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Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

https://doi.org/10.1038/nm.4475
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Possible epigenetic mechanisms of tumor progression: Induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment
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Epigenetic contributions to cancer metastasis
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Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes
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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
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Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
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Super-Enhancers in the Control of Cell Identity and Disease
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Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
inferredcites →https://doi.org/10.1016/j.cell.2017.07.007openalex-snapshot
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
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An Optimized microRNA Backbone for Effective Single-Copy RNAi
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Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1
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A Computational Algorithm to Predict shRNA Potency
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Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency
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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition
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ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions
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A multigenic program mediating breast cancer metastasis to bone
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An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
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Genes that mediate breast cancer metastasis to lung
inferredcites →https://doi.org/10.1038/nature07829openalex-snapshot
Histone modifications at human enhancers reflect global cell-type-specific gene expression
inferredcites →https://doi.org/10.1038/nature08021openalex-snapshot
Genes that mediate breast cancer metastasis to the brain
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The patterns and dynamics of genomic instability in metastatic pancreatic cancer
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Selective inhibition of BET bromodomains
inferredcites →https://doi.org/10.1038/nature09515openalex-snapshot
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
inferredcites →https://doi.org/10.1038/nature09692openalex-snapshot
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inferredcites →https://doi.org/10.1038/ncomms4511openalex-snapshot
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inferredcites →https://doi.org/10.1038/ncomms7605openalex-snapshot
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inferredcites →https://doi.org/10.1038/ng.3753openalex-snapshot
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inferredcites →https://doi.org/10.1038/ng1060openalex-snapshot
A molecular signature of metastasis in primary solid tumors
inferredcites →https://doi.org/10.1038/nm.1944openalex-snapshot
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inferredcites →https://doi.org/10.1038/nmeth.2173openalex-snapshot
Robust 4C-seq data analysis to screen for regulatory DNA interactions
inferredcites →https://doi.org/10.1038/nrc2894openalex-snapshot
Targeting the ANGPT–TIE2 pathway in malignancy
inferredcites →https://doi.org/10.1038/nrc3838openalex-snapshot
Translational biology of osteosarcoma
inferredcites →https://doi.org/10.1038/nrc865openalex-snapshot
Dissemination and growth of cancer cells in metastatic sites
inferredcites →https://doi.org/10.1038/nrendo.2010.171openalex-snapshot
Growth hormone, the insulin-like growth factor axis, insulin and cancer risk
inferredcites →https://doi.org/10.1038/onc.2014.94openalex-snapshot
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Comparative lesion sequencing provides insights into tumor evolution
inferredcites →https://doi.org/10.1093/bioinformatics/btp120openalex-snapshot
TopHat: discovering splice junctions with RNA-Seq
inferredcites →https://doi.org/10.1093/bioinformatics/btp352openalex-snapshot
The Sequence Alignment/Map format and SAMtools
inferredcites →https://doi.org/10.1093/jnci/87.23.1787openalex-snapshot
Inhibition of Growth of Human Osteosarcomas by Antagonists of Growth Hormone-Releasing Hormone
