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Atomic basis for therapeutic activation of neuronal potassium channels
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Physicochemical Basis for Binding and Voltage‐Dependent Block of hERG Channels by Structurally Diverse Drugs
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Exome Sequencing of Ion Channel Genes Reveals Complex Profiles Confounding Personal Risk Assessment in Epilepsy
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Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs
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The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels
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Retigabine, a KV7 (KCNQ) potassium channel opener, attenuates l-DOPA-induced dyskinesias in 6-OHDA-lesioned rats
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Antiepileptic drug therapy the story so far
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The ketogenic diet: metabolic influences on brain excitability and epilepsy
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Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds
inferredcites →https://doi.org/10.1016/s0026-895x(24)12060-3openalex-snapshot
Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine
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Effects of the Anticonvulsant Retigabine on Cultured Cortical Neurons: Changes in Electroresponsive Properties and Synaptic Transmission
inferredcites →https://doi.org/10.1016/s0026-895x(24)12425-xopenalex-snapshot
Retigabine, A Novel Anti-Convulsant, Enhances Activation of KCNQ2/Q3 Potassium Channels
inferredcites →https://doi.org/10.1016/s0076-6879(98)93031-2openalex-snapshot
[28] In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system
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Unnatural amino acid mutagenesis in mapping ion channel function
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Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions
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Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener
inferredcites →https://doi.org/10.1021/jm0305826openalex-snapshot
Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers
inferredcites →https://doi.org/10.1038/nature03650openalex-snapshot
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
inferredcites →https://doi.org/10.1038/nchembio874openalex-snapshot
Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants
inferredcites →https://doi.org/10.1038/ncomms1351openalex-snapshot
Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels
inferredcites →https://doi.org/10.1038/ncomms2761openalex-snapshot
A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel
inferredcites →https://doi.org/10.1038/sj.bjp.0703861openalex-snapshot
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells
inferredcites →https://doi.org/10.1073/pnas.0911294107openalex-snapshot
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Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of Huntington’s disease
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Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions
inferredcites →https://doi.org/10.1085/jgp.201210827openalex-snapshot
Intermediate state trapping of a voltage sensor
inferredcites →https://doi.org/10.1111/bph.12065openalex-snapshot
The new KCNQ2 activator 4‐ C hlor‐ N ‐(6‐chlor‐pyridin‐3‐yl)‐benzamid displays anticonvulsant potential
inferredcites →https://doi.org/10.1111/epi.12296openalex-snapshot
Issues related to development of new antiseizure treatments
inferredcites →https://doi.org/10.1111/j.1476-5381.2012.02133.xopenalex-snapshot
One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
inferredcites →https://doi.org/10.1111/j.1527-3458.2005.tb00033.xopenalex-snapshot
Retigabine: Chemical Synthesis to Clinical Application
inferredcites →https://doi.org/10.1111/j.1528-1167.2008.01843.xopenalex-snapshot
Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet
inferredcites →https://doi.org/10.1111/j.1528-1167.2009.02397.xopenalex-snapshot
Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
inferredcites →https://doi.org/10.1111/j.1749-6632.1987.tb32892.xopenalex-snapshot
Intracellular pH as Measured by 19F NMRa
inferredcites →https://doi.org/10.1113/jphysiol.2002.028571openalex-snapshot
Molecular correlates of the M‐current in cultured rat hippocampal neurons
inferredcites →https://doi.org/10.1124/mol.108.052282openalex-snapshot
Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K+ Channels
inferredcites →https://doi.org/10.1126/science.271.5246.163openalex-snapshot
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
inferredcites →https://doi.org/10.1126/science.3892686openalex-snapshot
Aromatic-Aromatic Interaction: A Mechanism of Protein Structure Stabilization
inferredcites →https://doi.org/10.1159/000329965openalex-snapshot
Structural Basis of Slow Activation Gating in the Cardiac IKs Channel Complex
inferredcites →https://doi.org/10.1212/wnl.0b013e3181fd6170openalex-snapshot
Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy
inferredcites →https://doi.org/10.1371/journal.pone.0001332openalex-snapshot
A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives
inferredcites →https://doi.org/10.1517/14656566.2012.706278openalex-snapshot
Retigabine/Ezogabine, a KCNQ/KV7 channel opener: pharmacological and clinical data
inferredcites →https://doi.org/10.1523/jneurosci.0128-05.2005openalex-snapshot
Molecular Determinants of KCNQ (K v 7) K + Channel Sensitivity to the Anticonvulsant Retigabine
inferredcites →https://doi.org/10.1523/jneurosci.21-15-05535.2001openalex-snapshot
Activation of Expressed KCNQ Potassium Currents and Native Neuronal M-Type Potassium Currents by the Anti-Convulsant Drug Retigabine
inferredcites →https://doi.org/10.1529/biophysj.108.137604openalex-snapshot
Determinants within the Turret and Pore-Loop Domains of KCNQ3 K+ Channels Governing Functional Activity
inferredcites →https://doi.org/10.2174/0929867053363045openalex-snapshot
Recent Developments on KCNQ Potassium Channel Openers
inferredcites →https://doi.org/10.3949/ccjm.77a.09061openalex-snapshot
Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies
inferredcites →https://doi.org/10.3998/ark.5550190.0005.313openalex-snapshot
Nucleophilic addition to an achiral dehydroalanine Schiff base Ni(II) complex as a route to amino acids. A case of stereodetermining asymmetric protonation in the presence of TADDOL
inferredcites →https://doi.org/10.7554/elife.01289openalex-snapshot
Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4086889openalex-extracted
Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype
inferred← citeshttps://doi.org/10.1002/cphy.c190047openalex-snapshot
Molecular Modeling is an Enabling Approach to Complement and Enhance Channelopathy Research
inferred← citeshttps://doi.org/10.1002/ddr.70317openalex-snapshot
A Medicinal Chemistry Perspective on Anticonvulsant Drug Design: Targets, Mechanisms, and Spiro Compounds
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2022.tb00209.xopenalex-snapshot
Molecular Modeling is an Enabling Approach to Complement and Enhance Channelopathy Research
inferred← citeshttps://doi.org/10.1007/978-3-031-52197-3_1openalex-snapshot
Ion Channels as Targets in Drug Discovery: Outlook and Perspectives
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Exploring the bioactive ingredients of three traditional Chinese medicine formulas against age-related hearing loss through network pharmacology and experimental validation
inferred← citeshttps://doi.org/10.1007/s00232-020-00113-6openalex-snapshot
Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel
inferred← citeshttps://doi.org/10.1007/s00424-022-02692-wopenalex-snapshot
Triclosan is a KCNQ3 potassium channel activator
inferred← citeshttps://doi.org/10.1016/j.bbi.2024.08.023openalex-snapshot
Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149218openalex-snapshot
Voltage-gated potassium channels KCNQs: Structures, mechanisms, and modulations
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105909openalex-snapshot
Diversity-oriented synthesis of marine polybrominated diphenyl ethers as potential KCNQ potassium channel activators
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114952openalex-snapshot
The novel KV7 channel activator URO-K10 exerts enhanced pulmonary vascular effects independent of the KCNE4 regulatory subunit
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128841openalex-snapshot
Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116476openalex-snapshot
Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117660openalex-snapshot
Design, synthesis, and structure-activity relationship of 5,7- dimethylbenzo[d]thiazoles as novel Kv7.2/7.3 activators with antiepileptic effects
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174278openalex-snapshot
Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system
inferred← citeshttps://doi.org/10.1016/j.jpha.2024.101132openalex-snapshot
Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain
inferred← citeshttps://doi.org/10.1016/j.molcel.2020.10.037openalex-snapshot
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs
inferred← citeshttps://doi.org/10.1016/j.neuron.2021.10.029openalex-snapshot
Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2026.110889openalex-snapshot
Autism-related phenotypes in a heterozygous Scn2aR854Q mouse model and their partial rescue via a potassium channel opener
inferred← citeshttps://doi.org/10.1016/j.virusres.2022.198903openalex-snapshot
Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour
inferred← citeshttps://doi.org/10.1021/acs.chemrev.4c00306openalex-snapshot
Genetic Code Expansion for Mechanistic Studies in Ion Channels: An (Un)natural Union of Chemistry and Biology
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00911openalex-snapshot
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c03112openalex-snapshot
Lead Optimization of Positive Allosteric KV7.2/3 Channel Modulators toward Improved Balance of Lipophilicity and Aqueous Solubility
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00796openalex-snapshot
Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.9b00097openalex-snapshot
Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity
inferred← citeshttps://doi.org/10.1021/acsptsci.0c00077openalex-snapshot
An iPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening
inferred← citeshttps://doi.org/10.1038/s12276-019-0300-9openalex-snapshot
Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment
inferred← citeshttps://doi.org/10.1038/s41422-020-00410-8openalex-snapshot
Molecular basis for ligand activation of the human KCNQ2 channel
inferred← citeshttps://doi.org/10.1038/s41467-018-04266-wopenalex-snapshot
Direct neurotransmitter activation of voltage-gated potassium channels
inferred← citeshttps://doi.org/10.1038/s41467-018-06339-2openalex-snapshot
Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket
inferred← citeshttps://doi.org/10.1038/s41467-024-46813-8openalex-snapshot
The binding and mechanism of a positive allosteric modulator of Kv3 channels
inferred← citeshttps://doi.org/10.1038/s41598-018-23201-zopenalex-snapshot
Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte
inferred← citeshttps://doi.org/10.1038/s42003-019-0648-3openalex-snapshot
In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner
inferred← citeshttps://doi.org/10.1038/s42003-020-1089-8openalex-snapshot
The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator
inferred← citeshttps://doi.org/10.1038/s42003-021-02729-3openalex-snapshot
PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel
inferred← citeshttps://doi.org/10.1038/s42004-024-01318-9openalex-snapshot
Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant
inferred← citeshttps://doi.org/10.1038/srep35080openalex-snapshot
The anticonvulsant retigabine suppresses neuronal KV2-mediated currents
inferred← citeshttps://doi.org/10.1039/c9ob00511kopenalex-snapshot
Flupirtine and retigabine as templates for ligand-based drug design of K V 7.2/3 activators
inferred← citeshttps://doi.org/10.1039/d0md00328jopenalex-snapshot
Chemical modulation of Kv7 potassium channels
inferred← citeshttps://doi.org/10.1073/pnas.1705802114openalex-snapshot
PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels
inferred← citeshttps://doi.org/10.1073/pnas.1907511116openalex-snapshot
KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines
inferred← citeshttps://doi.org/10.1073/pnas.2616367123openalex-snapshot
Voltage-sensor conformational microenvironments encode isoform-selective ion channel activation
inferred← citeshttps://doi.org/10.1080/17460441.2024.2438226openalex-snapshot
Advances in the design and development of chemical modulators of the voltage-gated potassium channels K V 7.4 and K V 7.5
inferred← citeshttps://doi.org/10.1080/19336950.2016.1243190openalex-snapshot
Hysteresis in voltage-gated channels
inferred← citeshttps://doi.org/10.1085/jgp.201511517openalex-snapshot
Retigabine holds KV7 channels open and stabilizes the resting potential
inferred← citeshttps://doi.org/10.1085/jgp.201812013openalex-snapshot
One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels
inferred← citeshttps://doi.org/10.1085/jgp.201812014openalex-snapshot
Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener
inferred← citeshttps://doi.org/10.1085/jgp.201812070openalex-snapshot
Pore- and voltage sensor–targeted KCNQ openers have distinct state-dependent actions
inferred← citeshttps://doi.org/10.1085/jgp.202012576openalex-snapshot
Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity
inferred← citeshttps://doi.org/10.1085/jgp.202012598openalex-snapshot
Chemical regulation of Kv7 channels: Diverse scaffolds, sites, and mechanisms of action
inferred← citeshttps://doi.org/10.1085/jgp.202213191openalex-snapshot
Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols
inferred← citeshttps://doi.org/10.1089/adt.2019.942openalex-snapshot
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda
inferred← citeshttps://doi.org/10.1093/function/zqad021openalex-snapshot
Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels
inferred← citeshttps://doi.org/10.1096/fj.201900485ropenalex-snapshot
Cilantro leaf harbors a potent potassium channel–activating anticonvulsant
inferred← citeshttps://doi.org/10.1111/bph.70119openalex-snapshot
The fast‐dissociating D 2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment
inferred← citeshttps://doi.org/10.1111/bph.70186openalex-snapshot
State‐dependent regulation of the K v 7.2 channel voltage sensor by QO‐58
inferred← citeshttps://doi.org/10.1111/bph.70531openalex-snapshot
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
inferred← citeshttps://doi.org/10.1111/epi.16592openalex-snapshot
Functional and behavioral signatures of Kv7 activator drug subtypes
inferred← citeshttps://doi.org/10.1111/jnc.16292openalex-snapshot
Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity
inferred← citeshttps://doi.org/10.1113/jp272762openalex-snapshot
Sequence determinants of subtype‐specific actions of KCNQ channel openers
inferred← citeshttps://doi.org/10.1113/jp273250openalex-snapshot
Specificity of M‐channel activators: binding or effect?
