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Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200705762openalex-snapshot
Total Synthesis of the Glycopeptide Recognition Domain of the P‐Selectin Glycoprotein Ligand 1
inferredcites →https://doi.org/10.1002/anie.200805999openalex-snapshot
Sulfated and Non‐Sulfated Glycopeptide Recognition Domains of P‐Selectin Glycoprotein Ligand 1 and their Binding to P‐ and E‐Selectin
inferredcites →https://doi.org/10.1002/jcc.20290openalex-snapshot
The Amber biomolecular simulation programs
inferredcites →https://doi.org/10.1002/jcc.20820openalex-snapshot
GLYCAM06: A generalizable biomolecular force field. Carbohydrates
inferredcites →https://doi.org/10.1002/jcc.21666openalex-snapshot
Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking
inferredcites →https://doi.org/10.1007/978-1-62703-845-4_15openalex-snapshot
Detection of Bidirectional Signaling During Integrin Activation and Neutrophil Adhesion
inferredcites →https://doi.org/10.1016/0092-8674(93)80055-jopenalex-snapshot
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
inferredcites →https://doi.org/10.1016/j.ab.2006.12.003openalex-snapshot
Stability of tyrosine sulfate in acidic solutions
inferredcites →https://doi.org/10.1016/j.bmc.2008.10.005openalex-snapshot
Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry
inferredcites →https://doi.org/10.1016/j.bpj.2012.12.005openalex-snapshot
Effect of Extracellular pH on Selectin Adhesion: Theory and Experiment
inferredcites →https://doi.org/10.1016/j.carres.2006.04.047openalex-snapshot
Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide
inferredcites →https://doi.org/10.1016/j.carres.2010.05.004openalex-snapshot
Synthesis of an Fmoc-threonine bearing core-2 glycan: A building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis
inferredcites →https://doi.org/10.1016/j.chembiol.2008.11.004openalex-snapshot
Novel Fluorescent Glycan Microarray Strategy Reveals Ligands for Galectins
inferredcites →https://doi.org/10.1016/j.pupt.2005.07.004openalex-snapshot
Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo-controlled clinical cross-over-trial
inferredcites →https://doi.org/10.1016/j.semcancer.2010.04.005openalex-snapshot
Selectins promote tumor metastasis
inferredcites →https://doi.org/10.1016/j.thromres.2013.02.020openalex-snapshot
Pharmacological control of platelet-leukocyte interactions by the human anti-P-selectin antibody inclacumab – preclinical and clinical studies
inferredcites →https://doi.org/10.1016/s0002-9440(10)62314-0openalex-snapshot
L- and P-Selectins Collaborate to Support Leukocyte Rolling in Vivo When High-Affinity P-Selectin-P-Selectin Glycoprotein Ligand-1 Interaction Is Inhibited
inferredcites →https://doi.org/10.1016/s0021-9258(18)42162-xopenalex-snapshot
Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha.
inferredcites →https://doi.org/10.1021/ar000033jopenalex-snapshot
Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models
inferredcites →https://doi.org/10.1021/bc900465yopenalex-snapshot
Stabilized111In-Labeled sCCK8 Analogues for Targeting CCK2-Receptor Positive Tumors: Synthesis and Evaluation
inferredcites →https://doi.org/10.1021/cb200068bopenalex-snapshot
Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry
inferredcites →https://doi.org/10.1021/ci100275aopenalex-snapshot
Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
inferredcites →https://doi.org/10.1021/ct8003707openalex-snapshot
MM-PBSA Captures Key Role of Intercalating Water Molecules at a Protein−Protein Interface
inferredcites →https://doi.org/10.1021/ja0004938openalex-snapshot
Chemoenzymatic Synthesis of a PSGL-1 N-Terminal Glycopeptide Containing Tyrosine Sulfate and α-O-Linked Sialyl Lewis X
inferredcites →https://doi.org/10.1021/ja003834qopenalex-snapshot
Use of MM-PBSA in Reproducing the Binding Free Energies to HIV-1 RT of TIBO Derivatives and Predicting the Binding Mode to HIV-1 RT of Efavirenz by Docking and MM-PBSA
inferredcites →https://doi.org/10.1021/ja056086jopenalex-snapshot
A Comprehensive Approach to the Synthesis of Sulfate Esters
inferredcites →https://doi.org/10.1021/ja990935jopenalex-snapshot
Computational Alanine Scanning To Probe Protein−Protein Interactions: A Novel Approach To Evaluate Binding Free Energies
inferredcites →https://doi.org/10.1021/ja993820oopenalex-snapshot
Tyrosine Sulfation on a PSGL-1 Glycopeptide Influences the Reactivity of Glycosyltransferases Responsible for Synthesis of the Attached O-Glycan
inferredcites →https://doi.org/10.1021/jm060536gopenalex-snapshot
Rational Design of Novel, Potent Small Molecule Pan-Selectin Antagonists
inferredcites →https://doi.org/10.1021/jm9013696openalex-snapshot
Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury
inferredcites →https://doi.org/10.1021/jo901135kopenalex-snapshot
Rapid Assembly of Oligosaccharides: A Highly Convergent Strategy for the Assembly of a Glycosylated Amino Acid Derived from PSGL-1
inferredcites →https://doi.org/10.1021/ol102750hopenalex-snapshot
One-Pot Azidochlorination of Glycals
inferredcites →https://doi.org/10.1034/j.1399-3011.2000.00746.xopenalex-snapshot
Stabilization of a tyrosine O‐sulfate residue by a cationic functional group: formation of a conjugate acid–base pair
inferredcites →https://doi.org/10.1038/359848a0openalex-snapshot
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
inferredcites →https://doi.org/10.1038/ni1491openalex-snapshot
P-selectin primes leukocyte integrin activation during inflammation
inferredcites →https://doi.org/10.1038/nm1565openalex-snapshot
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
inferredcites →https://doi.org/10.1038/nri2156openalex-snapshot
Getting to the site of inflammation: the leukocyte adhesion cascade updated
inferredcites →https://doi.org/10.1038/nri3298openalex-snapshot
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
inferredcites →https://doi.org/10.1038/nri3399openalex-snapshot
Neutrophil recruitment and function in health and inflammation
inferredcites →https://doi.org/10.1038/sj.emboj.7601522openalex-snapshot
PSGL‐1 and mTOR regulate translation of ROCK‐1 and physiological functions of macrophages
inferredcites →https://doi.org/10.1039/b823425fopenalex-snapshot
A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides
inferredcites →https://doi.org/10.1056/nejmoa020888openalex-snapshot
Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease
inferredcites →https://doi.org/10.1073/pnas.1411082111openalex-snapshot
Platelets guide the formation of early metastatic niches
inferredcites →https://doi.org/10.1073/pnas.85.7.2135openalex-snapshot
The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.
inferredcites →https://doi.org/10.1074/jbc.272.45.28750openalex-snapshot
Engagement of P-selectin Glycoprotein Ligand-1 Enhances Tyrosine Phosphorylation and Activates Mitogen-activated Protein Kinases in Human Neutrophils
inferredcites →https://doi.org/10.1074/jbc.273.49.32506openalex-snapshot
Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1
inferredcites →https://doi.org/10.1074/jbc.274.35.24838openalex-snapshot
A Novel Glycosulfopeptide Binds to P-selectin and Inhibits Leukocyte Adhesion to P-selectin
inferredcites →https://doi.org/10.1074/jbc.m005005200openalex-snapshot
Binding of Glycosulfopeptides to P-selectin Requires Stereospecific Contributions of Individual Tyrosine Sulfate and Sugar Residues
inferredcites →https://doi.org/10.1074/jbc.m303551200openalex-snapshot
Model Glycosulfopeptides from P-selectin Glycoprotein Ligand-1 Require Tyrosine Sulfation and a Core 2-branched O-Glycan to Bind to L-selectin
inferredcites →https://doi.org/10.1074/jbc.m304204200openalex-snapshot
Endoglycan, a Member of the CD34 Family, Functions as an L-selectin Ligand through Modification with Tyrosine Sulfation and Sialyl Lewis x
inferredcites →https://doi.org/10.1084/jem.186.8.1357openalex-snapshot
Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice
inferredcites →https://doi.org/10.1084/jem.20021868openalex-snapshot
Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin
inferredcites →https://doi.org/10.1084/jem.20112322openalex-snapshot
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00797.xopenalex-snapshot
PSGL‐1 function in immunity and steady state homeostasis
inferredcites →https://doi.org/10.1126/science.1256478openalex-snapshot
Neutrophils scan for activated platelets to initiate inflammation
inferredcites →https://doi.org/10.1161/01.atv.0000106320.40933.e5openalex-snapshot
Platelet-Monocyte Complexes Support Monocyte Adhesion to Endothelium by Enhancing Secondary Tethering and Cluster Formation
inferredcites →https://doi.org/10.1161/01.cir.101.19.2290openalex-snapshot
Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice
inferredcites →https://doi.org/10.1161/circulationaha.108.771048openalex-snapshot
P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice
inferredcites →https://doi.org/10.1161/jaha.112.000067openalex-snapshot
Impact of Global Geographic Region on Time in Therapeutic Range on Warfarin Anticoagulant Therapy: Data From the ROCKET AF Clinical Trial
inferredcites →https://doi.org/10.1161/jaha.112.006007openalex-snapshot
Effect of PSI‐697, a Novel P‐Selectin Inhibitor, on Platelet–Monocyte Aggregate Formation in Humans
inferredcites →https://doi.org/10.1172/jci116029openalex-snapshot
Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140).