inferredcites →https://doi.org/10.1093/nar/gkr218openalex-snapshot
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
inferredcites →https://doi.org/10.1093/nar/gkr378openalex-snapshot
g:Profiler—a web server for functional interpretation of gene lists (2011 update)
inferredcites →https://doi.org/10.1097/mph.0b013e318223d0c1openalex-snapshot
Evaluation of eIF4E Expression in an Osteosarcoma-Specific Tissue Microarray
inferredcites →https://doi.org/10.1101/gr.122382.111openalex-snapshot
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions
inferredcites →https://doi.org/10.1101/gr.164079.113openalex-snapshot
Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
inferredcites →https://doi.org/10.1101/pdb.prot5384openalex-snapshot
DNase-seq: A High-Resolution Technique for Mapping Active Gene Regulatory Elements across the Genome from Mammalian Cells
inferredcites →https://doi.org/10.1111/gtc.12037openalex-snapshot
Efficient TALEN construction and evaluation methods for human cell and animal applications
inferredcites →https://doi.org/10.1126/science.1217277openalex-snapshot
Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-2281openalex-snapshot
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inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0418openalex-snapshot
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inferredcites →https://doi.org/10.1172/jci40252openalex-snapshot
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inferredcites →https://doi.org/10.1182/blood-2007-07-101048openalex-snapshot
Inhibition of tissue factor signaling suppresses tumor growth
inferredcites →https://doi.org/10.1182/blood-2011-06-317685openalex-snapshot
The relationship between tissue factor and cancer progression: insights from bench and bedside
inferredcites →https://doi.org/10.1186/gb-2008-9-9-r137openalex-snapshot
Model-based Analysis of ChIP-Seq (MACS)
inferredcites →https://doi.org/10.1186/gb-2009-10-3-r25openalex-snapshot
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
inferredcites →https://doi.org/10.1186/gb-2010-11-8-r86openalex-snapshot
Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences
inferredcites →https://doi.org/10.1186/gb-2011-12-8-r83openalex-snapshot
Cistrome: an integrative platform for transcriptional regulation studies
inferredcites →https://doi.org/10.1371/journal.pcbi.1000598openalex-snapshot
An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data
inferredcites →https://doi.org/10.1371/journal.pone.0013984openalex-snapshot
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inferredcites →https://doi.org/10.18632/oncotarget.5177openalex-snapshot
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells
inferredcites →https://doi.org/10.2353/ajpath.2009.071006openalex-snapshot
Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis of Murine Osteosarcoma
inferredcites →https://doi.org/10.4137/cmo.s531openalex-snapshot
The Metastasectomy and Timing of Pulmonary Metastases on the Outcome of Osteosarcoma Patients

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4661833openalex-extracted
Oligopeptide Modified ICG/Cisplatin@CaCO 3 for Targeted Osteosarcoma NIR-II Imaging Guided Multimodal Therapy
inferred← citeshttps://doi.org/10.1002/adbi.202200194openalex-snapshot
Establishment and Characterization of Single and Triple‐Agent Resistant Osteosarcoma Cell Lines
inferred← citeshttps://doi.org/10.1002/advs.202101895openalex-snapshot
Pharmacological Inhibition of Core Regulatory Circuitry Liquid–liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma
inferred← citeshttps://doi.org/10.1002/cac2.70075openalex-snapshot
HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism
inferred← citeshttps://doi.org/10.1002/cncr.32351openalex-snapshot
Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group
inferred← citeshttps://doi.org/10.1002/ddr.70207openalex-snapshot
Next‐Generation Therapies for Bone Cancer: Targeted Therapy, Immunotherapy, and Nanomedicine Innovations
inferred← citeshttps://doi.org/10.1002/jbmr.3537openalex-snapshot
Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells
inferred← citeshttps://doi.org/10.1002/path.6219openalex-snapshot
Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway
inferred← citeshttps://doi.org/10.1002/pbc.29188openalex-snapshot
Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Force
inferred← citeshttps://doi.org/10.1002/pbc.30583openalex-snapshot
Children's Oncology Group's 2023 blueprint for research: Bone tumors
inferred← citeshttps://doi.org/10.1002/rth2.12363openalex-snapshot
Evaluation of different commercial antibodies for their ability to detect human and mouse tissue factor by western blotting
