthetic Approach to Naturally Abundant S-Amino Acid Based Benzannulated Enantiomerically Pure Medium Ring Heterocyclic Scaffolds Employing Inter- and Intramolecular Mitsunobu Reactions
inferredcites →https://doi.org/10.1021/cc700187topenalex-snapshot
Application of Combinatorial Chemistry Science on Modern Drug Discovery
inferredcites →https://doi.org/10.1021/ci025599wopenalex-snapshot
Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity
inferredcites →https://doi.org/10.1021/ja0010507openalex-snapshot
Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings
inferredcites →https://doi.org/10.1021/ja017248oopenalex-snapshot
Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform
inferredcites →https://doi.org/10.1021/ja0352698openalex-snapshot
Discovery of an Inhibitor of a Transcription Factor Using Small Molecule Microarrays and Diversity-Oriented Synthesis
inferredcites →https://doi.org/10.1021/ja0457415openalex-snapshot
A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially
inferredcites →https://doi.org/10.1021/ja065724aopenalex-snapshot
An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis
inferredcites →https://doi.org/10.1021/jm9010687openalex-snapshot
Identification of Lead Compounds As Antagonists of Protein Bcl-xL with a Diversity-Oriented Multidisciplinary Approach
inferredcites →https://doi.org/10.1021/jm901241eopenalex-snapshot
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
inferredcites →https://doi.org/10.1021/jo8001276openalex-snapshot
Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry
inferredcites →https://doi.org/10.1021/np068054vopenalex-snapshot
Natural Products as Sources of New Drugs over the Last 25 Years
inferredcites →https://doi.org/10.1021/ol047945wopenalex-snapshot
Skeletal Diversity via a Folding Pathway: Synthesis of Indole Alkaloid-Like Skeletons
inferredcites →https://doi.org/10.1021/ol100436ropenalex-snapshot
Multistep Microwave-Assisted Divergent Synthesis of Indolo-Fused Pyrazino-/Diazepinoquinoxalinones on PEG Support
inferredcites →https://doi.org/10.1021/ol100574yopenalex-snapshot
The tert-Butylsulfinamide Lynchpin in Transition-Metal-Mediated Multiscaffold Library Synthesis
inferredcites →https://doi.org/10.1021/ol100914bopenalex-snapshot
Stereochemical and Skeletal Diversity Arising from Amino Propargylic Alcohols
inferredcites →https://doi.org/10.1021/ol802467fopenalex-snapshot
“Click, Click, Cyclize”: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchpins
inferredcites →https://doi.org/10.1038/416653aopenalex-snapshot
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
inferredcites →https://doi.org/10.1038/nature03193openalex-snapshot
Navigating chemical space for biology and medicine
inferredcites →https://doi.org/10.1038/nbt0308-303openalex-snapshot
What is principal component analysis?
inferredcites →https://doi.org/10.1038/nchembio.142openalex-snapshot
A small molecule that binds Hedgehog and blocks its signaling in human cells
inferredcites →https://doi.org/10.1038/nchembio.187openalex-snapshot
Interactive exploration of chemical space with Scaffold Hunter
inferredcites →https://doi.org/10.1038/nchembio.188openalex-snapshot
Bioactivity-guided mapping and navigation of chemical space
inferredcites →https://doi.org/10.1038/nchembio0705-74openalex-snapshot
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
inferredcites →https://doi.org/10.1038/nchembio0807-442openalex-snapshot
Scaffold composition and biological relevance of screening libraries
inferredcites →https://doi.org/10.1038/nrd2201openalex-snapshot
Drugs for bad bugs: confronting the challenges of antibacterial discovery
inferredcites →https://doi.org/10.1038/nrd2220openalex-snapshot
A decade of fragment-based drug design: strategic advances and lessons learned
inferredcites →https://doi.org/10.1038/sj.jid.5700853openalex-snapshot
Chemical Genetics: Elucidating Biological Systems with Small-Molecule Compounds
inferredcites →https://doi.org/10.1039/b310752nopenalex-snapshot
Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990 and 2002. See…
inferredcites →https://doi.org/10.1039/b312875jopenalex-snapshot
Chemical genetics to chemical genomics: small molecules offer big insights
inferredcites →https://doi.org/10.1039/b406488gopenalex-snapshot
Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesisElectronic supplementary information (ESI) available: experimental techniques, apparatus, characterisation and spectroscopic data.…