inferred← citeshttps://doi.org/10.1113/jp276695openalex-snapshot
The current chemical biology tool box for studying ion channels
inferred← citeshttps://doi.org/10.11131/2018/101384openalex-snapshot
Diclofenac Influence on the Anticonvulsant Effect of Retigabine: The Potential Role of KCNQ Channels
inferred← citeshttps://doi.org/10.1124/jpet.119.263350openalex-snapshot
M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate
inferred← citeshttps://doi.org/10.1124/jpet.119.264507openalex-snapshot
Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine
inferred← citeshttps://doi.org/10.1124/mol.115.103200openalex-snapshot
Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators
inferred← citeshttps://doi.org/10.1124/mol.118.112953openalex-snapshot
Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels
inferred← citeshttps://doi.org/10.1124/mol.120.119644openalex-snapshot
Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy
inferred← citeshttps://doi.org/10.1126/sciadv.abo3625openalex-snapshot
Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-052120-104249openalex-snapshot
KCNQ Potassium Channels as Targets of Botanical Folk Medicines
inferred← citeshttps://doi.org/10.1523/jneurosci.2307-22.2023openalex-snapshot
Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain
inferred← citeshttps://doi.org/10.2147/jpr.s467535openalex-snapshot
Kv7 Channel Activators Flupirtine and ML213 Alleviate Neuropathic Pain Behavior in the Streptozotocin Rat Model of Diabetic Neuropathy
inferred← citeshttps://doi.org/10.22541/au.171828190.03748784/v1openalex-snapshot
Discovery of a novel compound E0199 that simultaneously targets both peripheral NaV and KV7 ion channels to alleviate neuropathic pain
inferred← citeshttps://doi.org/10.2478/aiht-2020-71-3466openalex-snapshot
Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents
inferred← citeshttps://doi.org/10.33594/000000397openalex-snapshot
The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels.
inferred← citeshttps://doi.org/10.3389/fmolb.2022.839249openalex-snapshot
Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine
inferred← citeshttps://doi.org/10.3389/fphar.2020.00735openalex-snapshot
Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels
inferred← citeshttps://doi.org/10.3389/fphar.2020.00895openalex-snapshot
Modulation of KV7 Channel Deactivation by PI(4,5)P2
inferred← citeshttps://doi.org/10.3389/fphys.2019.01407openalex-snapshot
Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive
inferred← citeshttps://doi.org/10.3389/fphys.2020.00583openalex-snapshot
KCNQs: Ligand- and Voltage-Gated Potassium Channels
inferred← citeshttps://doi.org/10.3389/fphys.2020.00634openalex-snapshot
Kv7 Channels in Lung Diseases
inferred← citeshttps://doi.org/10.3390/ijms21249440openalex-snapshot
Insights into Cardiac IKs (KCNQ1/KCNE1) Channels Regulation
inferred← citeshttps://doi.org/10.3390/molecules29133234openalex-snapshot
In Silico Methods for the Discovery of Kv7.2/7.3 Channels Modulators: A Comprehensive Review
inferred← citeshttps://doi.org/10.33915/etd.7241openalex-snapshot
A Study of Epithelial Cl- Secretion in the Murine Distal Colon
inferred← citeshttps://doi.org/10.4155/fmc-2018-0350openalex-snapshot
How to Replace the Lost keys? Strategies Toward Safer K V 7 Channel Openers
inferred← citeshttps://doi.org/10.7554/elife.18976openalex-snapshot
Atomic mutagenesis in ion channels with engineered stoichiometry
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