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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/s0021-9258(18)43836-7openalex-snapshot
Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216.
inferredcites →https://doi.org/10.1016/s0021-9258(18)53096-9openalex-snapshot
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
inferredcites →https://doi.org/10.1016/s1097-2765(00)80002-7openalex-snapshot
Is a p53-Regulated Inhibitor of G2/M Progression
inferredcites →https://doi.org/10.1016/s1097-2765(00)80238-5openalex-snapshot
Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line
inferredcites →https://doi.org/10.1016/s1097-2765(00)80466-9openalex-snapshot
Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells
inferredcites →https://doi.org/10.1038/16488openalex-snapshot
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
inferredcites →https://doi.org/10.1038/35004614openalex-snapshot
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
inferredcites →https://doi.org/10.1038/90108openalex-snapshot
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
inferredcites →https://doi.org/10.1038/sj.onc.1203165openalex-snapshot
Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2
inferredcites →https://doi.org/10.1073/pnas.96.9.4983openalex-snapshot
BRCA1 interacts with components of the histone deacetylase complex
inferredcites →https://doi.org/10.1074/jbc.275.4.2777openalex-snapshot
BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression
inferredcites →https://doi.org/10.1091/mbc.3.1.73openalex-snapshot
cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.
inferredcites →https://doi.org/10.1096/fasebj.11.1.9034168openalex-snapshot
A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins
inferredcites →https://doi.org/10.1101/gad.11.4.504openalex-snapshot
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.
inferredcites →https://doi.org/10.1101/gad.851000openalex-snapshot
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
inferredcites →https://doi.org/10.1126/science.277.5331.1495openalex-snapshot
Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase
inferredcites →https://doi.org/10.1126/science.277.5331.1497openalex-snapshot
Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25
inferredcites →https://doi.org/10.1126/science.277.5331.1501openalex-snapshot
Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216
inferredcites →https://doi.org/10.1126/science.282.5395.1893openalex-snapshot
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
inferredcites →https://doi.org/10.1126/science.285.5428.747openalex-snapshot
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
inferredcites →https://doi.org/10.1126/science.286.5442.1162openalex-snapshot
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
inferredcites →https://doi.org/10.1126/science.8266103openalex-snapshot
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control
inferredcites →https://doi.org/10.1128/mcb.21.10.3445-3450.2001openalex-snapshot
Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4760496openalex-extracted
Physalin a Interferes with Human DNA Topoisomerase Ii Alpha/Beta Interacts with DNA and Induces DNA Damage Responses Mediating Atm/Atr Signaling for Cell Cycle Arrest in Hsc-3 Cells
inferred← citeshttps://doi.org/10.1001/jama.2011.1456openalex-snapshot
Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer
inferred← citeshttps://doi.org/10.1002/bies.20277openalex-snapshot
Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking
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Structure‐Guided Synthesis and Evaluation of Small‐Molecule Inhibitors Targeting Protein–Protein Interactions of BRCA1 tBRCT Domain
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Laboratory variability does not preclude identification of biological functions impacted by hydroxyurea
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Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer
inferred← citeshttps://doi.org/10.1002/ijc.26309openalex-snapshot
Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells
inferred← citeshttps://doi.org/10.1002/ijc.28226openalex-snapshot
Roles of Chk1 in cell biology and cancer therapy
inferred← citeshttps://doi.org/10.1002/jcb.10642openalex-snapshot
