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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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IL‐23‐mediated regulation of IL‐17 production in Helicobacter pylori‐infected gastric mucosa
inferredcites →https://doi.org/10.1016/j.ccr.2005.04.014openalex-snapshot
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
inferredcites →https://doi.org/10.1016/j.ccr.2008.04.001openalex-snapshot
TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis
inferredcites →https://doi.org/10.1016/j.ccr.2008.12.018openalex-snapshot
Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment
inferredcites →https://doi.org/10.1016/j.ccr.2009.01.001openalex-snapshot
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
inferredcites →https://doi.org/10.1016/j.ccr.2009.01.002openalex-snapshot
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
inferredcites →https://doi.org/10.1016/j.cell.2004.07.013openalex-snapshot
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
inferredcites →https://doi.org/10.1016/j.cell.2006.07.035openalex-snapshot
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
inferredcites →https://doi.org/10.1016/j.femsle.2005.01.029openalex-snapshot
Sporadic colorectal cancer – role of the commensal microbiota
inferredcites →https://doi.org/10.1016/j.immuni.2007.02.009openalex-snapshot
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
inferredcites →https://doi.org/10.1016/j.molmed.2007.12.007openalex-snapshot
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
inferredcites →https://doi.org/10.1016/s0002-9440(10)63863-1openalex-snapshot
CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice
inferredcites →https://doi.org/10.1038/nature04754openalex-snapshot
Transforming growth factor-β induces development of the TH17 lineage
inferredcites →https://doi.org/10.1038/nature04808openalex-snapshot
IL-23 promotes tumour incidence and growth
inferredcites →https://doi.org/10.1038/nature06309openalex-snapshot
Adaptive immunity maintains occult cancer in an equilibrium state
inferredcites →https://doi.org/10.1038/ni0907-903openalex-snapshot
TH-17 differentiation: of mice and men
inferredcites →https://doi.org/10.1038/nm1743openalex-snapshot
Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
inferredcites →https://doi.org/10.1038/nrc1275openalex-snapshot
The STATs of cancer — new molecular targets come of age
inferredcites →https://doi.org/10.1038/nri1703openalex-snapshot
NF-κB: linking inflammation and immunity to cancer development and progression
inferredcites →https://doi.org/10.1038/nri1961openalex-snapshot
Interferons, immunity and cancer immunoediting
inferredcites →https://doi.org/10.1038/nri1995openalex-snapshot
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
inferredcites →https://doi.org/10.1038/nri2340openalex-snapshot
The genetics and immunopathogenesis of inflammatory bowel disease
inferredcites →https://doi.org/10.1038/nrm909openalex-snapshot
STATs: transcriptional control and biological impact
inferredcites →https://doi.org/10.1053/gast.2003.50047openalex-snapshot
Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation
inferredcites →https://doi.org/10.1053/gast.2003.50094openalex-snapshot
Pathology of mouse models of intestinal cancer: Consensus report and recommendations
inferredcites →https://doi.org/10.1053/j.gastro.2007.04.061openalex-snapshot
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
inferredcites →https://doi.org/10.1056/nejmra020542openalex-snapshot
Helicobacter pylori Infection
inferredcites →https://doi.org/10.1073/pnas.0600666103openalex-snapshot
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
inferredcites →https://doi.org/10.1073/pnas.95.25.14979openalex-snapshot
Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
inferredcites →https://doi.org/10.1084/jem.20061082openalex-snapshot
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
inferredcites →https://doi.org/10.1084/jem.20061099openalex-snapshot
