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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Association of Early-Life Adversity With Measures of Accelerated Biological Aging Among Children in China
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Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017
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Influence ofCRTC1Polymorphisms on Body Mass Index and Fat Mass in Psychiatric Patients and the General Adult Population
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Genetics of Age at Menarche
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Human Genetics of GnRH Neuron Function
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The relationship among the age at menarche, anthropometric characteristics, and socio‐economic factors in Bengali girls from Kolkata, India
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Adolescent growth and BMI and their associations with early childhood growth in an urban South African cohort
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Genetic risk for earlier menarche also influences peripubertal body mass index
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Modernization and the onset of overweight and obesity in bougainville and solomon islands children: Cross‐sectional and longitudinal comparisons between 1966 and 1986
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Copper and zinc isotope ratios in human bone and enamel
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Age at menarche and epithelial ovarian cancer risk: A meta‐analysis and Mendelian randomization study
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Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: Implications for adolescent mental health
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Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts
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Predictive accuracy of combined genetic and environmental risk scores
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Gene Polymorphisms in Female Reproduction
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Genetics of Delayed Puberty
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Genetic Association Studies and Next Generation Sequencing in Stroke: Methods
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Age at menarche is associated with prediabetes and diabetes in women (aged 32–81 years) from the general population: the KORA F4 Study
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Interactions Between Genetic, Prenatal Substance Use, Puberty, and Parenting are Less Important for Understanding Adolescents’ Internalizing, Externalizing, and Substance Use than Developmental Cascades in Multifactorial Models
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Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue
inferred← citeshttps://doi.org/10.1007/s10549-017-4511-2openalex-snapshot
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mTOR pathway candidate genes and physical activity interaction on breast cancer risk in black women from the women’s circle of health study
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mTOR pathway candidate genes and obesity interaction on breast cancer risk in black women from the Women’s Circle of Health Study
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ApoE genotypes are associated with age at natural menopause in Chinese females
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Age at menarche and age at natural menopause in East Asian women: a genome-wide association study
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Improved Semiparametric Analysis of Polygenic Gene–Environment Interactions in Case–Control Studies
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Replication of genomewide association studies on age at menarche in the Korean population
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Association of age at menarche with metabolic syndrome and components of metabolic syndrome in premenopausal women, Korea National Health and nutrition examination survey VI
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Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States
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The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)
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Indications of younger age at menarche in Greek adolescents but with no relation to body mass index
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Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review
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Development, Aging and Cancer
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The Genetic Epidemiology of Growth and Development
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Keeping Puberty on Time
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Follicular Development
