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Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Association of Computed Tomography Morphologic Criteria With Pathologic Response and Survival in Patients Treated With Bevacizumab for Colorectal Liver Metastases
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Biomarkers of response and resistance to antiangiogenic therapy
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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
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inferredcites →https://doi.org/10.1046/j.1365-2559.2001.01061.xopenalex-snapshot
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Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1093/neuonc/nop027openalex-snapshot
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Lack of Angiogenesis in Experimental Brain Metastases
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inferredcites →https://doi.org/10.1111/j.1477-2574.2009.00119.xopenalex-snapshot
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inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-0823openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.2008.21.6457openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.2010.28.0982openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.2010.34.1255openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.2012.45.2854openalex-snapshot
Optimal Morphologic Response to Preoperative Chemotherapy: An Alternate Outcome End Point Before Resection of Hepatic Colorectal Metastases
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Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update
inferredcites →https://doi.org/10.1371/journal.pone.0005857openalex-snapshot
The Vascular Basement Membrane as “Soil” in Brain Metastasis
inferredcites →https://doi.org/10.2214/ajr.11.6459openalex-snapshot
CT Findings of Response and Recurrence, Independent of Change in Tumor Size, in Colorectal Liver Metastasis Treated With Bevacizumab
inferredcites →https://doi.org/10.2353/ajpath.2007.060302openalex-snapshot
Alternative Vascularization Mechanisms in Cancer
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American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer
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American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Unabridged Version)
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/cnr2.1318openalex-snapshot
Vascular co‐option and vasculogenic mimicry mediate resistance to antiangiogenic strategies
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Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
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The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells
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Tumor angiogenesis revisited: Regulators and clinical implications
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Vessel co‐option is common in human lung metastases and mediates resistance to anti‐angiogenic therapy in preclinical lung metastasis models
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Hostile takeover: how tumours hijack pre‐existing vascular environments to thrive
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Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth
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Neutrophils expressing lysyl oxidase‐like 4 protein are present in colorectal cancer liver metastases resistant to anti‐angiogenic therapy
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Challenges and future directions
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Tumor Microenvironment
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Cancer therapy depending on tumor vasculature and EPR effects
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Vascular mimicry: Triggers, molecular interactions and in vivo models
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2023.10.001openalex-snapshot
Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach
inferred← citeshttps://doi.org/10.1016/j.acra.2024.04.038openalex-snapshot
Estimating Efficacy of Conversion Therapy on Patients with Initially Unresectable Colorectal Cancer Liver Metastases by using MRI: Development of a Predictive Score
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Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbagen.2021.130059openalex-snapshot
Pro-angiogenic approach for skeletal muscle regeneration
inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188779openalex-snapshot
Stimuli-responsive nanoassemblies for targeted delivery against tumor and its microenvironment
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188958openalex-snapshot
Therapeutic advances targeting tumor angiogenesis in pancreatic cancer: Current dilemmas and future directions
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189597openalex-snapshot
Functional vasculature in tumor organoids: Enabling precision medicine in oncology
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189618openalex-snapshot