inferredcites →https://doi.org/10.1039/b409813gopenalex-snapshot
Molecular similarity: a key technique in molecular informatics
inferredcites →https://doi.org/10.1039/b607710bopenalex-snapshot
Skeletal diversity construction via a branching synthetic strategy
inferredcites →https://doi.org/10.1039/b719372fopenalex-snapshot
Diversity-oriented synthesis; a spectrum of approaches and results
inferredcites →https://doi.org/10.1039/b809038fopenalex-snapshot
Gemmacin B: bringing diversity back into focus
inferredcites →https://doi.org/10.1039/b812901kopenalex-snapshot
Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis
inferredcites →https://doi.org/10.1039/b816852kopenalex-snapshot
The discovery of antibacterial agents using diversity-oriented synthesis
inferredcites →https://doi.org/10.1039/b917965hopenalex-snapshot
Diversity-oriented synthesis of bicyclic and tricyclic alkaloids
inferredcites →https://doi.org/10.1039/b927161aopenalex-snapshot
Reagent based DOS: A “Click, Click, Cyclize” strategy to probe chemical space
inferredcites →https://doi.org/10.1039/c003211popenalex-snapshot
On the potential of natural products in the discovery of pharma leads: A case for reassessment
inferredcites →https://doi.org/10.1073/pnas.0503647102openalex-snapshot
Charting biologically relevant chemical space: A structural classification of natural products (SCONP)
inferredcites →https://doi.org/10.1073/pnas.0601490103openalex-snapshot
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis
inferredcites →https://doi.org/10.1093/jac/48.1.141openalex-snapshot
Dormancy and persistence in chronic infection: role of the general stress response in resistance to chemotherapy
inferredcites →https://doi.org/10.1093/jac/48.1.143openalex-snapshot
Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS)
inferredcites →https://doi.org/10.1099/0022-1317-51-6-516openalex-snapshot
Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16
inferredcites →https://doi.org/10.1126/science.1089946openalex-snapshot
Generating Diverse Skeletons of Small Molecules Combinatorially
inferredcites →https://doi.org/10.1126/science.287.5460.1964openalex-snapshot
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
inferredcites →https://doi.org/10.1186/1897-4287-9-s1-p24openalex-snapshot
Thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis (FAP): Memorial Sloan-Kettering Cancer Center (MSKCC) registry experience
inferredcites →https://doi.org/10.1517/17460440902916606openalex-snapshot
Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?
inferredcites →https://doi.org/10.1586/14789450.1.2.141openalex-snapshot
Breaking the spell: drug discovery based on modulating protein–protein interactions
inferredcites →https://doi.org/10.2174/1386207043328544openalex-snapshot
Privileged Structures: Applications in Drug Discovery
inferredcites →https://doi.org/10.2174/187231307779814066openalex-snapshot
Properties and Architecture of Drugs and Natural Products Revisited
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4820110openalex-extracted
Diversity-Oriented Repurposing of Pyrimidin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamides as Promising Antifungals that inhibit Ergosterol Biosynthesis of Candida albicans
inferred← citeshttps://doi.org/10.1002/0471266949.bmc019.pub3openalex-snapshot
Combinatorial Chemistry and Its Associated Technologies
inferred← citeshttps://doi.org/10.1002/9781118618110.ch1openalex-snapshot
The Basics of Diversity‐Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/9781118618110.ch17openalex-snapshot
Diversity‐Oriented Synthesis and Drug Development: Facilitating the Discovery of Novel Probes and Therapeutics
inferred← citeshttps://doi.org/10.1002/9781118618110.ch3openalex-snapshot
Cycloaddition reactions in Diversity‐Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/9781118618110.ch4openalex-snapshot
Phosphine Organocatalysis as a Platform for Diversity‐Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/9781118618110.ch9openalex-snapshot
Diversity‐Oriented Synthesis of Natural Product–Like Libraries
inferred← citeshttps://doi.org/10.1002/9781118771723.ch4openalex-snapshot
New Advances in Diversity‐Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/9781118940228.ch1openalex-snapshot