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Puberty in Non-human Primates and Man
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Female Puberty Overview
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Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation
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The genetic epidemiology of growth and development
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Puberty in the Female and Its Disorders
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Puberty and Its Disorders in the Male
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Female Puberty Overview
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Hormones in systemic lupus erythematosus
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Puberty development: determinants and health impacts
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Discovery and Characterization of Cancer Genetic Susceptibility Alleles
inferred← citeshttps://doi.org/10.1016/b978-1-4557-4858-7.00024-xopenalex-snapshot
Puberty and its disorders in the female
inferred← citeshttps://doi.org/10.1016/b978-1-4557-4858-7.00026-3openalex-snapshot
Puberty and its disorders in the male
inferred← citeshttps://doi.org/10.1016/j.ajhg.2013.12.016openalex-snapshot
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
inferred← citeshttps://doi.org/10.1016/j.ajhg.2016.09.002openalex-snapshot
An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression
inferred← citeshttps://doi.org/10.1016/j.ajhg.2018.08.009openalex-snapshot
An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F
inferred← citeshttps://doi.org/10.1016/j.archger.2015.11.003openalex-snapshot
Association between reproductive variables and metabolic syndrome in chinese community elderly women
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2013.01.035openalex-snapshot
Reproductive factors and its association with peripheral arterial disease in women aged 52–81 years: The KORA F4 study
inferred← citeshttps://doi.org/10.1016/j.beem.2022.101618openalex-snapshot
Genetics of pubertal timing
inferred← citeshttps://doi.org/10.1016/j.canep.2013.12.001openalex-snapshot
Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan
inferred← citeshttps://doi.org/10.1016/j.clim.2013.03.014openalex-snapshot
Role of puberty in multiple sclerosis risk and course
inferred← citeshttps://doi.org/10.1016/j.clinsp.2023.100244openalex-snapshot
Serum 25-hydroxyvitamin D levels and the risk of idiopathic central precocious puberty in girls
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.01.002openalex-snapshot
Reproductive risk factors across the female lifecourse and later metabolic health
inferred← citeshttps://doi.org/10.1016/j.coemr.2020.05.003openalex-snapshot
Next-generation sequencing approach in the diagnosis of delayed puberty
inferred← citeshttps://doi.org/10.1016/j.coemr.2020.06.011openalex-snapshot
Pubertal timing and body mass: Genes involved
inferred← citeshttps://doi.org/10.1016/j.dib.2019.104323openalex-snapshot
Dataset of allele, genotype and haplotype frequencies of four LIN28B gene polymorphisms analyzed for association with age at menarche in Russian women
inferred← citeshttps://doi.org/10.1016/j.domaniend.2020.106446openalex-snapshot
Physiological and genomic insight into neuroendocrine regulation of puberty in gilts
inferred← citeshttps://doi.org/10.1016/j.envint.2020.105469openalex-snapshot
Onset and tempo of sexual maturation is differentially associated with gestational phthalate exposure between boys and girls in a Mexico City birth cohort
inferred← citeshttps://doi.org/10.1016/j.evolhumbehav.2017.06.002openalex-snapshot
Genetic and environmental contributions to age at menarche: Interactive effects of father absence and LIN28B
inferred← citeshttps://doi.org/10.1016/j.fertnstert.2013.06.026openalex-snapshot
FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study
inferred← citeshttps://doi.org/10.1016/j.fertnstert.2018.09.007openalex-snapshot
Links between age at menarche, antral follicle count, and body mass index in African American and European American women
inferred← citeshttps://doi.org/10.1016/j.gene.2018.11.042openalex-snapshot
Association of genetic polymorphisms with age at menarche in Russian women
inferred← citeshttps://doi.org/10.1016/j.gene.2020.144933openalex-snapshot
Candidate genes for age at menarche are associated with endometrial hyperplasia
inferred← citeshttps://doi.org/10.1016/j.ijcard.2016.10.115openalex-snapshot
Age at menarche and risk of major cardiovascular diseases: Evidence of birth cohort effects from a prospective study of 300,000 Chinese women
inferred← citeshttps://doi.org/10.1016/j.jaac.2013.12.028openalex-snapshot
A Genome-wide Association Meta-analysis of Preschool Internalizing Problems
inferred← citeshttps://doi.org/10.1016/j.jad.2016.03.031openalex-snapshot
Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression
inferred← citeshttps://doi.org/10.1016/j.jadohealth.2012.02.013openalex-snapshot