Hepatic stellate cell activation in vitro: Cell cycle arrest at G2/M and modification of cell motility
inferred← citeshttps://doi.org/10.1002/jcb.21693openalex-snapshot
Involvement of the role of Chk1 in lithium‐induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1002/jemt.10178openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/mc.10164openalex-snapshot
Antisense blocking of BRCA1 enhances sensitivity to plumbagin but not tamoxifen in BG‐1 ovarian cancer cells
inferred← citeshttps://doi.org/10.1002/mc.20165openalex-snapshot
Checkpoint kinase 1‐mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine‐induced G 2 /M phase cell‐cycle arrest and apoptosis
inferred← citeshttps://doi.org/10.1002/path.1706openalex-snapshot
Molecular mechanisms of drug resistance
inferred← citeshttps://doi.org/10.1002/pros.20746openalex-snapshot
Genetic changes and DNA damage responses in the prostate
inferred← citeshttps://doi.org/10.1007/1-4020-3764-3_15openalex-snapshot
Mammalian DNA Damage Response Pathway
inferred← citeshttps://doi.org/10.1007/1-4020-3764-3_6openalex-snapshot
Genomic Instability in Cancer Development
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Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin
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DNA Damage Response in Xenopus laevis Cell-Free Extracts
inferred← citeshttps://doi.org/10.1007/978-1-4419-1262-6-6openalex-snapshot
Circadian Clock, Cell Cycle and Cancer Circadian Rhythm and Cell Growth Regulation
inferred← citeshttps://doi.org/10.1007/978-1-4419-1262-6_6openalex-snapshot
Circadian Clock, Cell Cycle and Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-1770-6_11openalex-snapshot
Targeting Cyclin-Dependent Kinases for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4939-0888-2_3openalex-snapshot
Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-1-59745-200-7_5openalex-snapshot
Aberrations of DNA Damage in Checkpoints in Cancer
inferred← citeshttps://doi.org/10.1007/978-1-59745-221-2_11openalex-snapshot
Overview of the DNA Damage Checkpoint
inferred← citeshttps://doi.org/10.1007/978-1-59745-221-2_3openalex-snapshot
Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival
inferred← citeshttps://doi.org/10.1007/978-1-60761-178-3_5openalex-snapshot
Interplay of 14-3-3 Family of Proteins with DNA Damage-Regulated Molecules in Checkpoint Control
inferred← citeshttps://doi.org/10.1007/978-1-61779-273-1_10openalex-snapshot
Study of Cell Cycle Checkpoints Using Xenopus Cell-Free Extracts
inferred← citeshttps://doi.org/10.1007/978-3-030-73572-2_2openalex-snapshot
Par-4 in Cell Cycle Regulation
inferred← citeshttps://doi.org/10.1007/978-3-540-34506-0_3openalex-snapshot
Chronic Myeloid Leukemia: Biology of Advanced Phase
inferred← citeshttps://doi.org/10.1007/978-90-481-2561-6_18openalex-snapshot
BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment
inferred← citeshttps://doi.org/10.1007/978-981-16-1873-4_4openalex-snapshot
Genetic Alterations in Ovarian Cancer as Prognostic and Predictive Biomarkers of Therapy Response and Surgical Outcomes
inferred← citeshttps://doi.org/10.1007/b136684openalex-snapshot
Checkpoint and Coordinated Cellular Responses to DNA Damage
inferred← citeshttps://doi.org/10.1007/s00044-013-0471-1openalex-snapshot
Molecular docking and 3D-QSAR studies on checkpoint kinase 1 inhibitors
inferred← citeshttps://doi.org/10.1007/s00204-017-2004-zopenalex-snapshot
Low concentrations of antimony impair DNA damage signaling and the repair of radiation-induced DSB in HeLa S3 cells
inferred← citeshttps://doi.org/10.1007/s00277-023-05359-3openalex-snapshot
Enhanced efficacy of combined fluzoparib and chidamide targeting in natural killer/T-cell lymphoma
inferred← citeshttps://doi.org/10.1007/s00404-019-05292-9openalex-snapshot
The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature
inferred← citeshttps://doi.org/10.1007/s00775-015-1271-5openalex-snapshot
Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination
inferred← citeshttps://doi.org/10.1007/s10142-021-00806-8openalex-snapshot
Testis transcriptome profiling identified lncRNAs involved in spermatogenic arrest of cattleyak
inferred← citeshttps://doi.org/10.1007/s10269-005-0283-0openalex-snapshot
Quelle place tiennent les gènes BRCA1 et BRCA2 dans les risques héréditaires de cancer de l’ovaire?