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
inferredcites →https://doi.org/10.1086/321998openalex-snapshot
Bacterial Infection Promotes Colon Tumorigenesis in Apc Min/+ Mice
inferredcites →https://doi.org/10.1086/591130openalex-snapshot
Association of EnterotoxigenicBacteroides fragilisInfection with Inflammatory Diarrhea
inferredcites →https://doi.org/10.1093/carcin/bgm180openalex-snapshot
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
inferredcites →https://doi.org/10.1111/j.1469-0691.2006.01494.xopenalex-snapshot
A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
inferredcites →https://doi.org/10.1126/science.1140485openalex-snapshot
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
inferredcites →https://doi.org/10.1126/science.1140488openalex-snapshot
Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88
inferredcites →https://doi.org/10.1126/science.1350108openalex-snapshot
Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
inferredcites →https://doi.org/10.1128/cmr.00053-08openalex-snapshot
Enterotoxigenic Bacteroides fragilis : a Rogue among Symbiotes
inferredcites →https://doi.org/10.1128/iai.00814-08openalex-snapshot
Induction of Persistent Colitis by a Human Commensal, EnterotoxigenicBacteroides fragilis, in Wild-Type C57BL/6 Mice
inferredcites →https://doi.org/10.1128/iai.01604-07openalex-snapshot
Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c- Rag2 −/− Apc Min /+ Mouse
inferredcites →https://doi.org/10.1146/annurev.immunol.25.022106.141557openalex-snapshot
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2448openalex-snapshot
Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3445openalex-snapshot
Proinflammatory CD4+CD45RBhi Lymphocytes Promote Mammary and Intestinal Carcinogenesis in Apc Min/+ Mice
inferredcites →https://doi.org/10.4049/jimmunol.179.7.4313openalex-snapshot
Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity
inferredcites →https://doi.org/10.4049/jimmunol.180.1.559openalex-snapshot
Commensal Gut Flora Drives the Expansion of Proinflammatory CD4 T Cells in the Colonic Lamina Propria under Normal and Inflammatory Conditions

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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RORγt+ hematopoietic cells are necessary for tumor cell proliferation during colitis‐associated tumorigenesis in mice
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Th17 cytokines in non‐melanoma skin cancer
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inferred← citeshttps://doi.org/10.1002/hep.24486openalex-snapshot
Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
inferred← citeshttps://doi.org/10.1002/ibd.21248openalex-snapshot
IL-23/IL-17 axis in IBD
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Toll-like receptors in inflammatory bowel diseases: A decade later
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Shift from pStat6 to pStat3 Predominance Is Associated with Inflammatory Bowel Disease-Associated Dysplasia
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Multiomic spatial atlas shows deleted in malignant brain tumors 1 ( DMBT1 ) glycoprotein is lost in colonic dysplasia
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Microbiome and Diseases: Pathogen Infection
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The Family Coriobacteriaceae
inferred← citeshttps://doi.org/10.1007/978-3-662-44006-3_3openalex-snapshot
Role of Innate Immunity in Cancers and Antitumor Response
inferred← citeshttps://doi.org/10.1007/978-3-662-46410-6_11openalex-snapshot
Immunology and Immunotherapy of Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/978-3-662-46764-0_251-1openalex-snapshot
Infektionen als Tumorursache: Bakterien und Darmkrebs
inferred← citeshttps://doi.org/10.1007/978-3-662-70291-8_8openalex-snapshot
Ernährung zur Krebsprävention und -therapie
inferred← citeshttps://doi.org/10.1007/978-4-431-54442-5_3openalex-snapshot
