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LRP6 acts as a scaffold protein in cardiac gap junction assembly

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.950180907openalex-snapshot
Connexins in mammalian heart function
inferredcites →https://doi.org/10.1002/dvdy.20426openalex-snapshot
Developmental regulation and expression of the zebrafish connexin43 gene
inferredcites →https://doi.org/10.1007/s00418-009-0617-xopenalex-snapshot
Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway
inferredcites →https://doi.org/10.1016/0092-8674(88)90553-3openalex-snapshot
Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins
inferredcites →https://doi.org/10.1016/0092-8674(92)90630-uopenalex-snapshot
Wnt genes
inferredcites →https://doi.org/10.1016/0167-5273(90)90030-9openalex-snapshot
The cardiac gap junction and intercalated disc
inferredcites →https://doi.org/10.1016/j.hrthm.2011.07.028openalex-snapshot
The gap junction life cycle
inferredcites →https://doi.org/10.1016/j.tem.2012.10.003openalex-snapshot
LRP5 and LRP6 in development and disease
inferredcites →https://doi.org/10.1016/s0960-9822(01)00424-9openalex-snapshot
Gap junction protein connexin-43 interacts directly with microtubules
inferredcites →https://doi.org/10.1038/35035117openalex-snapshot
LDL-receptor-related proteins in Wnt signal transduction
inferredcites →https://doi.org/10.1038/35035124openalex-snapshot
An LDL-receptor-related protein mediates Wnt signalling in mice
inferredcites →https://doi.org/10.1038/cddis.2013.105openalex-snapshot
Gap junctional communication promotes apoptosis in a connexin-type-dependent manner
inferredcites →https://doi.org/10.1038/nrc2841openalex-snapshot
Implications and challenges of connexin connections to cancer
inferredcites →https://doi.org/10.1073/pnas.1615105114openalex-snapshot
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
inferredcites →https://doi.org/10.1073/pnas.162055899openalex-snapshot
Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells
inferredcites →https://doi.org/10.1074/jbc.m412612200openalex-snapshot
Defining a Minimal Motif Required to Prevent Connexin Oligomerization in the Endoplasmic Reticulum
inferredcites →https://doi.org/10.1091/mbc.e08-07-0790openalex-snapshot
ERp29 Restricts Connexin43 Oligomerization in the Endoplasmic Reticulum
inferredcites →https://doi.org/10.1093/toxsci/68.2.265openalex-snapshot
Intercellular Communication, Homeostasis, and Toxicology
inferredcites →https://doi.org/10.1101/gad.11.24.3286openalex-snapshot
Wnt signaling: a common theme in animal development
inferredcites →https://doi.org/10.1126/science.1136370openalex-snapshot
LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors
inferredcites →https://doi.org/10.1126/science.1231077openalex-snapshot
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
inferredcites →https://doi.org/10.1126/science.252.5009.1173openalex-snapshot
Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos
inferredcites →https://doi.org/10.1146/annurev.cellbio.20.010403.113126openalex-snapshot
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
inferredcites →https://doi.org/10.1161/01.cir.101.5.547openalex-snapshot
Accelerated Onset and Increased Incidence of Ventricular Arrhythmias Induced by Ischemia in Cx43-Deficient Mice
inferredcites →https://doi.org/10.1161/01.res.0000148664.33695.2aopenalex-snapshot
Modulation of Cardiac Gap Junction Expression and Arrhythmic Susceptibility
inferredcites →https://doi.org/10.1161/01.res.68.6.1638openalex-snapshot
Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart.