Principles for Synthetic Efficiency and Expansion of the Field
inferred← citeshttps://doi.org/10.1002/9781119708841.ch10openalex-snapshot
Modern Catalytic Enantioselective Approaches to Piperidines
inferred← citeshttps://doi.org/10.1002/9781394249190.ch2openalex-snapshot
Bioactive Small Molecules and Drug Discovery
inferred← citeshttps://doi.org/10.1002/9783527655908.ch1openalex-snapshot
High‐Throughput Screening in Agrochemical Research
inferred← citeshttps://doi.org/10.1002/9783527671304.ch13openalex-snapshot
Domino Reactions in Library Synthesis
inferred← citeshttps://doi.org/10.1002/9783527687503.ch26openalex-snapshot
Diversity‐Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems
inferred← citeshttps://doi.org/10.1002/9783527687503.ch27openalex-snapshot
Scaffold Diversity Synthesis with Branching Cascades Strategy
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Microwave‐Enhanced Efficient Regioselective Synthesis of 1,3,4‐Trisubstituted 2‐Mercaptoimidazoles on a Soluble Support
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A Facile Route to Benzo[a]fluorenes via a Palladium‐Catalyzed Reaction of 2‐Alkynylbromobenzene with 2‐(2‐Alkynylphenyl)malonate
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Assembly of Indeno[1,2‐c]chromenes via a Palladium‐Catalyzed Reaction of 1‐Bromo‐2‐(cyclopropylidenemethyl)benzene with 2‐Alkynylphenol
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Allene‐Based Gold‐Catalyzed Stereodivergent Synthesis of Azapolycyclic Derivatives of Unusual Structure
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Diversity‐Oriented Synthesis of Oxacyclic Spirooxindole Derivatives through Ring‐Closing Enyne Metathesis and Intramolecular Pauson–Khand (2+2+1) Cyclization of Oxindole Enynes
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Divergent Synthesis of Dihydropyranone Stereoisomers via N‐Heterocyclic Carbene Catalysis
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Diversity‐Oriented Synthesis of Complex Pyrrole‐Based Architectures from Very Simple Starting Materials
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Imidazodipyridines via DMAP Catalyzed Domino N−H Carbonylation and 6π‐Electrocyclization: Synthetic Scope and Application
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Diversity‐Oriented Synthesis of Spirocyclohexene Indane‐1,3‐diones and Coumarin‐Fused Cyclopentanes via an Organobase‐Controlled Cascade Reaction
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A Gold(I)‐Catalyzed Tandem Cyclization to Benzo[b]indeno[1,2‐e][1,4]diazepines from o‐Phenylenediamines and Ynones
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Diastereoselective Synthesis of Spirocyclic Ether from ortho‐Carbonylarylacetylenols via Silver‐Catalyzed Cyclization under Acidic Conditions
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One‐Pot Construction of Diverse Products using Versatile Cyclopropenones
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2‐(Alkynyl)anilines and Derivatives — Versatile Reagents for Heterocyclic Synthesis
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Catalytic Chemodivergent Annulations of o‐Aminotrifluoroacetophenone and Allenyl Imide through β’‐C−H Functionalization or β/γ‐Bisfunctionalization
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Diversity‐Oriented Synthesis of Spiro‐ and 3‐Methylene‐hydroquinoline‐Indandiones via an Organobase‐Controlled Cascade Strategy
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Organocatalytic Vinylogous Michael Addition/Cyclization Cascade of 2‐Alkylidene Indane‐1,3‐diones with Enals: A Regio‐ and Stereocontrolled Diversity‐Oriented Route to Indane‐1,3‐dione Derivatives
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Assembly of Functionalized 3,4‐Fused Tricyclic Benzosultams via Radical‐Promoted Cascade Reactions
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Chemoselective Acylation/Wittig or β‐Acylation Reactions: Diversity‐Oriented Synthesis of Indandione‐Tethered Benzofurans and β‐Acylated Arylidene Indandiones
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Substrate‐Dependent Asymmetric Allylic Alkylation of Morita–Baylis–Hillman Carbonates with 3‐Alkylidene Oxindoles
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Solvent‐Enabled Organocatalyst‐Assisted Enantioselective Regiodivergent Cascade Reactions: Overriding Intrinsic Reactivity of Vinylogous Pyrazolones