Shared Genetic Effects Between Age at Menarche and Disordered Eating
inferred← citeshttps://doi.org/10.1016/j.jadohealth.2012.09.019openalex-snapshot
Identifying Opportunities for Cancer Prevention During Preadolescence and Adolescence: Puberty as a Window of Susceptibility
inferred← citeshttps://doi.org/10.1016/j.jadohealth.2014.07.020openalex-snapshot
Associations Between Menarche-Related Genetic Variants and Pubertal Growth in Male and Female Adolescents
inferred← citeshttps://doi.org/10.1016/j.jid.2021.06.008openalex-snapshot
Sex Bias and Autoimmune Diseases
inferred← citeshttps://doi.org/10.1016/j.jpag.2016.02.011openalex-snapshot
Age at Menarche and Its Association with Excess Weight and Body Fat Percentage in Girls in the Southwestern Region of the Brazilian Amazon
inferred← citeshttps://doi.org/10.1016/j.jpag.2021.06.007openalex-snapshot
Analysis of the Timing of Puberty in a Recent Cohort of Italian Girls: Evidence for Earlier Onset Compared to Previous Studies
inferred← citeshttps://doi.org/10.1016/j.jped.2018.10.012openalex-snapshot
Association of body composition and age at menarche in girls and adolescents in the Brazilian Legal Amazon
inferred← citeshttps://doi.org/10.1016/j.jpedp.2019.04.007openalex-snapshot
Association of body composition and age at menarche in girls and adolescents in the Brazilian Legal Amazon
inferred← citeshttps://doi.org/10.1016/j.maturitas.2017.07.009openalex-snapshot
Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms
inferred← citeshttps://doi.org/10.1016/j.mce.2011.05.019openalex-snapshot
New genetic factors implicated in human GnRH-dependent precocious puberty: The role of kisspeptin system
inferred← citeshttps://doi.org/10.1016/j.mce.2011.07.014openalex-snapshot
Neurokinin B signalling in the human reproductive axis
inferred← citeshttps://doi.org/10.1016/j.mce.2012.05.003openalex-snapshot
Genome-wide association studies of age at menarche and age at natural menopause
inferred← citeshttps://doi.org/10.1016/j.mce.2012.10.025openalex-snapshot
Investigation of peripubertal expression of Lin28a and Lin28b in C57BL/6 female mice
inferred← citeshttps://doi.org/10.1016/j.mce.2018.05.001openalex-snapshot
Genes underlying delayed puberty
inferred← citeshttps://doi.org/10.1016/j.mce.2018.09.001openalex-snapshot
Transient modification of lin28b expression - permanent effects on zebrafish growth
inferred← citeshttps://doi.org/10.1016/j.molmed.2026.09.004openalex-snapshot
Hippo signaling and vestigial-like family member 3 at the stromal–immune interface in autoimmunity
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2016.06.008openalex-snapshot
microRNAs and the adolescent brain: Filling the knowledge gap
inferred← citeshttps://doi.org/10.1016/j.pedneo.2024.04.012openalex-snapshot
Mendelian randomization analysis on the impacts of age at menarche on adult height: A Taiwanese population study
inferred← citeshttps://doi.org/10.1016/j.prrv.2015.10.006openalex-snapshot
A new childhood asthma phenotype: obese with early menarche
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2025.107427openalex-snapshot
Risk factors for precocious puberty: A systematic review and meta‑analysis
inferred← citeshttps://doi.org/10.1016/j.rbmo.2020.04.016openalex-snapshot
Candidate genes for age at menarche are associated with endometriosis
inferred← citeshttps://doi.org/10.1016/j.tem.2011.03.002openalex-snapshot
Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory
inferred← citeshttps://doi.org/10.1016/j.tem.2011.05.006openalex-snapshot
Re-examining heritability: genetics, life history and plasticity
inferred← citeshttps://doi.org/10.1016/j.tem.2016.04.011openalex-snapshot
Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond
inferred← citeshttps://doi.org/10.1016/j.xgen.2025.101068openalex-snapshot
Leveraging protein language models to identify complex trait associations with previously inaccessible classes of functional rare variants
inferred← citeshttps://doi.org/10.1016/j.ydbio.2016.06.013openalex-snapshot
Conservation in the involvement of heterochronic genes and hormones during developmental transitions
inferred← citeshttps://doi.org/10.1016/j.yfrne.2014.08.003openalex-snapshot
Epigenetic regulation of female puberty
inferred← citeshttps://doi.org/10.1016/j.yfrne.2014.12.004openalex-snapshot
Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents
inferred← citeshttps://doi.org/10.1016/j.yfrne.2017.07.008openalex-snapshot
Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility
inferred← citeshttps://doi.org/10.1016/j.yhbeh.2012.09.013openalex-snapshot
A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates
inferred← citeshttps://doi.org/10.1016/j.yhbeh.2013.02.014openalex-snapshot
Puberty and dispersal in a wild primate population
inferred← citeshttps://doi.org/10.1016/j.ymeth.2017.03.012openalex-snapshot
Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways
inferred← citeshttps://doi.org/10.1016/s2352-4642(18)30306-7openalex-snapshot
Is there a causal relationship between obesity and puberty?
