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Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/clc.20452openalex-snapshot

Electrocardiograms of Collegiate Football Athletes

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Regulation of high‐voltage‐activated Ca2+ channel function, trafficking, and membrane stability by auxiliary subunits

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Changes in R-R variability before and after endurance training measured by power spectral analysis and by the effect of isometric muscle contraction

inferredcites →https://doi.org/10.1007/s003950170054openalex-snapshot

Electrophysiological characterization of murine myocardial ischemia and infarction

inferredcites →https://doi.org/10.1016/j.bbrc.2006.11.119openalex-snapshot

NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes

inferredcites →https://doi.org/10.1016/j.cardiores.2004.08.020openalex-snapshot

Structural and functional characterisation of cardiac fibroblasts

inferredcites →https://doi.org/10.1016/j.jacc.2003.03.002openalex-snapshot

Does sports activity enhance the risk of sudden death in adolescents and young adults?

inferredcites →https://doi.org/10.1016/j.jacc.2013.01.091openalex-snapshot

Atrial Fibrillation Promotion by Endurance Exercise

inferredcites →https://doi.org/10.1016/j.mayocp.2012.04.005openalex-snapshot

Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise

inferredcites →https://doi.org/10.1016/j.pharmthera.2013.04.010openalex-snapshot

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues

inferredcites →https://doi.org/10.1016/s0008-6363(98)00091-1openalex-snapshot

Low-frequency extracellular potentials recorded from the sinoatrial node

inferredcites →https://doi.org/10.1016/s0009-9236(98)90153-9openalex-snapshot

Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers*

inferredcites →https://doi.org/10.1016/s0195-668x(03)00282-3openalex-snapshot

High prevalence of right ventricular involvementin endurance athletes with ventricular arrhythmias Role of an electrophysiologic study in risk stratification

inferredcites →https://doi.org/10.1016/s0735-1097(02)01722-9openalex-snapshot

Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes

inferredcites →https://doi.org/10.1016/s0735-1097(02)01977-0openalex-snapshot

Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes

inferredcites →https://doi.org/10.1038/nbt.2465openalex-snapshot

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18

inferredcites →https://doi.org/10.1053/euhj.2001.2802openalex-snapshot

Long-lasting sport practice and lone atrial fibrillation

inferredcites →https://doi.org/10.1073/pnas.0810332106openalex-snapshot

Control of heart rate by cAMP sensitivity of HCN channels

inferredcites →https://doi.org/10.1073/pnas.1010122108openalex-snapshot

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

inferredcites →https://doi.org/10.1074/jbc.m307508200openalex-snapshot

Molecular Identification and Functional Roles of a Ca2+-activated K+ Channel in Human and Mouse Hearts

inferredcites →https://doi.org/10.1085/jgp.20028593openalex-snapshot

Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine

inferredcites →https://doi.org/10.1093/cvr/cvp171openalex-snapshot

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2

inferredcites →https://doi.org/10.1093/cvr/cvt262openalex-snapshot

Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes

inferredcites →https://doi.org/10.1093/eurheartj/ehm219openalex-snapshot

Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening

inferredcites →https://doi.org/10.1093/eurheartj/ehm555openalex-snapshot

Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists

inferredcites →https://doi.org/10.1093/eurheartj/ehr436openalex-snapshot

Exercise-induced arrhythmogenic right ventricular cardiomyopathy: fact or fallacy?

inferredcites →https://doi.org/10.1101/gad.416007openalex-snapshot

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

inferredcites →https://doi.org/10.1111/j.1476-5381.1994.tb13025.xopenalex-snapshot

Electrophysiological effects of S 16257, a novel sino‐atrial node modulator, on rabbit and guinea‐pig cardiac preparations: comparison with UL‐FS 49

inferredcites →https://doi.org/10.1111/j.1476-5381.2011.01627.xopenalex-snapshot

Long‐term treatment with ivabradine in post‐myocardial infarcted rats counteracts f‐channel overexpression

inferredcites →https://doi.org/10.1111/j.1540-8167.2010.01808.xopenalex-snapshot

Athletes and Arrhythmias

inferredcites →https://doi.org/10.1111/j.1600-0838.1997.tb00152.xopenalex-snapshot