The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders
inferred← citeshttps://doi.org/10.1007/978-94-007-0782-5_2openalex-snapshot
Horizontal Gene Transfers with or without Cell Fusions in All Categories of the Living Matter
inferred← citeshttps://doi.org/10.1007/978-94-007-5955-8_3openalex-snapshot
The Role of Bacteria in Cancer Development
inferred← citeshttps://doi.org/10.1007/978-94-007-5955-8_6openalex-snapshot
Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis
inferred← citeshttps://doi.org/10.1007/978-94-007-6217-6_13openalex-snapshot
T Cell Mulfunction in the Tumor Environment
inferred← citeshttps://doi.org/10.1007/978-94-017-8841-0_5openalex-snapshot
Lactic Acid Bacteria in Health and Disease
inferred← citeshttps://doi.org/10.1007/978-94-017-9487-9_5openalex-snapshot
Th17 Differentiation and Their Pro-inflammation Function
inferred← citeshttps://doi.org/10.1007/978-981-10-5987-2_7openalex-snapshot
Microbial Factors in Inflammatory Diseases and Cancers
inferred← citeshttps://doi.org/10.1007/978-981-16-3156-6_4openalex-snapshot
Diversity and Dynamics of the Gut Microbiome and Immune Cells
inferred← citeshttps://doi.org/10.1007/978-981-16-5759-7_2openalex-snapshot
Technologies for Identification and Validation of Cancer Biomarkers
inferred← citeshttps://doi.org/10.1007/978-981-16-5759-7_5openalex-snapshot
Microbiome as Cancer Biomarkers
inferred← citeshttps://doi.org/10.1007/978-981-19-4492-5_12openalex-snapshot
Animal Models in the Study of Microbiome in Gastrointestinal Cancer
inferred← citeshttps://doi.org/10.1007/978-981-19-4492-5_16openalex-snapshot
Targeting Gut Microbiota in Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/978-981-19-4492-5_2openalex-snapshot
Gut Microbiome in Health and Gastrointestinal Cancer
inferred← citeshttps://doi.org/10.1007/978-981-19-4492-5_3openalex-snapshot
Microbiome in Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/978-981-19-9786-0_24openalex-snapshot
Importance of Gut Microbiome-Based Therapeutics in Cancer Treatment
inferred← citeshttps://doi.org/10.1007/978-981-32-9393-9_8openalex-snapshot
Role of Inflammatory Cytokines in the Initiation and Progression of Pancreatic Cancer
inferred← citeshttps://doi.org/10.1007/978-981-95-9031-5_3openalex-snapshot
The Gut-Cancer Connection and Microbial Insights
inferred← citeshttps://doi.org/10.1007/978-981-97-4612-5_3openalex-snapshot
Prostate Cancer and Inflammation
inferred← citeshttps://doi.org/10.1007/978-981-99-1183-7_25openalex-snapshot
Systemic Onco-Sphere: Host Microbiome and Cancer
inferred← citeshttps://doi.org/10.1007/978-981-99-3126-2_18openalex-snapshot
Emerging Role of Gut Microbiome in Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-981-99-5114-7_12openalex-snapshot
Role of Microbiomes in Defining the Metabolic and Regulatory Networks that Distinguishes Between Good Health and a Continuum of Disease States
inferred← citeshttps://doi.org/10.1007/978-981-99-5114-7_3openalex-snapshot
Role of Gut Microbiome Composition in Shaping Host Immune System Development and Health
inferred← citeshttps://doi.org/10.1007/s00005-021-00641-6openalex-snapshot
The Role of Gut Microbiota in Gastrointestinal Tract Cancers
inferred← citeshttps://doi.org/10.1007/s00011-017-1067-xopenalex-snapshot
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells
inferred← citeshttps://doi.org/10.1007/s00018-012-1163-6openalex-snapshot
Diversity of IL-17-producing T lymphocytes
inferred← citeshttps://doi.org/10.1007/s00018-014-1636-xopenalex-snapshot
Colitis-associated neoplasia: molecular basis and clinical translation
inferred← citeshttps://doi.org/10.1007/s00018-015-2045-5openalex-snapshot
lnflammation-induced epigenetic switches in cancer
inferred← citeshttps://doi.org/10.1007/s00109-013-1021-5openalex-snapshot
The metastasis-promoting roles of tumor-associated immune cells
inferred← citeshttps://doi.org/10.1007/s00198-012-2204-6openalex-snapshot
How important is vitamin D in preventing infections?