inferred← citeshttps://doi.org/10.1007/s10549-006-9461-zopenalex-snapshot
Mutation analysis of five candidate genes in familial breast cancer
inferred← citeshttps://doi.org/10.1007/s10571-011-9760-8openalex-snapshot
Gossypin Induces G2/M Arrest in Human Malignant Glioma U251 Cells by the Activation of Chk1/Cdc25C Pathway
inferred← citeshttps://doi.org/10.1007/s10689-010-9360-7openalex-snapshot
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families
inferred← citeshttps://doi.org/10.1007/s11177-005-0180-zopenalex-snapshot
Population Genetic Analysis of the Association Between the BRCA1 and P53 Gene Polymorphisms and the Risk of Sporadic Breast Cancer
inferred← citeshttps://doi.org/10.1007/s11433-010-4022-1openalex-snapshot
BRCA1 and its phosphorylation involved in caffeine-inhibitable event upstream of G2 checkpoint
inferred← citeshttps://doi.org/10.1007/s13238-010-0010-5openalex-snapshot
The role of BRCA1 in DNA damage response
inferred← citeshttps://doi.org/10.1007/s40291-017-0302-zopenalex-snapshot
Checkpoint Kinase 1 Expression Predicts Poor Prognosis in Nigerian Breast Cancer Patients
inferred← citeshttps://doi.org/10.1016/b978-0-12-380866-0.60011-3openalex-snapshot
Epigenetic Drivers of Genetic Alterations
inferred← citeshttps://doi.org/10.1016/b978-0-12-380888-2.00003-0openalex-snapshot
The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage Signaling and Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-383834-6.00093-8openalex-snapshot
Cancer of the Breast and Female Reproductive Tract
inferred← citeshttps://doi.org/10.1016/b978-0-12-384999-1.10009-5openalex-snapshot
Defective DNA Mismatch Repair-dependent c-Abl-p73-GADD45α Expression Confers Cancer Chemoresistance
inferred← citeshttps://doi.org/10.1016/b978-0-323-85679-9.00020-9openalex-snapshot
Homologous recombination in mammalian cells: From molecular mechanisms to pathology
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2018.10.007openalex-snapshot
Claspin: From replication stress and DNA damage responses to cancer therapy
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2018.11.004openalex-snapshot
Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling
inferred← citeshttps://doi.org/10.1016/j.bbaexp.2005.02.006openalex-snapshot
Identification of a novel Wee1 isoform
inferred← citeshttps://doi.org/10.1016/j.bbapap.2014.07.019openalex-snapshot
Emergence of structure through protein–protein interactions and pH changes in dually predicted coiled-coil and disordered regions of centrosomal proteins
inferred← citeshttps://doi.org/10.1016/j.bbcan.2006.07.001openalex-snapshot
BRCA1—A good predictive marker of drug sensitivity in breast cancer treatment?
inferred← citeshttps://doi.org/10.1016/j.bbcan.2007.10.004openalex-snapshot
Taxanes, microtubules and chemoresistant breast cancer
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.11.008openalex-snapshot
Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells
inferred← citeshttps://doi.org/10.1016/j.biocel.2012.06.026openalex-snapshot
BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest
inferred← citeshttps://doi.org/10.1016/j.biocel.2018.12.013openalex-snapshot
Human RAD52 protein regulates homologous recombination and checkpoint function in BRCA2 deficient cells
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121458openalex-snapshot
Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.01.071openalex-snapshot
Effect of 3,4-ethylenedioxy-extension of thiophene core on the DNA/RNA binding properties and biological activity of bisbenzimidazole amidines
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.05.027openalex-snapshot
Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.canlet.2005.04.037openalex-snapshot
BRCA1 regulation of transcription
inferred← citeshttps://doi.org/10.1016/j.canlet.2007.07.019openalex-snapshot
Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations
inferred← citeshttps://doi.org/10.1016/j.canlet.2008.04.046openalex-snapshot
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites
inferred← citeshttps://doi.org/10.1016/j.cdev.2026.204093openalex-snapshot
Functions and mechanisms of BRCA1 in early embryonic development
inferred← citeshttps://doi.org/10.1016/j.cell.2006.10.020openalex-snapshot
A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?