Pronounced resting bradycardia in male elite runners is associated with high heart rate variability

inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

inferredcites →https://doi.org/10.1113/jphysiol.1981.sp013714openalex-snapshot

A study of the ionic nature of the pace‐maker current in calf Purkinje fibres.

inferredcites →https://doi.org/10.1113/jphysiol.1986.sp016177openalex-snapshot

Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node.

inferredcites →https://doi.org/10.1113/jphysiol.2004.074047openalex-snapshot

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart

inferredcites →https://doi.org/10.1113/jphysiol.2008.167718openalex-snapshot

Ablation of a Ca2+‐activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation

inferredcites →https://doi.org/10.1136/bjsm.33.4.239openalex-snapshot

Cardiac assessment of veteran endurance athletes: a 12 year follow up study.

inferredcites →https://doi.org/10.1136/bmj.298.6668.231openalex-snapshot

Is severe bradycardia in veteran athletes an indication for a permanent pacemaker?

inferredcites →https://doi.org/10.1136/hrt.61.2.155openalex-snapshot

Electrocardiographic findings in male veteran endurance athletes.

inferredcites →https://doi.org/10.1152/ajpheart.00534.2005openalex-snapshot

Differential expression of small-conductance Ca2+-activated K+channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes

inferredcites →https://doi.org/10.1152/ajpheart.1997.272.6.h2782openalex-snapshot

Variation in effects of Cs+, UL-FS-49, and ZD-7288 within sinoatrial node

inferredcites →https://doi.org/10.1152/ajpheart.2001.280.3.h1301openalex-snapshot

Intensity-controlled treadmill running in rats: V˙ o 2 max and cardiac hypertrophy

inferredcites →https://doi.org/10.1152/japplphysiol.01126.2012openalex-snapshot

Viewpoint: Is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone?

inferredcites →https://doi.org/10.1152/physiolgenomics.00161.2005openalex-snapshot

Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle

inferredcites →https://doi.org/10.1159/000218178openalex-snapshot

Transcriptional Control of Pacemaker Channel Genes HCN2 and HCN4 by Sp1 and Implications in Re-expression of These Genes in Hypertrophied Myocytes

inferredcites →https://doi.org/10.1161/01.cir.0000085658.98621.49openalex-snapshot

Ventricular Remodeling After Infarction and the Extracellular Collagen Matrix

inferredcites →https://doi.org/10.1161/circheartfailure.110.957647openalex-snapshot

Changes in Ion Channel Gene Expression Underlying Heart Failure-Induced Sinoatrial Node Dysfunction

inferredcites →https://doi.org/10.1161/circresaha.107.161778openalex-snapshot

Functional Roles of a Ca 2+ -Activated K + Channel in Atrioventricular Nodes

inferredcites →https://doi.org/10.1161/circresaha.108.188292openalex-snapshot

Cardiac-Specific Deletion of Mkk4 Reveals Its Role in Pathological Hypertrophic Remodeling but Not in Physiological Cardiac Growth

inferredcites →https://doi.org/10.1161/circresaha.109.208041openalex-snapshot

The Role of the Funny Current in Pacemaker Activity

inferredcites →https://doi.org/10.1161/circresaha.113.301283openalex-snapshot

Embryonic Stem Cell–Derived CD166 + Precursors Develop Into Fully Functional Sinoatrial-Like Cells

inferredcites →https://doi.org/10.1161/circulationaha.106.613182openalex-snapshot

Localization of Na + Channel Isoforms at the Atrioventricular Junction and Atrioventricular Node in the Rat

inferredcites →https://doi.org/10.1161/circulationaha.106.613562openalex-snapshot

The Heart of Trained Athletes

inferredcites →https://doi.org/10.1161/circulationaha.108.804369openalex-snapshot