inferredcites →https://doi.org/10.1161/01.res.86.7.723openalex-snapshot
Connexin Expression and Turnover
inferredcites →https://doi.org/10.1161/circresaha.110.219840openalex-snapshot
An Updated Overview on Wnt Signaling Pathways
inferredcites →https://doi.org/10.1161/circresaha.110.221531openalex-snapshot
The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development
inferredcites →https://doi.org/10.1161/circresaha.110.223768openalex-snapshot
WNT Signaling in Adult Cardiac Hypertrophy and Remodeling
inferredcites →https://doi.org/10.1161/circresaha.110.223776openalex-snapshot
Wnt Signaling and Aging-Related Heart Disorders
inferredcites →https://doi.org/10.1161/hypertensionaha.109.141127openalex-snapshot
Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling
inferredcites →https://doi.org/10.1172/jci76431openalex-snapshot
Canonical WNT signaling components in vascular development and barrier formation
inferredcites →https://doi.org/10.1172/jci7798openalex-snapshot
Wnt-1 regulation of connexin43 in cardiac myocytes
inferredcites →https://doi.org/10.1242/jcs.111.12.1741openalex-snapshot
Identification of connexin43 as a functional target for Wnt signalling
inferredcites →https://doi.org/10.1242/jcs.114.21.3845openalex-snapshot
Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels
inferredcites →https://doi.org/10.1371/journal.pone.0084345openalex-snapshot
Functional Analysis LRP6 Novel Mutations in Patients with Coronary Artery Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4139689openalex-extracted
LRP6 Modulates the Phosphorylation of Cx43 via Gα s in Ventricular Tachycardia of Myocardial Infarction
inferred← citeshttps://doi.org/10.2139/ssrn.4200787openalex-extracted
LRP6 Modulates the Phosphorylation of Cx43 Via Gα s in Ventricular Tachycardia of Myocardial Infarction
inferred← citeshttps://doi.org/10.1002/cphy.c160046openalex-snapshot
Cardiac Fibrosis and Arrhythmogenesis
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2017.tb00771.xopenalex-snapshot
Cardiac Fibrosis and Arrhythmogenesis
inferred← citeshttps://doi.org/10.1007/978-3-031-33588-4_14openalex-snapshot
Gap Junctions and Cardiac Impulse Propagation. New Aspects of Arrhythmogenesis and Antiarrhythmic Agents Targeting Gap Junctions
inferred← citeshttps://doi.org/10.1007/s00439-020-02124-8openalex-snapshot
Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities
inferred← citeshttps://doi.org/10.1007/s11427-016-9005-6openalex-snapshot
Mechanistic and therapeutic perspectives for cardiac arrhythmias: beyond ion channels
inferred← citeshttps://doi.org/10.1007/s11427-017-9007-yopenalex-snapshot
Profile of Yi-Han Chen
inferred← citeshttps://doi.org/10.1016/b978-0-12-817931-4.00001-7openalex-snapshot
Osteocyte Mechanobiology in Aging and Disease
inferred← citeshttps://doi.org/10.1016/j.actbio.2025.06.018openalex-snapshot
Janus hydrogels delivering low-density lipoprotein receptor-related protein 6 inhibitor enhance myocardial repair via m6A-dependent cuproptosis in bama pigs
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.04.134openalex-snapshot
Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation
inferred← citeshttps://doi.org/10.1016/j.cjca.2019.05.021openalex-snapshot
WITHDRAWN: Low Density Lipoprotein Receptor Related Protein 6-mediated Cardiovascular Diseases and associated signaling pathways
inferred← citeshttps://doi.org/10.1016/j.cjca.2019.06.030openalex-snapshot
Therapeutic Targeting of LRP6 in Cardiovascular Diseases: Challenging But Not Wnt-Possible!