inferred← citeshttps://doi.org/10.1016/j.cellbi.2008.07.018openalex-snapshot
Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2012.07.011openalex-snapshot
Down-regulation of estrogen receptor α (ERα) transcriptional activity by p27 is mediated by inhibition of ERα nuclear localization and modulation of the ERα transcriptional complex
inferred← citeshttps://doi.org/10.1016/j.cellsig.2021.110032openalex-snapshot
Regulation of PCTAIRE1 protein stability by AKT1, LKB1 and BRCA1
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107974openalex-snapshot
L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108058openalex-snapshot
LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108921openalex-snapshot
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111475openalex-snapshot
A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117997openalex-snapshot
Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma
inferred← citeshttps://doi.org/10.1016/j.chembiol.2018.02.012openalex-snapshot
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
inferred← citeshttps://doi.org/10.1016/j.cllc.2021.01.009openalex-snapshot
Therapeutic Potential of Olaparib in Combination With Pembrolizumab in a Young Patient With a Maternally Inherited BRCA2 Germline Variant: A Research Report
inferred← citeshttps://doi.org/10.1016/j.clon.2005.11.013openalex-snapshot
Radiotherapy and Genetic Predisposition to Breast Cancer
inferred← citeshttps://doi.org/10.1016/j.cub.2005.11.066openalex-snapshot
Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response
inferred← citeshttps://doi.org/10.1016/j.cub.2012.07.034openalex-snapshot
A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair
inferred← citeshttps://doi.org/10.1016/j.dnarep.2004.03.007openalex-snapshot
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
inferred← citeshttps://doi.org/10.1016/j.dnarep.2004.03.017openalex-snapshot
53BP1, an activator of ATM in response to DNA damage
inferred← citeshttps://doi.org/10.1016/j.dnarep.2004.03.026openalex-snapshot
The DNA double-strand break response pathway: becoming more BRCAish than ever
inferred← citeshttps://doi.org/10.1016/j.dnarep.2004.03.029openalex-snapshot
DNA damage-induced activation of ATM and ATM-dependent signaling pathways
inferred← citeshttps://doi.org/10.1016/j.dnarep.2006.12.009openalex-snapshot
Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications
inferred← citeshttps://doi.org/10.1016/j.dnarep.2009.01.013openalex-snapshot
Regulatory ubiquitylation in response to DNA double-strand breaks
inferred← citeshttps://doi.org/10.1016/j.dnarep.2010.09.011openalex-snapshot
The ubiquitous role of ubiquitin in the DNA damage response
inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.12.009openalex-snapshot
ATM kinase: Much more than a DNA damage responsive protein
inferred← citeshttps://doi.org/10.1016/j.dnarep.2021.103076openalex-snapshot
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses
inferred← citeshttps://doi.org/10.1016/j.ejcb.2014.01.005openalex-snapshot
Emerging roles of MCPH1: Expedition from primary microcephaly to cancer
inferred← citeshttps://doi.org/10.1016/j.eml.2015.10.002openalex-snapshot
Filtering noise from time series by means of elastic wave propagation and flux-corrected transport in a discrete medium
inferred← citeshttps://doi.org/10.1016/j.fct.2013.12.026openalex-snapshot
Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells
inferred← citeshttps://doi.org/10.1016/j.gde.2003.12.003openalex-snapshot
DNA damage tumor suppressor genes and genomic instability
inferred← citeshttps://doi.org/10.1016/j.gene.2011.11.016openalex-snapshot
Mouse Wee1 Gene Is Repressed by Krüppel-Like Factor 3 (KLF3) via Interaction with Multiple Upstream Elements
inferred← citeshttps://doi.org/10.1016/j.ijgc.2026.104679openalex-snapshot
Decoding BRCA1 and BRCA2 Mutations in High-Grade Serous Ovarian Cancer: Impact of Location and Type of Mutation on Prognosis and PARP Inhibitor Treatment
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2003.09.042openalex-snapshot
Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110180openalex-snapshot
A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114352openalex-snapshot
PP2Acα regulates cerebellar development via phosphorylation-dependent neuronal programs
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2016.09.006openalex-snapshot
Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2013.09.018openalex-snapshot
A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway
inferred← citeshttps://doi.org/10.1016/j.jtbi.2008.05.027openalex-snapshot