inferred← citeshttps://doi.org/10.1007/s00248-013-0245-9openalex-snapshot
Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients
inferred← citeshttps://doi.org/10.1007/s00253-020-10863-xopenalex-snapshot
Synbiotic VSL#3 and yacon-based product modulate the intestinal microbiota and prevent the development of pre-neoplastic lesions in a colorectal carcinogenesis model
inferred← citeshttps://doi.org/10.1007/s00253-025-13537-8openalex-snapshot
Colorectal cancer biofilm composition reveals distinct bacterial species signature
inferred← citeshttps://doi.org/10.1007/s00262-010-0849-6openalex-snapshot
Th17 cells: positive or negative role in tumor?
inferred← citeshttps://doi.org/10.1007/s00262-011-1046-yopenalex-snapshot
Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer
inferred← citeshttps://doi.org/10.1007/s00262-012-1312-7openalex-snapshot
Generation and immunologic functions of Th17 cells in malignant gliomas
inferred← citeshttps://doi.org/10.1007/s00262-015-1769-2openalex-snapshot
Deficiency of IL-17A, but not the prototypical Th17 transcription factor RORγt, decreases murine spontaneous intestinal tumorigenesis
inferred← citeshttps://doi.org/10.1007/s00262-017-1993-zopenalex-snapshot
Cancer immunotherapy: how low-level ionizing radiation can play a key role
inferred← citeshttps://doi.org/10.1007/s00277-011-1318-9openalex-snapshot
Circulating IL-17 levels during the peri-transplant period as a predictor for early leukemia relapse after myeloablative allogeneic stem cell transplantation
inferred← citeshttps://doi.org/10.1007/s00281-012-0352-6openalex-snapshot
Inflammation and colorectal cancer: colitis-associated neoplasia
inferred← citeshttps://doi.org/10.1007/s00281-014-0457-1openalex-snapshot
Microbiome and cancer
inferred← citeshttps://doi.org/10.1007/s00292-012-1642-4openalex-snapshot
Pathogenese des kolitisassoziierten Karzinoms
inferred← citeshttps://doi.org/10.1007/s00384-022-04192-wopenalex-snapshot
The role of gut microbiota in the development of colorectal cancer: a review
inferred← citeshttps://doi.org/10.1007/s00384-022-04202-xopenalex-snapshot
Risk of colon cancer-related death in people who had cancer in the past
inferred← citeshttps://doi.org/10.1007/s00384-024-04686-9openalex-snapshot
Role of blood metabolites in mediating the effect of gut microbiome on the mutated-RAS/BRAF metastatic colorectal cancer-specific survival
inferred← citeshttps://doi.org/10.1007/s00430-018-0542-5openalex-snapshot
Gut microbiome of Moroccan colorectal cancer patients
inferred← citeshttps://doi.org/10.1007/s00432-018-2816-0openalex-snapshot
Microbiota in cancer development and treatment
inferred← citeshttps://doi.org/10.1007/s00432-020-03462-wopenalex-snapshot
Uncovering the microbiota in renal cell carcinoma tissue using 16S rRNA gene sequencing
inferred← citeshttps://doi.org/10.1007/s00432-023-05244-6openalex-snapshot
Microbiota as the unifying factor behind the hallmarks of cancer
inferred← citeshttps://doi.org/10.1007/s00432-025-06401-9openalex-snapshot
Unveiling hidden players: the role of intratumoral microbiota in gastrointestinal cancer dynamics
inferred← citeshttps://doi.org/10.1007/s00439-020-02235-2openalex-snapshot
The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecular pathological epidemiology to analyze the tumor–immune–microbiome interaction
inferred← citeshttps://doi.org/10.1007/s00595-026-03489-5openalex-snapshot
Association between Clostridium septicum and Streptococcus gallolyticus bacteremia and colorectal neoplasms
inferred← citeshttps://doi.org/10.1007/s00761-020-00882-8openalex-snapshot
(Mögliche) Rolle des Mikrobioms in der Diagnostik, Therapie und Genese des Kolonkarzinoms
inferred← citeshttps://doi.org/10.1007/s10096-015-2425-7openalex-snapshot
Fecal detection of enterotoxigenic Bacteroides fragilis
