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Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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GFAP promoter-controlled EGFP-expressing transgenic mice: A tool to visualize astrocytes and astrogliosis in living brain tissue
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Lactosylceramide Synthase as a Therapeutic Target to Mitigate Multiple Human Diseases in Animal Models
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Derivation of Primary Choroid Plexus Epithelial Cells from the Mouse
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Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease
inferredcites →https://doi.org/10.1016/j.jneuroim.2012.01.002openalex-snapshot
Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis
inferredcites →https://doi.org/10.1016/j.neuron.2008.09.011openalex-snapshot
Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System
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Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice
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CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes
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Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
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Resolvin E1 and protectin D1 activate inflammation-resolution programmes
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Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
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Experimental autoimmune encephalomyelitis repressed by microglial paralysis
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Lipid microarrays identify key mediators of autoimmune brain inflammation
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Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
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Lactosylceramide recruits PKCα/ε and phospholipase A 2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells
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IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair
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β4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development
inferredcites →https://doi.org/10.1093/glycob/cwt054openalex-snapshot
4GalT6 is involved in the synthesis of lactosylceramide with less intensity than 4GalT5
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Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair
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Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
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A Novel Role of Lactosylceramide in the Regulation of Lipopolysaccharide/Interferon-γ-Mediated Inducible Nitric Oxide Synthase Gene Expression: Implications for Neuroinflammatory Diseases
inferredcites →https://doi.org/10.1523/jneurosci.1514-09.2009openalex-snapshot
Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS
inferredcites →https://doi.org/10.1523/jneurosci.4178-07.2008openalex-snapshot
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
inferredcites →https://doi.org/10.1523/jneurosci.6221-11.2012openalex-snapshot
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IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes
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Lactosylceramide Mediates the Expression of Adhesion Molecules in TNF-α and IFNγ-stimulated Primary Cultured Astrocytes
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inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.116032openalex-snapshot
Dynamic contributions of astrocytes in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e10198openalex-snapshot
The First Pediatric Anti-Lactosylceramide Antibody-Positive Encephalomyeloradiculoneuropathy
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e37504openalex-snapshot
Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.123351openalex-snapshot
Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.04.006openalex-snapshot
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β
inferred← citeshttps://doi.org/10.1016/j.immuni.2026.03.007openalex-snapshot
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108771openalex-snapshot
The matrine derivate MASM inhibits astrocyte reactivity and alleviates experimental autoimmune encephalomyelitis in mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116736openalex-snapshot
The role of astrocytic GSDME in Sepsis-associated cognitive dysfunction
inferred← citeshttps://doi.org/10.1016/j.it.2016.06.006openalex-snapshot
Astrocytes: Key Regulators of Neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.it.2020.07.007openalex-snapshot
The Role of Astrocytes in CNS Inflammation
inferred← citeshttps://doi.org/10.1016/j.jare.2022.04.015openalex-snapshot
Docosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet
inferred← citeshttps://doi.org/10.1016/j.jare.2026.05.017openalex-snapshot
From barrier invasion to niche formation: mechanisms and therapies in breast cancer brain metastases
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100527openalex-snapshot
Adult astrocytes from reptiles are resistant to proinflammatory activation via sustaining Vav1 expression
inferred← citeshttps://doi.org/10.1016/j.jchemneu.2020.101872openalex-snapshot
MiR-497 promotes microglia activation and proinflammatory cytokines production in chronic unpredictable stress-induced depression via targeting FGF2
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2015.08.007openalex-snapshot
Enteric Glia Mediate Neuron Death in Colitis Through Purinergic Pathways That Require Connexin-43 and Nitric Oxide
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2025.101634openalex-snapshot
Hyperactive Enteric Glia Contribute to Persistent Dysmotility Following Inflammation by Driving Aberrant Excitatory Responses in Neurons
inferred← citeshttps://doi.org/10.1016/j.jinf.2021.12.004openalex-snapshot
MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection
inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100912openalex-snapshot
Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2017.12.017openalex-snapshot
Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2023.578180openalex-snapshot
Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2025.578801openalex-snapshot
Cytokine and chemokine production by astrocytes is influenced by Cystatin C
inferred← citeshttps://doi.org/10.1016/j.jns.2015.12.022openalex-snapshot
Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.jns.2017.12.022openalex-snapshot
Autoimmunity in multiple sclerosis: role of sphingolipids, invariant NKT cells and other immune elements in control of inflammation and neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120446openalex-snapshot
Ceramide kinase knockout ameliorates multiple sclerosis-like behaviors and demyelination in cuprizone-treated mice
