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Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Detection and classification of thyroid follicular lesions based on nuclear structure from histopathology images
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Clinical relevance of Ki67 gene expression analysis using formalin-fixed paraffin-embedded breast cancer specimens
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Tumor heterogeneity: Causes and consequences
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The Life History of 21 Breast Cancers
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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
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Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
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Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity
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Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale
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Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization
inferredcites →https://doi.org/10.1038/nature12477openalex-snapshot
Signatures of mutational processes in human cancer
inferredcites →https://doi.org/10.1038/nature12634openalex-snapshot
Mutational landscape and significance across 12 major cancer types
inferredcites →https://doi.org/10.1038/nature13600openalex-snapshot
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
inferredcites →https://doi.org/10.1038/nbt.2514openalex-snapshot
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
inferredcites →https://doi.org/10.1038/nbt.2940openalex-snapshot
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inferredcites →https://doi.org/10.1038/nchembio.1367openalex-snapshot
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
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Inferring tumour purity and stromal and immune cell admixture from expression data
inferredcites →https://doi.org/10.1038/ncomms4756openalex-snapshot
Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden
inferredcites →https://doi.org/10.1038/ng.2760openalex-snapshot
Pan-cancer patterns of somatic copy number alteration
inferredcites →https://doi.org/10.1038/ng.2762openalex-snapshot
Emerging landscape of oncogenic signatures across human cancers
inferredcites →https://doi.org/10.1038/ng.2892openalex-snapshot
A general framework for estimating the relative pathogenicity of human genetic variants
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DGIdb: mining the druggable genome
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PyClone: statistical inference of clonal population structure in cancer
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Cancer Evolution Constrained by Mutation Order
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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
inferredcites →https://doi.org/10.1089/thy.2012.0614openalex-snapshot
Intratumor BRAF V600E Heterogeneity and Kinase Inhibitors in the Treatment of Thyroid Cancer: A Call for Participation
inferredcites →https://doi.org/10.1093/bib/bbu002openalex-snapshot
An assessment of computational methods for estimating purity and clonality using genomic data derived from heterogeneous tumor tissue samples
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Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV
inferredcites →https://doi.org/10.1093/bioinformatics/bts053openalex-snapshot
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data
inferredcites →https://doi.org/10.1093/bioinformatics/btt622openalex-snapshot
EXPANDS: expanding ploidy and allele frequency on nested subpopulations
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Quantifying tumor heterogeneity in whole-genome and whole-exome sequencing data
inferredcites →https://doi.org/10.1093/nar/gkn923openalex-snapshot
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
inferredcites →https://doi.org/10.1097/jto.0b013e318168be93openalex-snapshot
Tissue Heterogeneity of EGFR Mutation in Lung Adenocarcinoma
inferredcites →https://doi.org/10.1101/gr.180281.114openalex-snapshot
TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data
inferredcites →https://doi.org/10.1126/science.959840openalex-snapshot
The Clonal Evolution of Tumor Cell Populations
inferredcites →https://doi.org/10.1126/scitranslmed.aaa1408openalex-snapshot
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
inferredcites →https://doi.org/10.1158/0008-5472.can-10-3667openalex-snapshot
Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-11-0153openalex-snapshot
Heterogeneity Maintenance in Glioblastoma: A Social Network
inferredcites →https://doi.org/10.1158/1055-9965.epi-11-0343openalex-snapshot
Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
inferredcites →https://doi.org/10.1158/1940-6207.capr-10-0108openalex-snapshot
A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
inferredcites →https://doi.org/10.1186/gb-2006-7-10-r100openalex-snapshot
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
inferredcites →https://doi.org/10.1186/preaccept-5267400171382091openalex-snapshot