Immune remodeling of liver metastases: From molecular mechanisms to therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189713openalex-snapshot
Metabolic regulation of tumor angiogenesis in colorectal cancer: mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.canlet.2017.02.005openalex-snapshot
The potential clinical promise of ‘multimodality’ metronomic chemotherapy revealed by preclinical studies of metastatic disease
inferred← citeshttps://doi.org/10.1016/j.canlet.2022.01.011openalex-snapshot
Targeted delivery of exosomal miR-484 reprograms tumor vasculature for chemotherapy sensitization
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218610openalex-snapshot
Biomarker-guided strategies for tumor vasculature: From imaging advances to novel therapeutic interventions
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218824openalex-snapshot
Revisiting tumor vasculature in the era of cancer immunotherapy: from aberrant hallmark to therapeutic target
inferred← citeshttps://doi.org/10.1016/j.ccell.2017.03.009openalex-snapshot
A CD276 Antibody Guided Missile with One Warhead and Two Targets: The Tumor and Its Vasculature
inferred← citeshttps://doi.org/10.1016/j.ccell.2018.03.020openalex-snapshot
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment
inferred← citeshttps://doi.org/10.1016/j.ccell.2026.09.002openalex-snapshot
A transient MXD4-dependent proliferative pause enables survival of brain micrometastases
inferred← citeshttps://doi.org/10.1016/j.cej.2025.170761openalex-snapshot
A sequential nanotherapy potentiate anti-angiogenic therapy by disrupting lipid metabolism under metabolic stress
inferred← citeshttps://doi.org/10.1016/j.cell.2026.03.016openalex-snapshot
Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.02.035openalex-snapshot
Periostin Limits Tumor Response to VEGFA Inhibition
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109253openalex-snapshot
Tumor vessel co-option probed by single-cell analysis
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112328openalex-snapshot
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis
inferred← citeshttps://doi.org/10.1016/j.clcc.2024.05.010openalex-snapshot
Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease
inferred← citeshttps://doi.org/10.1016/j.cmet.2018.05.005openalex-snapshot
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2018.06.001openalex-snapshot
Antiangiogenic therapy: Markers of response, “normalization” and resistance
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2022.103712openalex-snapshot
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.03.026openalex-snapshot
The Extracellular Matrix Modulates the Metastatic Journey
inferred← citeshttps://doi.org/10.1016/j.dld.2019.03.028openalex-snapshot
Quantitative evaluation of liver metastases density on computed tomography: A new tool to evaluate early response to bevacizumab-containing chemotherapy
inferred← citeshttps://doi.org/10.1016/j.dld.2019.04.003openalex-snapshot
Evaluation of response to chemotherapy: Work still in progress
inferred← citeshttps://doi.org/10.1016/j.drup.2018.01.002openalex-snapshot
Redundant angiogenic signaling and tumor drug resistance
inferred← citeshttps://doi.org/10.1016/j.drup.2022.100849openalex-snapshot
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects
inferred← citeshttps://doi.org/10.1016/j.drup.2023.100975openalex-snapshot
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2
inferred← citeshttps://doi.org/10.1016/j.ejrad.2021.109863openalex-snapshot
Radiomics diagnosed histopathological growth pattern in prediction of response and 1-year progression free survival for colorectal liver metastases patients treated with bevacizumab containing chemotherapy
inferred← citeshttps://doi.org/10.1016/j.ejso.2019.06.038openalex-snapshot
Prognostic and predictive markers in liver limited stage IV colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ejso.2022.08.006openalex-snapshot
Tumor biology reflected by histological growth pattern is more important than surgical margin for the prognosis of patients undergoing resection of colorectal liver metastases
inferred← citeshttps://doi.org/10.1016/j.ejso.2025.110291openalex-snapshot
Tumor-Boundary Response Index (TBRI)- A promising indicator for predicting outcomes in colorectal liver metastases receiving neoadjuvant therapy: Insights from a single-center retrospective study
inferred← citeshttps://doi.org/10.1016/j.ejso.2026.111951openalex-snapshot
Prognostic value and spatial transcriptomic landscape of histopathological growth patterns in synchronous colorectal liver metastases
inferred← citeshttps://doi.org/10.1016/j.ejso.2026.111977openalex-snapshot
Vessel co-option negatively affects survival in patients with advanced hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.esmoop.2026.106923openalex-snapshot
New prognostic and predictive scoring systems for colorectal cancer liver metastases
inferred← citeshttps://doi.org/10.1016/j.esmoop.2026.108350openalex-snapshot
Heterogeneity of pathological tumour response in patients with multiple colorectal liver metastases undergoing resection after preoperative chemotherapy