inferred← citeshttps://doi.org/10.1016/j.lssr.2025.05.006openalex-snapshot
Shared mechanisms in neuromyelitis optica spectrum disorder and spaceflight-associated neuro-ocular syndrome: Insights into central nervous system fluid dynamics, glymphatic function, and astrocyte dysregulation
inferred← citeshttps://doi.org/10.1016/j.matbio.2018.03.022openalex-snapshot
Hyaluronan in immune dysregulation and autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.medmic.2023.100081openalex-snapshot
Regulation of host immune responses by Lactobacillus through aryl hydrocarbon receptors
inferred← citeshttps://doi.org/10.1016/j.msard.2019.101881openalex-snapshot
QKI-V5 is downregulated in CNS inflammatory demyelinating diseases
inferred← citeshttps://doi.org/10.1016/j.msard.2023.104565openalex-snapshot
Ceramide is implicated in humoral peripheral and intrathecal autoimmune response in MS patients
inferred← citeshttps://doi.org/10.1016/j.msard.2025.106319openalex-snapshot
Traditional Chinese medicine provides candidates for mutiple seclorsis: A review based on the progress of MS and potent treatment medicine
inferred← citeshttps://doi.org/10.1016/j.nbd.2019.104674openalex-snapshot
Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.105014openalex-snapshot
Ceramide signalling in inherited and multifactorial brain metabolic diseases
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105874openalex-snapshot
Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105914openalex-snapshot
The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE
inferred← citeshttps://doi.org/10.1016/j.nbd.2025.106999openalex-snapshot
Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration
inferred← citeshttps://doi.org/10.1016/j.neuint.2023.105591openalex-snapshot
Function and therapeutic value of astrocytes in diabetic cognitive impairment
inferred← citeshttps://doi.org/10.1016/j.neulet.2017.04.005openalex-snapshot
Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.neulet.2019.134532openalex-snapshot
Astrocytes in myelination and remyelination
inferred← citeshttps://doi.org/10.1016/j.neulet.2019.134599openalex-snapshot
Matrine alleviates astrogliosis through sphingosine 1-phosphate signaling in experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.neures.2018.08.013openalex-snapshot
Axonal and neuronal degeneration in myelin diseases
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2019.01.020openalex-snapshot
Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neuron.2018.01.021openalex-snapshot
Multiple Sclerosis: Mechanisms and Immunotherapy
inferred← citeshttps://doi.org/10.1016/j.neuron.2020.05.014openalex-snapshot
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes
inferred← citeshttps://doi.org/10.1016/j.neuron.2020.08.012openalex-snapshot
Astrocyte Crosstalk in CNS Inflammation
inferred← citeshttps://doi.org/10.1016/j.neuron.2024.06.020openalex-snapshot
Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.10.010openalex-snapshot
Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2015.05.053openalex-snapshot
Pathogenesis of depression: Insights from human and rodent studies
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.02.043openalex-snapshot
Role of β-1,3-galactosyltransferase 2 in trigeminal neuronal sensitization induced by peripheral inflammation
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.03.039openalex-snapshot
Mutual inhibitory interaction between M1 macrophages and Schwann cells in the myelin sheath of auditory nerves
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.10.017openalex-snapshot
Beyond Krabbe disease, the intriguing connection of galactocerebrosidase (GALC) with nervous system illness: A novel risk factor?
inferred← citeshttps://doi.org/10.1016/j.neurot.2025.e00602openalex-snapshot
Beyond relapses: How BTK inhibitors are shaping the future of progressive MS treatment
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105909openalex-snapshot
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108303openalex-snapshot
The regulatory mechanisms of Indole-3-carboxaldehyde in immune cells and its role in autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153676openalex-snapshot
The neuroprotective potential of carotenoids in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.plipres.2022.101162openalex-snapshot
Sphingolipid control of cognitive functions in health and disease
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2026.102913openalex-snapshot
Therapeutic ultrasound for the treatment of demyelinating diseases
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2017.03.024openalex-snapshot
Elucidating environmental dimensions of neurological disorders and disease: Understanding new tools from federal chemical testing programs
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.09.015openalex-snapshot
Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines
inferred← citeshttps://doi.org/10.1016/j.tem.2022.03.001openalex-snapshot
Metabolic changes favor the activity and heterogeneity of reactive astrocytes
inferred← citeshttps://doi.org/10.1016/j.tins.2020.06.002openalex-snapshot
The Gut–CNS Axis in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1016/j.toxlet.2017.07.214openalex-snapshot
Remodeling of brain lipidome in methamphetamine-sensitized mice
inferred← citeshttps://doi.org/10.1016/j.trsl.2024.10.002openalex-snapshot
Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism
inferred← citeshttps://doi.org/10.1016/j.xcrp.2021.100321openalex-snapshot
Sweet tailoring of glyco-modulatory extracellular matrix-inspired biomaterials to target neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.11.013openalex-snapshot
miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7
inferred← citeshttps://doi.org/10.1017/cjn.2015.302openalex-snapshot
Balancing Early Aggression Against Risk of Progression in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6c01274openalex-snapshot
Enzyme−Targeted Therapeutics for Neurological Disorders
inferred← citeshttps://doi.org/10.1021/acs.nanolett.8b04020openalex-snapshot
Polysialic-Acid-Based Micelles Promote Neural Regeneration in Spinal Cord Injury Therapy
inferred← citeshttps://doi.org/10.1021/acscentsci.9b00327openalex-snapshot
Targeting the Chondroitin Sulfate Proteoglycans: Evaluating Fluorinated Glucosamines and Xylosides in Screens Pertinent to Multiple Sclerosis
inferred← citeshttps://doi.org/10.1038/nm.3719openalex-snapshot
Astrocyte-derived lactosylceramide implicated in multiple sclerosis
inferred← citeshttps://doi.org/10.1038/nm.4106openalex-snapshot
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
inferred← citeshttps://doi.org/10.1038/nri3871openalex-snapshot
Immunopathology of multiple sclerosis
inferred← citeshttps://doi.org/10.1038/nrneurol.2016.171openalex-snapshot
Neuroinflammation — using big data to inform clinical practice
inferred← citeshttps://doi.org/10.1038/s12276-025-01627-6openalex-snapshot
The rise of astrocytes: are they guardians or troublemakers of the brain disorder?