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Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease
inferred← citeshttps://doi.org/10.1007/978-3-030-43085-6_1openalex-snapshot
Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies
inferred← citeshttps://doi.org/10.1007/978-3-030-43085-6_4openalex-snapshot
Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma
inferred← citeshttps://doi.org/10.1007/978-3-030-43085-6_7openalex-snapshot
Targetable Intercellular Signaling Pathways Facilitate Lung Colonization in Osteosarcoma
inferred← citeshttps://doi.org/10.1007/s00330-020-07338-yopenalex-snapshot
Prognostic value of tumoral and peritumoral magnetic resonance parameters in osteosarcoma patients for monitoring chemotherapy response
inferred← citeshttps://doi.org/10.1007/s00432-023-05165-4openalex-snapshot
Association of survivin positive circulating tumor cell levels with immune escape and prognosis of osteosarcoma
inferred← citeshttps://doi.org/10.1007/s00438-023-02010-8openalex-snapshot
DNA methylation patterns suggest the involvement of DNMT3B and TET1 in osteosarcoma development
inferred← citeshttps://doi.org/10.1007/s10555-026-10360-zopenalex-snapshot
Sarcoma metastasis: distinct biological principles beyond the carcinoma paradigm
inferred← citeshttps://doi.org/10.1007/s10637-019-00724-4openalex-snapshot
Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma
inferred← citeshttps://doi.org/10.1007/s11684-022-0919-0openalex-snapshot
Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance in osteosarcoma
inferred← citeshttps://doi.org/10.1007/s12672-024-01301-9openalex-snapshot
A useful mTORC1 signaling-related RiskScore model for the personalized treatment of osteosarcoma patients by using the bulk RNA-seq analysis
inferred← citeshttps://doi.org/10.1007/s12672-025-02920-6openalex-snapshot
Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma
inferred← citeshttps://doi.org/10.1007/s13402-023-00867-wopenalex-snapshot
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
inferred← citeshttps://doi.org/10.1007/s13402-024-00967-1openalex-snapshot
Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma
inferred← citeshttps://doi.org/10.1007/s44164-022-00008-xopenalex-snapshot
Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models
inferred← citeshttps://doi.org/10.1016/b978-0-12-821666-8.00039-6openalex-snapshot
Epigenetic heterogeneity in primary bone cancers
inferred← citeshttps://doi.org/10.1016/b978-0-12-821666-8.00054-2openalex-snapshot
Genomic and proteomic profiling of osteosarcoma
inferred← citeshttps://doi.org/10.1016/b978-0-323-59496-7.00002-5openalex-snapshot
Tumor Biology and Metastasis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2019.04.003openalex-snapshot
The AP-1 transcriptional complex: Local switch or remote command?
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.06.036openalex-snapshot
Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis
inferred← citeshttps://doi.org/10.1016/j.beha.2022.101349openalex-snapshot
Blood coagulation and cancer genes
inferred← citeshttps://doi.org/10.1016/j.bioadv.2026.215070openalex-snapshot
Engineering a tumor-homing ZIF-8 nanoplatform for safe and synergistic immunotherapy of osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122675openalex-snapshot
In situ hydrogel based on Cu–Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis/cuproptosis pathway for chemodynamic therapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122858openalex-snapshot
Ultra-pH-sensitive nanoplatform for precise tumor therapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.216902openalex-snapshot
Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.217302openalex-snapshot
Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.06.007openalex-snapshot
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
inferred← citeshttps://doi.org/10.1016/j.cej.2022.140466openalex-snapshot
Enzyme-induced morphological transformation of self-assembled peptide nanovehicles potentiates intratumoral aggregation and inhibits tumour immunosuppression
inferred← citeshttps://doi.org/10.1016/j.cej.2024.149018openalex-snapshot
Controlled domain gels with a wide stiffness gradient simultaneously promote bone regeneration and suppress tumor recurrence through DAPK activity
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107676openalex-snapshot
Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112560openalex-snapshot
5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.116968openalex-snapshot
Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2024.104575openalex-snapshot
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements
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Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy
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Inhibition of bromodomain and extra-terminal motif (BET) proteins in pediatric sarcoma: A systematic review of in vitro and in vivo studies
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Single-cell RNA sequencing reveals the immune microenvironment landscape of osteosarcoma before and after chemotherapy
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111364openalex-snapshot
Development and validation of neutrophil extracellular traps-derived signature to predict the prognosis for osteosarcoma patients
inferred← citeshttps://doi.org/10.1016/j.jmb.2026.169959openalex-snapshot
Proteome-wide Multi-omics Profiling of Osteosarcoma Transcription Factor Networks
inferred← citeshttps://doi.org/10.1016/j.matdes.2024.112965openalex-snapshot
Oligopeptide modified ICG/Cisplatin@CaCO3 for targeted osteosarcoma NIR-II imaging guided multimodal therapy
inferred← citeshttps://doi.org/10.1016/j.prp.2019.152534openalex-snapshot
KMT2C modulates migration and invasion processes in osteosarcoma cell lines
inferred← citeshttps://doi.org/10.1016/j.taap.2023.116798openalex-snapshot
Vitamin C enhances the sensitivity of osteosarcoma to arsenic trioxide via inhibiting aerobic glycolysis
inferred← citeshttps://doi.org/10.1038/nm.4487openalex-snapshot
Selective enhancer changes in osteosarcoma lung metastasis
inferred← citeshttps://doi.org/10.1038/nm0418-525copenalex-snapshot
Correction: Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
inferred← citeshttps://doi.org/10.1038/s41380-022-01477-yopenalex-snapshot
Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose
inferred← citeshttps://doi.org/10.1038/s41416-020-01127-6openalex-snapshot
Genomic control of metastasis
inferred← citeshttps://doi.org/10.1038/s41419-023-05966-yopenalex-snapshot
Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma
inferred← citeshttps://doi.org/10.1038/s41420-024-01875-xopenalex-snapshot
POLE2 promotes osteosarcoma progression by enhancing the stability of CD44
inferred← citeshttps://doi.org/10.1038/s41467-019-09676-yopenalex-snapshot
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
inferred← citeshttps://doi.org/10.1038/s41467-022-33377-8openalex-snapshot
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
inferred← citeshttps://doi.org/10.1038/s41467-023-42656-xopenalex-snapshot
Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis
inferred← citeshttps://doi.org/10.1038/s41467-024-46524-0openalex-snapshot
Oncogenic enhancers prime quiescent metastatic cells to escape NK immune surveillance by eliciting transcriptional memory
inferred← citeshttps://doi.org/10.1038/s41467-025-60329-9openalex-snapshot
SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
inferred← citeshttps://doi.org/10.1038/s41467-025-61558-8openalex-snapshot
Aberrant EZHIP expression drives tumorigenesis in osteosarcoma
inferred← citeshttps://doi.org/10.1038/s41571-021-00519-8openalex-snapshot
Advancing therapy for osteosarcoma
inferred← citeshttps://doi.org/10.1038/s41572-022-00409-yopenalex-snapshot
Osteosarcoma
inferred← citeshttps://doi.org/10.1038/s41588-020-00738-2openalex-snapshot
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
inferred← citeshttps://doi.org/10.1038/s41588-020-0664-8openalex-snapshot
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
inferred← citeshttps://doi.org/10.1038/s41598-023-33009-1openalex-snapshot
Integrative analyses of ferroptosis and immune related biomarkers and the osteosarcoma associated mechanisms
inferred← citeshttps://doi.org/10.1038/s41598-023-47412-1openalex-snapshot
Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
inferred← citeshttps://doi.org/10.1038/s42003-022-03117-1openalex-snapshot
Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma
inferred← citeshttps://doi.org/10.1038/s43018-021-00316-3openalex-snapshot
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes
inferred← citeshttps://doi.org/10.1039/d0bm00898bopenalex-snapshot
Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway
inferred← citeshttps://doi.org/10.1042/bcj20210084openalex-snapshot
The roles of epigenetics in cancer progression and metastasis
inferred← citeshttps://doi.org/10.1055/s-0039-1687891openalex-snapshot
Oncogenes and Clotting Factors: The Emerging Role of Tumor Cell Genome and Epigenome in Cancer-Associated Thrombosis
inferred← citeshttps://doi.org/10.1079/9781789245820.0005openalex-snapshot
Antimetastatic Therapy
inferred← citeshttps://doi.org/10.1079/9781789245820.0010openalex-snapshot