A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
inferred← citeshttps://doi.org/10.1016/j.kint.2022.07.003openalex-snapshot
Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1
inferred← citeshttps://doi.org/10.1016/j.mce.2010.01.019openalex-snapshot
AKT regulates BRCA1 stability in response to hormone signaling
inferred← citeshttps://doi.org/10.1016/j.mehy.2011.05.029openalex-snapshot
The short estrous cycle of mice may influence the effect of BRCA1 mutations
inferred← citeshttps://doi.org/10.1016/j.molcel.2008.12.022openalex-snapshot
Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization
inferred← citeshttps://doi.org/10.1016/j.molcel.2009.06.036openalex-snapshot
Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage
inferred← citeshttps://doi.org/10.1016/j.molcel.2012.02.015openalex-snapshot
BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.07.036openalex-snapshot
β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2005.02.014openalex-snapshot
Activation of DNA damage signaling
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2009.02.003openalex-snapshot
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2012.04.005openalex-snapshot
Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.mrrev.2012.06.002openalex-snapshot
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
inferred← citeshttps://doi.org/10.1016/j.mrrev.2012.12.001openalex-snapshot
Non-targeted effects of ionising radiation—Implications for low dose risk
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2016.02.007openalex-snapshot
Cancer TARGETases: DSB repair as a pharmacological target
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.108009openalex-snapshot
The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2022.102356openalex-snapshot
BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance
inferred← citeshttps://doi.org/10.1016/j.semcancer.2004.09.007openalex-snapshot
Can chromosomal instability initiate tumorigenesis?
inferred← citeshttps://doi.org/10.1016/j.semcancer.2006.03.002openalex-snapshot
14-3-3 proteins in cell cycle regulation
inferred← citeshttps://doi.org/10.1016/j.semcancer.2006.03.009openalex-snapshot
Regulation of the p53-MDM2 pathway by 14-3-3 σ and other proteins
inferred← citeshttps://doi.org/10.1016/j.semcdb.2005.02.011openalex-snapshot
The S phase checkpoint: When the crowd meets at the fork
inferred← citeshttps://doi.org/10.1016/j.semcdb.2011.10.007openalex-snapshot
DNA double-strand break repair pathways, chromosomal rearrangements and cancer
inferred← citeshttps://doi.org/10.1016/j.str.2004.06.002openalex-snapshot
Structural Basis of BACH1 Phosphopeptide Recognition by BRCA1 Tandem BRCT Domains
inferred← citeshttps://doi.org/10.1016/j.tips.2016.06.006openalex-snapshot
Targeting WEE1 Kinase in Cancer
inferred← citeshttps://doi.org/10.1016/j.tox.2005.07.026openalex-snapshot
Prolonged exposure to arecoline arrested human KB epithelial cell growth: Regulatory mechanisms of cell cycle and apoptosis
inferred← citeshttps://doi.org/10.1016/j.toxlet.2014.03.015openalex-snapshot
Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS/JNK pathway in human breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.tree.2007.12.007openalex-snapshot
Evolutionary dynamics of cancer
inferred← citeshttps://doi.org/10.1016/j.xgen.2023.100362openalex-snapshot
Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity
inferred← citeshttps://doi.org/10.1016/j.yexcr.2004.05.004openalex-snapshot
BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
inferred← citeshttps://doi.org/10.1016/j.yexcr.2012.11.013openalex-snapshot
The role of BRCA1 in DNA double-strand repair: Past and present
inferred← citeshttps://doi.org/10.1016/s0006-291x(02)02751-1openalex-snapshot
Identification of genes induced by BRCA1 in breast cancer cells
inferred← citeshttps://doi.org/10.1016/s0014-5793(03)00978-5openalex-snapshot
BRCA1 interacts with FHL2 and enhances FHL2 transactivation function
inferred← citeshttps://doi.org/10.1016/s0027-5107(02)00217-8openalex-snapshot
Polymorphisms in DNA repair and environmental interactions
inferred← citeshttps://doi.org/10.1016/s0027-5107(02)00224-5openalex-snapshot
Recombinational DNA repair and human disease
inferred← citeshttps://doi.org/10.1016/s0070-2153(04)63001-8openalex-snapshot
Early Events in the DNA Damage Response
inferred← citeshttps://doi.org/10.1016/s0092-8674(02)01113-3openalex-snapshot
ATR Regulates Fragile Site Stability
inferred← citeshttps://doi.org/10.1016/s0168-9525(03)00193-8openalex-snapshot
BRCA1: a scaffold for p53 response?