Molecular Architecture of the Human Sinus Node

inferredcites →https://doi.org/10.1161/hc4701.099582openalex-snapshot

Ventricular Arrhythmia Vulnerability in Cardiomyopathic Mice With Homozygous Mutant Myosin-Binding Protein C Gene

inferredcites →https://doi.org/10.1186/1472-6793-1-6openalex-snapshot

Method for non-invasively recording electrocardiograms in conscious mice

inferredcites →https://doi.org/10.1249/mss.0b013e318172cefdopenalex-snapshot

Clinical Significance of Cardiac Damage and Changes in Function after Exercise

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Characterization of Multiple Ion Channels in Cultured Human Cardiac Fibroblasts

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Should We Abandon the t-Test in the Analysis of Gene Expression Microarray Data: A Comparison of Variance Modeling Strategies

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Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

inferredcites →https://doi.org/10.14232/issn.1588-4082openalex-snapshot

Acta Biologica Szegediensis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system

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Increased Ca2+ content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete’s heart model

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RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart

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The regulatory function of microRNA-1 in arrhythmias

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Preconditioning by Moderate-Intensity Exercise Prevents Gentamicin-Induced Acute Kidney Injury

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Asymptomatic bradycardia amongst endurance athletes

inferred← citeshttps://doi.org/10.1080/07315724.2021.1953417openalex-snapshot

DHA-Rich Fish Oil Increases the Omega-3 Index in Healthy Adults and Slows Resting Heart Rate without Altering Cardiac Autonomic Reflex Modulation

inferred← citeshttps://doi.org/10.1080/08037051.2021.1980372openalex-snapshot

Influence of early life risk factors and lifestyle on systemic vascular resistance in later adulthood: the cardiovascular risk in young Finns study

inferred← citeshttps://doi.org/10.1080/14779072.2019.1550720openalex-snapshot

Determining the best approach to reduce the impact of exercise-induced atrial fibrillation: prevention, screening, or symptom-based treatment?

inferred← citeshttps://doi.org/10.1080/19336950.2018.1532255openalex-snapshot

Potassium channels in the sinoatrial node and their role in heart rate control

inferred← citeshttps://doi.org/10.1085/jgp.202513873openalex-snapshot

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

inferred← citeshttps://doi.org/10.1088/1361-6579/ac2130openalex-snapshot

Continuous cardiorespiratory monitoring is a dominant source of predictive signal in machine learning for risk stratification and clinical decision support *

inferred← citeshttps://doi.org/10.1093/cvr/cvaa116openalex-snapshot

Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies

inferred← citeshttps://doi.org/10.1093/cvr/cvad115openalex-snapshot

Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training

inferred← citeshttps://doi.org/10.1093/ehjci/jew122openalex-snapshot

Determinants of myocardial mechanics in top-level endurance athletes: three-dimensional speckle tracking evaluation

inferred← citeshttps://doi.org/10.1093/eurheartj/ehag358openalex-snapshot

Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate

inferred← citeshttps://doi.org/10.1093/eurheartj/ehag560openalex-snapshot

Atrial fibrillation in athletes: you can’t start a fire without a spark

inferred← citeshttps://doi.org/10.1093/eurheartj/ehy365openalex-snapshot

Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications

inferred← citeshttps://doi.org/10.1093/europace/euab142openalex-snapshot

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

inferred← citeshttps://doi.org/10.1093/europace/euae279openalex-snapshot

Ventricular arrhythmias in association with athletic cardiac remodelling

inferred← citeshttps://doi.org/10.1093/europace/eux294openalex-snapshot

The athlete’s heart is a proarrhythmic heart, and what that means for clinical decision making

inferred← citeshttps://doi.org/10.1097/crd.0000000000000416openalex-snapshot

Exercise, Physical Activity, and Cardiometabolic Health: Insights into the Prevention and Treatment of Cardiometabolic Diseases

inferred← citeshttps://doi.org/10.1097/fjc.0000000000001583openalex-snapshot

Exercise Preconditioning Preserves Cardiac Function and Enhances Cardiac Recovery Following Dobutamine Stimulation in Doxorubicin-Treated Rat Hearts