inferred← citeshttps://doi.org/10.1007/s10096-016-2881-8openalex-snapshot
Gut microbiota and colorectal cancer
inferred← citeshttps://doi.org/10.1007/s10456-017-9583-4openalex-snapshot
Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions
inferred← citeshttps://doi.org/10.1007/s10522-024-10146-2openalex-snapshot
The dynamic crosslinking between gut microbiota and inflammation during aging: reviewing the nutritional and hormetic approaches against dysbiosis and inflammaging
inferred← citeshttps://doi.org/10.1007/s10555-010-9223-6openalex-snapshot
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity
inferred← citeshttps://doi.org/10.1007/s10555-015-9570-4openalex-snapshot
Targeting roles of inflammatory microenvironment in lung cancer and metastasis
inferred← citeshttps://doi.org/10.1007/s10555-022-10028-4openalex-snapshot
Inflammatory bowel disease and carcinogenesis
inferred← citeshttps://doi.org/10.1007/s10555-025-10256-4openalex-snapshot
Microbiota and cancer: unraveling the significant influence of microbial communities on cancer treatment
inferred← citeshttps://doi.org/10.1007/s10620-015-3646-4openalex-snapshot
Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1007/s10620-016-4238-7openalex-snapshot
Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer
inferred← citeshttps://doi.org/10.1007/s10753-022-01706-0openalex-snapshot
Phenotyping of Fecal Microbiota of Winnie, a Rodent Model of Spontaneous Chronic Colitis, Reveals Specific Metabolic, Genotoxic, and Pro-inflammatory Properties
inferred← citeshttps://doi.org/10.1007/s11033-022-07357-6openalex-snapshot
Gut microbiota: Role and Association with Tumorigenesis in Different Malignancies
inferred← citeshttps://doi.org/10.1007/s11102-011-0292-5openalex-snapshot
The expression of interleukin (IL)-17 and IL-17 receptor and MMP-9 in human pituitary adenomas
inferred← citeshttps://doi.org/10.1007/s11274-023-03742-wopenalex-snapshot
Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend
inferred← citeshttps://doi.org/10.1007/s11356-021-14593-zopenalex-snapshot
Microbiota’s role in health and diseases
inferred← citeshttps://doi.org/10.1007/s11356-023-25236-wopenalex-snapshot
Epigenetics and the role of nutraceuticals in health and disease
inferred← citeshttps://doi.org/10.1007/s11377-009-0398-8openalex-snapshot
UEGW-Update
inferred← citeshttps://doi.org/10.1007/s11695-021-05702-5openalex-snapshot
Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial
inferred← citeshttps://doi.org/10.1007/s11725-015-0608-4openalex-snapshot
Le système immunitaire dans la carcinogenèse colorectale : ami ou ennemi ?
inferred← citeshttps://doi.org/10.1007/s11739-012-0867-9openalex-snapshot
Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s11745-013-3816-0openalex-snapshot
Fish Oil Decreases C‐Reactive Protein/Albumin Ratio Improving Nutritional Prognosis and Plasma Fatty Acid Profile in Colorectal Cancer Patients
inferred← citeshttps://doi.org/10.1007/s11864-022-00960-6openalex-snapshot
The Microbiome: the Link to Colorectal Cancer and Research Opportunities
inferred← citeshttps://doi.org/10.1007/s11888-012-0153-2openalex-snapshot
Probiotics in the Prevention of Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/s11888-012-0158-xopenalex-snapshot
Intestinal Microbes, Diet, and Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/s11888-013-0196-zopenalex-snapshot
The Microbiota: A New Player in the Etiology of Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/s11888-019-00431-5openalex-snapshot
Deciphering the Colorectal Cancer Gut Microbiota: Association vs. Causality
inferred← citeshttps://doi.org/10.1007/s11888-020-00456-1openalex-snapshot
Immunotherapy in Colorectal Cancer: Potential of Fecal Transplant and Microbiota-Augmented Clinical Trials
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