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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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High‐resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization
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Detection and precise mapping of germline rearrangements inBRCA1, BRCA2, MSH2, andMLH1using zoom-in array comparative genomic hybridization (aCGH)
inferredcites →https://doi.org/10.1016/j.ccr.2005.01.009openalex-snapshot
Lack of PTEN sequesters CHK1 and initiates genetic instability
inferredcites →https://doi.org/10.1016/j.ccr.2006.10.008openalex-snapshot
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
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PTEN Enters the Nuclear Age
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Molecular portraits of human breast tumours
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Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors
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Patterns of somatic mutation in human cancer genomes
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Homologous repair of DNA damage and tumorigenesis:the BRCA connection
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Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects
inferredcites →https://doi.org/10.1038/sj.onc.1209876openalex-snapshot
Basal-like breast cancer and the BRCA1 phenotype
inferredcites →https://doi.org/10.1073/pnas.0702507104openalex-snapshot
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
inferredcites →https://doi.org/10.1073/pnas.0932692100openalex-snapshot
Repeated observation of breast tumor subtypes in independent gene expression data sets
inferredcites →https://doi.org/10.1073/pnas.191367098openalex-snapshot
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
inferredcites →https://doi.org/10.1073/pnas.96.4.1563openalex-snapshot
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
inferredcites →https://doi.org/10.1093/jnci/52.3.921openalex-snapshot
Heterotransplantation of Human Malignant Tumors in “Nude” Thymusless Mice. II. Malignant Tumors Induced by Injection of Cell Cultures Derived From Human Solid Tumors 2
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Family History of Breast and Ovarian Cancers and BRCA1 and BRCA2 Mutations in a Population-Based Series of Early-Onset Breast Cancer
inferredcites →https://doi.org/10.1126/science.1073096openalex-snapshot
Addiction to Oncogenes--the Achilles Heal of Cancer
inferredcites →https://doi.org/10.1126/science.1117679openalex-snapshot
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
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The Consensus Coding Sequences of Human Breast and Colorectal Cancers
inferredcites →https://doi.org/10.1126/science.275.5308.1943openalex-snapshot
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
inferredcites →https://doi.org/10.1126/science.7761852openalex-snapshot
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
inferredcites →https://doi.org/10.1136/jcp.2006.041731openalex-snapshot
Demystifying basal-like breast carcinomas: Figure 1
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PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2853openalex-snapshot
BRCA1 Mutation Analysis of 41 Human Breast Cancer Cell Lines Reveals Three New Deleterious Mutants
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Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer
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PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data
inferredcites →https://doi.org/10.15537/smj.2016.2.12285openalex-snapshot
Ki67 expression in breast cancer
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth
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Genetically engineered mouse models of PI3K signaling in breast cancer
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PTEN mutations prevalence in HER2-positive breast cancer patients
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The role of PTEN tumor suppressor pathway staining in carcinoma in situ of the bladder
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PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland
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Therapeutic Delivery of miR-29b Enhances Radiosensitivity in Cervical Cancer
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Chapter 2 An Evolutionary Perspective on Parasitism as a Cause of Cancer
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Breast Cancer Stem Cells and Tumor Suppressor Genes
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Evolutionary Medicine and the Causes of Chronic Disease
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Basic science: (January 2008)
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Breast cancer susceptibility: current knowledge and implications for genetic counselling
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The expanded human disease network combining protein–protein interaction information
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Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer
inferred← citeshttps://doi.org/10.1038/nature08486openalex-snapshot
Pten in stromal fibroblasts suppresses mammary epithelial tumours
inferred← citeshttps://doi.org/10.1038/nature11412openalex-snapshot
Comprehensive molecular portraits of human breast tumours
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Proteomic maps of breast cancer subtypes
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Genome-wide transcriptome profiling of homologous recombination DNA repair
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BRCA1—sowing the seeds crooked in the furrow
