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EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Collagen‐Induced Arthritis
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Collagen‐Induced Arthritis
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DNA polymerase η is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation
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Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
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Pirin down‐regulates the EAF 2/ U 19 protein and alleviates its growth inhibition in prostate cancer cells
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Current protocols in immunology
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The imperfect control of self-reactive germinal center B cells
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Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis
inferredcites →https://doi.org/10.1016/j.immuni.2012.07.017openalex-snapshot
Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen
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Germinal center reaction: antigen affinity and presentation explain it all
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Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process
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Fas Is Required for Clonal Selection in Germinal Centers and the Subsequent Establishment of the Memory B Cell Repertoire
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Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers
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Peanut lectin binding properties of germinal centers of mouse lymphoid tissue
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The role of clonal selection and somatic mutation in autoimmunity
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Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
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Antigen-induced B-cell death and elimination during germinal-centre immune responses
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Clonal selection in the germinal centre by regulated proliferation and hypermutation
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The role of BH3-only proteins in the immune system
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The BCL-2 protein family: opposing activities that mediate cell death
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U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia
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ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL
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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
inferredcites →https://doi.org/10.1073/pnas.92.25.11628openalex-snapshot
FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.
inferredcites →https://doi.org/10.1073/pnas.93.5.2019openalex-snapshot
Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease.
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Genes regulated by androgen in the rat ventral prostate
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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.
inferredcites →https://doi.org/10.1084/jem.184.3.831openalex-snapshot
Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.
inferredcites →https://doi.org/10.1084/jem.190.3.399openalex-snapshot
Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-xL Transgenic Mice
inferredcites →https://doi.org/10.1084/jem.191.3.475openalex-snapshot
bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells
inferredcites →https://doi.org/10.1093/nar/25.10.1913openalex-snapshot
Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice
inferredcites →https://doi.org/10.1111/j.1600-065x.2012.01123.xopenalex-snapshot
Through a glass less darkly: apoptosis and the germinal center response to antigen
inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb05419.xopenalex-snapshot
The Role of Bim, a Proapoptotic BH3‐Only Member of the Bcl‐2 Family, in Cell‐Death Control
inferredcites →https://doi.org/10.1126/science.1191793openalex-snapshot
Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory
inferredcites →https://doi.org/10.1126/science.286.5445.1735openalex-snapshot
Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity
inferredcites →https://doi.org/10.1146/annurev.immunol.12.1.487openalex-snapshot
Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies
inferredcites →https://doi.org/10.1182/blood-2002-06-1664openalex-snapshot
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties
inferredcites →https://doi.org/10.1182/blood-2007-05-091306openalex-snapshot
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
inferredcites →https://doi.org/10.1182/blood-2011-04-347096openalex-snapshot
Regulation of memory B-cell survival by the BH3-only protein Puma
inferredcites →https://doi.org/10.1182/blood-2011-09-378877openalex-snapshot
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
inferredcites →https://doi.org/10.1182/blood.v98.1.201openalex-snapshot
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein
inferredcites →https://doi.org/10.1186/gb-2009-10-11-r130openalex-snapshot
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources
inferredcites →https://doi.org/10.1371/journal.pone.0079542openalex-snapshot
Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice
inferredcites →https://doi.org/10.3109/08916934.2012.748751openalex-snapshot
The role of somatic hypermutation in the generation of pathogenic antibodies in SLE
inferredcites →https://doi.org/10.3109/08916934.2012.757597openalex-snapshot
Somatic mutagenesis in autoimmunity
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A Role for Lysosomal-Associated Protein Transmembrane 5 in the Negative Regulation of Surface B Cell Receptor Levels and B Cell Activation
inferredcites →https://doi.org/10.4049/jimmunol.167.1.15openalex-snapshot
Cutting Edge: Germinal Centers Can Be Induced in the Absence of T Cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Systematic expression analysis of EAF family reveals the importance of EAF2 in melanoma
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EAF2 deficiency attenuates autoimmune disease in Faslpr mice by modulating B cell activation and apoptosis
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Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion
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MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation
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Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses
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SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
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Dysregulated translational factors and epigenetic regulations orchestrate in B cells contributing to autoimmune diseases
inferred← citeshttps://doi.org/10.1093/intimm/dxaa060openalex-snapshot
Bim establishes the B-cell repertoire from early to late in the immune response
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Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development
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Ageing-Associated Transcriptomic Alterations in Peri-Implantitis Pathology: A Bioinformatic Study
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The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation
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Florfenicol Induces Proliferation of Splenic Germinal Centers in Chick Embryos Model
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What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology
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Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation
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Cell Cycle-Associated CXCR4 Expression in Germinal Center B Cells and Its Implications on Affinity Maturation
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EAF2: a tumor suppressor gene with multi-aspect functions
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Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes–Prone Mice
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