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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

https://doi.org/10.1038/ncomms9089
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s11010-010-0583-6openalex-snapshot
Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders
inferredcites →https://doi.org/10.1007/s11154-007-9049-xopenalex-snapshot
Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis
inferredcites →https://doi.org/10.1016/j.bcp.2004.07.041openalex-snapshot
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides
inferredcites →https://doi.org/10.1016/j.coph.2014.08.006openalex-snapshot
Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment
inferredcites →https://doi.org/10.1016/j.jsbmb.2005.01.004openalex-snapshot
Conformational adaptation of nuclear receptor ligand binding domains to agonists: Potential for novel approaches to ligand design
inferredcites →https://doi.org/10.1016/j.jsbmb.2011.08.007openalex-snapshot
Endocrine disrupting chemicals and disease susceptibility
inferredcites →https://doi.org/10.1016/j.mce.2009.02.023openalex-snapshot
Bisphenol A: Perinatal exposure and body weight
inferredcites →https://doi.org/10.1016/j.tiv.2005.06.001openalex-snapshot
Environmental xenobiotics and nuclear receptors—Interactions, effects and in vitro assessment
inferredcites →https://doi.org/10.1016/j.toxlet.2006.11.016openalex-snapshot
Estrogens and antiestrogens activate hPXR
inferredcites →https://doi.org/10.1016/s0009-2797(97)00072-0openalex-snapshot
Long-term primary cultures of adult human hepatocytes
inferredcites →https://doi.org/10.1016/s0022-2836(03)00795-2openalex-snapshot
Coactivator Binding Promotes the Specific Interaction Between Ligand and the Pregnane X Receptor
inferredcites →https://doi.org/10.1016/s1097-2765(01)00353-7openalex-snapshot
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
inferredcites →https://doi.org/10.1038/ncomms4571openalex-snapshot
An alternate binding site for PPARγ ligands
inferredcites →https://doi.org/10.1038/nsmb.1474openalex-snapshot
Structural basis for the activation of PPARγ by oxidized fatty acids
inferredcites →https://doi.org/10.1038/sj.emboj.7600288openalex-snapshot
Structural mechanism of the simultaneous binding of two drugs to a multidrug‐binding protein
inferredcites →https://doi.org/10.1038/sj.embor.7400963openalex-snapshot
Structural plasticity in the oestrogen receptor ligand‐binding domain
inferredcites →https://doi.org/10.1073/pnas.0510596103openalex-snapshot
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor β
inferredcites →https://doi.org/10.1073/pnas.0603236103openalex-snapshot
Structural basis for ligand promiscuity in cytochrome P450 3A4
inferredcites →https://doi.org/10.1073/pnas.0705356104openalex-snapshot
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
inferredcites →https://doi.org/10.1073/pnas.2136689100openalex-snapshot
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
inferredcites →https://doi.org/10.1074/jbc.m201323200openalex-snapshot
Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes
inferredcites →https://doi.org/10.1074/jbc.m402195200openalex-snapshot
Structural Basis for the Deactivation of the Estrogen-related Receptor γ by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity
inferredcites →https://doi.org/10.1093/toxsci/kfj173openalex-snapshot
Identification of New Human Pregnane X Receptor Ligands among Pesticides Using a Stable Reporter Cell System
inferredcites →https://doi.org/10.1107/97809553602060000865openalex-snapshot
PHENIX: a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444909042073openalex-snapshot
MolProbity : all-atom structure validation for macromolecular crystallography
inferredcites →https://doi.org/10.1107/s0907444909047337openalex-snapshot
XDS
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1124/mol.106.033415openalex-snapshot
Discovery of a Highly Active Ligand of Human Pregnane X Receptor: A Case Study from Pharmacophore Modeling and Virtual Screening to “In Vivo” Biological Activity
inferredcites →https://doi.org/10.1124/pr.58.4.2openalex-snapshot
Overview of Nomenclature of Nuclear Receptors
inferredcites →https://doi.org/10.1126/science.1060762openalex-snapshot
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
inferredcites →https://doi.org/10.1128/mcb.01541-07openalex-snapshot
Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol
inferredcites →https://doi.org/10.1155/2012/713696openalex-snapshot
Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action
inferredcites →https://doi.org/10.1161/jaha.113.000492openalex-snapshot
Bisphenol A Increases Atherosclerosis in Pregnane X Receptor‐Humanized ApoE Deficient Mice
inferredcites →https://doi.org/10.1172/jci3703openalex-snapshot
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
inferredcites →https://doi.org/10.1177/1087057114521867openalex-snapshot
A New Bliss Independence Model to Analyze Drug Combination Data
inferredcites →https://doi.org/10.1186/1471-2148-8-103openalex-snapshot
Evolution of pharmacologic specificity in the pregnane X receptor
inferredcites →https://doi.org/10.1186/1476-4598-9-46openalex-snapshot
Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation
inferredcites →https://doi.org/10.1210/er.2009-0002openalex-snapshot
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
inferredcites →https://doi.org/10.1210/me.14.1.27openalex-snapshot
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