A general framework for analyzing tumor subclonality using SNP array and DNA sequencing data
inferredcites →https://doi.org/10.1200/jco.2013.50.7921openalex-snapshot
Clonal Heterogeneity As Detected by Metaphase Karyotyping Is an Indicator of Poor Prognosis in Acute Myeloid Leukemia
inferredcites →https://doi.org/10.1371/journal.pgen.1004239openalex-snapshot
Cancer Evolution Is Associated with Pervasive Positive Selection on Globally Expressed Genes
inferredcites →https://doi.org/10.1371/journal.pmed.1001786openalex-snapshot
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inferredcites →https://doi.org/10.4103/2153-3539.119005openalex-snapshot
OpenSlide: A vendor-neutral software foundation for digital pathology
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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FluxAtlas is a pan-cancer metabolic flux atlas that identifies tumor-selective dependencies and prognostic biomarkers
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Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures
inferred← citeshttps://doi.org/10.1016/j.cels.2021.07.006openalex-snapshot
DeCiFering the elusive cancer cell fraction in tumor heterogeneity and evolution
inferred← citeshttps://doi.org/10.1016/j.clim.2023.109345openalex-snapshot
Identification of a single cell-based signature for predicting prognosis risk and immunotherapy response in patients with glioblastoma
inferred← citeshttps://doi.org/10.1016/j.clineuro.2017.12.007openalex-snapshot
Quantitative texture analysis in the prediction of IDH status in low-grade gliomas
inferred← citeshttps://doi.org/10.1016/j.clon.2018.09.001openalex-snapshot
Science in Focus: Genomic Instability and its Implications for Clinical Cancer Care
inferred← citeshttps://doi.org/10.1016/j.coisb.2019.09.002openalex-snapshot
Systems biology approaches to measure and model phenotypic heterogeneity in cancer
inferred← citeshttps://doi.org/10.1016/j.crad.2016.09.013openalex-snapshot
Unravelling tumour heterogeneity using next-generation imaging: radiomics, radiogenomics, and habitat imaging
inferred← citeshttps://doi.org/10.1016/j.crad.2020.07.037openalex-snapshot
Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2017.09.011openalex-snapshot
Complexity of the genomic landscape of renal cell carcinoma: Implications for targeted therapy and precision immuno-oncology
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2019.102827openalex-snapshot
Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2021.103477openalex-snapshot
Extra chromosomal DNA in different cancers: Individual genome with important biological functions
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2021.103544openalex-snapshot
State of the art of radiomic analysis in the clinical management of prostate cancer: A systematic review
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2022.103865openalex-snapshot
Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.105109openalex-snapshot
Chinese expert consensus on precision diagnosis and treatment of refractory tumors
inferred← citeshttps://doi.org/10.1016/j.crmeth.2024.100866openalex-snapshot
Mimicking and analyzing the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.crmeth.2026.101411openalex-snapshot
A network-based deep learning model integrating subclonal architecture for therapy response prediction in cancer
inferred← citeshttps://doi.org/10.1016/j.csbj.2020.01.008openalex-snapshot
Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models
inferred← citeshttps://doi.org/10.1016/j.curpro.2026.100155openalex-snapshot
Exploration of the immunogenomics connection between chronic obstructive pulmonary disease and lung cancer: The role of liquid biopsy in early diagnosis and precision prognosis
inferred← citeshttps://doi.org/10.1016/j.devcel.2021.07.006openalex-snapshot
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
inferred← citeshttps://doi.org/10.1016/j.drup.2017.10.003openalex-snapshot
Not only P-glycoprotein: Amplification of the ABCB1- containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins
inferred← citeshttps://doi.org/10.1016/j.ejca.2021.01.044openalex-snapshot
Hypermutated tumours across 11 cancer types show three distinct immune subtypes
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111682openalex-snapshot
Novel HER2-Targeting Antibody-Drug Conjugates of Trastuzumab Beyond T-DM1 in Breast Cancer: Trastuzumab Deruxtecan(DS-8201a) and (Vic-)Trastuzumab Duocarmazine (SYD985)
inferred← citeshttps://doi.org/10.1016/j.ejrad.2025.112547openalex-snapshot
Mr-based radiomics analysis of intra-tumor heterogeneity for early treatment response prediction in locally advanced cervical cancer treated with concurrent chemoradiotherapy
inferred← citeshttps://doi.org/10.1016/j.ejro.2026.100800openalex-snapshot
DCE-MRI kinetic heterogeneity facilitates the discrimination of benignity and malignancy of breast in combination with the DWI and morphological features
inferred← citeshttps://doi.org/10.1016/j.esmoop.2023.101642openalex-snapshot
Precision medicine in the era of multi-omics: can the data tsunami guide rational treatment decision?