inferred← citeshttps://doi.org/10.1016/s0169-5002(02)00188-5openalex-snapshot
β-Tubulin mutational analysis: tantalizing findings
inferred← citeshttps://doi.org/10.1016/s0169-5002(02)00224-6openalex-snapshot
DNA repair and cisplatin resistance in non-small-cell lung cancer
inferred← citeshttps://doi.org/10.1016/s1471-4914(02)02434-6openalex-snapshot
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition
inferred← citeshttps://doi.org/10.1016/s1535-6108(03)00110-7openalex-snapshot
Chk1 and Chk2 kinases in checkpoint control and cancer
inferred← citeshttps://doi.org/10.1021/acs.jproteome.8b00129openalex-snapshot
HTRA1-Dependent Cell Cycle Proteomics
inferred← citeshttps://doi.org/10.1021/bi049550qopenalex-snapshot
Solution Structure, Backbone Dynamics, and Association Behavior of the C-Terminal BRCT Domain from the Breast Cancer-Associated Protein BRCA1,
inferred← citeshttps://doi.org/10.1021/cr800414eopenalex-snapshot
The Multiple Layers of Ubiquitin-Dependent Cell Cycle Control
inferred← citeshttps://doi.org/10.1021/jm061247vopenalex-snapshot
Structure-Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors
inferred← citeshttps://doi.org/10.1023/b:canc.0000031762.91306.b4openalex-snapshot
Radiation and the cell cycle, revisited
inferred← citeshttps://doi.org/10.1038/bjc.2014.576openalex-snapshot
Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response
inferred← citeshttps://doi.org/10.1038/ncb1969openalex-snapshot
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
inferred← citeshttps://doi.org/10.1038/ng1627openalex-snapshot
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
inferred← citeshttps://doi.org/10.1038/nrc1011openalex-snapshot
ATM and related protein kinases: safeguarding genome integrity
inferred← citeshttps://doi.org/10.1038/nrc1321openalex-snapshot
Tracing the network connecting brca and fanconi anaemia proteins
inferred← citeshttps://doi.org/10.1038/nrc1412openalex-snapshot
Pathways of apoptotic and non-apoptotic death in tumour cells
inferred← citeshttps://doi.org/10.1038/nrc2147openalex-snapshot
Chronic myeloid leukaemia as a model of disease evolution in human cancer
inferred← citeshttps://doi.org/10.1038/nrc2169openalex-snapshot
CDC25 phosphatases in cancer cells: key players? Good targets?