inferred← citeshttps://doi.org/10.1016/j.gassur.2026.102527openalex-snapshot
Nondesmoplastic growth pattern plus RAS-BRAF/TP53 co-mutation predicts poor survival after resection of colorectal liver metastases
inferred← citeshttps://doi.org/10.1016/j.hpb.2019.10.015openalex-snapshot
Histopathological growth patterns and positive margins after resection of colorectal liver metastases
inferred← citeshttps://doi.org/10.1016/j.hpb.2021.07.009openalex-snapshot
Histopathological growth patterns modify the prognostic impact of microvascular invasion in non-cirrhotic hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.humpath.2022.02.015openalex-snapshot
Histological growth patterns of colorectal cancer liver metastases: a strong prognostic marker associated with invasive patterns of the primary tumor and p53 alteration
inferred← citeshttps://doi.org/10.1016/j.iliver.2025.100186openalex-snapshot
Research advances in treatment strategies for breast cancer liver metastases: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.imu.2024.101481openalex-snapshot
Predictive biomarker discovery in cancer using a unique AI model based on set theory
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107702openalex-snapshot
Deep learning-derived spatial organization features on histology images predicts prognosis in colorectal liver metastasis patients after hepatectomy
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109718openalex-snapshot
Cell competition promotes metastatic intestinal cancer through a multistage process
inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.09.016openalex-snapshot
Overcoming key biological barriers to cancer drug delivery and efficacy
inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.10.006openalex-snapshot
Vascular changes in tumors resistant to a vascular disrupting nanoparticle treatment
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.09.003openalex-snapshot
Brain-tumor-seeking and serpin-inhibiting outer membrane vesicles restore plasmin-mediated attacks against brain metastases
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105192openalex-snapshot
Targeting angiogenesis in gliomas: Potential role of phytochemicals
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.02.001openalex-snapshot
Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122499openalex-snapshot
Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122734openalex-snapshot
Cancer therapy with the viral and bacterial pathogens: The past enemies can be considered the present allies
inferred← citeshttps://doi.org/10.1016/j.matbio.2024.12.008openalex-snapshot
Basement membranes in lung metastasis growth and progression
inferred← citeshttps://doi.org/10.1016/j.mtnano.2021.100172openalex-snapshot
A novel second near-infrared theranostic agent: a win–win strategy of tracing and blocking tumor-associated vessels for oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.nano.2018.06.011openalex-snapshot
Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and Photothermal therapy
inferred← citeshttps://doi.org/10.1016/j.omto.2023.02.001openalex-snapshot
Mechanisms of drug resistance in breast cancer liver metastases: Dilemmas and opportunities
inferred← citeshttps://doi.org/10.1016/j.omton.2024.200828openalex-snapshot
High CIB1 expression in colorectal cancer liver metastases correlates with worse survival and the replacement histopathological growth pattern
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108764openalex-snapshot
EGFL7: An emerging biomarker with great therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155261openalex-snapshot
Kaempferol inhibits colorectal cancer metastasis through circ_0000345 mediated JMJD2C/β-catenin signalling pathway
inferred← citeshttps://doi.org/10.1016/j.prp.2022.153956openalex-snapshot
Role of anti-angiogenic factors in the pathogenesis of breast cancer: A review of therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.prp.2023.154401openalex-snapshot
Histopathological growth pattern evolution of tumor in VX2 liver cancer model
inferred← citeshttps://doi.org/10.1016/j.semcancer.2018.01.009openalex-snapshot
Histopathological growth patterns as a candidate biomarker for immunomodulatory therapy
inferred← citeshttps://doi.org/10.1016/j.semcancer.2019.10.012openalex-snapshot
The macro-metastasis/organ parenchyma interface (MMPI) - A hitherto unnoticed area
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.05.001openalex-snapshot
Melanoma in the liver: Oxidative stress and the mechanisms of metastatic cell survival
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.05.003openalex-snapshot
Uveal melanoma pathobiology: Metastasis to the liver
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.06.004openalex-snapshot
Extracellular matrix proteins in metastases to the liver – Composition, function and potential applications
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.07.002openalex-snapshot
Can medical imaging identify the histopathological growth patterns of liver metastases?