inferred← citeshttps://doi.org/10.1016/j.euf.2017.03.007openalex-snapshot
Small-cell Carcinomas of the Urinary Bladder and Prostate: TERT Promoter Mutation Status Differentiates Sites of Malignancy and Provides Evidence of Common Clonality Between Small-cell Carcinoma of the Urinary Bladder and Urothelial Carcinoma
inferred← citeshttps://doi.org/10.1016/j.eururo.2018.09.036openalex-snapshot
Devil in the Detail: Intratumour Heterogeneity and Personalised Medicine for Bladder Cancer
inferred← citeshttps://doi.org/10.1016/j.eururo.2019.07.049openalex-snapshot
Reply to Mengxin Lu, Yi Zhang, Yu Xiao’s Letter to the Editor, re: Kimmo Kettunen, Peter J. Boström, Tarja Lamminen, et al. Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells. Eur Urol 2019;76:430–4
inferred← citeshttps://doi.org/10.1016/j.gde.2020.12.002openalex-snapshot
Spatially resolved transcriptomics and its applications in cancer
inferred← citeshttps://doi.org/10.1016/j.gendis.2024.101239openalex-snapshot
Research progress and the prospect of using single-cell sequencing technology to explore the characteristics of the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.gene.2016.09.023openalex-snapshot
A genome-wide assessment of variations of primary colorectal cancer maintained in metastases
inferred← citeshttps://doi.org/10.1016/j.gene.2026.150161openalex-snapshot
From “Simulation” to “Mirror”: Gene editing and humanization redefines the next-generation precision oncology animal model
inferred← citeshttps://doi.org/10.1016/j.humpath.2017.02.010openalex-snapshot
Multisite tumor sampling: a new tumor selection method to enhance intratumor heterogeneity detection
inferred← citeshttps://doi.org/10.1016/j.humpath.2025.105758openalex-snapshot
Molecular mapping in head and neck adenoid cystic carcinoma by pathological grade using whole-exome sequencing and spatial transcriptome
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.150143openalex-snapshot
Multi-omics integration defines an ECM-associated intratumoral heterogeneity signature enabling prognosis assessment and therapeutic stratification in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.isci.2019.10.018openalex-snapshot
Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105244openalex-snapshot
A compendium of co-regulated mitoribosomal proteins in pan-cancer uncovers collateral defective events in tumor malignancy
inferred← citeshttps://doi.org/10.1016/j.jhep.2021.06.028openalex-snapshot
Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma
inferred← citeshttps://doi.org/10.1016/j.jid.2020.12.007openalex-snapshot
Deciphering Melanoma Cell States and Plasticity with Zebrafish Models
inferred← citeshttps://doi.org/10.1016/j.jid.2021.06.011openalex-snapshot
Activation of cGMP-Dependent Protein Kinase Restricts Melanoma Growth and Invasion by Interfering with the EGF/EGFR Pathway
inferred← citeshttps://doi.org/10.1016/j.jmoldx.2019.08.006openalex-snapshot
Using R and Bioconductor in Clinical Genomics and Transcriptomics
inferred← citeshttps://doi.org/10.1016/j.jtho.2023.09.276openalex-snapshot
Genetic Intratumor Heterogeneity Remodels the Immune Microenvironment and Induces Immune Evasion in Brain Metastasis of Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.neo.2018.07.001openalex-snapshot
Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma
inferred← citeshttps://doi.org/10.1016/j.neo.2022.100864openalex-snapshot
Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model
inferred← citeshttps://doi.org/10.1016/j.oooo.2023.12.785openalex-snapshot
Spatial heterogeneity of tumor cells and the tissue microenvironment in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2018.08.009openalex-snapshot
Three distinct genomic subtypes of head and neck squamous cell carcinoma associated with clinical outcomes
inferred← citeshttps://doi.org/10.1016/j.preme.2024.100006openalex-snapshot
Intratumor heterogeneity in breast cancer: Tracing its origins and translating findings into clinical practice
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.11.016openalex-snapshot
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.02.013openalex-snapshot
Impact of cancer evolution on immune surveillance and checkpoint inhibitor response
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.08.028openalex-snapshot
Clonal cooperativity in heterogenous cancers
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.09.002openalex-snapshot
Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer
inferred← citeshttps://doi.org/10.1016/j.semradonc.2021.09.002openalex-snapshot
Chromosome Missegregation as a Modulator of Radiation Sensitivity
inferred← citeshttps://doi.org/10.1016/j.semradonc.2025.04.002openalex-snapshot
Novel biomarkers for guiding treatment for prostate cancer
inferred← citeshttps://doi.org/10.1016/j.tcb.2019.01.003openalex-snapshot
Mutational and Antigenic Landscape in Tumor Progression and Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1016/j.tig.2018.05.007openalex-snapshot
Harnessing Tumor Evolution to Circumvent Resistance
inferred← citeshttps://doi.org/10.1016/j.tips.2024.01.009openalex-snapshot
Targeting chromosomal instability and aneuploidy in cancer