inferred← citeshttps://doi.org/10.1097/hco.0000000000000130openalex-snapshot

Atrial fibrillation and the athletic heart

inferred← citeshttps://doi.org/10.1097/hjh.0000000000001715openalex-snapshot

Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study

inferred← citeshttps://doi.org/10.1098/rsif.2021.0612openalex-snapshot

Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell

inferred← citeshttps://doi.org/10.1101/2020.07.31.20165969openalex-snapshot

Factors associated with accelerated resting heart rate among college freshmen : a cross-sectional study

inferred← citeshttps://doi.org/10.1101/2020.10.28.360065openalex-snapshot

Enhanced diastolic dysfunction but preserved systolic function after acute pressure overload in the absence of smoothelin-like 1 protein

inferred← citeshttps://doi.org/10.1101/2020.11.16.385021openalex-snapshot

Comparison of changes in electrical activity, in isolated and in vivo hearts, induced by voluntary exercise in female rats

inferred← citeshttps://doi.org/10.1101/2024.01.04.24300784openalex-snapshot

Accuracy, Utility and Applicability of the WHOOP Wearable Monitoring Device in Health, Wellness and Performance - a systematic review

inferred← citeshttps://doi.org/10.1109/jsen.2026.3709367openalex-snapshot

Physiological Stratified Models for Personalized Cuffless Blood Pressure Estimation Using Wearable Multimodal Sensors

inferred← citeshttps://doi.org/10.1111/1440-1681.12458openalex-snapshot

Pyridostigmine enhances atrial tachyarrhythmias in aging spontaneously hypertensive rats

inferred← citeshttps://doi.org/10.1111/apha.13564openalex-snapshot

No impact of sex and age on beta‐adrenoceptor‐mediated inotropy in human right atrial trabeculae

inferred← citeshttps://doi.org/10.1111/bph.16390openalex-snapshot

Identification and characterisation of functional K ir 6.1‐containing ATP‐sensitive potassium channels in the cardiac ventricular sarcolemmal membrane

inferred← citeshttps://doi.org/10.1111/echo.15634openalex-snapshot

Left atrial dyssynchrony in veteran endurance athletes with and without paroxysmal atrial fibrillation

inferred← citeshttps://doi.org/10.1111/jcmm.71218openalex-snapshot

Aerobic Endurance Training Modulates Cardiac Renin‐Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress

inferred← citeshttps://doi.org/10.1111/jpc.70558openalex-snapshot

Physiological and Cardiac Effects of Weight Loss in Adolescents With Atypical Anorexia Nervosa Versus Those Undergoing Bariatric Surgery: A Retrospective Comparative Study

inferred← citeshttps://doi.org/10.1111/jvim.16427openalex-snapshot

Electrocardiographic characteristics of trained and untrained standardbred racehorses

inferred← citeshttps://doi.org/10.1111/pace.12879openalex-snapshot

Exercise and Arrhythmias: A Double‐Edged Sword

inferred← citeshttps://doi.org/10.1113/ep086293openalex-snapshot

β1‐Adrenoceptor, but not β2‐adrenoceptor, subtype regulates heart rate in type 2 diabetic rats in vivo

inferred← citeshttps://doi.org/10.1113/ep087437openalex-snapshot

β2‐Adrenoceptors indirectly support impaired β1‐adrenoceptor responsiveness in the isolated type 2 diabetic rat heart

inferred← citeshttps://doi.org/10.1113/jp270256openalex-snapshot

Rebuttal from Alicia D'Souza, Sanjay Sharma and Mark R. Boyett

inferred← citeshttps://doi.org/10.1113/jp270678openalex-snapshot

Rescuing cardiac automaticity in L‐type Cav1.3 channelopathies and beyond

inferred← citeshttps://doi.org/10.1113/jp275303openalex-snapshot

HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node

inferred← citeshttps://doi.org/10.1113/jp277501openalex-snapshot

CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed

inferred← citeshttps://doi.org/10.1113/jp285697openalex-snapshot

The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation

inferred← citeshttps://doi.org/10.1113/jphysiol.2014.284356openalex-snapshot

CrossTalk opposing view: Bradycardia in the trained athlete is attributable to a downregulation of a pacemaker channel in the sinus node