inferredcites →https://doi.org/10.1172/jci119556openalex-snapshot
Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment.
inferredcites →https://doi.org/10.1172/jci72305openalex-snapshot
Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation
inferredcites →https://doi.org/10.1182/blood-2004-03-1108openalex-snapshot
P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of αMβ2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils
inferredcites →https://doi.org/10.1182/blood-2009-12-259556openalex-snapshot
E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin αLβ2-mediated slow leukocyte rolling
inferredcites →https://doi.org/10.1182/blood-2009-12-260513openalex-snapshot
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
inferredcites →https://doi.org/10.1182/blood-2011-07-343566openalex-snapshot
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow
inferredcites →https://doi.org/10.1248/cpb.41.376openalex-snapshot
Evaluation of the Final Deprotection System for the Solid-Phase Synthesis of Tyr(SO3H)-Containing Peptides with 9-Fluorenylmethyloxycarbonyl (Fmoc)-Strategy and Its Application to the Synthesis of Cholecystokinin (CCK)-12.
inferredcites →https://doi.org/10.2337/db09-1894openalex-snapshot
P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
inferredcites →https://doi.org/10.4049/jimmunol.164.8.4348openalex-snapshot
Neutrophil Tethering on E-Selectin Activates β2 Integrin Binding to ICAM-1 Through a Mitogen-Activated Protein Kinase Signal Transduction Pathway
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4622797openalex-extracted
Sialyl Lewis x Glycomimetics Bearing an Extended Anionic Chain Targeting E- and P- Selectin Binding Sites
inferred← citeshttps://doi.org/10.1002/adhm.70968openalex-snapshot
Navigating P‐Selectin for Targeted Drug Delivery and Therapeutic Applications in Cancer and Inflammatory Disorders
inferred← citeshttps://doi.org/10.1002/ange.201610395openalex-snapshot
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Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition**
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Chemoenzymatic Synthesis of Highly O ‐Glycosylated MUC7 Glycopeptides for Probing Inhibitory Activity against Pseudomonas aeruginosa Biofilm Formation
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Chemoenzymatic Synthesis of Glycopeptide Library Decodes Sialylation‐Dependent Immunodominance to Enable a Potent Multicomponent Antitumor Vaccine
inferred← citeshttps://doi.org/10.1002/anie.201610395openalex-snapshot
Polymeric Selectin Ligands Mimicking Complex Carbohydrates: From Selectin Binders to Modifiers of Macrophage Migration
inferred← citeshttps://doi.org/10.1002/anie.202302437openalex-snapshot
Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition**
inferred← citeshttps://doi.org/10.1002/anie.202424312openalex-snapshot
Chemoenzymatic Synthesis of Highly O ‐Glycosylated MUC7 Glycopeptides for Probing Inhibitory Activity against Pseudomonas aeruginosa Biofilm Formation
inferred← citeshttps://doi.org/10.1002/anie.202525026openalex-snapshot
Chemoenzymatic Synthesis of Glycopeptide Library Decodes Sialylation‐Dependent Immunodominance to Enable a Potent Multicomponent Antitumor Vaccine
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Targeting SELPLG/P‐selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter
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The physiological and pathological roles and applications of sialyl Lewis x, a common carbohydrate ligand of the three selectins
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AI-driven peptide discovery for endometrial cancer: deep generative modeling and molecular simulation in the big data era
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Underlying Mechanisms of Thrombosis Associated with Cancer and Anticancer Therapies
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sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity
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AOS ameliorates monocrotaline-induced pulmonary hypertension by restraining the activation of P-selectin/p38MAPK/NF-κB pathway in rats
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Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation
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Sequence variety in the CC’ loop of Siglec-8/9/3 determines the recognitions to sulfated oligosaccharides
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Sialyl Lewis X (sLex):Biological functions, synthetic methods and therapeutic implications
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The role of protein glycosylation in the occurrence and outcome of acute ischemic stroke
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Opportunities for the treatment of atherosclerosis: Selectins
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Insights into the Loop at the E‑Selectin Binding Site: From Open to Close Conformation
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Computational Pipeline for Accelerating the Design of Glycomimetics
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Defining the Specificity of Carbohydrate–Protein Interactions by Quantifying Functional Group Contributions
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Insights Derived from the Synthesis of a Complex Core 2 Glycan
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Convergent Synthesis of Sialyl LewisX-O-Core-1 Threonine
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Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study