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Peptide Multifunctionalization via Modular Construction of Trans ‐AB 2 C Porphyrin on Resin
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Transition‐Metal‐Free C2‐H Sulfonylation of Quinoline N‐Oxides via Insertion of Sulfur Dioxide
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Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection
inferred← citeshttps://doi.org/10.1002/ange.202206797openalex-snapshot
Diversification of Aryl Sulfonyl Compounds through Ligand‐Controlledmeta‐ andpara‐C−H Borylation
inferred← citeshttps://doi.org/10.1002/ange.202207067openalex-snapshot
The Impact of Boron Hybridisation on Photocatalytic Processes
inferred← citeshttps://doi.org/10.1002/ange.202210312openalex-snapshot
Dearomative Aminocarbonylation of Arenes via Bifunctional Coordination to Chromium
inferred← citeshttps://doi.org/10.1002/ange.202214049openalex-snapshot
Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines
inferred← citeshttps://doi.org/10.1002/ange.202403917openalex-snapshot
Umpolung‐Enabled Divergent Dearomative Carbonylations
inferred← citeshttps://doi.org/10.1002/ange.202505625openalex-snapshot
Branched‐Selective Functionalization of 2‐Alkyl Aziridines Through Ni‐Catalyzed Dynamic Kinetic Activation
inferred← citeshttps://doi.org/10.1002/ange.202513342openalex-snapshot
Enantioselective Synthesis of Cyclobutane‐fused Heterocycles via Lewis Acid‐Catalyzed Dearomative [2+2] Photocycloaddition of Indoles, Benzofurans, and Benzothiophenes with Alkenes
inferred← citeshttps://doi.org/10.1002/ange.202522817openalex-snapshot
Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐ Bis ‐Carbofunctionalization
inferred← citeshttps://doi.org/10.1002/ange.6748265openalex-snapshot
Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes
inferred← citeshttps://doi.org/10.1002/ange.7785903openalex-snapshot
Cobalt‐Catalyzed Reductive Asymmetric Dimerization of 1,3‐Enynes: Rapid Synthesis of Enantioenriched Skipped 1,3,6‐Trienes
inferred← citeshttps://doi.org/10.1002/ange.9599258openalex-snapshot
Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden
inferred← citeshttps://doi.org/10.1002/anie.201208738openalex-snapshot
Relay Catalytic Branching Cascade: A Technique to Access Diverse Molecular Scaffolds
inferred← citeshttps://doi.org/10.1002/anie.201303987openalex-snapshot
Diversity‐Oriented Three‐Component Reactions of Diazo Compounds with Anilines and 4‐Oxo‐Enoates
inferred← citeshttps://doi.org/10.1002/anie.201308743openalex-snapshot
Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid
inferred← citeshttps://doi.org/10.1002/anie.201310136openalex-snapshot
Desymmetrization of Diolefinic Diols by Enantioselective Amino‐thiocarbamate‐Catalyzed Bromoetherification: Synthesis of Chiral Spirocycles
inferred← citeshttps://doi.org/10.1002/anie.201400241openalex-snapshot
Asymmetric Organocatalytic Epoxidations: Reactions, Scope, Mechanisms, and Applications
inferred← citeshttps://doi.org/10.1002/anie.201405747openalex-snapshot
Synthesis of a Natural Product‐Like Compound Collection through Oxidative Cleavage and Cyclization of Linear Peptides
inferred← citeshttps://doi.org/10.1002/anie.201406865openalex-snapshot
Diversity‐Oriented Synthesis of Drug‐Like Macrocyclic Scaffolds Using an Orthogonal Organo‐ and Metal Catalysis Strategy
inferred← citeshttps://doi.org/10.1002/anie.201508818openalex-snapshot
Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery
inferred← citeshttps://doi.org/10.1002/anie.201600878openalex-snapshot
Dienamine Activation of Diazoenals: Application to the Direct Synthesis of Functionalized 1,4‐Oxazines
inferred← citeshttps://doi.org/10.1002/anie.201605460openalex-snapshot
A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
inferred← citeshttps://doi.org/10.1002/anie.201710592openalex-snapshot
A Gold‐Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks
inferred← citeshttps://doi.org/10.1002/anie.201711524openalex-snapshot
Diversity‐Oriented Synthesis of Furo[3,2‐c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction
inferred← citeshttps://doi.org/10.1002/anie.201801976openalex-snapshot
[1+1+3] Annulation of Diazoenals and Vinyl Azides: Direct Synthesis of Functionalized 1‐Pyrrolines through Olefination
inferred← citeshttps://doi.org/10.1002/anie.201806961openalex-snapshot