Epigenetic Targeting of Cancer
inferred← citeshttps://doi.org/10.1097/bto.0000000000000408openalex-snapshot
Cancer Stem Cells and Osteosarcoma: Opportunities and Limitations
inferred← citeshttps://doi.org/10.1101/2021.06.15.447736openalex-snapshot
Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid dependence
inferred← citeshttps://doi.org/10.1101/2021.10.31.466636openalex-snapshot
Air plasma-activated medium exerts tumor-specific cytotoxicity via the oxidative stress-induced perinuclear mitochondrial clustering
inferred← citeshttps://doi.org/10.1101/2022.01.31.478548openalex-snapshot
HOXD13 is a direct EWS-FLI1 target and moderates fusion-dependent transcriptional states
inferred← citeshttps://doi.org/10.1101/2025.01.24.633933openalex-snapshot
Metastatic cell plasticity is maintained by SOX9 function during mitosis in breast cancer
inferred← citeshttps://doi.org/10.1101/cshperspect.a040956openalex-snapshot
Chromatin Mechanisms Driving Cancer
inferred← citeshttps://doi.org/10.1111/bph.14999openalex-snapshot
Bone sarcomas in the immunotherapy era
inferred← citeshttps://doi.org/10.1111/brv.12562openalex-snapshot
The genetic script of metastasis
inferred← citeshttps://doi.org/10.1111/sji.12741openalex-snapshot
Treating osteosarcoma with CAR T cells
inferred← citeshttps://doi.org/10.1111/vco.12927openalex-snapshot
Patterns of metastatic progression and association with clinical outcomes in canine osteosarcoma: A necropsy study of 83 dogs
inferred← citeshttps://doi.org/10.1126/sciadv.abq3951openalex-snapshot
ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis
inferred← citeshttps://doi.org/10.1126/sciadv.aeb4348openalex-snapshot
Genome-wide screenings identify BAP1 as a synthetic-lethality target with CDK4/6 inhibitors
inferred← citeshttps://doi.org/10.1126/science.abh1645openalex-snapshot
Mapping genomic and epigenomic evolution in cancer ecosystems
inferred← citeshttps://doi.org/10.1136/esmoopen-2019-000635openalex-snapshot
223-Radium for metastatic osteosarcoma: combination therapy with other agents and external beam radiotherapy
inferred← citeshttps://doi.org/10.1136/jitc-2025-012591openalex-snapshot
Etoposide activates CD8 + T cell anti-tumor immunity in osteosarcoma through MHC I upregulation via tumor-secreted IL-33 mediated signaling
inferred← citeshttps://doi.org/10.1142/s0192415x21500956openalex-snapshot
11-O-Galloyl Bergenin from Corylopsis coreanas Leaves Induces Autophagy and Apoptosis in Human Osteosarcoma
inferred← citeshttps://doi.org/10.1155/2022/6103649openalex-snapshot
Mechanism of Antibacterial Enhancement and Drug Resistance Based on Smart Medical Imaging on Antibiotics
inferred← citeshttps://doi.org/10.1158/0008-5472.can-21-1191openalex-snapshot
Recent Advances in Pediatric Cancer Research
inferred← citeshttps://doi.org/10.1158/1078-0432.25232540openalex-snapshot
Figure S1-S14, Table S1-S2 & S4-S6 from Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
inferred← citeshttps://doi.org/10.1158/1078-0432.25232540.v1openalex-snapshot
Figure S1-S14, Table S1-S2 & S4-S6 from Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
inferred← citeshttps://doi.org/10.1158/1078-0432.c.7077821openalex-snapshot
Data from Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
inferred← citeshttps://doi.org/10.1158/1078-0432.c.7077821.v1openalex-snapshot
Data from Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-18-1222openalex-snapshot
Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-22-0384openalex-snapshot
EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-23-0873openalex-snapshot
Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-24-1317openalex-snapshot
Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-24-1027openalex-snapshot
Therapeutic Targeting of BET Proteins in Sarcoma
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-23-0055openalex-snapshot
Intrinsic Epigenetic State of Primary Osteosarcoma Drives Metastasis
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-17-1211openalex-snapshot
NF-κB–Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis
inferred← citeshttps://doi.org/10.1172/jci127718openalex-snapshot
Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma
inferred← citeshttps://doi.org/10.1177/15230864251394744openalex-snapshot
Polypeptide Nanomicrospheres Delivering Dexmedetomidine Mitigate Intestinal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammation
inferred← citeshttps://doi.org/10.1177/1758835920937891openalex-snapshot
Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
inferred← citeshttps://doi.org/10.11817/j.issn.1672-7347.2025.240628openalex-snapshot
Application and mechanisms of targeting BRD4 in osteosarcoma.