inferred← citeshttps://doi.org/10.1016/j.cyto.2020.155376openalex-snapshot
Wnt3a upregulation is involved in TGFβ1-induced cardiac hypertrophy
inferred← citeshttps://doi.org/10.1016/j.ijcard.2018.06.029openalex-snapshot
LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel
inferred← citeshttps://doi.org/10.1016/j.isci.2023.106160openalex-snapshot
LRP6-mediated phosphorylation of connexin43 in myocardial infarction
inferred← citeshttps://doi.org/10.1016/j.jmccpl.2025.100488openalex-snapshot
Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
inferred← citeshttps://doi.org/10.1016/j.mcp.2019.01.004openalex-snapshot
Downregulated low-density lipoprotein receptor-related protein 6 induces the maldevelopment of extravillous trophoblast via Wnt/β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1016/j.rbmo.2022.12.013openalex-snapshot
Cutting-edge techniques provide insights regarding repeated implantation failure patients
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101699openalex-snapshot
Low density lipoprotein receptor related protein 6 (LRP6) protects heart against oxidative stress by the crosstalk of HSF1 and GSK3β
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2024.06.009openalex-snapshot
SNX5-Rab11a protects against cardiac hypertrophy through regulating LRP6 membrane translocation
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c01635openalex-snapshot
Gap Junction Protein Connexin 43 as a Target Is Internalized in Astrocyte Neurotoxicity Caused by Di-(2-ethylhexyl) Phthalate
inferred← citeshttps://doi.org/10.1038/s41401-024-01415-4openalex-snapshot
Low-density lipoprotein receptor-related protein 6 ameliorates cardiac hypertrophy by regulating CTSD/HSP90α signaling during pressure overload
inferred← citeshttps://doi.org/10.1038/s41419-020-02850-xopenalex-snapshot
Exosomal arrow (Arr)/lipoprotein receptor protein 6 (LRP6) in Drosophila melanogaster increases the extracellular level of Sol narae (Sona) in a Wnt-independent manner
inferred← citeshttps://doi.org/10.1038/s41422-020-00411-7openalex-snapshot
LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration
inferred← citeshttps://doi.org/10.1038/s41598-025-32260-yopenalex-snapshot
Investigating the mechanisms of lactulose on gut health and uric acid metabolism in geese via transcriptomics
inferred← citeshttps://doi.org/10.1038/s44161-026-00800-yopenalex-snapshot
Spastin-mediated severing of glutamylated microtubules controls cardiomyocyte coupling
inferred← citeshttps://doi.org/10.1073/pnas.1615105114openalex-snapshot
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
inferred← citeshttps://doi.org/10.1093/hmg/ddw389openalex-snapshot
Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene
inferred← citeshttps://doi.org/10.1111/cge.14501openalex-snapshot
Novel variant in LRP6 associated with unusual and severe clinical presentation: Case report
inferred← citeshttps://doi.org/10.1111/gtc.12727openalex-snapshot
Lipoprotein receptor‐related protein 6 is required to maintain intercalated disk integrity
inferred← citeshttps://doi.org/10.1111/jcmm.13682openalex-snapshot
Low‐density lipoprotein receptor‐related protein 6 regulates alternative pre‐ mRNA splicing
inferred← citeshttps://doi.org/10.1111/jcmm.17311openalex-snapshot
LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway
inferred← citeshttps://doi.org/10.1111/tra.12830openalex-snapshot
ERGIC2 and ERGIC3 regulate the ER‐to‐Golgi transport of gap junction proteins in metazoans
inferred← citeshttps://doi.org/10.1371/journal.pone.0353861openalex-snapshot
Targeted sequencing provides genetic insights into familial cardiovascular disease among young adults in a high consanguinity population
inferred← citeshttps://doi.org/10.14744/anatoljcardiol.2023.2823openalex-snapshot
Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1180971/v1openalex-snapshot
LRP6 modulates the phosphorylation of Cx43 via Gαs in ventricular tachycardia of myocardial infarction
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1180971/v2openalex-snapshot
LRP6 modulates the phosphorylation of Cx43 via Gαs in ventricular tachycardia of myocardial infarction
inferred← citeshttps://doi.org/10.3389/fcvm.2021.815595openalex-snapshot
LRP6 Polymorphisms Is Associated With Sudden Cardiac Death in Patients With Chronic Heart Failure in the Chinese Han Population
inferred← citeshttps://doi.org/10.3390/cells10092422openalex-snapshot
Remodeling of Cardiac Gap Junctional Cell–Cell Coupling
inferred← citeshttps://doi.org/10.3390/genes13010120openalex-snapshot
LRP6 Receptor Plays Essential Functions in Development and Human Diseases
inferred← citeshttps://doi.org/10.3390/ijms22126581openalex-snapshot
LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium
inferred← citeshttps://doi.org/10.7150/thno.22177openalex-snapshot
Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling
inferred← citeshttps://doi.org/10.7150/thno.37678openalex-snapshot
Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells
inferred← citeshttps://doi.org/10.7150/thno.48787openalex-snapshot
Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis
inferred← citeshttps://doi.org/10.7554/elife.19083openalex-snapshot
Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6
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