Synthesis of Bifunctional Allylic Compounds by Using Cyclopropenes as Functionalized Allyl Equivalents
inferred← citeshttps://doi.org/10.1002/anie.201808823openalex-snapshot
Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA‐Binding Scaffold
inferred← citeshttps://doi.org/10.1002/anie.201903534openalex-snapshot
Divergent Synthesis of Chiral Covalent Organic Frameworks
inferred← citeshttps://doi.org/10.1002/anie.201903860openalex-snapshot
A Fused Hexacyclic Ring System: Diastereoselective Polycyclization of 2,4‐Dienals through an Interrupted iso‐Nazarov Reaction
inferred← citeshttps://doi.org/10.1002/anie.201908860openalex-snapshot
Merging Regiodivergent Catalysis with Atom‐Economical Radical Arylation
inferred← citeshttps://doi.org/10.1002/anie.201909987openalex-snapshot
Autonomous Discovery in the Chemical Sciences Part I: Progress
inferred← citeshttps://doi.org/10.1002/anie.201910707openalex-snapshot
Copper‐Catalyzed Enantioselective Allylboration of Alkynes: Synthesis of Highly Versatile Multifunctional Building Blocks
inferred← citeshttps://doi.org/10.1002/anie.201911109openalex-snapshot
Cascade Cross‐Coupling of Dienes: Photoredox and Nickel Dual Catalysis
inferred← citeshttps://doi.org/10.1002/anie.202010338openalex-snapshot
Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds
inferred← citeshttps://doi.org/10.1002/anie.202016575openalex-snapshot
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
inferred← citeshttps://doi.org/10.1002/anie.202100583openalex-snapshot
Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation
inferred← citeshttps://doi.org/10.1002/anie.202104228openalex-snapshot
Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity
inferred← citeshttps://doi.org/10.1002/anie.202106654openalex-snapshot
Combination of Pseudo‐Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo‐Sesquiterpenoid Alkaloids
inferred← citeshttps://doi.org/10.1002/anie.202108818openalex-snapshot
Catalytic Carbochlorocarbonylation of Unsaturated Hydrocarbons via C−COCl Bond Cleavage**
inferred← citeshttps://doi.org/10.1002/anie.202110149openalex-snapshot
Divergent Synthesis of Skeletally Distinct Arboridinine and Arborisidine
inferred← citeshttps://doi.org/10.1002/anie.202111639openalex-snapshot
Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection
inferred← citeshttps://doi.org/10.1002/anie.202206797openalex-snapshot
Diversification of Aryl Sulfonyl Compounds through Ligand‐Controlledmeta‐ andpara‐C−H Borylation
inferred← citeshttps://doi.org/10.1002/anie.202207067openalex-snapshot
The Impact of Boron Hybridisation on Photocatalytic Processes
inferred← citeshttps://doi.org/10.1002/anie.202210312openalex-snapshot
Dearomative Aminocarbonylation of Arenes via Bifunctional Coordination to Chromium
inferred← citeshttps://doi.org/10.1002/anie.202214049openalex-snapshot
Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines
inferred← citeshttps://doi.org/10.1002/anie.202403917openalex-snapshot
Umpolung‐Enabled Divergent Dearomative Carbonylations
inferred← citeshttps://doi.org/10.1002/anie.202505625openalex-snapshot
Branched‐Selective Functionalization of 2‐Alkyl Aziridines Through Ni‐Catalyzed Dynamic Kinetic Activation
inferred← citeshttps://doi.org/10.1002/anie.202513342openalex-snapshot
Enantioselective Synthesis of Cyclobutane‐fused Heterocycles via Lewis Acid‐Catalyzed Dearomative [2+2] Photocycloaddition of Indoles, Benzofurans, and Benzothiophenes with Alkenes
inferred← citeshttps://doi.org/10.1002/anie.202522817openalex-snapshot
Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐ Bis ‐Carbofunctionalization
inferred← citeshttps://doi.org/10.1002/anie.6748265openalex-snapshot
Photochemical Reaction Discovery Enabled by the Dynamic Speciation of Copper Complexes
inferred← citeshttps://doi.org/10.1002/anie.7785903openalex-snapshot
Cobalt‐Catalyzed Reductive Asymmetric Dimerization of 1,3‐Enynes: Rapid Synthesis of Enantioenriched Skipped 1,3,6‐Trienes
inferred← citeshttps://doi.org/10.1002/anie.9599258openalex-snapshot
Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes
inferred← citeshttps://doi.org/10.1002/aoc.5201openalex-snapshot
Preparation and characterization of new inorganic–organic hybrid catalyst H3PMo12O40/Hyd‐SBA‐15 and its application in the domino multi‐component reaction
inferred← citeshttps://doi.org/10.1002/aoc.7393openalex-snapshot