inferred← citeshttps://doi.org/10.1186/s12920-020-0695-0openalex-snapshot
Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain
inferred← citeshttps://doi.org/10.1186/s12943-019-1070-7openalex-snapshot
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
inferred← citeshttps://doi.org/10.1186/s13072-023-00502-wopenalex-snapshot
Etiology of super-enhancer reprogramming and activation in cancer
inferred← citeshttps://doi.org/10.1186/s13148-019-0690-5openalex-snapshot
ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells
inferred← citeshttps://doi.org/10.1186/s43046-025-00269-zopenalex-snapshot
Upregulated ATG4B predicts poor prognosis and correlates with angiogenesis in osteosarcoma
inferred← citeshttps://doi.org/10.1200/edbk_390306openalex-snapshot
Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas
inferred← citeshttps://doi.org/10.1200/jco.23.02717openalex-snapshot
Pediatric Leukemia Roadmaps Are a Guide for Positive Metastatic Bone Sarcoma Trials
inferred← citeshttps://doi.org/10.1200/jop.18.00684openalex-snapshot
Sarcoma as a Model for Adolescent and Young Adult Care
inferred← citeshttps://doi.org/10.15252/embr.201948375openalex-snapshot
Class I HDAC inhibitors enhance YB‐1 acetylation and oxidative stress to block sarcoma metastasis
inferred← citeshttps://doi.org/10.20517/cdr.2021.130openalex-snapshot
Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1088745/v1openalex-snapshot
RPL34 regulates osteosarcoma cells proliferation through c-Myc/RPL34 signaling axis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-117697/v1openalex-snapshot
CXCR4 Blockade Enhances The Sensitivity Of Osteosarcoma To Doxorubicin By Inducing Autophagic Cell Death Via PI3K-Akt-Mtor Pathway Inhibition
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2709282/v1openalex-snapshot
Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
inferred← citeshttps://doi.org/10.2147/ott.s251843openalex-snapshot
lncRNA LSINCT5 Regulates miR-20a-5p/XIAP to Inhibit the Growth and Metastasis of Osteosarcoma Cells
inferred← citeshttps://doi.org/10.3233/thc-213163openalex-snapshot
Identification of hub genes specific to pulmonary metastasis in osteosarcoma through integrated bioinformatics analysis
inferred← citeshttps://doi.org/10.3389/fcell.2020.00534openalex-snapshot
Functions and Clinical Significance of Super-Enhancers in Bone-Related Diseases
inferred← citeshttps://doi.org/10.3389/fgene.2025.1603687openalex-snapshot
Machine learning tools for deciphering the regulatory logic of enhancers in health and disease
inferred← citeshttps://doi.org/10.3389/fonc.2020.00013openalex-snapshot
Understanding and Modeling Metastasis Biology to Improve Therapeutic Strategies for Combating Osteosarcoma Progression
inferred← citeshttps://doi.org/10.3389/fonc.2021.593127openalex-snapshot
Combined Anticancer Effect of Plasma-Activated Infusion and Salinomycin by Targeting Autophagy and Mitochondrial Morphology
inferred← citeshttps://doi.org/10.3389/fonc.2021.645757openalex-snapshot
NSG Mice Facilitate ex vivo Characterization of Ewing Sarcoma Lung Metastasis Using the PuMA Model
inferred← citeshttps://doi.org/10.3389/fonc.2023.1111570openalex-snapshot
Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma
inferred← citeshttps://doi.org/10.3389/fonc.2023.1114461openalex-snapshot
Histone methyltransferase SETD2: An epigenetic driver in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2023.1188641openalex-snapshot
Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition
inferred← citeshttps://doi.org/10.3389/fphar.2021.679610openalex-snapshot
Light-Responsive Micelles Loaded With Doxorubicin for Osteosarcoma Suppression