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.07.007openalex-snapshot
Predicting liver metastases growth patterns: Current status and future possibilities
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.09.001openalex-snapshot
Tumor microenvironment conditions that favor vessel co-option in colorectal cancer liver metastases: A theoretical model
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.11.003openalex-snapshot
Role of extracellular vesicles in cancer-specific interactions between tumour cells and the vasculature
inferred← citeshttps://doi.org/10.1016/j.surg.2022.06.032openalex-snapshot
The desmoplastic growth pattern is associated with second-stage completion and longer survival in 2-stage hepatectomy for colorectal cancer liver metastases
inferred← citeshttps://doi.org/10.1016/j.tranon.2019.04.022openalex-snapshot
Limitations of Anti-Angiogenic Treatment of Tumors
inferred← citeshttps://doi.org/10.1016/j.tranon.2025.102480openalex-snapshot
MetInfilt: A prospective trial highlighting the importance of the histological growth pattern in brain metastases
inferred← citeshttps://doi.org/10.1016/j.trecan.2017.05.002openalex-snapshot
Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
inferred← citeshttps://doi.org/10.1016/j.trecan.2019.09.007openalex-snapshot
Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment
inferred← citeshttps://doi.org/10.1016/j.trecan.2019.10.006openalex-snapshot
Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga
inferred← citeshttps://doi.org/10.1016/j.trecan.2024.08.003openalex-snapshot
Accessing the vasculature in cancer: revising an old hallmark
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101838openalex-snapshot
Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy
inferred← citeshttps://doi.org/10.1021/acsnano.4c12599openalex-snapshot
Applying Spatiotemporal Modeling of Cell Dynamics to Accelerate Drug Development
inferred← citeshttps://doi.org/10.1038/bjc.2017.334openalex-snapshot
International consensus guidelines for scoring the histopathological growth patterns of liver metastasis
inferred← citeshttps://doi.org/10.1038/d41586-026-01747-7openalex-snapshot
Liver fat steers the outcome of advanced colorectal cancer
inferred← citeshttps://doi.org/10.1038/nm.4228openalex-snapshot
Improving treatment of liver metastases by targeting nonangiogenic mechanisms
inferred← citeshttps://doi.org/10.1038/nrc.2017.51openalex-snapshot
Microenvironmental regulation of tumour angiogenesis
inferred← citeshttps://doi.org/10.1038/nrc.2018.14openalex-snapshot
Non-angiogenic tumours and their influence on cancer biology
inferred← citeshttps://doi.org/10.1038/nrgastro.2016.183openalex-snapshot
Therapy for colorectal cancer liver metastases: understanding resistance
inferred← citeshttps://doi.org/10.1038/onc.2017.1openalex-snapshot
Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy
inferred← citeshttps://doi.org/10.1038/s41388-018-0242-zopenalex-snapshot
Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis
inferred← citeshttps://doi.org/10.1038/s41388-018-0271-7openalex-snapshot
Glycosylation controls cooperative PECAM-VEGFR2-β3 integrin functions at the endothelial surface for tumor angiogenesis
inferred← citeshttps://doi.org/10.1038/s41392-023-01460-1openalex-snapshot
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
inferred← citeshttps://doi.org/10.1038/s41401-026-01820-xopenalex-snapshot
The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis
inferred← citeshttps://doi.org/10.1038/s41416-018-0015-zopenalex-snapshot
Differential histopathologic parameters in colorectal cancer liver metastases resected after triplets plus bevacizumab or cetuximab: a pooled analysis of five prospective trials
inferred← citeshttps://doi.org/10.1038/s41416-020-0812-zopenalex-snapshot
Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases
inferred← citeshttps://doi.org/10.1038/s41416-020-0881-zopenalex-snapshot
Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis
inferred← citeshttps://doi.org/10.1038/s41416-020-0954-zopenalex-snapshot
Tumour budding and its clinical implications in gastrointestinal cancers
inferred← citeshttps://doi.org/10.1038/s41416-021-01667-5openalex-snapshot
Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns
inferred← citeshttps://doi.org/10.1038/s41416-021-01686-2openalex-snapshot
Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?
inferred← citeshttps://doi.org/10.1038/s41416-022-01859-7openalex-snapshot
Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights
inferred← citeshttps://doi.org/10.1038/s41419-022-05171-3openalex-snapshot
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1038/s41419-023-05666-7openalex-snapshot
VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry
inferred← citeshttps://doi.org/10.1038/s41467-023-40688-xopenalex-snapshot
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
inferred← citeshttps://doi.org/10.1038/s41523-020-00209-1openalex-snapshot
Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
inferred← citeshttps://doi.org/10.1038/s41568-018-0006-7openalex-snapshot
A history of exploring cancer in context
inferred← citeshttps://doi.org/10.1038/s41568-024-00736-0openalex-snapshot
Targeting the tumour vasculature: from vessel destruction to promotion
inferred← citeshttps://doi.org/10.1038/s41568-025-00872-1openalex-snapshot
The immune microenvironment of colorectal cancer
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