inferredcites →https://doi.org/10.1210/me.2004-0346openalex-snapshot
Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin
inferredcites →https://doi.org/10.1210/me.2006-0323openalex-snapshot
Crystal Structure of the Pregnane X Receptor-Estradiol Complex Provides Insights into Endobiotic Recognition
inferredcites →https://doi.org/10.1289/ehp.0800045openalex-snapshot
Prenatal Exposure to Bisphenol A at Environmentally Relevant Doses Adversely Affects the Murine Female Reproductive Tract Later in Life
inferredcites →https://doi.org/10.1385/1-59259-998-2:283openalex-snapshot
Human Hepatocyte Culture
inferredcites →https://doi.org/10.1517/17425255.2.3.381openalex-snapshot
Functional evolution of the pregnane X receptor
inferredcites →https://doi.org/10.1677/jme-08-0132openalex-snapshot
Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders
inferredcites →https://doi.org/10.2210/pdb2vv1/pdbopenalex-snapshot
hPPARgamma Ligand binding domain in complex with 4-HDHA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4762372openalex-extracted
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inferred← citeshttps://doi.org/10.1001/jamanetworkopen.2019.2093openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9781394417773.ch10openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9781394417773.ch11openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cbic.201700059openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cmdc.201700730openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-14265-0_2openalex-snapshot
Crystallographic Studies of Steroid-Protein Interactions
inferred← citeshttps://doi.org/10.1007/978-3-030-78315-0_7openalex-snapshot
Pregnane X Receptor: Understanding Its Function and Activity at the Molecular Level
inferred← citeshttps://doi.org/10.1007/978-981-13-9447-8_1openalex-snapshot
The Exposome: Pursuing the Totality of Exposure
inferred← citeshttps://doi.org/10.1007/978-981-33-4141-8_5openalex-snapshot
Insights into Mechanisms and Models for Studying Neurological Adverse Events Mediated by Pharmacokinetic Interactions between Clinical Drugs and Illicit Substances of Herbal and Fungal Origin
inferred← citeshttps://doi.org/10.1007/s00018-020-03505-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-020-02685-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-020-02936-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-023-03649-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-025-04235-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00210-016-1304-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10616-018-0213-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11356-016-6062-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11356-016-6387-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11518-017-5336-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s44203-025-00006-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.64376-3openalex-snapshot
Toxicant Actions: Mode of Action of Endocrine Disruptors
inferred← citeshttps://doi.org/10.1016/b978-0-443-21477-6.00368-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/bs.ctdb.2017.02.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbagrm.2016.02.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbagrm.2016.02.015openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbagrm.2016.03.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.07.067openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2017.08.105openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2020.129212openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cnd.2017.03.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cnd.2017.06.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.coemr.2019.04.008openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.coesh.2020.05.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.comtox.2017.01.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cotox.2018.01.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.crvi.2017.08.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.dib.2018.12.033openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.drudis.2019.01.021openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.112416openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113330openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113986openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ejps.2017.07.026openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envint.2020.105585openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envint.2021.107009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envint.2025.109861openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envpol.2024.125394openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envres.2024.119836openalex-snapshot
Main factors influencing the perceived health risk of endocrine-disrupting chemicals: A systematic literature review
inferred← citeshttps://doi.org/10.1016/j.envres.2025.121612openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.envres.2026.123877openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.fct.2017.11.049openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.fct.2023.113976openalex-snapshot
Environmental endocrine disruptors and pregnane X receptor action: A review