inferred← citeshttps://doi.org/10.1038/nrc3037openalex-snapshot
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
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The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
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The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
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PTEN: a new guardian of the genome
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The role of PTEN signaling perturbations in cancer and in targeted therapy
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Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors
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Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin
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Opportunities and hurdles in the treatment of BRCA1-related breast cancer
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Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance
inferred← citeshttps://doi.org/10.1038/s41467-017-00388-9openalex-snapshot
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
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Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
inferred← citeshttps://doi.org/10.1038/s41467-020-17537-2openalex-snapshot
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
inferred← citeshttps://doi.org/10.1038/s41523-017-0025-7openalex-snapshot
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial
inferred← citeshttps://doi.org/10.1038/s41568-023-00660-9openalex-snapshot
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
inferred← citeshttps://doi.org/10.1038/s41588-024-01958-6openalex-snapshot
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer
inferred← citeshttps://doi.org/10.1038/s41598-017-08209-1openalex-snapshot
Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach
inferred← citeshttps://doi.org/10.1038/s41598-026-43678-3openalex-snapshot
Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC
inferred← citeshttps://doi.org/10.1038/s41698-020-00129-0openalex-snapshot
Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s41698-022-00339-8openalex-snapshot
Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer
inferred← citeshttps://doi.org/10.1038/s42003-021-01825-8openalex-snapshot
NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer
inferred← citeshttps://doi.org/10.1038/sj.bjc.6604321openalex-snapshot
The role of early life genistein exposures in modifying breast cancer risk
inferred← citeshttps://doi.org/10.1038/sj.bjc.6604471openalex-snapshot
The ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.1038/sj.bjc.6605350openalex-snapshot
Preclinical mouse models for BRCA1-associated breast cancer
inferred← citeshttps://doi.org/10.1039/c5mb00101copenalex-snapshot
The PI3K/AKT/mTOR interactive pathway
inferred← citeshttps://doi.org/10.1051/mbcb/2011003openalex-snapshot
Syndrome de Cowden : mise au point (1èrepartie)
inferred← citeshttps://doi.org/10.1051/mbcb/2011108openalex-snapshot
Syndrome de Cowden : présentation de 7 cas (2èmepartie)
inferred← citeshttps://doi.org/10.1073/pnas.0806882106openalex-snapshot
Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency
inferred← citeshttps://doi.org/10.1073/pnas.1324136111openalex-snapshot
Estrogen controls the survival of BRCA1-deficient cells via a PI3K–NRF2-regulated pathway
inferred← citeshttps://doi.org/10.1073/pnas.1403033111openalex-snapshot
Tissue-specific tumor suppression by BRCA1
inferred← citeshttps://doi.org/10.1073/pnas.1613859113openalex-snapshot
Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression
inferred← citeshttps://doi.org/10.1073/pnas.1701512114openalex-snapshot
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification
inferred← citeshttps://doi.org/10.1074/jbc.m109.018937openalex-snapshot
PTEN Deficiency in a Luminal ErbB-2 Mouse Model Results in Dramatic Acceleration of Mammary Tumorigenesis and Metastasis
inferred← citeshttps://doi.org/10.1074/jbc.m111.246397openalex-snapshot
Unrestrained Mammalian Target of Rapamycin Complexes 1 and 2 Increase Expression of Phosphatase and Tensin Homolog Deleted on Chromosome 10 to Regulate Phosphorylation of Akt Kinase
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010710openalex-snapshot
Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1074/mcp.m115.049783openalex-snapshot
Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer*
inferred← citeshttps://doi.org/10.1080/07391102.2023.2243352openalex-snapshot
Evaluating chemotherapeutic potential of soya-isoflavonoids against high penetrance genes in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1080/15384101.2016.1203493openalex-snapshot
PTEN regulates PLK1 and controls chromosomal stability during cell division
inferred← citeshttps://doi.org/10.1083/jcb.201002124openalex-snapshot
A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA
inferred← citeshttps://doi.org/10.1084/jem.20121337openalex-snapshot
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
inferred← citeshttps://doi.org/10.1093/annonc/mdq659openalex-snapshot
BRCA genes: lessons learned from experimental and clinical cancer
inferred← citeshttps://doi.org/10.1093/annonc/mds188openalex-snapshot
Understanding the biology of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1093/annonc/mdt306openalex-snapshot
BRCAness: a deeper insight into basal-like breast tumors
inferred← citeshttps://doi.org/10.1093/annonc/mdt384openalex-snapshot
PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
inferred← citeshttps://doi.org/10.1093/carcin/bgn157openalex-snapshot
An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes
inferred← citeshttps://doi.org/10.1093/carcin/bgp117openalex-snapshot