inferred← citeshttps://doi.org/10.1113/jphysiol.2014.284364openalex-snapshot

CrossTalk proposal: Bradycardia in the trained athlete is attributable to high vagal tone

inferred← citeshttps://doi.org/10.1124/pr.117.014035openalex-snapshot

The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

inferred← citeshttps://doi.org/10.1134/s002209302407007xopenalex-snapshot

A Comprehensive Analysis of Voluntary Wheel Running Effects on Neural Control of the Heart Rate in Rats

inferred← citeshttps://doi.org/10.1136/heartjnl-2016-310744openalex-snapshot

Management of mature athletes with cardiovascular conditions

inferred← citeshttps://doi.org/10.1136/heartjnl-2017-312901openalex-snapshot

Electrocardiography in athletes: normal and abnormal findings

inferred← citeshttps://doi.org/10.1136/openhrt-2021-001771openalex-snapshot

Young endurance training starting age in non-elite athletes is associated with higher proximal aortic distensibility

inferred← citeshttps://doi.org/10.1139/apnm-2022-0340openalex-snapshot

The influence of training status and parasympathetic blockade on the cardiac rate, rhythm, and functional response to autonomic stress

inferred← citeshttps://doi.org/10.1139/cjpp-2018-0115openalex-snapshot

Hyperpolarization-activated cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological insights into their function in cellular excitability

inferred← citeshttps://doi.org/10.1139/cjpp-2018-0610openalex-snapshot

The impact of high-intensity interval training and moderate-intensity continuous training regimes on cardiodynamic parameters in isolated heart of normotensive and hypertensive rats

inferred← citeshttps://doi.org/10.1139/cjpp-2019-0286openalex-snapshot

Combined effects of exercise training and high doses of anabolic steroids on cardiac autonomic modulation and ventricular repolarization properties in rats

inferred← citeshttps://doi.org/10.1140/epjs/s11734-026-02187-0openalex-snapshot

Neurocardiac diving reflex dynamics: assessment and prediction

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-031120-115815openalex-snapshot

Pharmacologic Approach to Sinoatrial Node Dysfunction

inferred← citeshttps://doi.org/10.1152/ajpheart.00233.2020openalex-snapshot

Stimulus-specific functional remodeling of the left ventricle in endurance and resistance-trained men

inferred← citeshttps://doi.org/10.1152/ajpheart.00379.2020openalex-snapshot

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice

inferred← citeshttps://doi.org/10.1152/ajpheart.00446.2025openalex-snapshot

Modifying the electrical excitability of cardiomyocytes in rainbow trout ( Oncorhynchus mykiss ) through exercise training

inferred← citeshttps://doi.org/10.1152/ajpheart.00509.2020openalex-snapshot

The counterintuitive role of exercise in the prevention and cause of atrial fibrillation

inferred← citeshttps://doi.org/10.1152/japplphysiol.00224.2025openalex-snapshot

Exercise during artificial gravity preserves cardiorespiratory fitness but not orthostatic tolerance following 60 days of head-down bed rest (BRACE)

inferred← citeshttps://doi.org/10.1152/japplphysiol.00546.2017openalex-snapshot

Point:Counterpoint

inferred← citeshttps://doi.org/10.1152/japplphysiol.00585.2014openalex-snapshot

Metabolomic analysis of long-term spontaneous exercise in mice suggests increased lipolysis and altered glucose metabolism when animals are at rest

inferred← citeshttps://doi.org/10.1152/japplphysiol.00604.2017openalex-snapshot

Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function

inferred← citeshttps://doi.org/10.1152/japplphysiol.00605.2017openalex-snapshot

Counterpoint: Exercise training-induced bradycardia: the case for enhanced parasympathetic regulation

inferred← citeshttps://doi.org/10.1152/japplphysiol.00606.2017openalex-snapshot

Rebuttal from Boyett et al.