inferred← citeshttps://doi.org/10.1016/j.impact.2024.100526openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.lpm.2018.08.001openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.mce.2019.01.022openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.mce.2019.110665openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.measurement.2024.115305openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101779openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.molpha.2026.100140openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.142294openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.02.201openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.153322openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.str.2024.09.016openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.talanta.2021.122919openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tiv.2017.02.023openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tox.2019.04.003openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tox.2021.152892openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.toxicon.2021.01.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.toxlet.2016.08.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.toxlet.2016.11.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.toxlet.2023.09.012openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.watres.2019.115267openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.watres.2020.116247openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.xphs.2017.03.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.yrtph.2016.05.020openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.analchem.9b02377openalex-snapshot
Simplify: A Mass Spectrometry Metabolomics Approach to Identify Additives and Synergists from Complex Mixtures
inferred← citeshttps://doi.org/10.1021/acs.est.1c00872openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.est.5b04083openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.est.5c18068openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.est.6c02272openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jcim.2c01175openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00692openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00914openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c02245openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01354openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.langmuir.0c00194openalex-snapshot
Individual Roles of Peptides PGLa and Magainin 2 in Synergistic Membrane Poration
inferred← citeshttps://doi.org/10.1021/acsesttox.6c00014openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/onc.2017.296openalex-snapshot
Berberine binds RXRα to suppress β-catenin signaling in colon cancer cells
inferred← citeshttps://doi.org/10.1038/s41467-017-00780-5openalex-snapshot
SPA70 is a potent antagonist of human pregnane X receptor
inferred← citeshttps://doi.org/10.1038/s41467-024-46559-3openalex-snapshot
Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands
inferred← citeshttps://doi.org/10.1038/s41467-024-48472-1openalex-snapshot
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
inferred← citeshttps://doi.org/10.1038/s41467-025-56624-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41585-025-01031-9openalex-snapshot
Endocrine-disrupting chemicals as prostate carcinogens
inferred← citeshttps://doi.org/10.1038/s41598-017-04654-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-018-34373-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-019-54579-zopenalex-snapshot
Upregulation of vitamin D-binding protein is associated with changes in insulin production in pancreatic beta-cells exposed to p,p′-DDT and p,p′-DDE
inferred← citeshttps://doi.org/10.1038/srep43786openalex-snapshot
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos
inferred← citeshttps://doi.org/10.1039/c5cp05212bopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c7fo02058aopenalex-snapshot
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inferred← citeshttps://doi.org/10.1051/jbio/2019009openalex-snapshot
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inferred← citeshttps://doi.org/10.1051/medsci/20163204005openalex-snapshot
L’association fait le poison
inferred← citeshttps://doi.org/10.1073/pnas.2020551118openalex-snapshot
Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
inferred← citeshttps://doi.org/10.1073/pnas.2217804120openalex-snapshot
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein
inferred← citeshttps://doi.org/10.1080/10408398.2018.1514580openalex-snapshot
Saponins as modulators of nuclear receptors
inferred← citeshttps://doi.org/10.1080/10408398.2021.1995322openalex-snapshot
Dietary phytochemicals as modulators of human pregnane X receptor
inferred← citeshttps://doi.org/10.1080/17425255.2018.1476488openalex-snapshot
A current structural perspective on PXR and CAR in drug metabolism
inferred← citeshttps://doi.org/10.1080/17425255.2024.2309212openalex-snapshot
Regulation of PXR in drug metabolism: chemical and structural perspectives
inferred← citeshttps://doi.org/10.1080/17425255.2025.2470792openalex-snapshot
Mechanisms of altered hepatic drug disposition during pregnancy: small molecules
inferred← citeshttps://doi.org/10.1080/19390211.2022.2050875openalex-snapshot
Assessment of Herb-Drug Interaction Potential of Five Common Species of Licorice and Their Phytochemical Constituents
inferred← citeshttps://doi.org/10.1093/eep/dvx017openalex-snapshot
Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view
inferred← citeshttps://doi.org/10.1093/humrep/dey275openalex-snapshot
Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals
inferred← citeshttps://doi.org/10.1093/toxsci/kfae025openalex-snapshot
Towards a more effective REACH legislation in protecting human health
inferred← citeshttps://doi.org/10.1093/toxsci/kfy269openalex-snapshot
Sequence Variations inpxr (nr1i2)From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function
inferred← citeshttps://doi.org/10.1093/toxsci/kfz246openalex-snapshot
CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae
inferred← citeshttps://doi.org/10.1101/252817openalex-snapshot
Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ
inferred← citeshttps://doi.org/10.1107/s2053230x2500069xopenalex-snapshot
A two-in-one expression construct for biophysical and structural studies of the human pregnane X receptor ligand-binding domain, a pharmaceutical and environmental target
inferred← citeshttps://doi.org/10.1124/dmd.122.000858openalex-snapshot
Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-061724-080642openalex-snapshot
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants
inferred← citeshttps://doi.org/10.1159/000504668openalex-snapshot
Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development
inferred← citeshttps://doi.org/10.1172/jci.insight.125657openalex-snapshot
The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling
inferred← citeshttps://doi.org/10.1177/1010428317698340openalex-snapshot
The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1177/1934578x251395169openalex-snapshot
Pharmacological Activities of Licoisoflavone A and Licoisoflavone B
inferred← citeshttps://doi.org/10.1183/16000617.0034-2016openalex-snapshot
The exposome concept: a challenge and a potential driver for environmental health research
inferred← citeshttps://doi.org/10.1210/en.2016-1342openalex-snapshot
Androgen Receptor Involvement in Rat Amelogenesis: An Additional Way for Endocrine-Disrupting Chemicals to Affect Enamel Synthesis
inferred← citeshttps://doi.org/10.1210/en.2018-00081openalex-snapshot
27-Hydroxycholesterol Is an Estrogen Receptor β–Selective Negative Allosteric Modifier of 17β-Estradiol Binding
inferred← citeshttps://doi.org/10.1210/en.2019-00382openalex-snapshot
In Silico Predictions of Endocrine Disruptors Properties
inferred← citeshttps://doi.org/10.1289/ehp2877openalex-snapshot
Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor
inferred← citeshttps://doi.org/10.1515/reveh-2020-0033openalex-snapshot
Testing the low dose mixtures hypothesis from the Halifax project
inferred← citeshttps://doi.org/10.15252/emmm.201911621openalex-snapshot
Targeting the pregnane X receptor using microbial metabolite mimicry
inferred← citeshttps://doi.org/10.15255/kui.2016.013openalex-snapshot
Farmakoekologija – okolišna sudbina lijekova
inferred← citeshttps://doi.org/10.1530/ec-18-0029openalex-snapshot
Thyroid-disrupting chemicals and brain development: an update
inferred← citeshttps://doi.org/10.17179/excli2023-6884openalex-snapshot
Effects of okadaic acid, azaspiracid-1, yessotoxin and their binary mixtures on human intestinal Caco-2 cells
inferred← citeshttps://doi.org/10.21294/1814-4861-2023-22-5-145-160openalex-snapshot
Endocrine disruptors as promoters of biosphere carcinogenic background
inferred← citeshttps://doi.org/10.31219/osf.io/vd3cropenalex-snapshot
Main Factors Influencing the Perceived Health Risk of Endocrine-Disrupting Chemicals: A Systematic Literature Review
inferred← citeshttps://doi.org/10.3389/fendo.2018.00582openalex-snapshot
Environmental Pollutants and Metabolic Disorders: The Multi-Exposure Scenario of Life
inferred← citeshttps://doi.org/10.3389/fendo.2021.665521openalex-snapshot
A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays
inferred← citeshttps://doi.org/10.3389/fendo.2024.1398462openalex-snapshot
Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor
inferred← citeshttps://doi.org/10.3389/fphar.2020.01122openalex-snapshot
Assessing the Selectivity of FXR, LXRs, CAR, and RORγ Pharmaceutical Ligands With Reporter Cell Lines
inferred← citeshttps://doi.org/10.3389/fphar.2026.1823615openalex-snapshot
The landscape of biased agonism in aryl hydrocarbon receptor signaling: current clues and future directions
inferred← citeshttps://doi.org/10.3390/cells11192974openalex-snapshot
Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites
inferred← citeshttps://doi.org/10.3390/cells12081201openalex-snapshot
Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides
inferred← citeshttps://doi.org/10.3390/cells13110940openalex-snapshot
Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin
inferred← citeshttps://doi.org/10.3390/cells9061469openalex-snapshot
High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor
inferred← citeshttps://doi.org/10.3390/cells9071641openalex-snapshot
The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor
inferred← citeshttps://doi.org/10.3390/ijerph13020181openalex-snapshot
Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room
inferred← citeshttps://doi.org/10.3390/ijerph15102231openalex-snapshot
Determinants of Risk Perception Related to Exposure to Endocrine Disruptors during Pregnancy: A Qualitative and Quantitative Study on French Women
inferred← citeshttps://doi.org/10.3390/ijerph17249403openalex-snapshot
Adipose Tissue and Endocrine-Disrupting Chemicals: Does Sex Matter?