DNA double-strand break repair activities in mammary epithelial cells--influence of endogenous p53 variants
inferred← citeshttps://doi.org/10.1093/carcin/bgs198openalex-snapshot
miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression
inferred← citeshttps://doi.org/10.1093/hmg/ddq434openalex-snapshot
Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53
inferred← citeshttps://doi.org/10.1093/jmcb/mjq055openalex-snapshot
BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability
inferred← citeshttps://doi.org/10.1096/fba.2021-00055openalex-snapshot
RhoA‐ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic‐like flow
inferred← citeshttps://doi.org/10.1097/cad.0000000000000328openalex-snapshot
Potential role of targeted therapies in the treatment of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1097/cco.0b013e3283139173openalex-snapshot
Hereditary breast cancer: from bench to bedside
inferred← citeshttps://doi.org/10.1097/cco.0b013e32833b5126openalex-snapshot
PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers
inferred← citeshttps://doi.org/10.1097/cco.0b013e328358a2b5openalex-snapshot
Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway inhibition
inferred← citeshttps://doi.org/10.1100/2012/252457openalex-snapshot
PTEN Gene: A Model for Genetic Diseases in Dermatology
inferred← citeshttps://doi.org/10.1101/137760openalex-snapshot
Loss of PTEN promotes formation of signaling-capable clathrin-coated pits
inferred← citeshttps://doi.org/10.1101/2025.02.09.636592openalex-snapshot
Inducible re-epithelialization of cancer cells increases autophagy and DNA damage: implications for breast cancer dormancy
inferred← citeshttps://doi.org/10.1101/cshperspect.a003236openalex-snapshot
Oncogenes and Tumor Suppressor Genes
inferred← citeshttps://doi.org/10.1109/tcbb.2018.2846599openalex-snapshot
HetRCNA: A Novel Method to Identify Recurrent Copy Number Alternations from Heterogeneous Tumor Samples Based on Matrix Decomposition Framework
inferred← citeshttps://doi.org/10.1111/cas.70460openalex-snapshot
Genetic Evolution in BRCA1 ‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis
inferred← citeshttps://doi.org/10.1111/j.1349-7006.2009.01225.xopenalex-snapshot
BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer
inferred← citeshttps://doi.org/10.1111/j.1349-7006.2012.02359.xopenalex-snapshot
Efficacy of everolimus, a novel m TOR inhibitor, against basal‐like triple‐negative breast cancer cells
inferred← citeshttps://doi.org/10.1126/scisignal.2005840openalex-snapshot
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion
inferred← citeshttps://doi.org/10.1126/scisignal.aao6604openalex-snapshot
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
inferred← citeshttps://doi.org/10.1126/scisignal.ado3473openalex-snapshot
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse
inferred← citeshttps://doi.org/10.1126/scitranslmed.3001875openalex-snapshot
Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis
inferred← citeshttps://doi.org/10.1136/jmg.2008.061697openalex-snapshot
Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations
inferred← citeshttps://doi.org/10.1146/annurev.pathol.3.121806.151422openalex-snapshot
Linking the Cellular Functions ofBRCAGenes to Cancer Pathogenesis and Treatment
inferred← citeshttps://doi.org/10.1146/annurev.pathol.4.110807.092311openalex-snapshot
PTEN and the PI3-Kinase Pathway in Cancer
inferred← citeshttps://doi.org/10.1155/2014/209845openalex-snapshot
A Paradoxical Chemoresistance and Tumor Suppressive Role of Antioxidant in Solid Cancer Cells: A Strange Case of Dr. Jekyll and Mr. Hyde
inferred← citeshttps://doi.org/10.1158/0008-5472.22389515openalex-snapshot
Supplementary Figures 1-6, Tables 1-15, Methods from Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.22389515.v1openalex-snapshot
Supplementary Figures 1-6, Tables 1-15, Methods from Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.22396404openalex-snapshot
Supplementary Data Legends and Methods from Novel Oncogene–Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures
inferred← citeshttps://doi.org/10.1158/0008-5472.22396404.v1openalex-snapshot
Supplementary Data Legends and Methods from Novel Oncogene–Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures
inferred← citeshttps://doi.org/10.1158/0008-5472.22421448openalex-snapshot
Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.22421448.v1openalex-snapshot
Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6497703openalex-snapshot
Data from Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53–Mediated Mouse Mammary Tumors
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-5480openalex-snapshot
Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53 –Mediated Mouse Mammary Tumors
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-5727openalex-snapshot
Phosphatase and Tensin Homologue Deleted on Chromosome 10 Deficiency Accelerates Tumor Induction in a Mouse Model of ErbB-2 Mammary Tumorigenesis
inferred← citeshttps://doi.org/10.1158/0008-5472.can-07-6854openalex-snapshot
An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-08-0861openalex-snapshot
AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51
inferred← citeshttps://doi.org/10.1158/0008-5472.can-08-1560openalex-snapshot
High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors
inferred← citeshttps://doi.org/10.1158/0008-5472.can-08-2660openalex-snapshot
PIK3CA Mutations in In situ and Invasive Breast Carcinomas
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-2488openalex-snapshot
PTEN Level in Tumor Suppression: How Much Is Too Little?
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-2653openalex-snapshot
A Multistage Association Study Identifies a Breast Cancer Genetic Locus at NCOA7
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