inferred← citeshttps://doi.org/10.1152/japplphysiol.01111.2014openalex-snapshot

Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node function

inferred← citeshttps://doi.org/10.1152/physiol.00009.2019openalex-snapshot

Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

inferred← citeshttps://doi.org/10.1152/physiol.00041.2018openalex-snapshot

Cardiac Vagus and Exercise

inferred← citeshttps://doi.org/10.1152/physrev.00024.2019openalex-snapshot

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

inferred← citeshttps://doi.org/10.1155/2022/6589758openalex-snapshot

A Case of Profound Bradycardia in Endurance Athlete with Severe Anorexia Nervosa

inferred← citeshttps://doi.org/10.11606/t.42.2016.tde-09112016-154518openalex-snapshot

Efeitos sequenciais do treinamento aeróbio sobre o sistema renina angiotensina plasmático e cardíaco de SHR: análise do estresse oxidativo, perfil inflamatório e remodelamento cardíaco.

inferred← citeshttps://doi.org/10.1161/circep.124.013180openalex-snapshot

Mechanisms Underlying Sinus Node Dysfunction in a Rat Model of Genetic Atrial Cardiomyopathy

inferred← citeshttps://doi.org/10.1161/circresaha.117.311607openalex-snapshot

Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

inferred← citeshttps://doi.org/10.1161/circresaha.117.311922openalex-snapshot

Novel Pathways for Regulation of Sinoatrial Node Plasticity and Heart Rate

inferred← citeshttps://doi.org/10.1161/circresaha.119.316386openalex-snapshot

Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

inferred← citeshttps://doi.org/10.1161/circulationaha.114.008141openalex-snapshot

Can Intensive Exercise Harm the Heart?

inferred← citeshttps://doi.org/10.1161/circulationaha.114.011515openalex-snapshot

Letter by Monfredi et al Regarding Article, “Physical Activity and Heart Rate Variability in Older Adults: The Cardiovascular Health Study”

inferred← citeshttps://doi.org/10.1161/circulationaha.123.068280openalex-snapshot

Long-Term Incidence of Bradycardia and Pacemaker Implantations Among Cross-Country Skiers: A Cohort Study

inferred← citeshttps://doi.org/10.1161/circulationaha.124.071607openalex-snapshot

Can Exercise Injure the Sinus Node?

inferred← citeshttps://doi.org/10.1161/circulationaha.125.076170openalex-snapshot

Bradycardia in Athletes: Prevalence, Mechanisms, and Risks

inferred← citeshttps://doi.org/10.1161/jaha.115.003078openalex-snapshot

Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm

inferred← citeshttps://doi.org/10.1177/2047487319830534openalex-snapshot

Left ventricular hypertrophy in world class elite athletes is associated with signs of improved cardiac autonomic regulation

inferred← citeshttps://doi.org/10.1186/s12995-024-00414-9openalex-snapshot

Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science

inferred← citeshttps://doi.org/10.1242/jeb.215210openalex-snapshot

A rapid intrinsic heart rate resetting response with thermal acclimation in rainbow trout, Oncorhynchus mykiss

inferred← citeshttps://doi.org/10.1253/circj.cj-14-0419openalex-snapshot

Fibrosis, Electrics and Genetics

inferred← citeshttps://doi.org/10.13107/jcorth.2022.v07i02.535openalex-snapshot

Prevention and Management of Sudden Cardiac Death in Athletes

inferred← citeshttps://doi.org/10.1371/journal.pcbi.1014267openalex-snapshot

A new Fight-or-Flight Pacemaker Mechanism via Ryanodine Receptor abundance and superclustering

inferred← citeshttps://doi.org/10.1371/journal.pone.0143095openalex-snapshot

Effects of High Intensity Interval Training on Pregnant Rats, and the Placenta, Heart and Liver of Their Fetuses

inferred← citeshttps://doi.org/10.1371/journal.pone.0148036openalex-snapshot

Predominance of Intrinsic Mechanism of Resting Heart Rate Control and Preserved Baroreflex Sensitivity in Professional Cyclists after Competitive Training