inferred← citeshttps://doi.org/10.1016/j.tranon.2017.09.007openalex-snapshot
Intratumor and Intertumor Heterogeneity in Melanoma
inferred← citeshttps://doi.org/10.1016/j.tranon.2018.09.003openalex-snapshot
Biomarkers Associated with Tumor Heterogeneity in Prostate Cancer
inferred← citeshttps://doi.org/10.1016/j.tranon.2023.101763openalex-snapshot
Circulating tumor DNA based minimal residual disease detection and adjuvant treatment decision-making for muscle-invasive bladder cancer guided by modern clinical trials
inferred← citeshttps://doi.org/10.1016/j.tranon.2023.101855openalex-snapshot
Heterogeneity of computational pathomic signature predicts drug resistance and intra-tumor heterogeneity of ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.tranon.2026.102840openalex-snapshot
Multi-regional transcriptomics reveals robust consensus subtypes beyond tumor heterogeneity of breast cancer
inferred← citeshttps://doi.org/10.1016/j.trecan.2016.09.003openalex-snapshot
Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer
inferred← citeshttps://doi.org/10.1016/j.trecan.2017.02.001openalex-snapshot
Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities
inferred← citeshttps://doi.org/10.1016/j.trecan.2017.04.005openalex-snapshot
Molecular Events in the Natural History of Pancreatic Cancer
inferred← citeshttps://doi.org/10.1016/j.trecan.2017.06.004openalex-snapshot
Multiregional Tumor Trees Are Not Phylogenies
inferred← citeshttps://doi.org/10.1016/j.trecan.2017.08.001openalex-snapshot
Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors
inferred← citeshttps://doi.org/10.1016/j.trecan.2020.01.010openalex-snapshot
Understanding the Cause and Consequence of Tumor Heterogeneity
inferred← citeshttps://doi.org/10.1016/j.trecan.2020.02.016openalex-snapshot
Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity
inferred← citeshttps://doi.org/10.1016/j.trecan.2021.09.002openalex-snapshot
Chromosomal instability and aneuploidy as causes of cancer drug resistance
inferred← citeshttps://doi.org/10.1016/j.urolonc.2016.05.012openalex-snapshot
Using the neoadjuvant chemotherapy paradigm to develop precision therapy for muscle-invasive bladder cancer
inferred← citeshttps://doi.org/10.1016/j.urolonc.2018.11.015openalex-snapshot
Molecular tumor heterogeneity in muscle invasive bladder cancer: Biomarkers, subtypes, and implications for therapy
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101394openalex-snapshot
Lineage and ecology define liver tumor evolution in response to treatment
inferred← citeshttps://doi.org/10.1016/j.xgen.2022.100165openalex-snapshot
Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
inferred← citeshttps://doi.org/10.1016/j.ygeno.2022.110412openalex-snapshot
Systematic investigation of the prognostic impact of clonal status of somatic mutations across multiple cancer types
inferred← citeshttps://doi.org/10.1016/j.ygyno.2019.11.013openalex-snapshot
Intratumor heterogeneity and homologous recombination deficiency of high-grade serous ovarian cancer are associated with prognosis and molecular subtype and change in treatment course
inferred← citeshttps://doi.org/10.1016/s1470-2045(21)00541-6openalex-snapshot
Radiotherapy with genomic-adjusted radiation dose
inferred← citeshttps://doi.org/10.1016/s2589-7500(20)30225-9openalex-snapshot
A prognostic model for overall survival of patients with early-stage non-small cell lung cancer: a multicentre, retrospective study
inferred← citeshttps://doi.org/10.1017/erm.2021.5openalex-snapshot
Biological bases of cancer immunotherapy
inferred← citeshttps://doi.org/10.1038/bjc.2017.171openalex-snapshot
Tumour heterogeneity poses a significant challenge to cancer biomarker research
inferred← citeshttps://doi.org/10.1038/nature21356openalex-snapshot
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
inferred← citeshttps://doi.org/10.1038/ncomms14565openalex-snapshot
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/ng.3489openalex-snapshot
Identification of neutral tumor evolution across cancer types
inferred← citeshttps://doi.org/10.1038/ng.3838openalex-snapshot
Spatial heterogeneity in medulloblastoma
inferred← citeshttps://doi.org/10.1038/ng.3967openalex-snapshot
Patient-derived xenografts undergo mouse-specific tumor evolution
inferred← citeshttps://doi.org/10.1038/nrc.2017.102openalex-snapshot
An evolutionary perspective on field cancerization
inferred← citeshttps://doi.org/10.1038/nrc.2017.69openalex-snapshot
Classifying the evolutionary and ecological features of neoplasms
inferred← citeshttps://doi.org/10.1038/nrc.2018.11openalex-snapshot
The molecular landscape of head and neck cancer
inferred← citeshttps://doi.org/10.1038/nrclinonc.2015.219openalex-snapshot
Intratumour heterogeneity — a game of snakes and ladders
inferred← citeshttps://doi.org/10.1038/nrclinonc.2017.166openalex-snapshot
Tumour heterogeneity and resistance to cancer therapies
inferred← citeshttps://doi.org/10.1038/nrclinonc.2017.198openalex-snapshot
Determinants and clinical implications of chromosomal instability in cancer
inferred← citeshttps://doi.org/10.1038/nrg.2016.170openalex-snapshot
The evolution of tumour phylogenetics: principles and practice
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