Synergistic applications of nanocomposite, ultrasound, and on‐water synthesis for efficient and green synthesis of spirooxindole derivatives via cascade C–N, C–O, and C–S bond formation
inferred← citeshttps://doi.org/10.1002/ardp.202200305openalex-snapshot
Synthesis and antitumoral evaluation of natural product‐like compounds based on tropolone and benzotropolone derivatives
inferred← citeshttps://doi.org/10.1002/ardp.202300656openalex-snapshot
Development and evaluation of 2,4‐disubstituted‐5‐aryl pyrimidine derivatives as antibacterial agents
inferred← citeshttps://doi.org/10.1002/ardp.202400372openalex-snapshot
Synthesis, biological activities, and structure–activity relationships of Morita–Baylis–Hillman adducts: An update
inferred← citeshttps://doi.org/10.1002/asia.201200385openalex-snapshot
Reagent‐Based DOS: Developing a Diastereoselective Methodology to Access Spirocyclic‐ and Fused Heterocyclic Ring Systems
inferred← citeshttps://doi.org/10.1002/asia.201200636openalex-snapshot
An Efficient Approach for the Construction of Benzazepine and Benzoxepine Derivatives
inferred← citeshttps://doi.org/10.1002/asia.201600211openalex-snapshot
Facile Assembly of Benzo[b]naphtho[2,3‐d]azocin‐6(5 H)‐ones by a Palladium‐Catalyzed Double Carbometalation
inferred← citeshttps://doi.org/10.1002/asia.202100956openalex-snapshot
Selective Transformation of Norbornadiene into Functionalized Azaheterocycles and β‐Amino Esters with Stereo‐ and Regiocontrol
inferred← citeshttps://doi.org/10.1002/asia.202101123openalex-snapshot
A Carbohydrate‐based Synthetic Approach to Diverse Structurally and Stereochemically Complex Chiral Polyheterocycles
inferred← citeshttps://doi.org/10.1002/asia.202101345openalex-snapshot
AgF‐Mediated Electrophilic Amination of Alkoxyarylsilanes with Azodicarboxylates
inferred← citeshttps://doi.org/10.1002/bkcs.11698openalex-snapshot
Microwave‐assisted Transition Metal‐catalyzed Coupling Approach to Indazole Diversity
inferred← citeshttps://doi.org/10.1002/cbic.201800751openalex-snapshot
Smart Design of Small‐Molecule Libraries: When Organic Synthesis Meets Cheminformatics
inferred← citeshttps://doi.org/10.1002/cctc.201600766openalex-snapshot
Catalytic Branching Cascades in Diversity Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/cctc.202400405openalex-snapshot
The Integral Role of Conjugate Acids in Brønsted Base‐Catalyzed Regiodivergent Synthesis
inferred← citeshttps://doi.org/10.1002/ceur.202500212openalex-snapshot
Sequential Carboborylation–Suzuki Coupling of α,β‐Unsaturated Tosylhydrazones: A Dual CC Bond‐Forming Strategy for Molecular Diversification
inferred← citeshttps://doi.org/10.1002/ceur.202500225openalex-snapshot
Stereoselective and Enantiospecific Synthesis of Trisubstituted 1,3a,4,6a‐Tetrahydropentalene via Cuneane Scaffold Editing
inferred← citeshttps://doi.org/10.1002/ceur.70248openalex-snapshot
Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids
inferred← citeshttps://doi.org/10.1002/ceur.70283openalex-snapshot
Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis
inferred← citeshttps://doi.org/10.1002/ceur.70360openalex-snapshot
1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines
inferred← citeshttps://doi.org/10.1002/chem.201101676openalex-snapshot
Diverted Domino Reactivity in Tertiary Skipped Diynes: A Convenient Access to Polyfunctionalized Cyclohexadienones and Multivalent Aromatic Scaffolds
inferred← citeshttps://doi.org/10.1002/chem.201102285openalex-snapshot
Aryl–Aryl Bond Formation by the Fluoride‐Free Cross‐Coupling of Aryldisiloxanes with Aryl Bromides
inferred← citeshttps://doi.org/10.1002/chem.201103530openalex-snapshot
A Concise Total Synthesis of Deoxyschizandrin and Exploration of Its Antiproliferative Effects and those of Structurally Related Derivatives
inferred← citeshttps://doi.org/10.1002/chem.201103562openalex-snapshot
New Types of Reactivity of α,β‐Unsaturated N,N‐Dimethylhydrazones: Chemodivergent Diastereoselective Synthesis of Functionalized Tetrahydroquinolines and Hexahydropyrrolo[3,2‐b]indoles
inferred← citeshttps://doi.org/10.1002/chem.201103604openalex-snapshot
InCl3‐Mediated Addition of Indole to Isatogens: An Expeditious Synthesis of 13‐deoxy‐Isatisine A
inferred← citeshttps://doi.org/10.1002/chem.201200431openalex-snapshot
Palladium‐Catalysed Cross‐Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates
inferred← citeshttps://doi.org/10.1002/chem.201204293openalex-snapshot
Synthesis of Molecular Frameworks Containing Two Distinct Heterocycles Connected in a Single Molecule with Enhanced Three‐Dimensional Shape Diversity
inferred← citeshttps://doi.org/10.1002/chem.201300662openalex-snapshot
Structural Diversity from the Transannular Cyclizations of Natural Germacrone and Epoxy Derivatives: A Theoretical–Experimental Study
inferred← citeshttps://doi.org/10.1002/chem.201402070openalex-snapshot
Direct Metal‐Catalyzed Regioselective Functionalization of Enamides
inferred← citeshttps://doi.org/10.1002/chem.201402149openalex-snapshot
A Substrate‐Based Approach to Skeletal Diversity from Dicobalt Hexacarbonyl (C1)‐Alkynyl Glycals by Exploiting Its Combined Ferrier–Nicholas Reactivity
inferred← citeshttps://doi.org/10.1002/chem.201402804openalex-snapshot
Natural Product Synthesis at the Interface of Chemistry and Biology
inferred← citeshttps://doi.org/10.1002/chem.201403268openalex-snapshot
Solvent‐Controlled Bifurcated Cascade Process for the Selective Preparation of Dihydrocarbazoles or Dihydropyridoindoles
inferred← citeshttps://doi.org/10.1002/chem.201405736openalex-snapshot
Catalyst‐Dependent Selectivity in the Relay Catalytic Branching Cascade
inferred← citeshttps://doi.org/10.1002/chem.201500839openalex-snapshot
Generating Skeletal Diversity from the C19‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach
inferred← citeshttps://doi.org/10.1002/chem.201600735openalex-snapshot
Highly Stereoselective [3+2] Cycloadditions of Chiral Palladium‐Containing N1‐1,3‐Dipoles: A Divergent Approach to Enantioenriched Spirooxindoles
inferred← citeshttps://doi.org/10.1002/chem.201601970openalex-snapshot
Diversification of ortho‐Fused Cycloocta‐2,5‐dien‐1‐one Cores and Eight‐ to Six‐Ring Conversion by σ Bond C−C Cleavage
inferred← citeshttps://doi.org/10.1002/chem.201603993openalex-snapshot
Regiodivergent Catalysis: A Powerful Tool for Selective Catalysis
inferred← citeshttps://doi.org/10.1002/chem.201700744openalex-snapshot
NHC‐Catalyzed Metathesis and Phosphorylation Reactions of Disulfides: Development and Mechanistic Insights
inferred← citeshttps://doi.org/10.1002/chem.201702495openalex-snapshot
Modular Bi‐Directional One‐Pot Strategies for the Diastereoselective Synthesis of Structurally Diverse Collections of Constrained β‐Carboline‐Benzoxazepines
inferred← citeshttps://doi.org/10.1002/chem.201704169openalex-snapshot
Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks
inferred← citeshttps://doi.org/10.1002/chem.201803309openalex-snapshot
Heterocyclization and Spirocyclization Processes Based on Domino Reactions of N‐Tosylhydrazones and Boronic Acids Involving Intramolecular Allylborylations of Nitriles
inferred← citeshttps://doi.org/10.1002/chem.201805295openalex-snapshot
Diversity‐Orientated Stereoselective Synthesis through Pd‐Catalyzed Switchable Decarboxylative C−N/C−S Bond Formation in Allylic Surrogates
inferred← citeshttps://doi.org/10.1002/chem.201805985openalex-snapshot
Bio‐Organometallic Derivatives of Antibacterial Drugs
inferred← citeshttps://doi.org/10.1002/chem.201902596openalex-snapshot
Domino Transformations of Ene/Yne Tethered Salicylaldehyde Derivatives: Pluripotent Platforms for the Construction of High sp3 Content and Privileged Architectures
inferred← citeshttps://doi.org/10.1002/chem.201903232openalex-snapshot
The Symbiotic Relationship Between Drug Discovery and Organic Chemistry
inferred← citeshttps://doi.org/10.1002/chem.201904220openalex-snapshot
A Mild and Versatile Friedel–Crafts Methodology for the Diversity‐Oriented Synthesis of Redox‐Active 3‐Benzoylmenadiones with Tunable Redox Potentials
inferred← citeshttps://doi.org/10.1002/chem.202101440openalex-snapshot
Synthesis of Three‐Dimensional (Di)Azatricyclododecene Scaffold and Its Application to Peptidomimetics
inferred← citeshttps://doi.org/10.1002/chem.202101824openalex-snapshot
Access to Indole‐Fused Benzannulated Medium‐Sized Rings through a Gold(I)‐Catalyzed Cascade Cyclization of Azido‐Alkynes
inferred← citeshttps://doi.org/10.1002/chem.202202180openalex-snapshot
Metalloenzyme‐Mediated Thiol‐Yne Addition Towards Photoisomerizable Fluorescent Dyes
inferred← citeshttps://doi.org/10.1002/chem.202203731openalex-snapshot
Diastereoselectivity Switch During Alkene Reductions: Diastereodivergent Syntheses of Molecular Fossils via MHAT or Homogeneous Catalytic Hydrogenation Reactions