inferred← citeshttps://doi.org/10.1371/journal.pone.0153934openalex-snapshot

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat

inferred← citeshttps://doi.org/10.1371/journal.pone.0194008openalex-snapshot

Cardiac electrophysiological adaptations in the equine athlete—Restitution analysis of electrocardiographic features

inferred← citeshttps://doi.org/10.1371/journal.pone.0209085openalex-snapshot

Effect of chronic exercise on myocardial electrophysiological heterogeneity and stability. Role of intrinsic cholinergic neurons: A study in the isolated rabbit heart

inferred← citeshttps://doi.org/10.1371/journal.pone.0219281openalex-snapshot

Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men

inferred← citeshttps://doi.org/10.1371/journal.pone.0254505openalex-snapshot

Resting heart rate is associated with colorectal advanced adenoma

inferred← citeshttps://doi.org/10.14260/jemds/2015/99openalex-snapshot

ECG CHANGES IN YOUNG COMPETITIVE INDIAN ATHLETES

inferred← citeshttps://doi.org/10.14800/rd.1442openalex-snapshot

microRNA-mediated cardiac remodeling in athletes

inferred← citeshttps://doi.org/10.15282/mohe.v10i1.499openalex-snapshot

CHARACTERISTICS OF RESTING ECG AMONG SABAH PROFESSIONAL MALE FOOTBALLERS

inferred← citeshttps://doi.org/10.1536/ihj.17-498openalex-snapshot

Screening and Function Analysis of MicroRNAs Involved in Exercise Preconditioning-Attenuating Pathological Cardiac Hypertrophy

inferred← citeshttps://doi.org/10.15381/rivep.v29i1.14251openalex-snapshot

Efecto del entrenamiento en Agility en gran altitud en perros Border Collie en algunas variables electrocardiográficas: análisis preliminar

inferred← citeshttps://doi.org/10.15420/aer.2015.4.1.28openalex-snapshot

Biology of the Sinus Node and its Disease

inferred← citeshttps://doi.org/10.15420/aer.2015.4.1.9openalex-snapshot

HCN4, Sinus Bradycardia and Atrial Fibrillation

inferred← citeshttps://doi.org/10.15420/aer.2021.68openalex-snapshot

Arrhythmogenesis of Sports: Myth or Reality?

inferred← citeshttps://doi.org/10.15857/ksep.2020.29.1.24openalex-snapshot

The Prognostic Value of Resting Heart Rate for Health Status

inferred← citeshttps://doi.org/10.17219/acem/73700openalex-snapshot

Electrocardiographic abnormalities in amateur male marathon runners

inferred← citeshttps://doi.org/10.19080/crdoj.2019.10.555793openalex-snapshot

Cardiovascular Parameters of People with Diabetes Mellitus: An Intervention Study

inferred← citeshttps://doi.org/10.20381/ruor-26205openalex-snapshot

Wnt/β-Catenin Signalling Inhibits T-Type Calcium Channels in Cardiomyocytes

inferred← citeshttps://doi.org/10.2139/ssrn.5164050openalex-snapshot

Physiological Markers and Athletic Performance in Firefighters: A Cross-Sectional Analysis of Task-Specific Associations

inferred← citeshttps://doi.org/10.22551/msj.2022.03.05openalex-snapshot

The effects of cardiac rehabilitation on resting heart rate and blood pressure in heart failure patients

inferred← citeshttps://doi.org/10.2298/vsp191127027dopenalex-snapshot

Training/detraining-induced gender specific functional adaptations of isolated rat heart

inferred← citeshttps://doi.org/10.2337/db14-0955openalex-snapshot

Increased Efferent Cardiac Sympathetic Nerve Activity and Defective Intrinsic Heart Rate Regulation in Type 2 Diabetes

inferred← citeshttps://doi.org/10.23736/s0026-4725.19.04998-3openalex-snapshot

Exercise and atrial fibrillation: how health turns harm, and how to turn it back

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