inferred← citeshttps://doi.org/10.3390/ijms21239139openalex-snapshot
Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer
inferred← citeshttps://doi.org/10.3390/ijms231810825openalex-snapshot
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity
inferred← citeshttps://doi.org/10.3390/ijms242015246openalex-snapshot
Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis
inferred← citeshttps://doi.org/10.3390/md17100554openalex-snapshot
Marine Ligands of the Pregnane X Receptor (PXR): An Overview
inferred← citeshttps://doi.org/10.3892/wasj.2019.17openalex-snapshot
Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach (Review)
inferred← citeshttps://doi.org/10.4049/jimmunol.1600203openalex-snapshot
Human Xenobiotic Nuclear Receptor PXR Augments Mycobacterium tuberculosis Survival
inferred← citeshttps://doi.org/10.4331/wjbc.v8.i2.108openalex-snapshot
Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders
inferred← citeshttps://doi.org/10.70675/12c724ccz3922z4544za902z12625ec83070openalex-snapshot
Perturbateurs endocriniens et patients en insuffisance rénale chronique terminale : impact des techniques d'hémodialyse sur l'exposition au Bisphénol A et à ses dérivés chlorés
inferred← citeshttps://doi.org/10.70675/13b7f02dzefc0z4823zbb48z0a74191ff4beopenalex-snapshot
Outils d'évaluation d'une intervention d'éducation pour la santé environnementale périnatale
inferred← citeshttps://doi.org/10.70675/14bee111z9037z4a55z8033z0803605d3b7bopenalex-snapshot
Vulnérabilité du circuit neural du comportement sexuel à l'exposition adulte à de faibles doses de perturbateurs endocriniens
inferred← citeshttps://doi.org/10.70675/1bc72f02z87b4z4e1bzaf8fz0c12580ba2b4openalex-snapshot
Caractérisation des effets métaboliques d’un mélange de polluants à faibles doses dans un modèle de souris déficientes en oestrogènes
inferred← citeshttps://doi.org/10.70675/6e16ccffzdcbfz4863z8e20zf2b081916690openalex-snapshot
Implication de PXR, Pregnane X Receptor, dans la résistance aux inhibiteurs de kinases en cancérologie : application au cancer de la prostate et mélanome
inferred← citeshttps://doi.org/10.70675/72a12df7z67aez4f4dza865zc5f35a2d5eb0openalex-snapshot
Toxicocinétique en santé environnementale : application à la mesure de l'exposition aux perturbateurs endocriniens
inferred← citeshttps://doi.org/10.70675/881e84fazadd6z4a73zafdfzcf838fd002b4openalex-snapshot
Rôle dimorphique du récepteur nucléaire CAR dans la régulation de l'homéostasie énergétique et des perturbations métaboliques induites par un mélange de pesticides
inferred← citeshttps://doi.org/10.70675/a11e1fbczf25ez4e7aza943zad2e1523fb13openalex-snapshot
Nouvelles approches en toxicologie prédictive pour l'étude de la toxicité des mélanges de contaminants présents dans l'alimentation française
inferred← citeshttps://doi.org/10.70675/c2460f1azc108z41efz9228za26d6f941c1dopenalex-snapshot
Développement de la technologie des récepteurs couplés à un canal ionique pour la caractérisation fonctionnelle des récepteurs couplés aux protéines G
inferred← citeshttps://doi.org/10.70675/c94fdd4cz73bez40cezb5a2zd71a6afdee58openalex-snapshot
Effets des perturbateurs endocriniens sur le développement embryonnaire de Phallusia mammillata
inferred← citeshttps://doi.org/10.70675/cc018908zb45cz4772z9f32z5dc930e07ae5openalex-snapshot
Impacts métaboliques d'un mélange faiblement dosé de polluants alimentaires dans un modèle murin : effets dépendants de l'âge, du sexe et du contexte nutritionnel
inferred← citeshttps://doi.org/10.70675/dade83e0zd417z4190zb0a0zf6a5e174c2aeopenalex-snapshot
Identification de nouveaux inhibiteurs de l'axe androgénique pour contourner la résistance à la castration des cancers de la prostate
inferred← citeshttps://doi.org/10.70675/f8535eb9z782dz40b8zb1d0z583132d3fd1bopenalex-snapshot
Effets de l’exposition aux phtalates sur les comportements de reproduction de la souris femelle
inferred← citeshttps://doi.org/10.71450/80329044openalex-snapshot
Critical windows of susceptibility for breast development
inferred← citeshttps://doi.org/10.7554/elife.43320openalex-snapshot
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
inferred← citeshttps://doi.org/10.7916/d8-fj0m-bn64openalex-snapshot
Metabolic evaluation of genetic and environmental contributors to Alzheimer’s disease
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