inferred← citeshttps://doi.org/10.1002/chem.202203992openalex-snapshot
Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp 3 ‐Rich Compounds With Distinct Phenotypic Effects
inferred← citeshttps://doi.org/10.1002/chem.202302620openalex-snapshot
Late‐Stage C−H Activation of Drug (Derivative) Molecules with Pd(ll) Catalysis
inferred← citeshttps://doi.org/10.1002/chem.202400477openalex-snapshot
Modular Divergent Synthesis of Indole Alkaloid Derivatives by an Atypical Ugi Multicomponent Reaction
inferred← citeshttps://doi.org/10.1002/chem.202500681openalex-snapshot
DOS‐Like Strategy for the Spirocyclic MedChem Relevant Building Blocks via Petasis / Grubbs Reactions Sequence
inferred← citeshttps://doi.org/10.1002/chin.201121232openalex-snapshot
ChemInform Abstract: Diversity‐Oriented Synthesis as a Tool for the Discovery of Novel Biologically Active Small Molecules
inferred← citeshttps://doi.org/10.1002/cjoc.201200809openalex-snapshot
Organocatalytic Asymmetric Branching Sequence of MBH Carbonates: Access to Chiral Benzofuran‐2(3H)‐one Derivatives with Three Stereocenters
inferred← citeshttps://doi.org/10.1002/cjoc.202100693openalex-snapshot
Diversity‐Oriented Synthesis of Flavones and Isoflavones via Palladium/Norbornene Cooperative Catalysis
inferred← citeshttps://doi.org/10.1002/cjoc.202500016openalex-snapshot
Dual Cu/Ir Catalyzed Asymmetric Allylation and Pictet‐Spengler Cyclization: Stereodivergent Access to Chiral Indole Fused 9‐Azabicyclo[4.2.1]nonanes†
inferred← citeshttps://doi.org/10.1002/cmdc.201800001openalex-snapshot
Discovery of Novel Muscarinic Receptor Modulators by Integrating a Natural Product Framework and a Bioactive Molecule
inferred← citeshttps://doi.org/10.1002/cmdc.202000402openalex-snapshot
Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity
inferred← citeshttps://doi.org/10.1002/cmdc.202001010openalex-snapshot
Construction and Biological Evaluation of Small Libraries Based on the Intermediates within the Total Synthesis of Uvaretin
inferred← citeshttps://doi.org/10.1002/cmdc.202100474openalex-snapshot
Coupling Interrupted Fischer and Multicomponent Joullié‐Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics
inferred← citeshttps://doi.org/10.1002/cmdc.202400420openalex-snapshot
Isoflavone Derivatives as Potential Anticancer Agents: Synthesis and Bioactivity Studies
inferred← citeshttps://doi.org/10.1002/cmdc.202500477openalex-snapshot
Harnessing Chemical Diversity to Disarm Bacterial Communication for 25 Years: Natural Products, Repurposed Drugs, Peptides, and Synthetic Quorum Sensing Inhibitors
inferred← citeshttps://doi.org/10.1002/cplu.202300633openalex-snapshot
Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics
inferred← citeshttps://doi.org/10.1002/cssc.202001327openalex-snapshot
Sustainable Chemistry – An Interdisciplinary Matrix Approach
inferred← citeshttps://doi.org/10.1002/cssc.202101868openalex-snapshot
Privileged Biorenewable Secologanin‐Based Diversity‐Oriented Synthesis for Pseudo‐Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks
inferred← citeshttps://doi.org/10.1002/cssc.202201301openalex-snapshot
Diversity‐Oriented Metal‐Free Synthesis of Nitrogen‐Containing Heterocycles Using Atropaldehyde Acetals as a Dual C3/C2‐Synthon
inferred← citeshttps://doi.org/10.1002/cssc.202501012openalex-snapshot
A Telescoped Strategy for the Preparation of Five‐Membered Hetero‐ and Carbocycles via Hydrogen Atom Transfer Photocatalysis in Flow
inferred← citeshttps://doi.org/10.1002/ddr.21218openalex-snapshot
Network Measures for Chemical Library Design
inferred← citeshttps://doi.org/10.1002/ejoc.201100116openalex-snapshot
Synthesis of Skeletally Diverse Alkaloid‐Like Small Molecules
inferred← citeshttps://doi.org/10.1002/ejoc.201300201openalex-snapshot
Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity‐Oriented Synthesis
inferred← citeshttps://doi.org/10.1002/ejoc.201300667openalex-snapshot
Selective Synthesis of 5,6‐Dihydroindolo[1,2‐a]quinoxalines and 6,7‐Dihydroindolo[2,3‐c]quinolines by Orthogonal Copper and Palladium Catalysis
inferred← citeshttps://doi.org/10.1002/ejoc.201301426openalex-snapshot
Generation of Tetrahydro‐3H‐indeno[2,1‐d]pyrimidines by the Tandem Reaction of 2‐(2‐Alkynylphenyl)aziridines with 2‐Isocyanoacetates
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