inferred← citeshttps://doi.org/10.1017/cbo9781139628938.035openalex-snapshot
Pediatric and adolescent gynecology
inferred← citeshttps://doi.org/10.1017/s0033291711000961openalex-snapshot
Environmental and genetic pathways between early pubertal timing and dieting in adolescence: distinguishing between objective and subjective timing
inferred← citeshttps://doi.org/10.1017/s0954579416000900openalex-snapshot
Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one?
inferred← citeshttps://doi.org/10.1017/s2040174416000313openalex-snapshot
Infection and pubertal timing: a systematic review
inferred← citeshttps://doi.org/10.1017/thg.2012.140openalex-snapshot
The Adult Netherlands Twin Register: Twenty-Five Years of Survey and Biological Data Collection
inferred← citeshttps://doi.org/10.1017/thg.2012.62openalex-snapshot
The Minnesota Center for Twin and Family Research Genome-Wide Association Study
inferred← citeshttps://doi.org/10.1017/thg.2012.89openalex-snapshot
The UK Adult Twin Registry (TwinsUK Resource)
inferred← citeshttps://doi.org/10.1017/thg.2019.17openalex-snapshot
Heritability of Age at Menarche in South Korean Female Twins
inferred← citeshttps://doi.org/10.1017/thg.2022.9openalex-snapshot
Heritability of Age at Menarche in Nigerian Adolescent Twins
inferred← citeshttps://doi.org/10.1017/thg.2024.44openalex-snapshot
Late Age at First Birth is a Protective Factor for Preterm Labor and Delivery: The Evidence From the Genetic Study
inferred← citeshttps://doi.org/10.1037/a0033564openalex-snapshot
Genetic influences on adolescent sexual behavior: Why genes matter for environmentally oriented researchers.
inferred← citeshttps://doi.org/10.1038/ejhg.2015.102openalex-snapshot
Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes
inferred← citeshttps://doi.org/10.1038/ijo.2012.177openalex-snapshot
Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1038/ijo.2015.254openalex-snapshot
Women’s reproductive health factors and body adiposity: findings from the UK Biobank
inferred← citeshttps://doi.org/10.1038/ijo.2017.304openalex-snapshot
Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI
inferred← citeshttps://doi.org/10.1038/jhg.2013.130openalex-snapshot
Confounding by linkage disequilibrium
inferred← citeshttps://doi.org/10.1038/jhg.2015.160openalex-snapshot
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP
inferred← citeshttps://doi.org/10.1038/jid.2013.196openalex-snapshot
Genome-Wide Association Analysis Implicates Elastic Microfibrils in the Development of Nonsyndromic Striae Distensae
inferred← citeshttps://doi.org/10.1038/nature13545openalex-snapshot
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
inferred← citeshttps://doi.org/10.1038/nature14132openalex-snapshot
New genetic loci link adipose and insulin biology to body fat distribution
inferred← citeshttps://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferred← citeshttps://doi.org/10.1038/nature16062openalex-snapshot
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon
inferred← citeshttps://doi.org/10.1038/ncomms10195openalex-snapshot
Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression
inferred← citeshttps://doi.org/10.1038/ncomms13298openalex-snapshot
C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
inferred← citeshttps://doi.org/10.1038/ncomms14694openalex-snapshot
Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
inferred← citeshttps://doi.org/10.1038/ncomms9842openalex-snapshot
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes
inferred← citeshttps://doi.org/10.1038/ng.2796openalex-snapshot
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus
inferred← citeshttps://doi.org/10.1038/ng.3011openalex-snapshot
Genome-wide association analysis identifies six new loci associated with forced vital capacity
inferred← citeshttps://doi.org/10.1038/ng.3014openalex-snapshot
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
inferred← citeshttps://doi.org/10.1038/ng.3063openalex-snapshot
Genome-wide association analyses identify variants in developmental genes associated with hypospadias
inferred← citeshttps://doi.org/10.1038/ng.3570openalex-snapshot
Detection and interpretation of shared genetic influences on 42 human traits
inferred← citeshttps://doi.org/10.1038/ng.3660openalex-snapshot
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