inferred← citeshttps://doi.org/10.1038/s41380-023-02061-8openalex-snapshot
Revisiting the critical roles of reactive astrocytes in neurodegeneration
inferred← citeshttps://doi.org/10.1038/s41392-023-01628-9openalex-snapshot
Astrocytes in human central nervous system diseases: a frontier for new therapies
inferred← citeshttps://doi.org/10.1038/s41419-018-0381-8openalex-snapshot
Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice
inferred← citeshttps://doi.org/10.1038/s41420-025-02812-2openalex-snapshot
Inhibition of astrocyte BMP signaling alleviates neuroinflammation in experimental models of Parkinson’s disease
inferred← citeshttps://doi.org/10.1038/s41423-020-00585-5openalex-snapshot
The aryl hydrocarbon receptor and the gut–brain axis
inferred← citeshttps://doi.org/10.1038/s41467-018-05929-4openalex-snapshot
Acute microglia ablation induces neurodegeneration in the somatosensory system
inferred← citeshttps://doi.org/10.1038/s41467-018-08140-7openalex-snapshot
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation
inferred← citeshttps://doi.org/10.1038/s41467-023-36759-8openalex-snapshot
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model
inferred← citeshttps://doi.org/10.1038/s41467-025-57330-7openalex-snapshot
Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction
inferred← citeshttps://doi.org/10.1038/s41467-025-60747-9openalex-snapshot
FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch
inferred← citeshttps://doi.org/10.1038/s41467-026-72997-2openalex-snapshot
Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders
inferred← citeshttps://doi.org/10.1038/s41568-021-00397-3openalex-snapshot
Glial and myeloid heterogeneity in the brain tumour microenvironment
inferred← citeshttps://doi.org/10.1038/s41573-019-0035-2openalex-snapshot
Progressive multiple sclerosis: from pathophysiology to therapeutic strategies
inferred← citeshttps://doi.org/10.1038/s41573-022-00390-xopenalex-snapshot
Function and therapeutic value of astrocytes in neurological diseases
inferred← citeshttps://doi.org/10.1038/s41577-026-01313-2openalex-snapshot
Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting
inferred← citeshttps://doi.org/10.1038/s41582-021-00537-1openalex-snapshot
Positron emission tomography in multiple sclerosis — straight to the target
inferred← citeshttps://doi.org/10.1038/s41582-022-00624-xopenalex-snapshot
The role of glial cells in multiple sclerosis disease progression
inferred← citeshttps://doi.org/10.1038/s41582-023-00801-6openalex-snapshot
Inflammation in multiple sclerosis: consequences for remyelination and disease progression
inferred← citeshttps://doi.org/10.1038/s41586-018-0119-xopenalex-snapshot
Microglial control of astrocytes in response to microbial metabolites
inferred← citeshttps://doi.org/10.1038/s41586-020-03116-4openalex-snapshot
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
inferred← citeshttps://doi.org/10.1038/s41586-020-1999-0openalex-snapshot
MAFG-driven astrocytes promote CNS inflammation
inferred← citeshttps://doi.org/10.1038/s41586-022-05613-0openalex-snapshot
Identification of astrocyte regulators by nucleic acid cytometry
inferred← citeshttps://doi.org/10.1038/s41586-024-07187-5openalex-snapshot
Disease-associated astrocyte epigenetic memory promotes CNS pathology
inferred← citeshttps://doi.org/10.1038/s41586-024-08474-xopenalex-snapshot
The neuroimmune connectome in health and disease
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