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Antidromic-rectifying gap junctions amplify chemical transmission at functionally mixed electrical-chemical synapses

https://doi.org/10.1038/ncomms14818
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Expression Profiling of GABAergic Motor Neurons in Caenorhabditis elegans
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Molecular Mechanism of Rectification at Identified Electrical Synapses in the Drosophila Giant Fiber System
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Presynaptic Miniature Gabaergic Currents in Developing Interneurons
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An Imbalancing Act: Gap Junctions Reduce the Backward Motor Circuit Activity to Bias C. elegans for Forward Locomotion
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Molecular and Functional Asymmetry at a Vertebrate Electrical Synapse
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Morphologically mixed chemical–electrical synapses formed by primary afferents in rodent vestibular nuclei as revealed by immunofluorescence detection of connexin36 and vesicular glutamate transporter-1
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Connexin36 identified at morphologically mixed chemical/electrical synapses on trigeminal motoneurons and at primary afferent terminals on spinal cord neurons in adult mouse and rat
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Making an escape: Development and function of the Drosophila giant fibre system
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The Kinetics of Inhibition of Nicotinic Acetylcholine Receptors by (+)-Tubocurarine and Pancuronium
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Active Currents Regulate Sensitivity and Dynamic Range in C. elegans Neurons
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Electrical Coupling and Neuronal Synchronization in the Mammalian Brain
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New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures
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One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction
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Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans
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The long-range interaction landscape of gene promoters
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Motor neurons control locomotor circuit function retrogradely via gap junctions
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Postsynaptic current bursts instruct action potential firing at a graded synapse
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SLO-2 potassium channel is an important regulator of neurotransmitter release in Caenorhabditis elegans
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Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
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Action potentials contribute to neuronal signaling in C. elegans
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Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene
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Expression and functions of neuronal gap junctions
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Electrical synapses and their functional interactions with chemical synapses
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Wiring optimization can relate neuronal structure and function
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Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor
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Action potentials drive body wall muscle contractions in Caenorhabditis elegans
inferredcites →https://doi.org/10.1073/pnas.1400615111openalex-snapshot
Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels
inferredcites →https://doi.org/10.1073/pnas.93.9.4235openalex-snapshot
Mixed synapses discovered and mapped throughout mammalian spinal cord.
inferredcites →https://doi.org/10.1074/jbc.m111.292078openalex-snapshot
Gap Junctions Synchronize Action Potentials and Ca2+ Transients in Caenorhabditis elegans Body Wall Muscle
inferredcites →https://doi.org/10.1093/genetics/133.3.527openalex-snapshot
Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion.
inferredcites →https://doi.org/10.1098/rstb.1976.0086openalex-snapshot
The structure of the ventral nerve cord of Caenorhabditis elegans
inferredcites →https://doi.org/10.1111/j.1460-9568.2007.05686.xopenalex-snapshot
The chemical component of the mixed GF‐TTMn synapse in Drosophila melanogaster uses acetylcholine as its neurotransmitter
inferredcites →https://doi.org/10.1111/j.1460-9568.2011.07930.xopenalex-snapshot
Mixed electrical–chemical transmission between hippocampal mossy fibers and pyramidal cells
inferredcites →https://doi.org/10.1113/jphysiol.2010.200683openalex-snapshot
Genetic dissection of ion currents underlying all‐or‐none action potentials in C. elegans body‐wall muscle cells
inferredcites →https://doi.org/10.1126/science.1152850openalex-snapshot
Gene Regulation in the Third Dimension
inferredcites →https://doi.org/10.1146/annurev.neuro.26.041002.131128openalex-snapshot
ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
inferredcites →https://doi.org/10.1146/annurev.neuro.27.070203.144259openalex-snapshot
NEURONAL SUBSTRATES OF COMPLEX BEHAVIORS IN C. ELEGANS
inferredcites →https://doi.org/10.1186/1471-2164-6-42openalex-snapshot
A gene expression fingerprint of C. elegans embryonic motor neurons
inferredcites →https://doi.org/10.1186/1749-8104-4-16openalex-snapshot
Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system
inferredcites →https://doi.org/10.1242/dev.121.9.2877openalex-snapshot
Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input
inferredcites →https://doi.org/10.1242/dev.129635openalex-snapshot
The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans
inferredcites →https://doi.org/10.1371/journal.pbio.1000265openalex-snapshot
A Neuronal Acetylcholine Receptor Regulates the Balance of Muscle Excitation and Inhibition in Caenorhabditis elegans
inferredcites →https://doi.org/10.1371/journal.pone.0043164openalex-snapshot
Specific Expression of Channelrhodopsin-2 in Single Neurons of Caenorhabditis elegans
inferredcites →https://doi.org/10.1523/jneurosci.05-04-00956.1985openalex-snapshot
The neural circuit for touch sensitivity in Caenorhabditis elegans
inferredcites →https://doi.org/10.1523/jneurosci.15-03-02434.1995openalex-snapshot
Integration of mechanosensory stimuli in Caenorhabditis elegans
inferredcites →https://doi.org/10.1523/jneurosci.1515-10.2010openalex-snapshot
A Dominant Mutation in a Neuronal Acetylcholine Receptor Subunit Leads to Motor Neuron Degeneration inCaenorhabditis elegans
inferredcites →https://doi.org/10.1523/jneurosci.17-15-05843.1997openalex-snapshot
Caenorhabditis elegans Levamisole Resistance Genes lev-1 , unc-29 , and unc-38 Encode Functional Nicotinic Acetylcholine Receptor Subunits
inferredcites →https://doi.org/10.1523/jneurosci.18-23-09954.1998openalex-snapshot
Nerve Terminal Currents Induced by Autoreception of Acetylcholine Release
inferredcites →https://doi.org/10.1523/jneurosci.5634-06.2007openalex-snapshot
Presynaptic Ca2+/Calmodulin-Dependent Protein Kinase II Modulates Neurotransmitter Release by Activating BK Channels atCaenorhabditis elegansNeuromuscular Junction
inferredcites →https://doi.org/10.1534/genetics.115.176099openalex-snapshot
A Transparent Window into Biology: A Primer on Caenorhabditis elegans
inferredcites →https://doi.org/10.1895/wormbook.1.131.1openalex-snapshot
Acetylcholine
inferredcites →https://doi.org/10.3389/fgene.2012.00055openalex-snapshot
The Function of Introns
inferredcites →https://doi.org/10.3389/fnana.2012.00013openalex-snapshot
Mixed Electrical–Chemical Synapses in Adult Rat Hippocampus are Primarily Glutamatergic and Coupled by Connexin-36
inferredcites →https://doi.org/10.7554/elife.12432openalex-snapshot
A cellular and regulatory map of the cholinergic nervous system of C. elegans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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