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Small lectin ligands as a basis for applications in glycoscience and glycomedicine
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Intact quantitation and evaluation of a PEG-glycosulfopeptide as a therapeutic P-selectin antagonist
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Validation and Application of an Innovative Protective Group Concept: Enhancing Substrate Reactivity in Glycosylations by Disrupting Intermolecular Interactions
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Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8
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Modification of immunological features in human platelets during sepsis
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Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction
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Global functions of O‐glycosylation: promises and challenges in O‐glycobiology
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Engineered mesenchymal stromal cells with bispecific polyvalent peptides suppress excessive neutrophil infiltration and boost therapy
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Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations
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Endothelial‐Leukocyte Interaction in Severe Malaria: Beyond the Brain
inferred← citeshttps://doi.org/10.1161/circresaha.115.306847openalex-snapshot
Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation
inferred← citeshttps://doi.org/10.1182/blood-2017-05-783027openalex-snapshot
Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow
inferred← citeshttps://doi.org/10.1182/blood.2020009428openalex-snapshot
A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis
inferred← citeshttps://doi.org/10.1186/s12967-025-06649-2openalex-snapshot
Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury
inferred← citeshttps://doi.org/10.1515/tjb-2020-0267openalex-snapshot
Relationship between JAK2-V617F mutation and hematologic parameters in Philadelphia-negative chronic myeloproliferative neoplasms
inferred← citeshttps://doi.org/10.1615/oncotherap.2022042541openalex-snapshot
Microenvironment-Dependent Endothelial Cell Glycosylation Influence on Angiogenesis and Cancer Spreading
inferred← citeshttps://doi.org/10.1681/asn.2022030286openalex-snapshot
Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses
inferred← citeshttps://doi.org/10.21037/tcr.2016.10.05openalex-snapshot
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3265278/v1openalex-snapshot
Identification of sialoylation-related genes as a new diagnostic biomarker of atherosclerosis by machine learning
inferred← citeshttps://doi.org/10.2147/ijn.s316863openalex-snapshot
Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models
inferred← citeshttps://doi.org/10.3389/fcell.2021.624082openalex-snapshot
Glycans and Glycan-Binding Proteins as Regulators and Potential Targets in Leukocyte Recruitment
inferred← citeshttps://doi.org/10.3389/fcimb.2022.899581openalex-snapshot
Experimental Models to Study the Pathogenesis of Malaria-Associated Acute Respiratory Distress Syndrome
inferred← citeshttps://doi.org/10.3389/fendo.2022.953165openalex-snapshot
Lipoprotein sialylation in atherosclerosis: Lessons from mice
inferred← citeshttps://doi.org/10.3389/fimmu.2016.00236openalex-snapshot
The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.636238openalex-snapshot
PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2021.663886openalex-snapshot
Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients
inferred← citeshttps://doi.org/10.3390/jcm8081266openalex-snapshot
Peptide Antagonists for P-selectin Discriminate between Sulfatide-Dependent Platelet Aggregation and PSGL-1-Mediated Cell Adhesion
inferred← citeshttps://doi.org/10.3390/md23060236openalex-snapshot
Exploring the Inhibitory Effects of Fucosylated Chondroitin Sulfate (FCS) Oligosaccharide Isolated from Stichopus horrens and the Derivatives on P-Selectin
inferred← citeshttps://doi.org/10.3390/md24050177openalex-snapshot
P-Selectin Inhibition and the Structure–Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides
inferred← citeshttps://doi.org/10.4049/jimmunol.1900599openalex-snapshot
Platelets Modulate IFN-γ Production against Candida albicans in Peripheral Blood Mononuclear Cells via Prostaglandins
inferred← citeshttps://doi.org/10.4155/fmc-2017-0001openalex-snapshot
The Progress in the Research of Antiplatelet Agents (1995–2017)
inferred← citeshttps://doi.org/10.4155/fmc-2017-0119openalex-snapshot
Downregulation of P-Selectin Glycoprotein Ligand-1 as a Potential Anti-Inflammatory Mechanism
inferred← citeshttps://doi.org/10.4155/fmc-2018-0345openalex-snapshot
Developments in Inhibiting Platelet Aggregation Based on Different Design Strategies
inferred← citeshttps://doi.org/10.70675/7bf3a005za763z44f3z9de3z8c886145847eopenalex-snapshot
Le gallium : applications en vue d'une utilisation en imagerie moléculaire
inferred← citeshttps://doi.org/10.70675/9b11dabdz736ez42d1zb6d1z4ff564c39ce6openalex-snapshot
Caractérisation des neutrophiles circulants et associés aux tumeurs aux stades précoces et tardifs de la tumorigenèse
inferred← citeshttps://doi.org/10.70675/db97d791zc861z4773zb985zebf7a06ffd32openalex-snapshot
Effet délétère de l’hyperglycémie sur la fonctionnalité des cellules endothéliales cérébrales et rôle protecteur de polyphénols antioxydants
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