inferred← citeshttps://doi.org/10.3390/biom16060778openalex-snapshot
AP1 Transcription Factor in the Regulation of the Urokinase Plasminogen Activation System
inferred← citeshttps://doi.org/10.3390/cancers12113097openalex-snapshot
Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis
inferred← citeshttps://doi.org/10.3390/cancers12113457openalex-snapshot
Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model
inferred← citeshttps://doi.org/10.3390/cancers13164199openalex-snapshot
Selective Targeting of Class I Histone Deacetylases in a Model of Human Osteosarcoma
inferred← citeshttps://doi.org/10.3390/cancers13194969openalex-snapshot
An Epigenetic Perspective on Intra-Tumour Heterogeneity: Novel Insights and New Challenges from Multiple Fields
inferred← citeshttps://doi.org/10.3390/cancers13205201openalex-snapshot
No Need to Stick Together to Be Connected: Multiple Types of Enhancers’ Networking
inferred← citeshttps://doi.org/10.3390/cells11213507openalex-snapshot
Current Status and Prospects of Targeted Therapy for Osteosarcoma
inferred← citeshttps://doi.org/10.3390/cells9112470openalex-snapshot
The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion
inferred← citeshttps://doi.org/10.3390/epigenomes2020008openalex-snapshot
Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer
inferred← citeshttps://doi.org/10.3390/ijms23031124openalex-snapshot
Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering
inferred← citeshttps://doi.org/10.3390/ijms241310463openalex-snapshot
Analysis of the Mutational Landscape of Osteosarcomas Identifies Genes Related to Metastasis and Prognosis and Disrupted Biological Pathways of Immune Response and Bone Development
inferred← citeshttps://doi.org/10.3390/ijms26041435openalex-snapshot
The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma
inferred← citeshttps://doi.org/10.3390/molecules27134108openalex-snapshot
Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.3410/f.736286746.793579340openalex-snapshot
Faculty Opinions recommendation of Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.
inferred← citeshttps://doi.org/10.3791/56332openalex-snapshot
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
inferred← citeshttps://doi.org/10.3791/56332-vopenalex-snapshot
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
inferred← citeshttps://doi.org/10.3892/etm.2021.9883openalex-snapshot
Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway
inferred← citeshttps://doi.org/10.3892/ijo.2019.4902openalex-snapshot
Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma
inferred← citeshttps://doi.org/10.3892/ijo.2021.5229openalex-snapshot
CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K‑Akt‑mTOR pathway inhibition
inferred← citeshttps://doi.org/10.53846/goediss-7561openalex-snapshot
The Role of ARID1A in Oncogenic Transcriptional (de)Regulation in Colorectal Cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.9859889openalex-snapshot
Additional file 1 of Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.9859892openalex-snapshot
Additional file 2 of Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.9859898openalex-snapshot
Additional file 3 of Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
inferred← citeshttps://doi.org/10.70675/1bd7b472z0fd4z4857z9077z81723aea4b86openalex-snapshot
Fra-1 transcriptional mechanisms in Triple Negative Breast Cancer
inferred← citeshttps://doi.org/10.7150/ijms.43506openalex-snapshot
Confocal Raman Spectral Imaging Study of DAPT, a γ-secretase Inhibitor, Induced Physiological and Biochemical Reponses in Osteosarcoma Cells
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