inferred← citeshttps://doi.org/10.1038/ng.3698openalex-snapshot
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
inferred← citeshttps://doi.org/10.1038/ng.3801openalex-snapshot
Diversity in non-repetitive human sequences not found in the reference genome
inferred← citeshttps://doi.org/10.1038/ng.941openalex-snapshot
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
inferred← citeshttps://doi.org/10.1038/nrendo.2013.227openalex-snapshot
The bigger picture of FTO—the first GWAS-identified obesity gene
inferred← citeshttps://doi.org/10.1038/nrendo.2013.71openalex-snapshot
Treatment of children and adolescents with idiopathic short stature
inferred← citeshttps://doi.org/10.1038/nrendo.2014.40openalex-snapshot
Pros and cons of GnRHa treatment for early puberty in girls
inferred← citeshttps://doi.org/10.1038/nutd.2012.20openalex-snapshot
Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health
inferred← citeshttps://doi.org/10.1038/pr.2011.69openalex-snapshot
Study of leptin levels and gene polymorphisms in patients with central precocious puberty
inferred← citeshttps://doi.org/10.1038/pr.2016.107openalex-snapshot
Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls
inferred← citeshttps://doi.org/10.1038/s10038-023-01124-6openalex-snapshot
Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene
inferred← citeshttps://doi.org/10.1038/s41380-022-01667-8openalex-snapshot
Shared genetic basis between reproductive behaviors and anxiety-related disorders
inferred← citeshttps://doi.org/10.1038/s41390-020-01270-zopenalex-snapshot
Familial central precocious puberty: two novel MKRN3 mutations
inferred← citeshttps://doi.org/10.1038/s41390-020-1001-8openalex-snapshot
Polygenic interactions with adiposity rebound in the prediction of thelarche
inferred← citeshttps://doi.org/10.1038/s41390-024-03168-6openalex-snapshot
Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty
inferred← citeshttps://doi.org/10.1038/s41398-025-03270-1openalex-snapshot
An evolutionary perspective on the genetics of anorexia nervosa
inferred← citeshttps://doi.org/10.1038/s41467-017-00031-7openalex-snapshot
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
inferred← citeshttps://doi.org/10.1038/s41467-018-04398-zopenalex-snapshot
Elucidating the genetic architecture of reproductive ageing in the Japanese population
inferred← citeshttps://doi.org/10.1038/s41467-020-18411-xopenalex-snapshot
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
inferred← citeshttps://doi.org/10.1038/s41467-022-33367-wopenalex-snapshot
MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis
inferred← citeshttps://doi.org/10.1038/s41467-024-53820-2openalex-snapshot
An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells
inferred← citeshttps://doi.org/10.1038/s41467-025-62430-5openalex-snapshot
Defective Olfactomedin-2 connects adipocyte dysfunction to obesity
inferred← citeshttps://doi.org/10.1038/s41467-026-72381-0openalex-snapshot
An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan
inferred← citeshttps://doi.org/10.1038/s41562-019-0757-5openalex-snapshot
Genetic correlates of social stratification in Great Britain
inferred← citeshttps://doi.org/10.1038/s41568-020-0266-xopenalex-snapshot
Key steps for effective breast cancer prevention
inferred← citeshttps://doi.org/10.1038/s41574-020-0370-8openalex-snapshot
Unravelling the role of epigenetics in reproductive adaptations to early-life environment
inferred← citeshttps://doi.org/10.1038/s41574-023-00919-zopenalex-snapshot
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
inferred← citeshttps://doi.org/10.1038/s41575-022-00662-2openalex-snapshot
Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies
inferred← citeshttps://doi.org/10.1038/s41588-018-0178-9openalex-snapshot
Relatedness disequilibrium regression estimates heritability without environmental bias
inferred← citeshttps://doi.org/10.1038/s41588-024-01798-4openalex-snapshot
Understanding the genetic complexity of puberty timing across the allele frequency spectrum
inferred← citeshttps://doi.org/10.1038/s41598-018-24580-zopenalex-snapshot
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
inferred← citeshttps://doi.org/10.1038/s41598-019-41850-6openalex-snapshot
Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto’s thyroiditis
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