inferred← citeshttps://doi.org/10.1038/nrm2831openalex-snapshot
BRCA1 and its toolbox for the maintenance of genome integrity
inferred← citeshttps://doi.org/10.1038/nsmb1277openalex-snapshot
CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response
inferred← citeshttps://doi.org/10.1038/nsmb1279openalex-snapshot
CCDC98 targets BRCA1 to DNA damage sites
inferred← citeshttps://doi.org/10.1038/nsmb953openalex-snapshot
BRCA1 participates in DNA decatenation
inferred← citeshttps://doi.org/10.1038/onc.2010.163openalex-snapshot
Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
inferred← citeshttps://doi.org/10.1038/onc.2012.522openalex-snapshot
BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation
inferred← citeshttps://doi.org/10.1038/onc.2013.329openalex-snapshot
Opportunities and hurdles in the treatment of BRCA1-related breast cancer
inferred← citeshttps://doi.org/10.1038/s12276-018-0169-zopenalex-snapshot
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors
inferred← citeshttps://doi.org/10.1038/s41388-018-0127-1openalex-snapshot
BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis
inferred← citeshttps://doi.org/10.1038/s41388-018-0535-2openalex-snapshot
PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response
inferred← citeshttps://doi.org/10.1038/s41419-018-0362-yopenalex-snapshot
Sei-1 promotes double minute chromosomes formation through activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts
inferred← citeshttps://doi.org/10.1038/s41467-021-21519-3openalex-snapshot
A synergetic effect of BARD1 mutations on tumorigenesis
inferred← citeshttps://doi.org/10.1038/s41598-017-03816-4openalex-snapshot
Structural basis to stabilize the domain motion of BARD1-ARD BRCT by CstF50
inferred← citeshttps://doi.org/10.1038/s41598-021-86070-zopenalex-snapshot
A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
inferred← citeshttps://doi.org/10.1038/s41598-021-89170-yopenalex-snapshot
Single-cell transcriptome profiling of buffelgrass (Cenchrus ciliaris) eggs unveils apomictic parthenogenesis signatures
inferred← citeshttps://doi.org/10.1038/s42256-019-0119-zopenalex-snapshot
Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach
inferred← citeshttps://doi.org/10.1038/sj.emboj.7600608openalex-snapshot
Regulation of NF‐κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
inferred← citeshttps://doi.org/10.1038/sj.onc.1205713openalex-snapshot
Roles of BRCA1 in centrosome duplication
inferred← citeshttps://doi.org/10.1038/sj.onc.1206177openalex-snapshot
The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans
inferred← citeshttps://doi.org/10.1038/sj.onc.1206439openalex-snapshot
BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest
inferred← citeshttps://doi.org/10.1038/sj.onc.1206676openalex-snapshot
The role of the ubiquitin/proteasome system in cellular responses to radiation
inferred← citeshttps://doi.org/10.1038/sj.onc.1206682openalex-snapshot
DNA damage checkpoint control in cells exposed to ionizing radiation
inferred← citeshttps://doi.org/10.1038/sj.onc.1207000openalex-snapshot
Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1
inferred← citeshttps://doi.org/10.1038/sj.onc.1208273openalex-snapshot
Polo-like kinases and oncogenesis
inferred← citeshttps://doi.org/10.1038/sj.onc.1208492openalex-snapshot
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
inferred← citeshttps://doi.org/10.1038/sj.onc.1208710openalex-snapshot
53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage
inferred← citeshttps://doi.org/10.1038/sj.onc.1209447openalex-snapshot
Chk1 is required to maintain Claspin stability
inferred← citeshttps://doi.org/10.1038/sj.onc.1209466openalex-snapshot
Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
inferred← citeshttps://doi.org/10.1038/sj.onc.1209481openalex-snapshot
Negative cell cycle regulator 14-3-3σ stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt
inferred← citeshttps://doi.org/10.1038/sj.onc.1209872openalex-snapshot
The role of BRCA1 in transcriptional regulation and cell cycle control
inferred← citeshttps://doi.org/10.1038/sj.onc.1209874openalex-snapshot
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability
inferred← citeshttps://doi.org/10.1042/bj20021284openalex-snapshot
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
inferred← citeshttps://doi.org/10.1053/j.seminoncol.2015.09.024openalex-snapshot
Targeting Cyclin-Dependent Kinases and Cell Cycle Progression in Human Cancers
inferred← citeshttps://doi.org/10.1073/pnas.0401847101openalex-snapshot
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
inferred← citeshttps://doi.org/10.1073/pnas.0409130102openalex-snapshot
DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint
inferred← citeshttps://doi.org/10.1073/pnas.0611584104openalex-snapshot
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes
inferred← citeshttps://doi.org/10.1073/pnas.1203326109openalex-snapshot
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation
inferred← citeshttps://doi.org/10.1073/pnas.1217781110openalex-snapshot
Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling
inferred← citeshttps://doi.org/10.1073/pnas.1619302114openalex-snapshot
Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice
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